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Article ; Online: Synthesis and characterization of noble metal/metal oxide nanoparticles and their potential antidiabetic effect on biochemical parameters and wound healing

Elobeid Mai A. / Awad Manal A. / Virk Promy / Ortashi Khalid M. / Merghani Nada M. / Asiri Atheer M. / Bashir Emadeldin Abdeljabar Ali

Green Processing and Synthesis, Vol 11, Iss 1, Pp 106-

2022 Volume 115

Abstract: The study assessed the antidiabetic effect of Solenostemma argel and its nanoformulations with silver/gold nanocomposites (CNPs), zinc oxide nanoparticles (ZnONPs), and metaformin drug. Experimental groups consisted of normal control, diabetic control, ... ...

Abstract	The study assessed the antidiabetic effect of Solenostemma argel and its nanoformulations with silver/gold nanocomposites (CNPs), zinc oxide nanoparticles (ZnONPs), and metaformin drug. Experimental groups consisted of normal control, diabetic control, and four diabetic groups treated with metformin, CNPs, ZnONPs, and bulk argel leaf extract (So-argel). Transmission electron microscopy characterization showed that the synthesized CNPs and ZnONPs were of variable sizes and dimensions and were quasi-spherical in shape. Particle sizes measured by dynamic light scattering were 106 and 139 nm for CNPs and ZnONPs, respectively. Also, the polydispersity index values were 0.473 and 0.269 for CNPs and ZnONPs, respectively. The biochemical parameters were as follows: the group treated with bulk So-argel (105.00 ± 4.041 mg·dL−1) and CNPs (109.00 ± 8.373 mg·dL−1) showed a more profound anti-hyperglycemic effect and were comparable to the control (88.40 ± 2.249). Liver and kidney functions (p ≤ 0.05) improved with So-argel and its nanoformulations compared to metformin. However, bulk argel (170.33 ± 20.431 and 38.00 ± 3.05 U·L−1) and the nanocomposite (228.33 ± 11.464 and 48.00 ± 5.291 U·L−1) were efficacious in lowering serum levels of liver enzymes (AST and ALT, respectively). No significant difference was observed between urea levels. Nevertheless, bulk So-argel (0.26 ± 0.007) and CNPs (0.24 ± 0.018) were more effective than ZnONPs (0.41 ± 0.289) on serum creatinine. Nanotreatment exhibited a reduction in lesions size/healing. Overall, nanoparticles may offer a safe potential for Type 2 diabetes management.
Keywords	a diabetic lesion ; diabetes mellitus ; nanoparticles ; solenostemma argel ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cytotoxicity of green-synthesized silver nanoparticles by Adansonia digitata fruit extract against HTC116 and SW480 human colon cancer cell lines

Almukaynizi Fatimah Basil / Daghestani Maha H. / Awad Manal A. / Althomali Arwa / Merghani Nada M. / Bukhari Wadha I. / Algahtani Norah M. / Al-Zuhairy Shatha S. / ALOthman Ahlam M. / Alsenani Eman A. / Alojayan Badrih O. / Al-Saif Khulud S. / Bhat Ramesa Shafi

Green Processing and Synthesis, Vol 11, Iss 1, Pp 411-

2022 Volume 422

Abstract: Nanoparticles synthesized from plants are being explored for cancer treatment therapies all over the world. This study reported the eco-friendly and low-cost method for the green synthesis of silver nanoparticles (AgNPs) from Adansonia digitata fruit as ... ...

Abstract	Nanoparticles synthesized from plants are being explored for cancer treatment therapies all over the world. This study reported the eco-friendly and low-cost method for the green synthesis of silver nanoparticles (AgNPs) from Adansonia digitata fruit as a reducing and capping agent. The anti-cancer potential of synthesized particles was explored against HTC116 and SW480 colon cancer cell lines. Prepared AgNPs were characterized by ultraviolet-visible spectroscopy, zeta potential, transmission electronic microscopy, scanning electronic microscopy, Fourier transform infrared, and energy-dispersive spectrum. The cytotoxicity was determined with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and expression levels of four genes (CTNNB1, APC, LRP5, and LRP6) were checked by reverse transcription polymerase chain reaction. The sharp peak of surface plasmon resonance at 400 nm confirms the formation of AgNPs. Dynamic light scattering showed average sizes of 16.34 nm with a polydispersity index of 0.193. A. digitata AgNPs were spherical with slight aggregated. AgNPs were more cytotoxic than A. digitata extract and decrease the expression of CTNNB1 and LRP6 genes while LRP5 gene expression was increased in both cell lines. APC gene expression was decreased in SW480 but increased in HTC116 with treatment. Overall, this study suggested that AgNPs synthesized by A. digitata fruit extract can be an attractive candidate for anticancer applications.
Keywords	adansonia digitata ; silver nanoparticles ; gene expression ; human colon cancer cell line ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Green nanogold activity in experimental breast carcinoma in vivo.

