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Article ; Online: Long Noncoding RNAs in Cholangiocarcinoma.

Merdrignac, Aude / Papoutsoglou, Panagiotis / Coulouarn, Cédric

2021 Volume 73, Issue 3, Page(s) 1213–1226

MeSH term(s)	Animals ; Bile Duct Neoplasms/etiology ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/metabolism ; Cholangiocarcinoma/etiology ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/metabolism ; Epigenesis, Genetic ; Humans ; RNA, Long Noncoding/metabolism
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2021-02-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1002/hep.31534
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Zs.A 1660: Show issues

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Article ; Online: Ileal-J-Pouch Volvulus After Restorative Proctocolectomy.

Corbière, Lisa / Desfourneaux, Véronique / Merdrignac, Aude

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

2020 Volume 25, Issue 1, Page(s) 325–326

MeSH term(s)	Anastomosis, Surgical ; Colitis, Ulcerative/surgery ; Colonic Pouches/adverse effects ; Humans ; Ileum/surgery ; Intestinal Volvulus/diagnostic imaging ; Intestinal Volvulus/etiology ; Intestinal Volvulus/surgery ; Proctocolectomy, Restorative/adverse effects
Language	English
Publishing date	2020-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012365-6
ISSN	1873-4626 ; 1934-3213 ; 1091-255X
ISSN (online)	1873-4626 ; 1934-3213
ISSN	1091-255X
DOI	10.1007/s11605-020-04630-6
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Zs.A 5207: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Ongoing convergent evolution of a selfing syndrome threatens plant-pollinator interactions.

Acoca-Pidolle, Samson / Gauthier, Perrine / Devresse, Louis / Deverge Merdrignac, Antoine / Pons, Virginie / Cheptou, Pierre-Olivier

The New phytologist

2023 Volume 242, Issue 2, Page(s) 717–726

Abstract: Plant-pollinator interactions evolved early in the angiosperm radiation. Ongoing environmental changes are however leading to pollinator declines that may cause pollen limitation to plants and change the evolutionary pressures shaping plant mating ... ...

Abstract	Plant-pollinator interactions evolved early in the angiosperm radiation. Ongoing environmental changes are however leading to pollinator declines that may cause pollen limitation to plants and change the evolutionary pressures shaping plant mating systems. We used resurrection ecology methodology to contrast ancestors and contemporary descendants in four natural populations of the field pansy (Viola arvensis) in the Paris region (France), a depauperate pollinator environment. We combine population genetics analysis, phenotypic measurements and behavioural tests on a common garden experiment. Population genetics analysis reveals 27% increase in realized selfing rates in the field during this period. We documented trait evolution towards smaller and less conspicuous corollas, reduced nectar production and reduced attractiveness to bumblebees, with these trait shifts convergent across the four studied populations. We demonstrate the rapid evolution of a selfing syndrome in the four studied plant populations, associated with a weakening of the interactions with pollinators over the last three decades. This study demonstrates that plant mating systems can evolve rapidly in natural populations in the face of ongoing environmental changes. The rapid evolution towards a selfing syndrome may in turn further accelerate pollinator declines, in an eco-evolutionary feedback loop with broader implications to natural ecosystems.
MeSH term(s)	Pollination ; Ecosystem ; Reproduction ; Plants ; Pollen ; Flowers
Language	English
Publishing date	2023-12-19
Publishing country	England
Document type	Journal Article
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.19422
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Article ; Online: Outcomes of bariatric surgery in patients with inflammatory bowel disease from a French nationwide database.

Corbière, Lisa / Scanff, Alexandre / Desfourneaux, Véronique / Merdrignac, Aude / Ingels, Anne / Thibault, Ronan / Bouguen, Guillaume / Bergeat, Damien

The British journal of surgery

2022

Abstract: Background: The outcomes of bariatric surgery (BS) in patients with chronic inflammatory bowel disease (IBD) remain rarely described. We aimed to evaluate the 90-day morbidity and mortality rates, and the risk of IBD complications 2 years after BS.: ... ...

