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Article ; Online: What is the future of illicit drug profiling in Switzerland? Condemned to disappear or forgotten treasure.

Meola, Susanna / Esseiva, Pierre

2021 Volume 14, Issue 3, Page(s) 411–415

Abstract: Illicit drug profiling bears a long history. Developments in the field from mid-90s have led to several international profiling programs. Several countries have put their efforts to develop and implement the routine use of illicit drug profiling in the ... ...

Abstract	Illicit drug profiling bears a long history. Developments in the field from mid-90s have led to several international profiling programs. Several countries have put their efforts to develop and implement the routine use of illicit drug profiling in the investigation and prosecution of illicit drug-related crimes. For more than 20 years, the School of Criminal Sciences (ESC) at the University of Lausanne has, through its illicit drug expertise laboratory, played a main role in promoting the use of illicit drug profiling. In Switzerland, there is no national illicit drug profiling practice and the ESC laboratory is the only one offering such service. However, only a limited number of Swiss jurisdictions send regularly all or part of their seized specimens for analysis to the ESC laboratory. Profiling results are furnished to investigators and prosecutors regardless if they have been requested or not and are stored in a database with limited contextual information with no further data treatment. In 2020, the interruption of a project intended to develop and implement an intercantonal database gathering traditional police data, forensic data (e.g., DNA, fingerprints, etc.), and physical and chemical links, to produce intelligence and support investigation, led to the fundamental question: Is illicit drug profiling in Switzerland condemned to disappear or is it a forgotten treasure, a neglected approach that deserves to be revalued? This paper reports the Swiss situation regarding illicit drug profiling practices and discusses some factors that are thought to impact its use in day-to-day work.
MeSH term(s)	Crime ; Illicit Drugs ; Laboratories ; Switzerland
Chemical Substances	Illicit Drugs
Language	English
Publishing date	2021-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2462336-2
ISSN	1942-7611 ; 1942-7603
ISSN (online)	1942-7611
ISSN	1942-7603
DOI	10.1002/dta.3167
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Article: Bronchogenic cyst with concurrent chronic suppurative bronchopneumonia in a 10-year-old German shepherd dog.

Burgers, Elisabeth M / Copple, Christina / Allen, Larie / Meola, Stacy / Corsi, Raffaella

The Canadian veterinary journal = La revue veterinaire canadienne

2022 Volume 64, Issue 10, Page(s) 923–929

Abstract: A 10-year-old spayed female German shepherd dog was transferred for acute respiratory distress and a bulla-like pulmonary lesion identified on referral radiographs. Computed tomography (CT) imaging identified a bronchiole from a dilated left cranial ... ...

Abstract	A 10-year-old spayed female German shepherd dog was transferred for acute respiratory distress and a bulla-like pulmonary lesion identified on referral radiographs. Computed tomography (CT) imaging identified a bronchiole from a dilated left cranial lobar bronchus terminating into a partially fluid-filled, cyst-like pulmonary lesion and surrounding multilobar pulmonary hyperattenuation. After failure of medical management, a left cranial lung lobectomy was done. Histopathology was consistent with a bronchogenic cyst and chronic, suppurative bronchopneumonia of the remaining parenchyma. Bronchogenic cysts with concurrent bronchopneumonia should be considered in older German shepherd dogs with acute respiratory distress that fail medical management. Key clinical message: Canine bronchogenic cyst is an uncommon condition that previously has only been reported in younger German shepherd dogs. This case highlights the importance of considering this condition in a senior German shepherd dog with no prior respiratory history, as well as the difficulty of medical management with concurrent bronchopneumonia.
MeSH term(s)	Dogs ; Animals ; Female ; Bronchogenic Cyst/veterinary ; Bronchopneumonia/diagnosis ; Bronchopneumonia/veterinary ; Dog Diseases/surgery ; Dog Diseases/pathology ; Lung/pathology ; Respiratory Distress Syndrome/veterinary
Language	English
Publishing date	2022-05-17
Publishing country	Canada
Document type	Case Reports
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
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Article ; Online: Letters to the editor.

