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  1. Book ; Thesis: Identifizierung und Charakterisierung stationärphaseinduzierter Gene von Lactococcus lactis

    Menzel, Matthias

    1999  

    Author's details von Matthias Menzel
    Language German
    Size 117 Bl. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1999
    Remark Abt. Nussallee/Bereichsbibl. ZBMed: AY 20089
    HBZ-ID HT011153050
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    994/1726 available for loan (reading room) Freihandmagazin (U1)

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  2. Book ; Thesis: Anwendung der kontinuierlichen Blutgasanalyse und der Temperaturmessung im Hirngewebe sowie in zerebrovenösen Blut nach neuronaler Schädigung

    Menzel, Matthias

    experimentelle und klinische Untersuchungen zu einem multimodalen Überwachungskonzept

    1999  

    Author's details von Matthias Menzel
    Language German
    Size 160 S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Halle, Univ., Habil.-Schr., 1999
    HBZ-ID HT013084619
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 E 2150 order to use in reading room Magazin

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  3. Book ; Thesis: Strahlenexposition pädiatrischer Patienten bei computertomographischen Untersuchungen

    Menzel, Matthias

    eine Feldstudie

    1996  

    Author's details vorgelegt von Matthias Menzel
    Language German
    Size 81 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Würzburg, Univ., Diss., 1996
    HBZ-ID HT007481229
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    97 D 1082 order for loan Magazin

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  4. Article ; Online: Is Protein BLAST a thing of the past?

    Al-Fatlawi, Ali / Menzel, Martin / Schroeder, Michael

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 8195

    MeSH term(s) Proteins/genetics ; Databases, Protein
    Chemical Substances Proteins
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44082-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molekulare Tumordiagnostik als Triebfeder der Präzisionsonkologie.

    Kazdal, Daniel / Menzel, Michael / Budczies, Jan / Stenzinger, Albrecht

    Deutsche medizinische Wochenschrift (1946)

    2023  Volume 148, Issue 18, Page(s) 1157–1165

    Abstract: Molecular pathological diagnostics plays a central role in personalized oncology and requires multidisciplinary teamwork. It is just as relevant for the individual patient who is being treated with an approved therapy method or an individual treatment ... ...

    Title translation Molecular tumor diagnostics as the driving force behind precision oncology.
    Abstract Molecular pathological diagnostics plays a central role in personalized oncology and requires multidisciplinary teamwork. It is just as relevant for the individual patient who is being treated with an approved therapy method or an individual treatment attempt as it is for prospective clinical studies that require the identification of specific therapeutic target structures or complex biomarkers for study inclusion. It is also of crucial importance for the generation of real-world data, which is becoming increasingly important for drug development. Future developments will be significantly shaped by improvements in scalable molecular diagnostics, in which increasingly complex and multi-layered data sets must be quickly converted into clinically useful information. One focus will be on the development of adaptive diagnostic strategies in order to be able to depict the enormous plasticity of a cancer disease over time.
    MeSH term(s) Humans ; Medical Oncology/methods ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Pathology, Molecular/methods ; Precision Medicine/methods ; Prospective Studies
    Language German
    Publishing date 2023-09-01
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1937-0347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Erratum: Molekulare Tumordiagnostik als Triebfeder der Präzisionsonkologie.

    Kazdal, Daniel / Menzel, Michael / Budczies, Jan / Stenzinger, Albrecht

    Deutsche medizinische Wochenschrift (1946)

    2023  Volume 148, Issue 18, Page(s) e111

    Title translation Correction: Molecular tumor diagnostics as the driving force behind precision oncology.
    Language German
    Publishing date 2023-10-09
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-2183-5845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Experimental investigation of drag loss behavior of dip-lubricated wet clutches for building a data-driven prediction model.

    Pointner-Gabriel, Lukas / Menzel, Max / Voelkel, Katharina / Schneider, Thomas / Stahl, Karsten

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9241

    Abstract: Fundamental knowledge of wet clutches' drag loss behavior is essential for designing low-loss clutch systems. In contrast to the widely investigated injection lubrication, more comprehensive knowledge is needed on the drag loss behavior of dip-lubricated ...

    Abstract Fundamental knowledge of wet clutches' drag loss behavior is essential for designing low-loss clutch systems. In contrast to the widely investigated injection lubrication, more comprehensive knowledge is needed on the drag loss behavior of dip-lubricated wet clutches. In the development phase, data-driven models allow drag loss predictions with low computational effort and, at the same time, sufficient accuracy. Therefore, this study aimed to deepen and expand knowledge of the drag loss behavior of dip-lubricated wet clutches based on experimental investigations. Moreover, the investigations were designed and conducted so that the generated data and findings can be used in further research for building data-driven prediction models. The investigations were conducted on two clutch systems from automotive and industrial applications. The practice-relevant parameters of clearance, oil level, oil viscosity, and plate shape were investigated based on a mixed-level full factorial design. The evaluation shows that a reduction in drag loss can be achieved primarily by increasing the clearance, reducing the oil viscosity, and choosing waved plates. The obtained drag loss behavior can be traced back to the form of oil displacement from the gaps. The displacement process, in turn, is influenced by the operating and geometry parameters. Although the flow in the gaps develops differently for dip and injection lubrication over differential speed, the study shows comparable integral effects of the influencing parameters for both types of lubrication. The generated datasets contain the investigated parameters as features and characteristic drag loss values as targets. The findings can support the selection and configuration of the machine learning algorithm and the validation of the trained models. The described procedure can serve as a template for generating and analyzing datasets for data-driven modeling of wet clutches' drag losses.
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59488-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Nano-CT characterization of dentinal tubule occlusion in SDF-treated dentin.

