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  1. Book ; Thesis: Biochemische Charakterisierung und funktionelle Unterschiede von humanem und bovinem CEACAM1 auf NK-Zellen

    Merkt, Wolfgang

    2013  

    Author's details vorgelegt von Wolfgang Merkt
    Language German
    Size 69 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2014
    HBZ-ID HT018524722
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 128 order for loan Magazin

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  2. Article ; Online: CD19.CAR-T cells versus Obinutuzumab-Who will win the race on deep B cell depletion in systemic autoimmunity?

    Kvacskay, Peter / Merkt, Wolfgang

    Rheumatology (Oxford, England)

    2024  

    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CAR T-Cell Therapy in Autoimmune Disease.

    Merkt, Wolfgang / Lorenz, Hanns-Martin / Schmitt, Michael

    The New England journal of medicine

    2024  Volume 390, Issue 17, Page(s) 1628–1629

    MeSH term(s) Animals ; Humans ; Autoimmune Diseases/therapy ; Autoimmune Diseases/immunology ; Immunotherapy, Adoptive ; Receptors, Antigen, T-Cell/therapeutic use ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes/immunology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/therapy ; Antigens, CD19
    Chemical Substances Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen ; Antigens, CD19
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2403705
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  4. Article: Activation of natural killer cells by rituximab in granulomatosis with polyangiitis

    https://orcid.org/0000-0001-8732-0645 / Watzl, Carsten / Merkt, Wolfgang

    Arthritis Research & Therapy, 21:277

    2019  

    Abstract: OBJECTIVE: In the last few years, anti-CD20 antibody rituximab profoundly changed the therapeutic landscape of granulomatosis with polyangiitis (GPA). Here, we investigated whether natural killer (NK) cells may play a role in rituximab’s mechanism of ... ...

    Institution Technische Universität Dortmund. Leibniz-Institut für Arbeitsforschung
    Abstract OBJECTIVE: In the last few years, anti-CD20 antibody rituximab profoundly changed the therapeutic landscape of granulomatosis with polyangiitis (GPA). Here, we investigated whether natural killer (NK) cells may play a role in rituximab’s mechanism of action in GPA. METHODS: B cell depletion, NK cell degranulation, and the expression of CD69 and CD16 on NK cells were measured in a series of in vitro experiments using peripheral blood mononuclear cells (PBMCs). In vivo activation of NK cells was investigated in patients receiving rituximab infusions. Cells were analyzed by seven-color flow cytometry. RESULTS: NK cells from GPA patients were activated by immobilized rituximab. Also soluble rituximab activated NK cells, provided that B cells were present. NK cells degranulated and expressed the activation marker CD69 while CD16 expression was decreased. This activation of NK cells by soluble rituximab was accompanied by a reduction of B cells. The next-generation anti-CD20 antibody obinutuzumab showed stronger effects compared to rituximab on both the reduction of B cells and the activation of NK cells. Finally, we found that rituximab led to the activation of NK cells in vivo, provided that B cells were not depleted due to prior rituximab infusions. CONCLUSION: B cell-bound rituximab activates NK cells in GPA. While NK cells therefore participate in rituximab’s mechanism of action in humans, their potential may be more efficiently exploited, e.g., by Fc engineering of therapeutic antibodies.
    Keywords ANCA-associated vasculitis ; Antibody-dependent cellular cytotoxicity (ADCC) ; B cell depletion ; Granulomatosis with polyangiitis ; Fc-γ-receptor IIIa (FcγRIIIa; CD16) ; Obinutuzumab ; Natural killer cells ; Rheumatic diseases ; Rituximab
    Language English
    Document type Article
    Database Repository for Life Sciences

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  5. Article ; Online: Leflunomide in combination with JAK inhibitors in the treatment of rheumatoid arthritis: a case series.

    Kvacskay, Peter / Blank, Nobert / Lorenz, Hanns-Martin / Merkt, Wolfgang

    Rheumatology (Oxford, England)

    2022  Volume 61, Issue 9, Page(s) e280–e281

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Humans ; Janus Kinase Inhibitors/therapeutic use ; Leflunomide/therapeutic use
    Chemical Substances Antirheumatic Agents ; Janus Kinase Inhibitors ; Leflunomide (G162GK9U4W)
    Language English
    Publishing date 2022-05-22
    Publishing country England
    Document type Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac240
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  6. Article ; Online: Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming.

    Merkt, Wolfgang / Zhou, Yan / Han, Hongwei / Lagares, David

    Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

    2021  Volume 29, Issue 4, Page(s) 678–691

    Abstract: In response to tissue injury, fibroblasts differentiate into professional repair cells called myofibroblasts, which orchestrate many aspects of the normal tissue repair programme including synthesis, deposition and contraction of extracellular matrix ... ...