Meola, Stacy

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

2009 Volume 19, Issue 4, Page(s) 310

MeSH term(s)	Animals ; Dog Diseases/therapy ; Respiratory Aspiration/veterinary
Language	English
Publishing date	2009-08
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	2077212-9
ISSN	1476-4431 ; 1479-3261
ISSN (online)	1476-4431
ISSN	1479-3261
DOI	10.1111/j.1476-4431.2009.00443_1.x
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Article: Illicit drug profiling practices in Finland: An exploratory study about end users’ perceptions

Meola, Susanna / Huhtala, Sami / Broséus, Julian / Jendly, Manon / Jalava, Kaisa / Aalberg, Laura / Esseiva, Pierre

Forensic science international. 2021 July, v. 324

2021

Abstract: Illicit drug profiling (i.e. chemical and/or physical profiling) to compare and relate illicit drugs samples has been actively used in routine case work at the National Bureau of Investigation (NBI) in Finland. This preliminary and exploratory work ... ...

Abstract	Illicit drug profiling (i.e. chemical and/or physical profiling) to compare and relate illicit drugs samples has been actively used in routine case work at the National Bureau of Investigation (NBI) in Finland. This preliminary and exploratory work reviews NBI’s illicit drug profiling practices. Particular emphasis is put on communication of forensic results and how the NBI has promoted the use of forensic data in an intelligence perspective by establishing a case coordination service. Moreover, our study evaluates the comprehension, integration and usefulness of illicit drug profiling from end users’ point of view by means of an online survey and face-to-face interviews. Findings are compared with theoretical aspects as described in literature. Results show that in the Finnish context illicit drug profiling is used and useful in the investigation and in court. From end users’ perspective, real practical relevance relies in its use as intelligence during the investigation. However, to be truly useful, illicit drug profiling results must be communicated promptly during the investigation, with sufficient clarity and interpreted correctly by end users. Factors influencing the integration of illicit drug profiling in the forensic process are addressed.
Keywords	forensic sciences ; illicit drugs ; surveys ; Finland
Language	English
Dates of publication	2021-07
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2021.110848
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Epidermolysis bullosa: a new technique for mask ventilation.

Meola, Salvatore

Paediatric anaesthesia

2008 Volume 18, Issue 11, Page(s) 1109–1111

MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Epidermolysis Bullosa/surgery ; Equipment Design ; Female ; Humans ; Male ; Masks ; Middle Aged ; Respiration, Artificial/instrumentation ; Respiration, Artificial/methods
Language	English
Publishing date	2008-11
Publishing country	France
Document type	Letter
ZDB-ID	1086049-6
ISSN	1460-9592 ; 1155-5645
ISSN (online)	1460-9592
ISSN	1155-5645
DOI	10.1111/j.1460-9592.2008.02594.x
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Article ; Online: Illicit drug profiling practices in Finland: An exploratory study about end users' perceptions.

Meola, Susanna / Huhtala, Sami / Broséus, Julian / Jendly, Manon / Jalava, Kaisa / Aalberg, Laura / Esseiva, Pierre

