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  1. Article ; Online: Thoracic ultrasound in the modern management of pleural disease.

    Hassan, Maged / Mercer, Rachel M / Rahman, Najib M

    European respiratory review : an official journal of the European Respiratory Society

    2020  Volume 29, Issue 156

    Abstract: Physician-led thoracic ultrasound (TUS) has substantially changed how respiratory disorders, and in particular pleural diseases, are managed. The use of TUS as a point-of-care test enables the respiratory physician to quickly and accurately diagnose ... ...

    Abstract Physician-led thoracic ultrasound (TUS) has substantially changed how respiratory disorders, and in particular pleural diseases, are managed. The use of TUS as a point-of-care test enables the respiratory physician to quickly and accurately diagnose pleural pathology and ensure safe access to the pleural space during thoracentesis or chest drain insertion. Competence in performing TUS is now an obligatory part of respiratory speciality training programmes in different parts of the world. Pleural physicians with higher levels of competence routinely use TUS during the planning and execution of more sophisticated diagnostic and therapeutic interventions, such as core needle pleural biopsies, image-guided drain insertion and medical thoracoscopy. Current research is gauging the potential of TUS in predicting the outcome of different pleural interventions and how it can aid in tailoring the optimum treatment according to different TUS-based parameters.
    MeSH term(s) Chest Tubes ; Clinical Decision-Making ; Drainage/adverse effects ; Drainage/instrumentation ; Humans ; Pleural Diseases/diagnostic imaging ; Pleural Diseases/therapy ; Point-of-Care Systems ; Point-of-Care Testing ; Predictive Value of Tests ; Thoracentesis/adverse effects ; Thoracoscopy/adverse effects ; Treatment Outcome ; Ultrasonography
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0136-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Survival and pleurodesis outcome in patients with malignant pleural effusion - a systematic review.

    Hassan, Maged / Harriss, Elinor / Mercer, Rachel M / Rahman, Najib M

    Pleura and peritoneum

    2021  Volume 6, Issue 1, Page(s) 1–5

    Abstract: Malignant pleural effusion (MPE) is a common condition that presents with progressive breathlessness. Long term solutions are often required due to recurrence of effusion after simple drainage. Pleurodesis is one of the main options resorted to for long ... ...

    Abstract Malignant pleural effusion (MPE) is a common condition that presents with progressive breathlessness. Long term solutions are often required due to recurrence of effusion after simple drainage. Pleurodesis is one of the main options resorted to for long term control of MPE. There is data to suggest there may be a survival benefit for patients with MPE who achieve successful pleurodesis. A systematic review was carried out to explore this correlation and results suggest that there could be a survival difference according to pleurodesis outcome in patients with MPE. Fifteen studies (reported in 13 papers) were included; 13 (86.6%) of the studies showed survival difference in favour of pleurodesis success. The median [interquartile range] difference in survival between the two groups among the different studies was five [3.5-5.8] months. Most of the included studies suffered moderate to severe risk of bias and, thus, large prospective studies of patients undergoing pleurodesis are required to ascertain this effect.
    Language English
    Publishing date 2021-02-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2861909-2
    ISSN 2364-768X ; 2364-7671
    ISSN (online) 2364-768X
    ISSN 2364-7671
    DOI 10.1515/pp-2020-0147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The role of pleurodesis in respiratory diseases.

    Mercer, Rachel M / Hassan, Maged / Rahman, Najib M

    Expert review of respiratory medicine

    2018  Volume 12, Issue 4, Page(s) 323–334

    Abstract: Introduction: Pleurodesis is used to obliterate the pleural space, most commonly in patients with symptomatic malignant pleural effusions but also in patients with benign effusions or pneumothorax. Areas covered: Traditionally, chemical pleurodesis has ... ...

