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  1. AU="Merani, Shaheed"
  2. AU="Tarver, James E"
  3. AU=Wirestam Lina
  4. AU="Karen Martz"
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  1. Article ; Online: Evaluation of Medicare Reimbursement and Surgical Patterns for Male and Female Colorectal Surgeons.

    Stefanou, Amalia / Sela, Nathalie / Merani, Shaheed / Hoffman, Arika

    The Journal of surgical research

    2023  Volume 293, Page(s) 539–545

    Abstract: Introduction: There are documented differences in salary for male and female surgeons. Understanding the differences in the clinical practice, composition of male and female surgeons may provide a better understanding of reimbursement differences. We ... ...

    Abstract Introduction: There are documented differences in salary for male and female surgeons. Understanding the differences in the clinical practice, composition of male and female surgeons may provide a better understanding of reimbursement differences. We aim to evaluate the differences of Medicare reimbursement for different categories of clinical practice for male and female colorectal surgeons.
    Methods: This retrospective cohort study compared Medicare claims made by male and female board-certified colorectal surgeons from the Medicare Provider Utilization and Payment Data between 2013 and 2017. Medicare claims were categorized by surgeon gender. Submitted claims were evaluated based on the following seven procedure categories: open abdominal surgery, laparoscopic abdominal surgery, anorectal surgery, diagnostic endoscopy, therapeutic endoscopy, and inpatient/outpatient services. The main outcomes were number of charges submitted by clinical activity category and procedural code variation billed through Medicare. Secondary outcome was category of procedure activity that each surgeon cohort had participated in.
    Results: A total of 62,866 claims were reviewed, of which 10,058 (16.0%) were made by female surgeons and 52,808 (84.0%) were made by male surgeons. On average, male surgeons submitted more claims per year, a greater variety of claims per year, and higher revenue generating claims than female surgeons (P < 0.001).
    Conclusions: Male and female colorectal surgeons may participate in different categories of clinical activities that result in male surgeons performing more and higher relative value units-generating activity than female surgeons.
    MeSH term(s) Aged ; Humans ; Male ; Female ; United States ; Retrospective Studies ; Medicare ; Surgeons ; Endoscopy ; Colorectal Neoplasms
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80170-7
    ISSN 1095-8673 ; 0022-4804
    ISSN (online) 1095-8673
    ISSN 0022-4804
    DOI 10.1016/j.jss.2023.09.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of serial monitoring of donor-specific antibodies in pediatric and adult intestinal/multivisceral transplant recipients.

    Klein, Kelsey / Keck, Megan / Langewisch, Eric / Merani, Shaheed / Hitchman, Kelley / Leick, Mary

    Pediatric transplantation

    2023  Volume 28, Issue 1, Page(s) e14638

    Abstract: Background: The study purpose was to add to limited literature assessing anti-HLA donor-specific antibody (DSA) appearance, clearance, specificity, and impact in intestinal/multivisceral (MV) transplant as well as the value of serial monitoring ... ...