    Abstract In response to tissue injury, fibroblasts differentiate into professional repair cells called myofibroblasts, which orchestrate many aspects of the normal tissue repair programme including synthesis, deposition and contraction of extracellular matrix proteins, leading to wound closure. Successful tissue repair responses involve termination of myofibroblast activities in order to prevent pathologic fibrotic scarring. Here, we discuss the cellular and molecular mechanisms limiting myofibroblast activities during physiological tissue repair, including myofibroblast deactivation, apoptosis, reprogramming and immune clearance of senescent myofibroblasts. In addition, we summarize pathological mechanisms leading to myofibroblast persistence and survival, a hallmark of fibrotic diseases. Finally, we discuss emerging anti-fibrotic therapies aimed at targeting myofibroblast fate such as senolytics, gene therapy, cellular immunotherapy and CAR-T cells.
    MeSH term(s) Apoptosis ; Cell Differentiation ; Fibrosis ; Humans ; Myofibroblasts/pathology ; Senotherapeutics ; Wound Healing
    Chemical Substances Senotherapeutics
    Language English
    Publishing date 2021-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1174873-4
    ISSN 1524-475X ; 1067-1927
    ISSN (online) 1524-475X
    ISSN 1067-1927
    DOI 10.1111/wrr.12952
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Book ; Online: Towards Agility

    Papatheodorou, Aristotelis / Merkt, Wolfgang / Mitchell, Alexander L. / Havoutis, Ioannis

    A Momentum Aware Trajectory Optimisation Framework using Full-Centroidal Dynamics & Implicit Inverse Kinematics

    2023  

    Abstract: Online planning and execution of acrobatic maneuvers pose significant challenges in legged locomotion. Their underlying combinatorial nature, along with the current hardware's limitations constitute the main obstacles in unlocking the true potential of ... ...

    Abstract Online planning and execution of acrobatic maneuvers pose significant challenges in legged locomotion. Their underlying combinatorial nature, along with the current hardware's limitations constitute the main obstacles in unlocking the true potential of legged-robots. This letter tries to expose the intricacies of these optimal control problems in a tangible way, directly applicable to the creation of more efficient online trajectory optimisation frameworks. By analysing the fundamental principles that shape the behaviour of the system, the dynamics themselves can be exploited to surpass its hardware limitations. More specifically, a trajectory optimisation formulation is proposed that exploits the system's high-order nonlinearities, such as the nonholonomy of the angular momentum, and phase-space symmetries in order to produce feasible high-acceleration maneuvers. By leveraging the full-centroidal dynamics of the quadruped ANYmal C and directly optimising its footholds and contact forces, the framework is capable of producing efficient motion plans with low computational overhead. The feasibility of the produced trajectories is ensured by taking into account the configuration-dependent inertial properties of the robot during the planning process, while its robustness is increased by supplying the full analytic derivatives & hessians to the solver. Finally, a significant portion of the discussion is centred around the deployment of the proposed framework on the ANYmal C platform, while its true capabilities are demonstrated through real-world experiments, with the successful execution of high-acceleration motion scenarios like the squat-jump.
    Keywords Computer Science - Robotics
    Subject code 629
    Publishing date 2023-10-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Book ; Online: Learning and Deploying Robust Locomotion Policies with Minimal Dynamics Randomization

    Campanaro, Luigi / Gangapurwala, Siddhant / Merkt, Wolfgang / Havoutis, Ioannis

    2022  

    Abstract: Training deep reinforcement learning (DRL) locomotion policies often require massive amounts of data to converge to the desired behaviour. In this regard, simulators provide a cheap and abundant source. For successful sim-to-real transfer, exhaustively ... ...

    Abstract Training deep reinforcement learning (DRL) locomotion policies often require massive amounts of data to converge to the desired behaviour. In this regard, simulators provide a cheap and abundant source. For successful sim-to-real transfer, exhaustively engineered approaches such as system identification, dynamics randomization, and domain adaptation are generally employed. As an alternative, we investigate a simple strategy of random force injection (RFI) to perturb system dynamics during training. We show that the application of random forces enables us to emulate dynamics randomization. This allows us to obtain locomotion policies that are robust to variations in system dynamics. We further extend RFI, referred to as extended random force injection (ERFI), by introducing an episodic actuation offset. We demonstrate that ERFI provides additional robustness for variations in system mass offering on average a 53% improved performance over RFI. We also show that ERFI is sufficient to perform a successful sim-to-real transfer on two different quadrupedal platforms, ANYmal C and Unitree A1, even for perceptive locomotion over uneven terrain in outdoor environments.

    Comment: 8 pages, 5 figures. Under review. Supplementary video: https://youtu.be/YwxUUL-4YIM. Project website: https://sites.google.com/view/erfi-video
    Keywords Computer Science - Robotics ; Computer Science - Artificial Intelligence
    Subject code 006
    Publishing date 2022-09-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Systemischer Lupus erythematodes - etablierte und neue Therapieoptionen

    Merkt, Wolfgang / Lorenz, Hanns-Martin

    Kompendium Rheumatologie

    2020  Volume 2020, Issue -, Page(s) 38

    Language German
    Document type Article
    ZDB-ID 2201780-X
    ISSN 1861-0250
    Database Current Contents Medicine

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    Zs.A 6143: Show issues Location:
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  10. Article ; Online: Obinutuzumab in connective tissue diseases after former rituximab-non-response: a case series.

    Kvacskay, Peter / Merkt, Wolfgang / Günther, Janine / Blank, Norbert / Lorenz, Hanns-Martin

    Annals of the rheumatic diseases

    2022  Volume 81, Issue 5, Page(s) 744–746

    MeSH term(s) Antibodies, Monoclonal, Humanized/adverse effects ; Connective Tissue Diseases/drug therapy ; Humans ; Lupus Erythematosus, Systemic ; Rituximab/therapeutic use
    Chemical Substances Antibodies, Monoclonal, Humanized ; Rituximab (4F4X42SYQ6) ; obinutuzumab (O43472U9X8)
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2021-221756
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