    Abstract Introduction: Pleurodesis is used to obliterate the pleural space, most commonly in patients with symptomatic malignant pleural effusions but also in patients with benign effusions or pneumothorax. Areas covered: Traditionally, chemical pleurodesis has been undertaken at thoracoscopy or using instillation of a slurry through a chest drain. The optimum method of achieving pleurodesis, whether surgical or medical, has yet to be proven. Evidence in the different disease areas will be reviewed, along with ongoing trial evidence, which may change practice. Expert commentary: Newer methods of achieving pleurodesis are being introduced. Studies have shown that instilling sclerosing agents via an indwelling pleural catheter or introducing drug-eluting catheters are safe and effective ways of inducing pleurodesis. There is evidence that pleurodesis might increase in survival, especially after pleural infection, possibly due to activation of the immune system. Multiple studies are currently underway to answer some of these questions and the future landscape may be very different from the present.
    MeSH term(s) Chest Tubes ; Humans ; Pleural Effusion, Malignant/therapy ; Pleurodesis/methods ; Pneumothorax/therapy ; Respiration Disorders/therapy ; Treatment Outcome
    Language English
    Publishing date 2018-02-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2018.1445971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Advances in Interventional Pulmonology.

    Moore, Alastair J / Mercer, Rachel M / Musani, Ali I

    Clinics in chest medicine

    2017  Volume 39, Issue 1, Page(s) 271–280

    Abstract: Much has changed since the last review of interventional pulmonology (IP) published in this Clinics series. The rate of development of new techniques and their complexities require IP physicians to be constantly maintaining and updating their skill set. ... ...

    Abstract Much has changed since the last review of interventional pulmonology (IP) published in this Clinics series. The rate of development of new techniques and their complexities require IP physicians to be constantly maintaining and updating their skill set. International agreed training pathways help ensure that the interventionalists of the present and future have the required knowledge of anatomy, manual dexterity, and clinical judgment to keep up with the continuing advances that are constantly expanding IP's diagnostic and therapeutic boundaries. IP remains one of the most desirable subspecialities in pulmonology, and the technologic advances make the future an exciting one.
    MeSH term(s) Bronchoscopy/methods ; Humans ; Pulmonary Medicine
    Language English
    Publishing date 2017-12-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2017.11.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ultrasound in the management of pleural disease.

    Mercer, Rachel M / Psallidas, Ioannis / Rahman, Najib M

    Expert review of respiratory medicine

    2017  Volume 11, Issue 4, Page(s) 323–331

    Abstract: Introduction: Pleural disease encompasses a large range of conditions, is a common presentation to the acute medical take and often requires comprehensive investigation and treatment. Ultrasound is well recognised as a useful investigative tool in ... ...

    Abstract Introduction: Pleural disease encompasses a large range of conditions, is a common presentation to the acute medical take and often requires comprehensive investigation and treatment. Ultrasound is well recognised as a useful investigative tool in pleural disease especially in the field of pleural effusion, pleural thickening and interventional procedures. Thoracic ultrasound (TUS) has gained widespread use by physicians as evidence has shown a reduced rate of complications when performing pleural procedures with ultrasound guidance. Areas covered: This article will review studies assessing the role of TUS in the management of pleural disease and examine ongoing research into how TUS could advance our knowledge and understanding over the next decade. Expert commentary: Physician lead thoracic ultrasound has become commonplace over the last decade, and now represents a minimum standard of safety in conducting the majority of 'bedside' pleural procedures. The current evidence points to important diagnostic and procedural roles of the use of bedside thoracic ultrasound. In the future, research developments are likely to lead to the use of thoracic ultrasound in prognostication, targeted treatment and understanding pathogenesis in pleural disease.
    MeSH term(s) Humans ; Pleural Diseases/diagnostic imaging ; Pleural Diseases/etiology ; Pleural Diseases/therapy ; Ultrasonography
    Language English
    Publishing date 2017-03-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2017.1300531
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  6. Article ; Online: Predictors of outcome of pleurodesis in patients with malignant pleural effusion: a systematic review and meta-analysis.

    Hassan, Maged / Gadallah, Mohamed / Mercer, Rachel M / Harriss, Elinor / Rahman, Najib M

    Expert review of respiratory medicine

    2020  Volume 14, Issue 6, Page(s) 645–654

    Abstract: ... ...