Abstract	Background: The outcomes of bariatric surgery (BS) in patients with chronic inflammatory bowel disease (IBD) remain rarely described. We aimed to evaluate the 90-day morbidity and mortality rates, and the risk of IBD complications 2 years after BS. Method: Patients from the French Programme de Médicalisation des Systèmes d'Information (PMSI) database who underwent a primary BS between 2016 and 2018 were included. We identified patients with a previous diagnosis of IBD. Postoperative 90-day (POD90) morbidity and mortality rates were compared between the two groups. The evolution of IBD was followed 2 years after BS. Results: Between 2016 and 2018, 138 980 patients underwent primary BS, including 587 patients with IBD: 326 (55.5 per cent) with Crohn's disease (CD) and 261 (44.5 per cent) with ulcerative colitis (UC). The preferred surgical technique was sleeve gastrectomy, especially in the IBD group (81.1 per cent), followed by gastric bypass (14.6 per cent). Patients with IBD had more comorbidities (Charlson Comorbidity Index of 1 or more, hypertension, and diabetes; P < 0.001) than those without IBD. The POD90 mortality rate did not differ between the two groups (0.049 per cent in the IBD group versus 0 per cent in the non-IBD group), but more unscheduled rehospitalizations at POD90 were observed in patients with IBD (6.0 per cent versus 3.7 per cent; P = 0.004). Two years after BS, 86 patients (14.6 per cent) in the IBD group had at least one unplanned readmission for the management of their IBD; 15 patients stayed for 3 or more days. After multivariable analysis, patients with CD had an independent elevated risk of IBD-related unplanned readmissions 2 years after BS versus UC (adjusted odds ratio 1.90, 95 per cent c.i. 1.22 to 2.97; P = 0.005). Conclusion: In a highly selected cohort of patients with well-controlled IBD, BS did not result in added mortality or morbidity. A point of vigilance must be underlined regarding BS in patients with CD.
Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znac398
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Article ; Online: Impact of prior interventional treatment on the complications after Frey procedure for chronic pancreatitis.

Merdrignac, A / Bergeat, D / Robin, F / Gaignard, E / Turner, K / Rayar, M / Meunier, B / Boudjema, K / Sulpice, Laurent

Langenbeck's archives of surgery

2019 Volume 404, Issue 7, Page(s) 825–830

Abstract: Purpose: Chronic pancreatitis is an inflammatory disease responsible for pain partially explained by pancreatic duct dilatation. Early surgery has become the treatment of choice for hypertrophic pancreatic head with main pancreatic duct dilatation. Frey ...

Abstract	Purpose: Chronic pancreatitis is an inflammatory disease responsible for pain partially explained by pancreatic duct dilatation. Early surgery has become the treatment of choice for hypertrophic pancreatic head with main pancreatic duct dilatation. Frey procedure (FP), combining both surgical resection and decompression, is one of the standard surgical procedures. However, a "step-up approach" with endoscopic or limited surgical procedures is still frequently proposed before referring to expert pancreatic centres. The aim of the study was to evaluate the impact of a prior treatment on post-operative complications of FP. Methods: All 61 consecutive patients who underwent FP between 2006 and 2017 were included. Perioperative data and outcomes were analyzed and compared according to the presence of a prior treatment. Results: Twenty-four patients did not receive any prior treatment and thirty-seven patients had a prior endoscopic or limited surgical treatment. Preoperative data and outcomes were similar between the 2 groups. The rate of biliary derivation during FP was significantly higher in the group without prior endoscopic procedure. A prior treatment was not a risk factor for major morbidity (Clavien grade ≥ III). Conclusions: A first attempt of endoscopic or limited surgical procedures before FP may not influence post-operative complications. Even if not recommended, a "step-up approach" proposing a first less invasive treatment could still be proposed to the patients who want to delay a morbid surgical procedure.
MeSH term(s)	Adult ; Dilatation, Pathologic ; Endoscopy ; Female ; Humans ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Pancreatic Ducts/pathology ; Pancreaticojejunostomy ; Pancreatitis, Chronic/surgery ; Postoperative Complications/surgery ; Reoperation ; Risk Factors
Language	English
Publishing date	2019-10-25
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	1423681-3
ISSN	1435-2451 ; 1435-2443
ISSN (online)	1435-2451
ISSN	1435-2443
DOI	10.1007/s00423-019-01832-8
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Article ; Online: Expression of long non-coding RNA ANRIL predicts a poor prognosis in intrahepatic cholangiocarcinoma.

