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  1. Book ; Thesis: CT-basierte Risikoabschätzung pulmonaler Komplikationen bei Patienten mit stumpfem Thoraxtrauma

    Merkel, Philipp

    2008  

    Author's details eingereicht von: Philipp Merkel
    Language German
    Size 76 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leipzig, Univ., Diss., 2008
    HBZ-ID HT016094454
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Efficacy and safety of avacopan in patients with ANCA-associated vasculitis receiving rituximab in a randomised trial.

    Geetha, Duvuru / Dua, Anisha / Yue, Huibin / Springer, Jason / Salvarani, Carlo / Jayne, David / Merkel, Peter

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 2, Page(s) 223–232

    Abstract: Objectives: To evaluate the efficacy and safety of avacopan in the subgroup of patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis receiving background induction therapy with rituximab in the phase 3 ADVOCATE trial.: ... ...

    Abstract Objectives: To evaluate the efficacy and safety of avacopan in the subgroup of patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis receiving background induction therapy with rituximab in the phase 3 ADVOCATE trial.
    Methods: Key efficacy outcomes were remission at week 26 and sustained remission at week 52. Additional outcomes included the Glucocorticoid Toxicity Index, estimated glomerular filtration rate, urinary albumin to creatinine ratio, health-related quality of life and safety.
    Results: Of the 330 patients who received study medication, 214 (64.8%) received rituximab (once weekly for 4 weeks), with a mean age of 59.8 years; 163 (76.2%) had renal vasculitis and 125 (58.4%) were newly diagnosed. Remission at week 26 and sustained remission at week 52 were achieved by 83/107 (77.6%) and 76/107 (71.0%) patients in the avacopan group and 81/107 (75.7%) and 60/107 (56.1%) in the prednisone taper group, respectively. The relapse rate, recovery of renal function, speed of reduction in albuminuria and glucocorticoid toxicity favoured the avacopan group. Serious adverse events occurred in 34.6% and 39.3% of patients in the avacopan and prednisone taper groups, respectively.
    Conclusions: These data suggest that in patients with ANCA-associated vasculitis receiving rituximab, efficacy of treatment with avacopan compared with a prednisone taper was similar at week 26 and greater at week 52, with a favourable safety profile. In addition, avacopan was associated with improved renal outcomes and lower glucocorticoid toxicity. These results demonstrate the efficacy and safety of avacopan in patients receiving background induction therapy with rituximab.
    Trial registration number: NCT02994927.
    MeSH term(s) Humans ; Middle Aged ; Rituximab/adverse effects ; Immunosuppressive Agents/therapeutic use ; Prednisone ; Glucocorticoids/adverse effects ; Quality of Life ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Remission Induction ; Antibodies, Antineutrophil Cytoplasmic ; Aniline Compounds ; Nipecotic Acids
    Chemical Substances Rituximab (4F4X42SYQ6) ; Immunosuppressive Agents ; avacopan (O880NM097T) ; Prednisone (VB0R961HZT) ; Glucocorticoids ; Antibodies, Antineutrophil Cytoplasmic ; Aniline Compounds ; Nipecotic Acids
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-224816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Untersuchung der Fremdbeurteilung von Pädophilie in Abhängigkeit von der persönlichen Einstellung zur Sexualität

    Merkel, Patric

    1995  

    Author's details vorgelegt von Patric Merkel
    Language German
    Size 70, [11] Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Saarbrücken, Univ., Diss., 1995
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT007301478
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Quick and safe: why a k-wire-extension-block-fixation of a bony mallet finger is the favoured treatment.

    Stumpfe, Maximilian C / Suffa, Nadine / Merkel, Pauline / Ludolph, Ingo / Arkudas, Andreas / Horch, Raymund E

    Archives of orthopaedic and trauma surgery

    2023  Volume 144, Issue 3, Page(s) 1437–1442

    Abstract: Introduction: Mallet fingers are the most common tendon injuries of the hand. Bony avulsion distal finger extensor tendon ruptures causing a mallet finger require special attention and management. In this monocentral study, we analyzed the clinical and ... ...