Forensic science international

2021 Volume 324, Page(s) 110848

Abstract	Illicit drug profiling (i.e. chemical and/or physical profiling) to compare and relate illicit drugs samples has been actively used in routine case work at the National Bureau of Investigation (NBI) in Finland. This preliminary and exploratory work reviews NBI's illicit drug profiling practices. Particular emphasis is put on communication of forensic results and how the NBI has promoted the use of forensic data in an intelligence perspective by establishing a case coordination service. Moreover, our study evaluates the comprehension, integration and usefulness of illicit drug profiling from end users' point of view by means of an online survey and face-to-face interviews. Findings are compared with theoretical aspects as described in literature. Results show that in the Finnish context illicit drug profiling is used and useful in the investigation and in court. From end users' perspective, real practical relevance relies in its use as intelligence during the investigation. However, to be truly useful, illicit drug profiling results must be communicated promptly during the investigation, with sufficient clarity and interpreted correctly by end users. Factors influencing the integration of illicit drug profiling in the forensic process are addressed.
MeSH term(s)	Drug Trafficking ; Finland ; Forensic Toxicology ; Humans ; Illicit Drugs/chemistry ; Law Enforcement
Chemical Substances	Illicit Drugs
Language	English
Publishing date	2021-05-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2021.110848
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Article ; Online: Prenatal diagnosis of HNF1b mutation allows recognition of neonatal dysglycemia.

Iafusco, Fernanda / Meola, Serena / Pecoraro, Carmine / Mazzaccara, Cristina / Iafusco, Dario / Tinto, Nadia

Acta diabetologica

2020 Volume 58, Issue 3, Page(s) 393–395

Language	English
Publishing date	2020-12-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-020-01641-2
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Article ; Online: Anesthetic management for right upper extremity amputation due to recidivous cutaneous carcinoma and acute postoperative pain control in patients affected by epidermolysis bullosa.

Meola, S / Olivieri, M / Mirabile, C / Mastrandrea, P

Minerva anestesiologica

2010 Volume 76, Issue 2, Page(s) 144–147

Abstract: A 22-year-old male who was affected by epidermolysis bullosa (EB) and xeroderma pigmentosa (with structural and pathological changes that preclude orotracheal intubation) underwent right upper extremity amputation and ipsilateral axillary lymphadenectomy. ...

Abstract	A 22-year-old male who was affected by epidermolysis bullosa (EB) and xeroderma pigmentosa (with structural and pathological changes that preclude orotracheal intubation) underwent right upper extremity amputation and ipsilateral axillary lymphadenectomy. The patient was operated without intubation, thereby assuring an optimal state of acute postoperative pain control by regional anesthesia. Intravenous administration of ketamine and remifentanil plus low-dose sevoflurane resulted in anesthesia with spontaneous breathing by the patient. Moreover, the intraoperative brachial plexus nerve block before amputation followed by positioning of an epidural catheter to deliver continuous infusion of local anesthetics close to the cut nerves during surgery obtained a very good level of acute postoperative pain control.
MeSH term(s)	Amputation/methods ; Anesthesia ; Anesthesia, Epidural ; Anesthetics, Local/therapeutic use ; Brachial Plexus/physiology ; Epidermolysis Bullosa/complications ; Epidermolysis Bullosa/physiopathology ; Humans ; Male ; Monitoring, Intraoperative ; Neoplasm Recurrence, Local ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Skin Neoplasms/complications ; Skin Neoplasms/surgery ; Upper Extremity/surgery ; Young Adult
Chemical Substances	Anesthetics, Local
Language	English
Publishing date	2010-02
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
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Article ; Online: Immune profiling of SARS-CoV-2 epitopes in asymptomatic and symptomatic pediatric and adult patients.

Tornesello, Anna Lucia / Botti, Chiara / Micillo, Alberto / Labonia, Francesco / Arpino, Sergio / Isgrò, Maria Antonietta / Meola, Serena / Russo, Luigi / Cavalcanti, Ernesta / Sale, Silvia / Nicastro, Carmine / Atripaldi, Luigi / Starita, Noemy / Cerasuolo, Andrea / Reimer, Ulf / Holenya, Pavlo / Buonaguro, Luigi / Buonaguro, Franco M / Tornesello, Maria Lina

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 123

Abstract: Background: The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has unpredictable manifestations of coronavirus disease (COVID-19) and variable clinical course with some patients being asymptomatic whereas others experiencing ...