Angenard, Gaëlle / Merdrignac, Aude / Louis, Corentin / Edeline, Julien / Coulouarn, Cédric

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

2019 Volume 51, Issue 9, Page(s) 1337–1343

Abstract: Background: Intrahepatic cholangiocarcinoma (iCCA) is a deadly cancer worldwide associated with an increased incidence, limited therapeutic options and absence of reliable prognostic biomarkers. Long non-coding RNAs (lncRNA) emerge as relevant ... ...

Abstract	Background: Intrahepatic cholangiocarcinoma (iCCA) is a deadly cancer worldwide associated with an increased incidence, limited therapeutic options and absence of reliable prognostic biomarkers. Long non-coding RNAs (lncRNA) emerge as relevant biomarkers in cancer being associated with tumor progression. However, lncRNA have been poorly investigated in iCCA. Aim: To identify lncRNA significantly associated with the survival of patients with iCCA after tumor resection for curative intent. Methods: Gene expression profiling and Q-RT-PCR were performed from a cohort of 39 clinically well-annotated iCCA. Univariate Cox proportional hazards model with Wald Statistic was used to identify lncRNA significantly associated with overall (OS) and/or disease-free (DFS) survival. Results: A signature made of 9 lncRNA was identified to be significantly (P < 0.05) associated with OS and DFS, including 4 lncRNA (lnc-CDK9-1, XLOC_l2_009441, CDKN2B-AS1, HOXC13-AS) highly expressed in poor prognosis iCCA and 5 lncRNA (lnc-CCHCR1-1, lnc-AF131215.3.1, lnc-CBLB-5, COL18A1-AS2, lnc-RELL2-1) highly expressed in better prognosis iCCA. We further validated CDKN2B-AS1 (ANRIL) as a poor prognosis biomarker, not only in iCCA, but also in hepatocellular carcinoma, kidney renal clear cell carcinoma and uterine corpus endometrial carcinoma. Conclusions: We report a prognosis lncRNA signature in iCCA and the clinical relevance of CDKN2B-AS1 (ANRIL) overexpression in several cancers.
MeSH term(s)	Aged ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/mortality ; Bile Duct Neoplasms/pathology ; Biomarkers, Tumor/genetics ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/mortality ; Cholangiocarcinoma/pathology ; Cohort Studies ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; RNA, Long Noncoding/biosynthesis ; Real-Time Polymerase Chain Reaction/methods
Chemical Substances	Biomarkers, Tumor ; CDKN2B antisense RNA, human ; RNA, Long Noncoding
Language	English
Publishing date	2019-04-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1459373-7
ISSN	1878-3562 ; 1125-8055
ISSN (online)	1878-3562
ISSN	1125-8055
DOI	10.1016/j.dld.2019.03.019
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Article ; Online: A weird polyp, 8 years after the Whipple procedure.

Courtin-Tanguy, Laetitia / Merdrignac, Aude / Meunier, Bernard / Sulpice, Laurent

Surgery

2017 Volume 162, Issue 1, Page(s) 188–190

Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2016.05.034
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Article: Comparison of alternative arterial anastomosis site during liver transplantation when the recipient's hepatic artery is unusable.

Beaurepaire, Jean Marie / Orlando, Francesco / Levi Sandri, Giovanni Battista / Jezequel, Caroline / Bardou-Jacquet, Edouard / Camus, Christophe / Lakehal, Mohamed / Desfourneaux, Veronique / Merdrignac, Aude / Gaignard, Elodie / Thobie, Alexandre / Bergeat, Damien / Meunier, Bernard / Rayar, Michel

Hepatobiliary surgery and nutrition

2022 Volume 11, Issue 1, Page(s) 1–12

Abstract: Background: Few studies have analyzed outcomes of liver transplantation (LT) when the recipient hepatic artery (HA) was not usable.: Methods: We retrospectively evaluated the outcomes of LT performed using the different alternative sites to HA.: ... ...