Hendi, Awatif A / El-Nagar, Doaa Mohamed / Awad, Manal A / Ortashi, Khalid M / Alnamlah, Reema Abdullah / Merghani, Nada M

Bioscience reports

2020 Volume 40, Issue 11

Abstract: Background: Over the past few years, fabrication of nanoparticles (NPs) has been deployed widely in technologies and many concerns have emerged about the hazardous effect on human health after NPs exposure.: Objective: Green synthesis of gold NPs ( ... ...

Abstract	Background: Over the past few years, fabrication of nanoparticles (NPs) has been deployed widely in technologies and many concerns have emerged about the hazardous effect on human health after NPs exposure. Objective: Green synthesis of gold NPs (AuNPs) and assessment of their activity in 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer mouse model. Methods: Chloroauric acid (HAuCl4) was used in formation of AuNPs with the help of Curcuma longa as aqueous reducing extract and stabilizing agent at room temperature. Formed NPs were characterized with UV-Vis spectrometry, Fourier-transform infrared spectroscopy (FTIR), Zetasizer measurement, Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Virgin female albino mice with DMBA-induced breast cancer were treated with formed AuNPs for 5 consecutive days and were dissected after 28 days of the beginning of treatment. Results: UV-Vis spectrometry showed absorbance maximum peak at 530 nm for formed AuNPs, FTIR confirmed formation of plant extract layer around formed NPs; zetasizer measurement revealed 278.2 nm as an average size of produced NPs; SEM and TEM approved formation of monodisperse spherical AuNPs. Biochemical analysis of untreated breast cancer group revealed marked changes in liver and kidney functions manifested by raised activity levels of alanine transaminase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN) and creatinine. Whereas, the treated group with AuNPs post-breast cancer induction displayed reduction in the activities (of ALT, AST and creatinine), while the BUN activity level was raised. Histopathological examination showed heavy incidence of tumor foci in the breast and lymph nodes belonged to the untreated breast cancer group confirmed with intense response to Ki-67 antibodies. While the treated group with AuNPs post-breast cancer induction showed degenerated tumor foci in the breast and lymph nodes with weak response to Ki-67 antibodies. Conclusion: AuNPs were successfully synthesized using HAuCl4 and C. longa extract confirmed their ability to control DMBA-induced breast cancer in virgin female Swiss albino mice.
MeSH term(s)	9,10-Dimethyl-1,2-benzanthracene ; Alanine Transaminase/blood ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Aspartate Aminotransferases/blood ; Blood Urea Nitrogen ; Breast Neoplasms/blood ; Breast Neoplasms/chemically induced ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Chlorides/chemistry ; Chlorides/pharmacology ; Creatinine/blood ; Curcuma/chemistry ; Excipients/chemistry ; Female ; Gold Compounds/chemistry ; Gold Compounds/pharmacology ; Green Chemistry Technology ; Metal Nanoparticles ; Mice ; Nanomedicine ; Neoplasms, Experimental/blood ; Neoplasms, Experimental/chemically induced ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Oxidation-Reduction ; Plant Extracts/chemistry ; Tumor Burden/drug effects
Chemical Substances	Antineoplastic Agents ; Chlorides ; Excipients ; Gold Compounds ; Plant Extracts ; 9,10-Dimethyl-1,2-benzanthracene (57-97-6) ; turmeric extract (856YO1Z64F) ; gold tetrachloride, acid (8H372EGX3V) ; Creatinine (AYI8EX34EU) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	English
Publishing date	2020-11-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20200115
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Article ; Online: Correction to: Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism.

Aabed, Kawther / Bhat, Ramesa Shafi / Al-Dbass, Abeer / Moubayed, Nadine / Algahtani, Norah / Merghani, Nada M / Alanazi, Azizah / Zayed, Naima / El-Ansary, Afaf

Lipids in health and disease

2021 Volume 20, Issue 1, Page(s) 61

Language	English
Publishing date	2021-07-04
Publishing country	England
Document type	Published Erratum
ISSN	1476-511X
ISSN (online)	1476-511X
DOI	10.1186/s12944-021-01484-y
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Article ; Online: Bactericidal and cytotoxic properties of green synthesized nanosilver using Rosmarinus officinalis leaves

Daghestani Maha / Al Rashed Sarah A. / Bukhari Wadha / Al-Ojayan Badryah / Ibrahim Eiman M. / Al-Qahtani Asma M. / Merghani Nada M. / Ramadan Rasha / Bhat Ramesa Shafi

Green Processing and Synthesis, Vol 9, Iss 1, Pp 230-

2020 Volume 236

Abstract: Green synthesized nanoparticles from plant extracts are being used in various biomedical applications, particularly because of their bactericidal and cytotoxic activities. In this study, silver nanoparticles (AgNPs) were successfully synthesized from the ...

