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  1. Article: Vocal Cord Monitoring by Flexible Fiberoptic Laryngoscopy During Thyroid Radiofrequency Ablation.

    Valcavi, Roberto / Gaino, Francesca / Novizio, Roberto / Mercante, Giuseppe

    VideoEndocrinology

    2023  Volume 10, Issue 3, Page(s) 41–43

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-09-25
    Publishing country United States
    Document type Journal Article
    ISSN 2329-9738
    ISSN 2329-9738
    DOI 10.1089/ve.2023.0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The impact of frailty on adjuvant treatment in patients with head and neck free flap reconstruction-A retrospective study using two independent frailty scores: Avoiding the wrong conclusion.

    Festa, Bianca Maria / Costantino, Andrea / Ferreli, Fabio / Spriano, Giuseppe / Mercante, Giuseppe / De Virgilio, Armando

    Oral oncology

    2022  Volume 134, Page(s) 106071

    MeSH term(s) Frailty ; Free Tissue Flaps ; Head and Neck Neoplasms/etiology ; Head and Neck Neoplasms/surgery ; Humans ; Neck ; Postoperative Complications/etiology ; Reconstructive Surgical Procedures/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2022-08-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.106071
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    Zs.A 4869: Show issues Location:
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  3. Article ; Online: A critical analysis of the classifications of squamous cell carcinoma of the nasal vestibule.

    Ferreli, Fabio / Pirola, Francesca / Di Santo, Davide / De Virgilio, Armando / Spriano, Giuseppe / Mercante, Giuseppe

    Oral oncology

    2022  Volume 129, Page(s) 105880

    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Humans ; Nasal Cavity/pathology ; Nose Neoplasms/pathology
    Language English
    Publishing date 2022-04-28
    Publishing country England
    Document type Letter
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2022.105880
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  4. Article: Reply to Adrian, G. Comment on "Russo et al. Does Tumor Volume Have a Prognostic Role in Oropharyngeal Squamous Cell Carcinoma? A Systematic Review and Meta-Analysis.

    Russo, Elena / Costantino, Andrea / Mercante, Giuseppe / Spriano, Giuseppe / De Virgilio, Armando

    Cancers

    2022  Volume 14, Issue 17

    Abstract: The authors raised some interesting points [ ... ]. ...

    Abstract The authors raised some interesting points [...].
    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14174302
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  5. Article ; Online: Sentinel lymph node biopsy in high-risk cutaneous squamous cell carcinoma of the head and neck: Systematic review and meta-analysis.

    Costantino, Andrea / Canali, Luca / Festa, Bianca Maria / Spriano, Giuseppe / Mercante, Giuseppe / De Virgilio, Armando

    Head & neck

    2022  Volume 44, Issue 10, Page(s) 2288–2300

    Abstract: The aim of our study was to better define the role of sentinel lymph node biopsy (SLNB) in high-risk cutaneous squamous cell carcinoma of the head and neck (cSCCHN). A systematic review and meta-analysis was performed according to the PRISMA statement. ... ...

    Abstract The aim of our study was to better define the role of sentinel lymph node biopsy (SLNB) in high-risk cutaneous squamous cell carcinoma of the head and neck (cSCCHN). A systematic review and meta-analysis was performed according to the PRISMA statement. Seven-hundred and five patients were included from 20 studies. The pooled SLN identification rate was 98.8% (95%CI: 97.0-99.8). The median number of SLN excised was 3.6 (n = 371, 95%CI: 2.0-4.4). The pooled SLNB positive rate and cumulative regional recurrence rate (RRR) in negative SLNB were 5.6% (95%CI: 2.6-9.6) and 2.9% (95%CI: 0.5-7.2), respectively. The high SLN identification rate demonstrates SLNB feasibility in cSCCHN. The low SLNB positive rate and the relatively high RRR raise some doubts concerning its clinical utility. Further studies are mandatory to define predictors of lymph node metastases able to better select patients that may benefit from a SLNB.
    MeSH term(s) Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/surgery ; Humans ; Lymph Nodes/pathology ; Lymph Nodes/surgery ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery ; Squamous Cell Carcinoma of Head and Neck/pathology ; Squamous Cell Carcinoma of Head and Neck/surgery
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27121
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    Zs.A 1493: Show issues Location:
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  6. Article ; Online: High-Definition 3D Exoscope in Thyroid Surgery.

