Article ; Online: The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia.
Indian journal of ophthalmology
2013 Volume 61, Issue 7, Page(s) 319–324
Abstract: Aims: To evaluate the effects of melatonin premedication on anxiety and pain scores of patients, operating conditions, and intraocular pressure during cataract surgery under topical anesthesia.: Materials and methods: Sixty patients were randomly ... ...
Abstract | Aims: To evaluate the effects of melatonin premedication on anxiety and pain scores of patients, operating conditions, and intraocular pressure during cataract surgery under topical anesthesia. Materials and methods: Sixty patients were randomly assigned to receive either sublingual melatonin 3 mg or placebo 60 min before surgery. Verbal anxiety scores and verbal pain scores, heart rate, systolic and diastolic blood pressure, intraocular pressure, and quality of operating conditions were recorded. Results: Melatonin significantly reduced the anxiety scores (median, interquartile range) from 5 and 5-3 to 3 and 2-4 after premedication and to 3 and 2-3 during surgery and to 0 and 0-1 postoperatively before discharge from the recovery room. There were significant differences between two groups in anxiety scores after premedication (95% CI 3-3.5; P = 0.023), intraoperatively (95% CI 2.5-3.5; P = 0.007), and postoperatively (95% CI 0.5-1; P = 0.007). The surgeon reported better quality of operating conditions in the melatonin group (P = 0.001). No significant difference in intraoperative and postoperative pain scores, intraocular pressure, heart rate, and systolic and diastolic blood pressure between two groups was recorded. Conclusion: Sublingual melatonin premedication for patients undergoing cataract surgery under topical anesthesia reduced the anxiety scores in patients and provided excellent operating conditions. |
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MeSH term(s) | Administration, Sublingual ; Adult ; Aged ; Aged, 80 and over ; Anesthesia, Local/methods ; Anxiety/complications ; Anxiety/diagnosis ; Anxiety/drug therapy ; Central Nervous System Depressants/administration & dosage ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Intraocular Pressure/physiology ; Intraoperative Period ; Male ; Melatonin/administration & dosage ; Middle Aged ; Pain/complications ; Pain/diagnosis ; Pain/drug therapy ; Pain Measurement ; Phacoemulsification/methods ; Retrospective Studies ; Treatment Outcome |
Chemical Substances | Central Nervous System Depressants ; Melatonin (JL5DK93RCL) |
Language | English |
Publishing date | 2013-04-03 |
Publishing country | India |
Document type | Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't |
ZDB-ID | 187392-1 |
ISSN | 1998-3689 ; 0301-4738 |
ISSN (online) | 1998-3689 |
ISSN | 0301-4738 |
DOI | 10.4103/0301-4738.99637 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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