    Abstract Objectives
    MeSH term(s) Aged ; Chest Tubes ; Drainage ; Female ; Humans ; Male ; Middle Aged ; Pleural Effusion, Malignant/drug therapy ; Pleurodesis ; Talc/administration & dosage ; Treatment Outcome
    Chemical Substances Talc (14807-96-6)
    Language English
    Publishing date 2020-04-04
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2020.1746647
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  7. Article ; Online: Physical Activity and Sedentary Behaviour in Patients With Malignant Pleural Effusion Undergoing Therapeutic Pleural Interventions (The ASPIRE Study).

    Hassan, Maged / Banka, Radhika / Castro-Añón, Olalla / Mercer, Rachel M / Bedawi, Eihab O / Asciak, Rachelle / Stradling, John / Rahman, Najib M

    Archivos de bronconeumologia

    2021  Volume 57, Issue 10, Page(s) 656–658

    MeSH term(s) Exercise ; Humans ; Pleura ; Pleural Effusion/etiology ; Pleural Effusion/therapy ; Pleural Effusion, Malignant/drug therapy ; Pleurodesis ; Sedentary Behavior
    Language English
    Publishing date 2021-08-26
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbr.2020.09.013
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  8. Article ; Online: Computed tomography abnormalities antedating mesothelioma diagnosis: a perspective on the natural history.

    Hassan, Maged / Tsikrika, Stamatoula / Asciak, Rachelle / Mercer, Rachel M / El-Ganady, Anwar / Rahman, Najib M

    The European respiratory journal

    2019  Volume 53, Issue 2

    MeSH term(s) Aged ; Aged, 80 and over ; Disease Progression ; Early Detection of Cancer ; Female ; Humans ; Lung Neoplasms ; Male ; Mesothelioma/complications ; Mesothelioma/diagnostic imaging ; Mesothelioma, Malignant ; Middle Aged ; Pleural Effusion/complications ; Pleural Effusion/diagnostic imaging ; Precancerous Conditions/diagnostic imaging ; Radiography, Thoracic ; Retrospective Studies ; Tomography, X-Ray Computed
    Language English
    Publishing date 2019-02-28
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00935-2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Interpreting pleural fluid results .

    Mercer, Rachel M / Corcoran, John P / Porcel, Jose M / Rahman, Najib M / Psallidas, Ioannis

    Clinical medicine (London, England)

    2019  Volume 19, Issue 3, Page(s) 213–217

    Abstract: Interpreting pleural fluid results correctly requires an awareness of the possible aetiologies of a pleural effusion and an understanding of the reliability of the outcome of each investigation. All results must be interpreted within each different ... ...

    Abstract Interpreting pleural fluid results correctly requires an awareness of the possible aetiologies of a pleural effusion and an understanding of the reliability of the outcome of each investigation. All results must be interpreted within each different clinical context and knowledge of the pitfalls for each test is necessary when the diagnosis is unclear. This review aims to discuss the common aetiologies of a pleural effusion and some of the pitfalls in interpretation that can occur when the diagnosis is unclear.
    MeSH term(s) Biomarkers/analysis ; Diagnosis, Differential ; Humans ; Pleural Diseases/diagnosis ; Pleural Diseases/pathology ; Pleural Effusion/diagnosis ; Pleural Effusion/pathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-04-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.19-3-213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Biological Role of Pleural Fluid PAI-1 and Sonographic Septations in Pleural Infection: Analysis of a Prospectively Collected Clinical Outcome Study.

    Bedawi, Eihab O / Kanellakis, Nikolaos I / Corcoran, John P / Zhao, Yu / Hassan, Maged / Asciak, Rachelle / Mercer, Rachel M / Sundaralingam, Anand / Addala, Dinesh N / Miller, Robert F / Dong, Tao / Condliffe, Alison M / Rahman, Najib M

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 6, Page(s) 731–739

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Fibrinolysis ; Infections/metabolism ; Plasminogen Activator Inhibitor 1/analysis ; Plasminogen Activator Inhibitor 1/metabolism ; Pleura/diagnostic imaging ; Pleura/metabolism ; Pleural Diseases/diagnostic imaging ; Pleural Diseases/metabolism ; Pleural Effusion/genetics ; Prospective Studies ; Tissue Plasminogen Activator/analysis ; Tissue Plasminogen Activator/metabolism ; Ultrasonography
    Chemical Substances Plasminogen Activator Inhibitor 1 ; SERPINE1 protein, human ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202206-1084OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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