    Abstract Background: The study purpose was to add to limited literature assessing anti-HLA donor-specific antibody (DSA) appearance, clearance, specificity, and impact in intestinal/multivisceral (MV) transplant as well as the value of serial monitoring following an institutional protocol shift implementing serial monitoring.
    Methods: This single-center retrospective review included intestinal/MV recipients transplanted 1/1/15-9/31/17 with completed DSA testing. Patients were divided into groups based on DSA presence post-transplant. The primary outcome was biopsy-proven acute rejection (BPAR). Secondary outcomes included graft loss and death. Descriptive analysis of DSA was completed.
    Results: Of the 35 intestinal/MV recipients (60% pediatric) with DSA testing, 24 patients had post-transplant DSA. Fifteen patients in the DSA(+) group had T-cell-mediated BPAR versus five in the DSA(-) group (63% vs 45%, p = .47). Days to BPAR were 25 [IQR 19-165] (DSA(+) group) versus 232 [IQR 25.5-632.5] (DSA(-) group) (p = .066). There were no differences between groups for graft loss or death. One hundred and five DSA were identified in the DSA(+) group with 63% being class II, and 54% cleared during follow-up. DSA were directed against 50 different HLA alleles, with the most common being directed against HLA- DQ (35%). Time to first DSA and to clearance did not differ between class I and II.
    Conclusion: Findings confirm previous data that suggest post-transplant DSA in this population may lead to increased BPAR or shorter time to BPAR, although not statistically significant. Most DSA were identified within the first month after transplant, and ahead of rejection identification on biopsy. DSA therefore may have utility as an early rejection biomarker and use may be considered in place of early protocol biopsies, particularly in pediatric patients. We identified novel findings of DSA directed against a large breadth of HLA in intestinal/MV patients.
    MeSH term(s) Adult ; Humans ; Child ; Transplant Recipients ; HLA Antigens ; Kidney Transplantation ; Antibodies ; Tissue Donors ; Retrospective Studies ; Antilymphocyte Serum ; Graft Rejection/diagnosis ; Graft Survival ; Isoantibodies
    Chemical Substances HLA Antigens ; Antibodies ; Antilymphocyte Serum ; Isoantibodies
    Language English
    Publishing date 2023-11-09
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Kidney injury and status 1 liver transplantation: Outcomes, kidney function, and listing for kidney transplantation.

    Cloonan, Daniel J / Cloonan, Madeline R / Westphal, Scott G / Dageforde, Leigh Anne / Merani, Shaheed

    Clinical transplantation

    2023  Volume 37, Issue 4, Page(s) e14921

    Abstract: Background: Effects of kidney injury (KI) at the time of liver transplantation (LT) for acute liver failure (ALF) remain poorly described. We hypothesized that patients with ALF and KI who undergo LT have persistent post-transplant KI, inferior survival, ...

    Abstract Background: Effects of kidney injury (KI) at the time of liver transplantation (LT) for acute liver failure (ALF) remain poorly described. We hypothesized that patients with ALF and KI who undergo LT have persistent post-transplant KI, inferior survival, and increased rate of kidney transplantation (KT).
    Methods: The US Scientific Registry of Transplant Recipients database was queried for patients transplanted with status 1 listing for LT between 2002 and 2021. KI was defined as estimated glomerular filtration rate (eGFR) ≤ 30 mL/min/1.73 m
    Results: A total of 2984 patients underwent LT for ALF with 1241 (41.6%) having KI. KI patients had lower eGFR at 6 months post-LT (57.8 vs. 68.7, p < .001) that persisted out to 5 years (59.9 vs. 69.7, p < .001). KI patients were more likely to be listed for KT (4.3% vs. 1.9%, p < .001) and undergo listing sooner after LT (.8 vs. 3.7 years, p < .001). Patients without KI had higher adjusted post-transplant OS compared to those with KI (HR .75, p < .001).
    Conclusion: KI in the setting of ALF portends a worse prognosis for both kidney recovery and OS.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Liver Transplantation/adverse effects ; Kidney ; Kidney Failure, Chronic ; Renal Dialysis ; Retrospective Studies
    Language English
    Publishing date 2023-02-13
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Presentation of preclinical gastrointestinal anatomy via laparoscopic simulation.

    McCumber, Travis L / Mott, Justin L / Merani, Shaheed / Rochling, Fedja A

    Clinical anatomy (New York, N.Y.)

    2022  Volume 35, Issue 7, Page(s) 953–960

    Abstract: In this report, the authors examine the integration of teaching anatomical science with clinical implications in minimally invasive surgery. The authors hypothesized that implementation of integrated laparoscopic simulation during undergraduate medical ... ...

