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  1. Article ; Online: The Metabolic Impact of Nonalcoholic Fatty Liver Disease on Cognitive Dysfunction: A Comprehensive Clinical and Pathophysiological Review.

    Giuffrè, Mauro / Merli, Nicola / Pugliatti, Maura / Moretti, Rita

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concerning cognitive ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) exponentially affects the global healthcare burden, and it is currently gaining increasing interest in relation to its potential impact on central nervous system (CNS) diseases, especially concerning cognitive deterioration and dementias. Overall, scientific research nowadays extends to different levels, exploring NAFLD's putative proinflammatory mechanism of such dysmetabolic conditions, spreading out from the liver to a multisystemic involvement. The aim of this review is to analyze the most recent scientific literature on cognitive involvement in NAFLD, as well as understand its underlying potential background processes, i.e., neuroinflammation, the role of microbiota in the brain-liver-gut axis, hyperammonemia neurotoxicity, insulin resistance, free fatty acids, and vitamins.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/metabolism ; Liver/metabolism ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/metabolism ; Cognition Disorders/metabolism ; Insulin Resistance
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gut Microbiota Changes during Dimethyl Fumarate Treatment in Patients with Multiple Sclerosis.

    Ferri, Caterina / Castellazzi, Massimiliano / Merli, Nicola / Laudisi, Michele / Baldin, Elisa / Baldi, Eleonora / Mancabelli, Leonardo / Ventura, Marco / Pugliatti, Maura

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: The gut microbiota is involved in the development of the immune system and can modulate the risk for immune-mediated disorders such as multiple sclerosis (MS). Dysbiosis has been demonstrated in MS patients and its restoration by disease-modifying ... ...

    Abstract The gut microbiota is involved in the development of the immune system and can modulate the risk for immune-mediated disorders such as multiple sclerosis (MS). Dysbiosis has been demonstrated in MS patients and its restoration by disease-modifying treatments (DMTs) is hypothesized. We aimed to study the changes in gut microbiota composition during the first 6 months of treatment with dimethyl fumarate (DMF), an oral DMT, and to identify the microorganisms associated with DMF side effects. We collected and analyzed the gut microbiota of 19 MS patients at baseline and after 1, 3, and 6 months of DMF treatment. We then cross-sectionally compared gut microbiota composition according to the presence of gastrointestinal (GI) symptoms and flushing. Overall, the gut microbiota biodiversity showed no changes over the 6-month follow-up. At the genus level, DMF was associated with decreased
    MeSH term(s) Humans ; Dimethyl Fumarate/adverse effects ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/microbiology ; Gastrointestinal Microbiome ; Gastrointestinal Diseases/drug therapy ; Bacteroidetes ; Drug-Related Side Effects and Adverse Reactions/drug therapy ; Immunosuppressive Agents/therapeutic use
    Chemical Substances Dimethyl Fumarate (FO2303MNI2) ; Immunosuppressive Agents
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reversible cerebral vasoconstriction syndrome: strategies to early diagnosis and the role of transcranial color-coded doppler ultrasonography (TCCD).

    Merli, Nicola / Padroni, Marina / Azzini, Cristiano / Bernardoni, Andrea / Marcialis, Carla / Tugnoli, Valeria / Inchingolo, Vincenzo / Pugliatti, Maura

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Volume 44, Issue 7, Page(s) 2541–2545

    Abstract: Background: Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular transitory condition characterized by severe headache, possible concomitant acute neurological symptoms, evidence of diffuse multifocal segmental constriction of ... ...

    Abstract Background: Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular transitory condition characterized by severe headache, possible concomitant acute neurological symptoms, evidence of diffuse multifocal segmental constriction of cerebral arteries, and usually spontaneously resolving within 3 months. Putative causes and/or precipitating factors are vasoactive drugs-e.g., antidepressants, α-sympathomimetics, triptans-post-partum, and immunosuppressants.
    Case presentation: We report the case of a middle-aged woman referred to the emergency room (ER) with a 7-day long intense headache and vomit. Cerebral non-contrast computed tomography (CT) was negative for acute ischemic lesions or intracranial bleedings. She was again referred to ER 7 days later with additional fluctuating episodes of weakness in left arm and both lower limbs. A new brain CT was negative. Due to worsening headache, a transcranial color-coded Doppler (TCCD) was performed, which showed diffuse multifocal blood flow acceleration in all principal intracranial vessels, and particularly on the right hemisphere. These findings were subsequently confirmed at MR angiogram and digital subtraction angiography.
    Conclusion: TCCD imaging is a non-invasive and relatively inexpensive tool which provides real-time information on cerebrovascular function, blood flow velocities, and hemodynamic changes. TCCD may be a powerful tool in the early detection of acute infrequent cerebrovascular conditions, as well as in monitoring their course and the therapeutic response.
    MeSH term(s) Female ; Humans ; Middle Aged ; Cerebrovascular Disorders/diagnosis ; Early Diagnosis ; Headache/complications ; Headache Disorders, Primary/diagnostic imaging ; Magnetic Resonance Angiography/adverse effects ; Ultrasonography, Doppler, Transcranial/methods ; Vasoconstriction/physiology ; Vasospasm, Intracranial/diagnostic imaging ; Vasospasm, Intracranial/complications
    Language English
    Publishing date 2023-04-04
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-06755-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Role of Advanced Hemodynamic Ultrasound Evaluation in the Differential Diagnosis of Middle Cerebral Artery Stenosis: Introducing Morphological Criteria.

