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  1. Article ; Online: Peripheral stem cell mobilization strategies in patients with autologous hematopoietic cell transplantation

    SİNEM NAMDAROĞLU / Tugçe Nur Yigenoglu / Hikmettullah Batgi / Bahar Uncu Ulu / Dicle İskender / Merih Çakar / Mehmet Sinan Dal / Fevzi Altuntaş

    Jurnal Teknologi Laboratorium, Vol 9, Iss 2, Pp 159-

    A single center's experience

    2020  Volume 167

    Abstract: This research is to investigate the parameters which may affect the mobilization of stem cells in patients receiving autologous hematopoietic peripheral blood stem cell transplantation (PBSCT). A retrospective study was carried out using the data derived ...

    Abstract This research is to investigate the parameters which may affect the mobilization of stem cells in patients receiving autologous hematopoietic peripheral blood stem cell transplantation (PBSCT). A retrospective study was carried out using the data derived from the medical files of 242 patients who received PBSCT. Descriptive, clinical, and laboratory parameters were compared between patients with successful and unsuccessful stem cell mobilization. Successful stem cell mobilization ratio was 4.463 times higher when preemptive plerixafor was administrated; 1.032 times higher when CD34+ cell count increased 1 unit at the beginning of mobilization. The white blood cell count was inversely correlated with the success of mobilization. An increase of 1 unit in WBC count was associated with a 1.027 times decrease in the success rate. The data indicated that the administration of preemptive plerixafor and CD34+ cell count at the beginning of mobilization were directly related to the success of mobilization after PBSCT. On contrary, WBC count was inversely associated with the success rate.
    Keywords bone marrow ; hematopoietic peripheral ; stem cell transplantation ; stem cell mobilization ; Medicine (General) ; R5-920
    Subject code 610 ; 571
    Language Indonesian
    Publishing date 2020-12-01T00:00:00Z
    Publisher Poltekkes Kemenkes Yogyakarta
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting

    Ali Hakan Kaya / Emre Tekgündüz / Fazilet Duygu / Dicle Koca / Filiz Bekdemir / Hikmetullah Batgi / Bahar Ulu Uncu / Tuğçe Nur Yiğenoğlu / Mehmet Sinan Dal / Merih Çakar Kızıl / Fevzi Altuntaş

    Balkan Medical Journal, Vol 34, Iss 2, Pp 132-

    2017  Volume 139

    Abstract: Background: Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. Aims: To investigate the outcomes ...

    Abstract Background: Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality. Aims: To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol in febrile neutropenia patients who have undergone haematopoietic stem cell transplantation at our clinic. Study Design: Descriptive study. Methods: The present study retrospectively evaluated febrile neutropenia attacks in haematopoietic stem cell transplantation recipients during the period June 2014 - January 2015 at our haematopoietic stem cell transplantation clinic. Results: A total of 72 febrile neutropenia attacks were evaluated in 53 patients. In 46 febrile neutropenia attacks, microbiologic cultures revealed positive results. In culture-positive febrile neutropenia episodes a single bacterium was isolated in 32 cases and multiple strains were isolated in 14. In 15 patients, empirical antibiotic therapy was discontinued after 72 hours. These patients were clinically stable, without evident focus of infection and had negative culture results. Only 4 recurrent episodes were observed (27%) after cessation of antibiotherapy. No patient died as a result of recurrent infection. The 30-day and 100-day post-transplantation mortality rates of patients with febrile neutropenia episodes were 11.3% (6/53) and 3.8% (2/53), respectively. Infection-related 30-day and 100-day mortality rates were 7.5% (4/53) and 0% (0/53), respectively. Conclusion: The main message of our study is that early cessation of empirical antibiotherapy seems to be feasible in eligible patients without increasing febrile neutropenia mortality rates
    Keywords Haematopoietic stem cell transplantation ; febrile neutropenia ; early cessation of empirical antibiotherapy ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2017-04-01T00:00:00Z
    Publisher Galenos Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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