    Abstract In this report, the authors examine the integration of teaching anatomical science with clinical implications in minimally invasive surgery. The authors hypothesized that implementation of integrated laparoscopic simulation during undergraduate medical education would improve student learning of anatomical structures from in situ, laparoscopic orientations; and subsequently improve student preparation for clinical rotations and clerkships. During the fall of 2020 and 2021, 260 (130 students/year) second year medical students at the University of Nebraska Medical Center participated in a six-week gastrointestinal curriculum. Following a traditional anatomy dissection experience, students completed a laparoscopic event consisting of narrated laparoscopic videos and hands-on laparoscopic simulation. To examine the integrated curricular event, outcome measures focused on technical performance using grasping forceps, anatomical knowledge, and perception of the educational innovation. Outcomes were analyzed via timed performance and a pre and post assessment that was designed to assess student anatomical knowledge and perception. Completion of the technical performance assessment ranged from 1 min, 17 s to 6 min. Student knowledge of anatomical structures from in situ, laparoscopic orientations following the laparoscopic simulation sessions was significantly improved (53.3% pre vs 81.0% post), and almost all students (98.9%) agreed that the simulation sessions improved their understanding of laparoscopic anatomy and procedures. This report demonstrates the implementation of a multidisciplinary, integrated simulation that satisfied basic science anatomy teaching objectives, while enhancing student enthusiasm for the content. Future studies will examine the subsequent impact of the innovation on student preparedness for clinical rotations and clerkships.
    MeSH term(s) Anatomy/education ; Curriculum ; Dissection/education ; Education, Medical, Undergraduate/methods ; Educational Measurement ; Humans ; Laparoscopy ; Students, Medical
    Language English
    Publishing date 2022-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1025505-9
    ISSN 1098-2353 ; 0897-3806
    ISSN (online) 1098-2353
    ISSN 0897-3806
    DOI 10.1002/ca.23912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Improved Early Post-Transplant Outcomes and Organ Use in Kidney Transplant Using Normothermic Regional Perfusion for Donation after Circulatory Death: National Experience in the US.

    Merani, Shaheed / Urban, Marian / Westphal, Scott G / Dong, James / Miles, Clifford D / Maskin, Alexander / Hoffman, Arika / Langnas, Alan N

    Journal of the American College of Surgeons

    2023  Volume 238, Issue 1, Page(s) 107–118

    Abstract: Background: Normothermic regional perfusion (NRP) is a technique that is intended to enhance organ transplant outcomes from donation circulatory death (DCD) donors.: Study design: A retrospective analysis of data from the Scientific Registry of ... ...

    Abstract Background: Normothermic regional perfusion (NRP) is a technique that is intended to enhance organ transplant outcomes from donation circulatory death (DCD) donors.
    Study design: A retrospective analysis of data from the Scientific Registry of Transplant Recipients was performed. DCD donors were screened for inclusion based on date of donation 2020 or later, and whether the heart was also recovered for transplantation. We grouped donors as either donation after brain death or DCD. DCD donors were further divided into groups including those in which the heart was not recovered for transplant (Non-Heart DCD) and those in which it was, based on recovery technique (thoracoabdominal-NRP [TA-NRP] Heart DCD and Super Rapid Recovery Heart DCD).
    Results: A total of 219 kidney transplant recipients receiving organs from TA-NRP Heart DCD donors were compared to 436 SRR Super Rapid Recovery DCD, 10,630 Super Rapid Recovery non-heart DCD, and 27,820 donations after brain death recipients. Kidney transplant recipients of TA-NRP DCD allografts experienced shorter length of stay, lower rates of delayed graft function, and lower serum creatinine at the time of discharge when compared with recipients of other DCD allografts.
    Conclusions: Our analysis demonstrates superior early kidney allograft function when TA-NRP is used for DCD organ recovery.
    MeSH term(s) Humans ; Kidney Transplantation ; Brain Death ; Retrospective Studies ; Perfusion/methods ; Tissue Donors ; Tissue and Organ Procurement ; Graft Survival ; Organ Preservation/methods ; Death
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1097/XCS.0000000000000880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Biliary Cancer: Current Multimodality Treatment and Future Directions.

    Copur, Mehmet Sitki / Merani, Shaheed / Vargas, Luciano M

    Oncology (Williston Park, N.Y.)