Abstract	Background: The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has unpredictable manifestations of coronavirus disease (COVID-19) and variable clinical course with some patients being asymptomatic whereas others experiencing severe respiratory distress, or even death. We aimed to evaluate the immunoglobulin G (IgG) response towards linear peptides on a peptide array containing sequences from SARS-CoV-2, Middle East respiratory syndrome-related coronavirus (MERS) and common-cold coronaviruses 229E, OC43, NL63 and HKU1 antigens, in order to identify immunological indicators of disease outcome in SARS-CoV-2 infected patients. Methods: We included in the study 79 subjects, comprising 19 pediatric and 30 adult SARS-CoV-2 infected patients with increasing disease severity, from mild to critical illness, and 30 uninfected subjects who were vaccinated with one dose of SARS-CoV-2 spike mRNA BNT162b2 vaccine. Serum samples were analyzed by a peptide microarray containing 5828 overlapping 15-mer synthetic peptides corresponding to the full SARS-CoV-2 proteome and selected linear epitopes of spike (S), envelope (E) and membrane (M) glycoproteins as well as nucleoprotein (N) of MERS, SARS and coronaviruses 229E, OC43, NL63 and HKU1 (isolates 1, 2 and 5). Results: All patients exhibited high IgG reactivity against the central region and C-terminus peptides of both SARS-CoV-2 N and S proteins. Setting the threshold value for serum reactivity above 25,000 units, 100% and 81% of patients with severe disease, 36% and 29% of subjects with mild symptoms, and 8% and 17% of children younger than 8-years reacted against N and S proteins, respectively. Overall, the total number of peptides in the SARS-CoV-2 proteome targeted by serum samples was much higher in children compared to adults. Notably, we revealed a differential antibody response to SARS-CoV-2 peptides of M protein between adults, mainly reacting against the C-terminus epitopes, and children, who were highly responsive to the N-terminus of M protein. In addition, IgG signals against NS7B, NS8 and ORF10 peptides were found elevated mainly among adults with mild (63%) symptoms. Antibodies towards S and N proteins of other coronaviruses (MERS, 229E, OC43, NL63 and HKU1) were detected in all groups without a significant correlation with SARS-CoV-2 antibody levels. Conclusions: Overall, our results showed that antibodies elicited by specific linear epitopes of SARS-CoV-2 proteome are age dependent and related to COVID-19 clinical severity. Cross-reaction of antibodies to epitopes of other human coronaviruses was evident in all patients with distinct profiles between children and adult patients. Several SARS-CoV-2 peptides identified in this study are of particular interest for the development of vaccines and diagnostic tests to predict the clinical outcome of SARS-CoV-2 infection.
MeSH term(s)	Adult ; Child ; Humans ; Antibodies, Viral ; BNT162 Vaccine ; Coronavirus 229E, Human ; COVID-19/immunology ; Epitopes ; Immunoglobulin G ; Middle East Respiratory Syndrome Coronavirus ; Proteome ; SARS-CoV-2
Chemical Substances	Antibodies, Viral ; BNT162 Vaccine ; Epitopes ; Immunoglobulin G ; Proteome
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-03963-5
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Article ; Online: Regional caudal blockade in a pediatric patient affected by the Joubert syndrome.

Galante, D / Meola, S / Cinnella, G / Dambrosio, M

Acta anaesthesiologica Scandinavica

2009 Volume 53, Issue 5, Page(s) 693–694

MeSH term(s)	Anesthesia, Caudal ; Apnea/complications ; Apnea/physiopathology ; Cerebellar Ataxia/complications ; Cerebellar Ataxia/congenital ; Developmental Disabilities/complications ; Digestive System Surgical Procedures ; Hernia, Inguinal/surgery ; Humans ; Infant ; Male ; Nerve Block ; Respiratory Tract Diseases/complications ; Respiratory Tract Diseases/physiopathology ; Syndrome
Language	English
Publishing date	2009-05
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80002-8
ISSN	1399-6576 ; 0001-5172
ISSN (online)	1399-6576
ISSN	0001-5172
DOI	10.1111/j.1399-6576.2009.01931.x
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