    Abstract Introduction: Mallet fingers are the most common tendon injuries of the hand. Bony avulsion distal finger extensor tendon ruptures causing a mallet finger require special attention and management. In this monocentral study, we analyzed the clinical and individual outcomes succeeding minimal invasive k-wire extension block treatment of bony mallet fingers.
    Materials and methods: In a retrospective study, we sent a self-designed template and a QUICK-DASH score questionnaire to all patients, who were treated because of a bony mallet finger between 2009 and 2022 and fulfilled the inclusion criteria. A total of 244 requests were sent out. 72 (29.5%) patients participated in the study. Forty-five men and twenty-seven women were included.
    Results: 98.7% (n = 75) of the cases were successfully treated. Patients were highly satisfied with the treatment (median 8.0; SD ± 2.9; range 1.0-10.0). Based on the QUICK-DASH score, all patients showed no difficulties in daily life. The extent of avulsion did not influence the outcome.
    Conclusion: We conclude that the minimally invasive treatment of a bony mallet finger should be offered to every patient, because it is safe, fast, and reliable. Thus, we propose to perform extension-block pinning independently of the articular area.
    MeSH term(s) Male ; Humans ; Female ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/surgery ; Fracture Fixation, Internal ; Retrospective Studies ; Finger Joint/diagnostic imaging ; Finger Joint/surgery ; Finger Injuries/diagnostic imaging ; Finger Injuries/surgery ; Tendon Injuries/surgery ; Hand Deformities, Acquired
    Language English
    Publishing date 2023-12-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-023-05119-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: Modellierung des Temperaturverhaltens und experimentelle Untersuchungen zum Einfluss der Reibbelagsgeometrie auf das Reibwertverhalten am Beispiel trockenlaufender Friktionssysteme

    Merkel, Philipp

    Modelling of the temperature behavior and experimental investigations of the friction lining shape on the friction behavior on the example of dry running friction systems

    (Forschungsberichte IPEK; 88)

    2015  

    Author's details von Philipp Merkel
    Series title Forschungsberichte IPEK; 88
    Language German
    Size Online-Ressource (199 Seiten)
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis KIT, Diss.--Karlsruhe, 2015
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article ; Online: Erratum: Temporäre Endgelenkstransfixation bei subkutanen Strecksehnenabrissen der Zone 1 am Fingerendglied.

    Suffa, Nadine / Merkel, Pauline / Horch, Raymund E / Arkudas, Andreas / Ludolph, Ingo / Stumpfe, Maximilian Christoph

    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...

    2021  Volume 53, Issue 5, Page(s) E1

    Title translation Correction: Temporary Transfixation of the distal interphalangeal Joint in Mallet fingers.
    Language German
    Publishing date 2021-10-18
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 392414-2
    ISSN 1439-3980 ; 0722-1819
    ISSN (online) 1439-3980
    ISSN 0722-1819
    DOI 10.1055/a-1660-6310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 670: Show issues Location:
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  7. Article ; Online: Temporäre Endgelenkstransfixation bei subkutanen Strecksehnenabrissen der Zone 1 am Fingerendglied.

    Suffa, Nadine / Merkel, Pauline / Horch, Raymund E / Arkudas, Andreas / Ludolph, Ingo / Stumpfe, Maximilian Christoph

    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...

    2021  Volume 53, Issue 5, Page(s) 441–446

    Abstract: Purpose: This retrospective, unicenter cohort study analyse the clinical and subjective results following temporarily K-wire transfixation of the distal interphalangeal joint (DIPJ) in hyperextension in Mallet fingers.: Patients and methods: By means ...

    Title translation Temporarily Transfixation of the distal interphalangeal Joint in Mallet fingers.
    Abstract Purpose: This retrospective, unicenter cohort study analyse the clinical and subjective results following temporarily K-wire transfixation of the distal interphalangeal joint (DIPJ) in hyperextension in Mallet fingers.
    Patients and methods: By means of a self-designed questionnaire demographic data, patient´s satisfaction (0 = unsatisfied, 10 = very satisfied), persisting pain (yes/no), postoperative complications, and the Quick-DASH score were evaluated. In addition, range of motion of the DIPJ was measured with use of a self-designed template for self-evaluation by the patients. Questionnaire and template were send to 132 patients in whom a Mallet finger was treated between January 2009 and December 2019 with K-wire transfixation of the DIPJ. 65 (49,2 %) questionnaires and templates from 40 men and 25 women with an average age of 53.3 years returned. There were 40 acute and 25 chronic Mallet fingers in 35 (54 %) middle, 19 (29 %) small, 10 (15 %) ring, and 1 (2 %) index fingers. The extension deficit was classified according to Crawford.
    Results: According to the Crawford classification, there were 75 % excellent, 14 % good, and 11 % satisfied results. With an average of 7,9 points the patients were very satisfied. 15 patients reported about complications with six complaining persisting pain. The Quick-DASH score averaged 5.4 points.
    Conclusion: The treatment of Mallet fingers by transfixation of the DIPJ using a K-wire is an appropriate method leading to a good.
    MeSH term(s) Cohort Studies ; Female ; Finger Injuries/surgery ; Finger Joint/surgery ; Fingers ; Hand Deformities, Acquired ; Humans ; Male ; Middle Aged ; Range of Motion, Articular ; Retrospective Studies ; Tendon Injuries ; Treatment Outcome
    Language German
    Publishing date 2021-09-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 392414-2
    ISSN 1439-3980 ; 0722-1819
    ISSN (online) 1439-3980
    ISSN 0722-1819
    DOI 10.1055/a-1551-3481
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    Zs.A 670: Show issues Location:
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  8. Article ; Online: The Interobserver Reliability of Grading of Distal Radius Volar Plate Prominence.