    2019  Volume 33, Issue 9

    Abstract: Biliary cancer is a highly aggressive malignancy arising from the biliary tree, with its incidence increasing steadily on a global level. Most biliary cancers are diagnosed in the advanced and metastatic stages due to the paucity of signs and symptoms in ...

    Abstract Biliary cancer is a highly aggressive malignancy arising from the biliary tree, with its incidence increasing steadily on a global level. Most biliary cancers are diagnosed in the advanced and metastatic stages due to the paucity of signs and symptoms in the early presentation. Only about one-third of the patients can be treated with curative intent with an overall median survival of less than 24 months for all-comers from the time of diagnosis. This fact and the poor results of the currently available local and systemic therapies, are responsible for the disappointing outcome of biliary cancer patients. There is an unmet need for novel therapeutic approaches. Surgery, the backbone of curative treatments for biliary cancer, is effective in early, completely-resectable stages or in combination with neoadjuvant or adjuvant chemotherapy and/or radiation therapy for locally advanced stages. Systemic therapies in unresectable and recurrent cases are associated with poor outcomes. The introduction of next-generation sequencing technologies has opened new horizons for a better understanding of the molecular basis of this cancer with potential identification and evaluation of new treatment options.
    MeSH term(s) Biliary Tract Neoplasms/diagnosis ; Biliary Tract Neoplasms/therapy ; Combined Modality Therapy ; Forecasting ; Humans ; Prognosis
    Language English
    Publishing date 2019-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1067950-9
    ISSN 0890-9091
    ISSN 0890-9091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Considerations for the use of porcine organ donation models in preclinical organ donor intervention research.

    Heinis, Frazer I / Merani, Shaheed / Markin, Nicholas W / Duncan, Kim F / Moulton, Michael J / Fristoe, Lance / Thorell, William E / Sherrick, Raechel A / Wells, Tami R / Andrews, Matthew T / Urban, Marian

    Animal models and experimental medicine

    2024  

    Abstract: Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical transplantation. Animal models of organ donation and preservation help to advance and improve technical elements of solid organ ... ...

    Abstract Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical transplantation. Animal models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury, organ preservation strategies, and future donor-based interventions. Important considerations include cost, public opinion regarding the conduct of animal research, translational value, and relevance of the animal model for clinical practice. We present an overview of two porcine models of organ donation: donation following brain death (DBD) and donation following circulatory death (DCD). The cardiovascular anatomy and physiology of pigs closely resembles those of humans, making this species the most appropriate for pre-clinical research. Pigs are also considered a potential source of organs for human heart and kidney xenotransplantation. It is imperative to minimize animal loss during procedures that are surgically complex. We present our experience with these models and describe in detail the use cases, procedural approach, challenges, alternatives, and limitations of each model.
    Language English
    Publishing date 2024-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2576-2095
    ISSN (online) 2576-2095
    DOI 10.1002/ame2.12411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Double Obstruction Following Third Renal Transplant: A Case Report.

    Anderson, Blaire / Merani, Shaheed / Maskin, Alexander

    Transplantation proceedings

    2019  Volume 51, Issue 9, Page(s) 3080–3083

    Abstract: As the field of transplant evolves and patients with chronic disease live longer, retransplant for end-stage renal disease becomes more common because kidney allografts have a limited lifespan. In renal retransplant, graft and patient survival is near ... ...