Abstract	Green synthesized nanoparticles from plant extracts are being used in various biomedical applications, particularly because of their bactericidal and cytotoxic activities. In this study, silver nanoparticles (AgNPs) were successfully synthesized from the Rosmarinus officinalis aqueous leaf extract. Different spectroscopic and microscopic analyses such as ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy, and energy-dispersive X-ray spectroscopy were performed to verify the biosynthesized AgNPs in our sample. The formation of nanosilver particles was preliminarily confirmed by UV-vis spectroscopy at 400 nm. The presence of carboxylic or amide groups was confirmed by FTIR, for the reduction of the silver ion. Transmission electron microscopy confirmed a particle size of 12–22 nm. The prepared AgNPs showed good antibacterial activity against human pathogens and good cytotoxic activity against the human breast cancer cell line (MDA MB 231). The nanoparticles prepared from R. officinalis can be used for various biomedical applications.
Keywords	rosmarinus officinalis ; green synthesis ; nanosilver ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
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Article ; Online: Anti-colon cancer activities of green-synthesized Moringa oleifera–AgNPs against human colon cancer cells

Althomali Arwa / Daghestani Maha H. / Basil Almukaynizi Fatimah / Al-Zahrani Sabah Ahmed / Awad Manal A. / Merghani Nada M. / Bukhari Wadha I. / Ibrahim Eiman M. / Alzahrani Sherifah M. / Altowair Nouf / AL-Ghamdi Afaf S. / AlQahtani Asma M. / Ramadan Rasha / Bhat Ramesa Shafi

Green Processing and Synthesis, Vol 11, Iss 1, Pp 545-

2022 Volume 554

Abstract: The anticancer activity of silver nanoparticles (AgNPs) is well known to be synthesized using green-synthesized methods, although its mechanism of action is not understood fully. Moringa oleifera leaves were used as reducing and stabilizing agents to ... ...

Abstract	The anticancer activity of silver nanoparticles (AgNPs) is well known to be synthesized using green-synthesized methods, although its mechanism of action is not understood fully. Moringa oleifera leaves were used as reducing and stabilizing agents to synthesize AgNPs. Green-synthesized AgNPs were characterized using ultraviolet-visible spectroscopy, dynamic light scattering, transmission electronic microscopy, scanning electronic microscopy, Fourier transform infrared, and energy-dispersive X-ray spectroscopy analyses. The synthesized nanoparticles were then characterized by their anticancer properties by performing a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The real-time polymerase chain reaction was used to check the expression levels of the four genes (β-catenin, adenomatous polyposis coli (APC), and lipoprotein receptor-related proteins 5 and 6 (LRP5/6)). The synthesized nanoparticles were 25 nm on average and spherical in shape and aggregated form. Noteworthy cytotoxicity is how green-synthesized M. oleifera–AgNPs were observed in comparison with the M. oleifera leaf extract against a cancerous cell line. The M. oleifera–AgNPs decreased the expression of CTNNB1 and LRP6 genes, while the LRP5 gene expression increased in both cell lines. With treatment, the APC gene expression decreased in SW480 but increased in HTC116. Our results imply that AgNPs synthesized by M. oleifera extract could be an ideal strategy to combat colon cancer.
Keywords	moringa oleifera ; plant extract ; nanosilver ; anticancer activity ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism.

Aabed, Kawther / Bhat, Ramesa Shafi / Al-Dbass, Abeer / Moubayed, Nadine / Algahtani, Norah / Merghani, Nada M / Alanazi, Azizah / Zayed, Naima / El-Ansary, Afaf

Lipids in health and disease

2019 Volume 18, Issue 1, Page(s) 200

Abstract: Background: Neuroinflammation plays a major role in the pathogenesis of autism because the cytokine levels are typically disturbed in the brain in autistic patients. Prebiotics-rich diet maintains the healthy gut microbiota and hence can regulate the ... ...