    Mercante, Giuseppe / Costantino, Andrea / De Virgilio, Armando / Ferreli, Fabio / Spriano, Giuseppe

    Surgical innovation

    2022  Volume 30, Issue 2, Page(s) 205–209

    Abstract: Background: The high-definition 3D exoscope is an innovative and promising tool that was recently introduced in the clinical practice. It may be used during open surgical procedures to enhance the ability to perform precise dissection of fine structures. ...

    Abstract Background: The high-definition 3D exoscope is an innovative and promising tool that was recently introduced in the clinical practice. It may be used during open surgical procedures to enhance the ability to perform precise dissection of fine structures. We describe our preliminary experience with the 3D exoscope in thyroid surgery, discussing potential advantages of this system.
    Methods: A high-definition 3D exoscope (3D VITOM
    Results: The 3D exoscope was used in three patients without significant intra-operative delay or complications. Both thyroidectomy and central compartment dissection were performed. The 3D exoscope allows to perform precise dissection in the identification and preservation of the recurrent laryngeal nerve and the parathyroid glands.
    Conclusions: 3D exoscope-assisted thyroid surgery seems to be feasible and safe. Further studies should be encouraged to analyze potential clinical benefit in the post-operative period.
    MeSH term(s) Humans ; Thyroid Gland/surgery ; Parathyroid Glands ; Thyroidectomy/methods ; Dissection ; Germany
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2182571-3
    ISSN 1553-3514 ; 1553-3506
    ISSN (online) 1553-3514
    ISSN 1553-3506
    DOI 10.1177/15533506221097553
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    Zs.A 4269: Show issues Location:
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  7. Article ; Online: Prognostic Impact of Tumor Immune Microenvironment and Its Predictive Role in Salivary Gland Cancer.

    Veneroni, Maria Vittoria / Festa, Bianca Maria / Costantino, Andrea / Spriano, Giuseppe / Mercante, Giuseppe / De Virgilio, Armando / Di Tommaso, Luca

    Head and neck pathology

    2023  Volume 17, Issue 2, Page(s) 515–527

    Abstract: Background: Recently, many studies have investigated the role of tumor immune microenvironment (TIME) in carcinogenesis, highlighting its relation to both tumor regression and progression. In particular, the "inflammatory system", made of innate and ... ...

    Abstract Background: Recently, many studies have investigated the role of tumor immune microenvironment (TIME) in carcinogenesis, highlighting its relation to both tumor regression and progression. In particular, the "inflammatory system", made of innate and adaptive immune cells, interacts with cancer cells and their surrounding stroma. In this setting, the aim of this review is to summarize the current literature regarding the TIME of major salivary gland carcinomas (MSGCs), with particular attention on the characteristics and prognostic role of tumor infiltrating lymphocytes (TILs), the mechanisms that lead to TILs exhaustion and the important additional immune infiltrating factors that help SGC progression or remission.
    Methods: A comprehensive literature search was performed concerning published articles on the role of TIME in MSGCs.
    Results: In this work we summarize the advancing knowledge on TIME in SGCs by demonstrating the key prognostic and/or predictive value of specific immune features.
    Conclusion: From the analysis of the current 'status of the art' it clearly emerges a need for precise, unambiguous phenotyping of immune cell populations, as well as a more thorough understanding of the frequencies and interactions of multiple immune cell types inside the TIME and their spatial localization (intratumoral vs. stromal).
    MeSH term(s) Humans ; Prognosis ; Salivary Gland Neoplasms ; Tumor Microenvironment ; Lymphocytes, Tumor-Infiltrating
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-023-01528-y
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  8. Article ; Online: Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?