Abstract	Background: Few studies have analyzed outcomes of liver transplantation (LT) when the recipient hepatic artery (HA) was not usable. Methods: We retrospectively evaluated the outcomes of LT performed using the different alternative sites to HA. Results: Between 2002 and 2017, 1,677 LT were performed in our institution among which 141 (8.4%) with unusable recipient HA were analyzed. Four groups were defined according to the site of anastomosis: the splenic artery (SA group, n=26), coeliac trunk (CT group, n=12), aorta using or not the donor's vessel (Ao group, n=91) and aorta using a vascular prosthesis (Ao-P group, n=12) as conduit. The median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups (5, 5, 8.5 and 16 for SA, CT, Ao and Ao-P group respectively, P=0.002), as well as fresh frozen plasma (4.5, 2.5, 10, 17 for the SA, CT, Ao and Ao-P groups respectively, P=0.001). Hospitalization duration was also significantly increased in the Ao and Ao-P groups (15, 16, 24, 26.5 days for the SA, CT, Ao and Ao-P groups respectively, P<0.001). The occurrence of early allograft dysfunction (EAD) (P=0.07) or arterial complications (P=0.26) was not statistically different. Level of factor V, INR, bilirubin and creatinine during the 7 Conclusions: In case of unusable HA, intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta.
Language	English
Publishing date	2022-02-24
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-20-10
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Article ; Online: Nasogastric Decompression vs No Decompression After Pancreaticoduodenectomy: The Randomized Clinical IPOD Trial.

Bergeat, Damien / Merdrignac, Aude / Robin, Fabien / Gaignard, Elodie / Rayar, Michel / Meunier, Bernard / Beloeil, Hélène / Boudjema, Karim / Laviolle, Bruno / Sulpice, Laurent

JAMA surgery

2020 Volume 155, Issue 9, Page(s) e202291

Abstract: Importance: Although standardization of pancreaticoduodenectomy (PD) has improved postoperative outcomes, morbidity remains high. Fast-track surgery programs appear to improve morbidity, and avoiding nasogastric tube decompression (NGTD), already ... ...

Abstract	Importance: Although standardization of pancreaticoduodenectomy (PD) has improved postoperative outcomes, morbidity remains high. Fast-track surgery programs appear to improve morbidity, and avoiding nasogastric tube decompression (NGTD), already outdated in most major abdominal surgery, is strongly suggested after PD by fast-track surgery programs but lacks high-level evidence, especially regarding safety. Objective: To assess in a randomized clinical trial whether the absence of systematic NGTD after PD reduces postoperative complications. Design, setting, and participants: The IPOD study (Impact of the Absence of Nasogastric Decompression After Pancreaticoduodenectomy) was an open-label, prospective, single-center, randomized clinical trial conducted at a high-volume pancreatic surgery university hospital in France. In total, 155 patients who were 18 to 75 years of age and required PD for benign or malignant disease were screened for study eligibility. Key exclusion criteria were previous gastric or esophageal surgery and severe comorbidities. Patients were randomly assigned (1:1) to systematic NGTD or to no nasogastric decompression and were followed up until 90 days after surgery. Interventions: For patients without NGTD, the NGT was removed immediately after surgery, whereas for patients with NGTD, the NGT was removed 3 to 5 days after surgery. Main outcomes and measures: The primary end point was the occurrence of postoperative complications grade II or higher using the Clavien-Dindo classification. The primary end point and safety were evaluated in the intent-to-treat population. Results: From January 2016 to August 2018, 125 screened patients were considered eligible for the study, and 111 were randomized to no NGTD (n = 52) or to NGTD (n = 59). No patient was lost to follow-up. The 2 groups had similar patient demographic and clinical characteristics at baseline. The median (interquartile range) age was 63.0 (57.0-66.5) years in the group with NGTD (38 [64.4%] were males) and 64.0 (58.0-68.0) years in the group without NGTD (31 [59.6%] were males). The postoperative complication rates grade II or higher were similar between the 2 groups (risk ratio, 0.99; 95% CI, 0.66-1.47; P > .99). Pulmonary complication rates (risk ratio, 0.59; 95% CI, 0.18-1.95; P = .44) and delayed gastric emptying rates (risk ratio, 1.07; 95% CI, 0.52-2.21; P > .99) were not significantly different between the groups. Median (interquartile) length of hospital stay for patients without NGTD was not significantly different compared with those with NGTD (10.0 [9.0-16.3] vs 12.0 [10.0-16.0] days; P = .14). Conclusions and relevance: The present study found no significant difference in postoperative complication occurrence of Clavien-Dindo classification grade II or higher between systematic NGTD and no NGTD after PD, suggesting that avoiding systematic nasogastric decompression is safe for this indication. Trial registration: ClinicalTrials.gov Identifier: NCT02594956.
MeSH term(s)	Aged ; Decompression, Surgical ; Female ; France ; Humans ; Intubation, Gastrointestinal ; Length of Stay ; Male ; Middle Aged ; Pancreatic Diseases/pathology ; Pancreatic Diseases/surgery ; Pancreaticoduodenectomy/adverse effects ; Postoperative Complications/prevention & control ; Prospective Studies
Language	English
Publishing date	2020-09-16
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2701841-6
ISSN	2168-6262 ; 2168-6254
ISSN (online)	2168-6262
ISSN	2168-6254
DOI	10.1001/jamasurg.2020.2291
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Article ; Online: Effect of the Use of Reinforced Stapling on the Occurrence of Pancreatic Fistula After Distal Pancreatectomy: Results of the REPLAY (REinforcement of the Pancreas in distaL pAncreatectomY) Multicenter Randomized Clinical Trial.