    Abstract As the field of transplant evolves and patients with chronic disease live longer, retransplant for end-stage renal disease becomes more common because kidney allografts have a limited lifespan. In renal retransplant, graft and patient survival is near equivalent to first-time transplant; however, these procedures present a unique surgical risk profile, especially third and subsequent transplants, which are reviewed in this manuscript. The risk of bowel obstruction in primary kidney transplant recipients is much lower than patients who have undergone laparotomy for second or third transplant because of the retroperitoneal location of the transplanted kidney. Internal hernia is an uncommon cause of small bowel obstruction, particularly after kidney transplant, and often diagnosis and intervention are delayed because of diagnostic uncertainty. We report a case of a 34-year-old man with acute kidney injury and bowel obstruction, whose final diagnosis was an internal hernia around the transplanted ureter of an intra-abdominally placed third renal transplant resulting in ureteric obstruction associated with small bowel obstruction-a case of double obstruction.
    MeSH term(s) Adult ; Humans ; Intestinal Obstruction/etiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Male ; Reoperation/adverse effects ; Ureteral Obstruction/etiology
    Language English
    Publishing date 2019-10-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2019.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Ciliated Hepatic Foregut Cyst: A Report of a Case Incidentally Discovered during Transplant Evaluation.

    Enke, Thomas / Manatsathit, Wuttiporn / Merani, Shaheed / Fisher, Kurt

    Case reports in gastrointestinal medicine

    2019  Volume 2019, Page(s) 7828427

    Abstract: Ciliated hepatic foregut cyst (CHFC) is a rare benign cyst of the liver derived from an embryonic remnant of foregut epithelium. CHFC is typically asymptomatic and is found incidentally. Recent reports of malignant transformation may warrant surgical ... ...

    Abstract Ciliated hepatic foregut cyst (CHFC) is a rare benign cyst of the liver derived from an embryonic remnant of foregut epithelium. CHFC is typically asymptomatic and is found incidentally. Recent reports of malignant transformation may warrant surgical removal of CHFC. We present the case of a 54-year-old male who was discovered to have a CHFC while undergoing kidney transplant evaluation.
    Language English
    Publishing date 2019-10-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627636-7
    ISSN 2090-6536 ; 2090-6528
    ISSN (online) 2090-6536
    ISSN 2090-6528
    DOI 10.1155/2019/7828427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Not as Rare as Initially Described: Transplant Ureter Incarceration Within Inguinal Hernia. Two Cases, Literature Review, and Management Algorithm.

    Merani, Shaheed / Aufhauser, David D / Maskin, Alexander T / Mezrich, Josh / Al-Adra, David

    Transplantation proceedings

    2021  Volume 53, Issue 7, Page(s) 2285–2290

    Abstract: Background: Obstructive uropathy after kidney transplant can present as acute kidney injury, urosepsis, and more rarely kidney allograft failure. We present a recent series of 2 cases and a literature review of 1 late etiology of ureteric obstruction: ... ...

    Abstract Background: Obstructive uropathy after kidney transplant can present as acute kidney injury, urosepsis, and more rarely kidney allograft failure. We present a recent series of 2 cases and a literature review of 1 late etiology of ureteric obstruction: incarceration of the transplant ureter within an inguinal hernia.
    Methods: We reviewed 2 cases of patients with ureteric incarceration in an inguinal hernia after kidney transplant and conducted a contemporary structured literature review. Relevant patient factors, management decisions, operative approaches, and clinical outcomes were abstracted and summarized.
    Results: Two cases of ureteric involvement in an inguinal hernia from 2 institutions as well as a literature review of 14 case reports are provided. The clinical features most commonly associated with this condition were male sex, obesity, and decade or more delay between kidney transplantation and presentation. Preoperative management with nephrostomy tube with or without antegrade ureteric stent was most frequently employed. Ultimately, most patients underwent surgical hernia repair, which occasionally required additional surgery for distal ureteric resection or re-anastomosis.
    Conclusions: Incarceration of a transplant allograft ureter in inguinal hernia is likely not as rare as initially described, although a true incidence rate has not been established. This surgically correctible condition most frequently presents as a late complication after kidney transplantation. We present a management algorithm that can be used for the workup and treatment of patients with history of kidney transplant who present with ureteric obstruction owing to incarceration within an inguinal hernia.
    MeSH term(s) Algorithms ; Hernia, Inguinal/surgery ; Herniorrhaphy ; Humans ; Male ; Ureter/diagnostic imaging ; Ureter/surgery ; Ureteral Obstruction/surgery
    Language English
    Publishing date 2021-08-24
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.07.012
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