    Crijns, Tom J / Merkel, Patrick / Kortlever, Joost T P / Wagner, K John / Ring, David / Vagner, Gregg / Teunis, Teun

    The Journal of hand surgery

    2022  Volume 47, Issue 11, Page(s) 1095–1100

    Abstract: Purpose: The 3-category rating of volar plate prominence in relation to the most volar edge of the distal radius (the watershed line) on lateral radiographs was reliable among a small group of surgeons and associated with the probability of flexor ... ...

    Abstract Purpose: The 3-category rating of volar plate prominence in relation to the most volar edge of the distal radius (the watershed line) on lateral radiographs was reliable among a small group of surgeons and associated with the probability of flexor tendon irritation and potential rupture. Classifications are often less reliable when tested among a large group of practicing surgeons in different environments.
    Methods: In this survey-based experiment, an international group of 115 fracture and upper extremity surgeons viewed 1 of 4 sets of 24 lateral radiographs (96 unique lateral radiographs) of patients with distal radius fractures who underwent volar plating in the practice of a single surgeon using 2 types of plates. Surgeons were asked to rate the following metrics: (1) the grade of plate prominence according to Soong, (2) whether the plate was more prominent than the watershed line, (3) whether the plate was separate from the bone distally, and (4) whether there is more than 5° of dorsal angulation of the distal radius articular surface.
    Results: The interobserver agreement of the classification was "fair" (κ = 0.32; 95% confidence interval [CI] = 0.27-0.36), and grading was more reliable among surgeons who do not supervise trainees. Volar prominence was less reliable (κ = 0.034; 95% CI = 0.013-0.055) than plate separation from bone (κ = 0.50; 95% CI = 0.42-0.59) and more than 5° of dorsal angulation (κ = 0.42; 95% CI = 0.35-0.48).
    Conclusions: Among a large number of international practicing surgeons, the classification of volar plate prominence in 3 categories was fair.
    Clinical relevance: The diagnosis of plate prominence might develop toward criteria with moderate reliability, such as separation of the plate from the bone and residual angulation of the distal radius.
    MeSH term(s) Humans ; Bone Plates ; Fracture Fixation, Internal/methods ; Observer Variation ; Palmar Plate/diagnostic imaging ; Palmar Plate/surgery ; Radius/diagnostic imaging ; Radius/surgery ; Radius Fractures/classification ; Radius Fractures/diagnostic imaging ; Radius Fractures/surgery ; Reproducibility of Results ; Tendon Injuries/diagnostic imaging ; Tendon Injuries/surgery ; Upper Extremity ; Health Care Surveys
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605716-0
    ISSN 1531-6564 ; 0363-5023
    ISSN (online) 1531-6564
    ISSN 0363-5023
    DOI 10.1016/j.jhsa.2022.07.013
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    Zs.A 1431: Show issues Location:
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  9. Article ; Online: Flow Water Proton NMR: In-Line Process Analytical Technology for Continuous Biomanufacturing.

    Taraban, Marc B / Briggs, Katharine T / Merkel, Peter / Yu, Y Bruce

    Analytical chemistry

    2019  Volume 91, Issue 21, Page(s) 13538–13546

    Abstract: Continuous manufacturing of biologics is one of the priorities of the biopharmaceutical industry. However, its widespread implementation is hampered by a lack of noninvasive/nondestructive process analytical technology (PAT) systems capable of real-time ... ...

    Abstract Continuous manufacturing of biologics is one of the priorities of the biopharmaceutical industry. However, its widespread implementation is hampered by a lack of noninvasive/nondestructive process analytical technology (PAT) systems capable of real-time in-line monitoring of product flow parameters, such as concentration and/or aggregate content. We have previously demonstrated that, under nonflow conditions, the water proton transverse relaxation rate,
    MeSH term(s) Chromatography, Gel ; Electric Conductivity ; Hydrogen-Ion Concentration ; Immunoglobulin G/chemistry ; Proton Magnetic Resonance Spectroscopy/methods ; Serum Albumin, Bovine/chemistry ; Technology, Pharmaceutical ; Water/chemistry
    Chemical Substances Immunoglobulin G ; Water (059QF0KO0R) ; Serum Albumin, Bovine (27432CM55Q)
    Language English
    Publishing date 2019-10-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.9b02622
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  10. Article: Der gesetzliche Mindestlohn in der Praxis

    Merkel, Philipp / Götz, Lenas

    Der Betrieb : mit Recht Innovation sichern Vol. 68, No. 24 , p. 1407-1413

    eine Bestandsaufnahme ; arbeitsrechtliche Probleme im betrieblichen Alltag

    2015  Volume 68, Issue 24, Page(s) 1407–1413

    Author's details Philipp Merkel; Lenas Götz
    Language German
    Publisher Handelsblatt Fachmedien
    Publishing place Düsseldorf
    Document type Article
    ZDB-ID 879-5
    ISSN 0005-9935
    Database ECONomics Information System

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