Abstract	Background: Neuroinflammation plays a major role in the pathogenesis of autism because the cytokine levels are typically disturbed in the brain in autistic patients. Prebiotics-rich diet maintains the healthy gut microbiota and hence can regulate the neuroinflammation indirectly. The study aimed to investigate the role of bee pollen and propolis in ameliorating neuroinflammation, including cytokine levels, in an animal model of autism. Methods: Hamsters were classified as four groups: Group I, control; Group II, autistic model/animals treated with 250 mg propionic acid (PPA)/kg body weight (BW)/day for 3 days; Group III, animals treated with bee pollen at a dose of 250 mg/kg BW/day for 4 weeks; and Group IV, animals treated with propolis at a dose of 250 mg/kg BW/day for 4 weeks. Neuroinflammatory responses were evaluated using the levels of interferon γ (IFN-γ), interleukin 1 alpha (IL-1α), IL-6, IL-10, IL-12 (p70), vascular endothelial growth factor (VEGF), and tumor necrosis factor α (TNFα). Results: Significant decrease of IL-10 (P<0.026), VEGF (P<0.005), and TNFα(P<0.005) levels and increased IL-1α (P<0.032), IL-6(P<0.028), and IFN-γ (P<0.013) levels were observed between the four studied groups. The neurotoxic effects of PPA was clearly presented as much higher IL-6, as pro-inflammatory cytokine (P<0.05), concomitant with much lower IL-10, as anti-inflammatory cytokine(P<0.015) compared to controls. Both bee pollen and propolis were effective in ameliorating the neurotoxic effects of PPA demonstrating non-significant changes of IL-6 and IL-10 when compared to control healthy hamsters. Conclusions: Our findings indicate that both bee pollen and propolis protect against neuroinflammation in the rodent model of autism. However, further studies are needed to investigate the clinical benefits of prebiotics-rich diet in neurodevelopmental disorders, such as autism.
MeSH term(s)	Animals ; Autistic Disorder/chemically induced ; Autistic Disorder/drug therapy ; Autistic Disorder/metabolism ; Brain Chemistry/drug effects ; Cytokines/analysis ; Disease Models, Animal ; Dysbiosis/chemically induced ; Dysbiosis/drug therapy ; Inflammation/chemically induced ; Inflammation/drug therapy ; Male ; Mesocricetus ; Pollen/metabolism ; Propionates/pharmacology ; Propolis/pharmacology
Chemical Substances	Cytokines ; Propionates ; Propolis (9009-62-5) ; propionic acid (JHU490RVYR)
Language	English
Publishing date	2019-11-16
Publishing country	England
Document type	Journal Article
ISSN	1476-511X
ISSN (online)	1476-511X
DOI	10.1186/s12944-019-1150-0
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Article ; Online: Understanding the roles of glutamine synthetase, glutaminase, and glutamate decarboxylase autoantibodies in imbalanced excitatory/inhibitory neurotransmission as etiological mechanisms of autism.

Hamed, Najat O / Al-Ayadhi, Laila / Osman, Mohamed A / Elkhawad, Abdalla O / Qasem, Hanan / Al-Marshoud, Majida / Merghani, Nada M / El-Ansary, Afaf

Psychiatry and clinical neurosciences

2018 Volume 72, Issue 5, Page(s) 362–373

Abstract: Aim: Autism is a heterogeneous neurological disorder that is characterized by impairments in communication and social interactions, repetitive behaviors, and sensory abnormalities. The etiology of autism remains unclear. Animal, genetic, and post-mortem ...

Abstract	Aim: Autism is a heterogeneous neurological disorder that is characterized by impairments in communication and social interactions, repetitive behaviors, and sensory abnormalities. The etiology of autism remains unclear. Animal, genetic, and post-mortem studies suggest that an imbalance exists in the neuronal excitation and inhibition system in autism. The aim of this study was to determine whether alterations of the measured parameters in children with autism are significantly associated with the risk of a sensory dysfunction. Methods: The glutamine synthetase (GS), kidney-type glutaminase (GLS1), and glutamic acid decarboxylase autoantibody levels were analyzed in 38 autistic children and 33 age- and sex-matched controls using enzyme-linked immunosorbent assays. Results: The obtained data demonstrated significant alterations in glutamate and glutamine cycle enzymes, as represented by GS and GLS1, respectively. While the glutamic acid decarboxylase autoantibodies levels were remarkably increased, no significant difference was observed compared to the healthy control participants. Conclusion: The obtained data indicate that GS and GLS1 are promising indicators of a neuronal excitation and inhibition system imbalance and that combined measured parameters are good predictive biomarkers of autism.
MeSH term(s)	Autism Spectrum Disorder/blood ; Autoantibodies/blood ; Child ; Glutamate Decarboxylase/immunology ; Glutamate-Ammonia Ligase/immunology ; Glutamic Acid/metabolism ; Glutaminase/immunology ; Humans ; Male ; Synaptic Transmission ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	Autoantibodies ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2) ; GLS protein, human (EC 3.5.1.2) ; Glutaminase (EC 3.5.1.2) ; Glutamate Decarboxylase (EC 4.1.1.15) ; Glutamate-Ammonia Ligase (EC 6.3.1.2)
Language	English
Publishing date	2018-03-10
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/pcn.12639
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