    Giombi, Francesco / Pace, Gian Marco / Pirola, Francesca / Cerasuolo, Michele / Ferreli, Fabio / Mercante, Giuseppe / Spriano, Giuseppe / Canonica, Giorgio Walter / Heffler, Enrico / Ferri, Sebastian / Puggioni, Francesca / Paoletti, Giovanni / Malvezzi, Luca

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Chronic rhinosinusitis (CRS) has recently undergone a significant paradigm shift, moving from a phenotypical classification towards an "endotype-based" definition that places more emphasis on clinical and therapeutic aspects. Similar to other airway ... ...

    Abstract Chronic rhinosinusitis (CRS) has recently undergone a significant paradigm shift, moving from a phenotypical classification towards an "endotype-based" definition that places more emphasis on clinical and therapeutic aspects. Similar to other airway diseases, like asthma, most cases of CRS in developed countries exhibit a dysregulated type-2 immune response and related cytokines. Consequently, the traditional distinction between upper and lower airways has been replaced by a "united airway" perspective. Additionally, type-2 related disorders extend beyond respiratory boundaries, encompassing conditions beyond the airways, such as atopic dermatitis. This necessitates a multidisciplinary approach. Moreover, consideration of possible systemic implications is crucial, particularly in relation to sleep-related breathing diseases like Obstructive Sleep Apnoea Syndrome (OSAS) and the alteration of systemic inflammatory mediators such as nitric oxide. The trends in epidemiological, economic, and social burden are progressively increasing worldwide, indicating syndemic characteristics. In light of these insights, this narrative review aims to present the latest evidence on respiratory type-2 related disorders, with a specific focus on CRS while promoting a comprehensive perspective on the "united airways". It also introduces a novel concept: viewing these conditions as a multiorgan, systemic, and syndemic disease.
    MeSH term(s) Humans ; Syndemic ; Asthma/epidemiology ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy ; Respiration ; Cytokines ; Sleep Wake Disorders
    Chemical Substances Cytokines
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020730
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  9. Article: Outcomes of Endoscopic Endonasal Dacryocystorhinostomy in Glaucoma Patients.

    Pace, Gian Marco / Giombi, Francesco / Muci, Giovanna / Giunta, Gianmarco / Pirola, Francesca / Serra, Egidio / Zuppardo, Jessica / Ferreli, Fabio / Vinciguerra, Paolo / Mercante, Giuseppe / Maria, Alessandra Di / Spriano, Giuseppe / Malvezzi, Luca

    Journal of personalized medicine

    2024  Volume 14, Issue 4

    Abstract: Background: Anti-glaucoma eye drops have been investigated due to their production of fibrotic changes on the conjunctival surface, undermining the functioning of the upper lacrimal drainage system. We aimed to assess whether these effects may impair ... ...

    Abstract Background: Anti-glaucoma eye drops have been investigated due to their production of fibrotic changes on the conjunctival surface, undermining the functioning of the upper lacrimal drainage system. We aimed to assess whether these effects may impair the effectiveness of endoscopic endonasal dacryocystorhinostomy (EE-DCR).
    Methods: This is a single-center observational retrospective study on EE-DCR via a posterior approach. Resolution of epiphora and dacryocystitis were analyzed after 1 (T1) and 6-months (T2) from surgery. Surgical success was defined as anatomical (patency at irrigation, no recurring dacryocystitis) or complete (zeroing of Munk score).
    Results: Twenty patients (32 sides) were enrolled. Preoperatively, 93.75% (
    Conclusions: Despite the chronic uptake of anti-glaucoma eye drops, EE-DCR guaranteed high rates of clinical relief from epiphora and remarkable decreases in the rates of recurrent dacryocystitis.
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14040348
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  10. Article ; Online: How to increase the SARS-CoV-2 detection rate through the nasopharyngeal swab?

    De Virgilio, Armando / Costantino, Andrea / Mercante, Giuseppe / Spriano, Giuseppe

    Oral oncology

    2020  Volume 106, Page(s) 104802

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Reverse Transcriptase Polymerase Chain Reaction ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2020.104802
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