Merdrignac, Aude / Garnier, Jonathan / Dokmak, Safi / Regenet, Nicolas / Lesurtel, Mickaël / Mabrut, Jean Yves / Sa Cunha, Antonio / Fuks, David / Bergeat, Damien / Robin, Fabien / Le Pabic, Estelle / Boudjema, Karim / Turrini, Olivier / Laviolle, Bruno / Sulpice, Laurent

Annals of surgery

2022 Volume 276, Issue 5, Page(s) 769–775

Abstract: Objective: The aim of the study was to evaluate the impact of the use of a reinforced stapler (RS) during distal pancreatectomy (DP) on postoperative outcomes.: Background: DP remains associated with significant postoperative morbidity owing to ... ...

Abstract	Objective: The aim of the study was to evaluate the impact of the use of a reinforced stapler (RS) during distal pancreatectomy (DP) on postoperative outcomes. Background: DP remains associated with significant postoperative morbidity owing to pancreatic fistula (PF). To date, there is no consensus on the management of the pancreatic stump. The use of an RS potentially represents a simple way to decrease the rate of PF. Methods: The REPLAY study (NCT03030170) is a prospective, multicenter, randomized study. Patients who underwent DP were randomized (1:1 ratio) in 2 groups for the use of a standard stapler (SS) or an RS to close remnant pancreatic parenchyma. The primary endpoint was the rate of overall PF. Secondary endpoints included severity of PF, length of hospital stay, overall morbidity, and rate of readmission for a PF within 90 days. Participants were blinded to the procedure actually carried out. Results: A total of 199 were analyzed (SS, n=99; RS, n=100). One patient who did not undergo surgery was excluded. Baseline characteristics were comparable in both groups. The rate of overall PF was higher in RS group (SS: 67.7%, RS: 83%, P =0.0121), but the rate of clinically relevant PF was similar (SS: 11.1%, RS: 14%, P =0.5387). Mean length of total hospital stay, readmission for PF, postoperative morbidity, and mortality at 90 days were similar. Conclusion: The results of this randomized clinical trial did not favor the use of RS during DP to reduce the rate of PF.
MeSH term(s)	Humans ; Pancreas/surgery ; Pancreatectomy/methods ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Pancreatic Fistula/prevention & control ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Prospective Studies ; Risk Factors
Language	English
Publishing date	2022-07-25
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000005618
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