    Menzel, Matthias / Kiesow, Andreas / de Souza E Silva, Juliana Martins

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 15895

    Abstract: Dentin hypersensitivity is an oral health concern affecting a large percentage of the world's adult population. Occlusion of the exposed dentinal tubules is among the treatment options available, and silver diammine fluoride (SDF) is an occluding agent ... ...

    Abstract Dentin hypersensitivity is an oral health concern affecting a large percentage of the world's adult population. Occlusion of the exposed dentinal tubules is among the treatment options available, and silver diammine fluoride (SDF) is an occluding agent used for interrupting or dampening the stimulus of the dental pulp nerves that produce pain. In addition to dentin permeability testing, the evaluation of desensitizing agents occluding dentinal tubules strongly relies on microscopic techniques, such as scanning electron microscopy (SEM). Limitations of SEM are that it provides only surface images that lack detailed information on the depth of penetration and amount of material present within the treated specimen, and it is prone to sample preparation artifacts. Here, we present high-resolution X-ray computed tomography (nano-CT) as a potential method for investigating dentin specimens with occluded tubules. We studied human dentin treated with SDF as an exemplary dentinal occlusion treatment option. We evaluated the silver deposits formed on the dentin surface region near the dentinal tubules and in the tubular regions using cross-section SEM, Energy Dispersive X-ray (EDX) analysis, and nano-CT. The resulting images obtained by SEM and nano-CT had comparable resolutions, and both techniques produced images of the tubules' occlusion. Nano-CT provided three-dimensional images adequate to quantitate tubule size and orientation in space. Moreover, it enabled clear visualization of dentinal tubules in any virtual plane and estimation of the amount and depth of occluding material. Thus, nano-CT has the potential to be a valuable technique for evaluating the occluding effects of virtually any material applied to dentinal tubules, supporting deciding between the best occluding treatment options.
    MeSH term(s) Adult ; Humans ; Tomography, X-Ray Computed ; Artifacts ; Microscopy, Electron, Scanning ; Dentin/diagnostic imaging
    Chemical Substances silver diamine fluoride (DDU19UEV1Y)
    Language English
    Publishing date 2023-09-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-42805-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endoscopic measurement of hiatal hernias: is it reliable and does it have a clinical impact? Results from a large prospective database.

    Adarkwah, Charles Christian / Hirsch, Oliver / Menzel, Merlissa / Labenz, Joachim

    Postgraduate medicine

    2023  Volume 135, Issue 6, Page(s) 615–622

    Abstract: Objectives: The aim of our study was to compare the results of endoscopy and manometry with regard to the presence and longitudinal size of hiatal hernias using a cohort of patients with PPI-refractory reflux symptoms. In addition, we aimed to ... ...

    Abstract Objectives: The aim of our study was to compare the results of endoscopy and manometry with regard to the presence and longitudinal size of hiatal hernias using a cohort of patients with PPI-refractory reflux symptoms. In addition, we aimed to investigate the clinical relevance of hiatal hernias and their size in relation to the occurrence of GERD.
    Methods: Five hundred patients with suspected GERD due to typical reflux symptoms (heartburn and regurgitation) and inadequate response to PPI therapy underwent standardized screening at a reflux center. After 2 weeks of PPI withdrawal, all patients underwent endoscopy, 24-h pH impedance measurement, and high-resolution manometry (HRM). Both endoscopy and HRM results were available for 487 patients.
    Results: There was a high correlation between the endoscopic and manometric measured longitudinal size of hernias (rho = .768 (
    Conclusion: In summary, endoscopically and manometrically measured hiatal hernia size are highly significantly correlated. Patients with refractory reflux symptoms and a hernia size of 4 cm are very likely to have GERD. In the future, this finding could greatly simplify the diagnosis of GERD.
    MeSH term(s) Humans ; Hernia, Hiatal/diagnosis ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/drug therapy ; Endoscopy, Gastrointestinal ; Manometry/methods
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.2023.2239135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.407: Show issues Location:
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  10. Book ; Thesis: Pathohistologische und Immunhistochemische (Glut-1) Charakterisierung von Mammakarzinomen im Vergleich zu in vivo Stoffwechseluntersuchungen mit der Positronen-Emissions-Tomographie und F-18-Deoxyglukose

    Menzel, Manuela

    2000  

    Author's details Manuela Menzel
    Language German
    Size 95 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Techn. Univ., Diss., 2000
    HBZ-ID HT012923099
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 D 274 order for loan Magazin

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