    Malferrari, Giovanni / Merli, Nicola / Inchingolo, Vincenzo / Siniscalchi, Antonio / Laterza, Domenico / Monaco, Daniela / Arnone, Giorgia / Zini, Andrea / Prada, Francesco / Azzini, Cristiano / Pugliatti, Maura

    Ultrasound in medicine & biology

    2023  Volume 49, Issue 11, Page(s) 2428–2435

    Abstract: Objective: The aim of the work described here was to determine the possible impact of the new technique advanced hemodynamic ultrasound evaluation (AHUSE) in identification of severe intracranial stenosis. Transcranial Doppler (TCD) and transcranial ... ...

    Abstract Objective: The aim of the work described here was to determine the possible impact of the new technique advanced hemodynamic ultrasound evaluation (AHUSE) in identification of severe intracranial stenosis. Transcranial Doppler (TCD) and transcranial color-coded Doppler (TCCD) provide reliable velocimetric data, the indirect analysis of which allows us to obtain information on the patency of vessels and assumed stenosis range. However, very tight stenoses (>95%) cannot be detected with velocimetric criteria because of spectrum drops and the absence of high velocities, so that the right curve of the Spencer equation cannot be solved. Likewise, high velocities are not detected when analyzing morphologically long stenosis. Furthermore, the current classifications based on velocimetric criteria do not provide any categorization on stenoses with multiple acceleration points (MAPs).
    Methods: With this Technical Note we aim to introduce, in addition to velocimetric criteria, more morphological criteria based on TCCD with the algorithm of AHUSE to optimize the characterization of intracranial stenosis (IS). TCCD-AHUSE relies on intensity-based next-generation techniques and can be used to identify IS with MAPs and simultaneously perform a morphological assessment of the stenosis length.
    Results: We introduce a new technical ultrasound (U) approach that we tested in a sample of four different types of stenoses combining velocimetric data and AHUSE using Esaote Microvascularization (MicroV) technique to the M1 tract of the middle cerebral artery (MCA).
    Conclusion: The authors believe that a multiparametric evaluation is more sensitive and supports the clinician by introducing the morphological concept, not just the velocimetric concept, to differentiate the IS pattern of MCA. The potential for developing a diagnostic/prognostic algorithm is discussed.
    MeSH term(s) Humans ; Middle Cerebral Artery/diagnostic imaging ; Constriction, Pathologic ; Diagnosis, Differential ; Cerebrovascular Disorders ; Ultrasonography, Doppler, Transcranial/methods ; Hemodynamics
    Language English
    Publishing date 2023-08-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2023.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Hepatitis C Virus-Related Central and Peripheral Nervous System Disorders.

    Moretti, Rita / Giuffrè, Mauro / Merli, Nicola / Caruso, Paola / Di Bella, Stefano / Tiribelli, Claudio / Crocè, Lory Saveria

    Brain sciences

    2021  Volume 11, Issue 12

    Abstract: Hepatitis C Virus (HCV), despite being a hepatotropic virus, is the causative agent of many systemic disorders, such as vasculitis, autoimmune diseases, lymphoproliferative disorders, and a broad spectrum of neurological and psychiatric manifestations. ... ...

    Abstract Hepatitis C Virus (HCV), despite being a hepatotropic virus, is the causative agent of many systemic disorders, such as vasculitis, autoimmune diseases, lymphoproliferative disorders, and a broad spectrum of neurological and psychiatric manifestations. Although symptoms have been misdiagnosed or underdiagnosed, only recently, evidence of direct (inflammatory) or indirect (immune-mediated) HCV-dependent cerebral effects has been established. HCV infection can promote acute inflammatory response, pro-coagulative status and ischemic disorders, and neurodegeneration. These effects rely on cerebral HCV replication, possibly mediated by blood-brain barrier alterations. Further study is needed to better understand the HCV-related mechanisms of brain damage.
    Language English
    Publishing date 2021-11-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci11121569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mechanical thrombectomy in patients with heart failure: the Italian registry of Endovascular Treatment in Acute Stroke.

    Gentile, Luana / Pracucci, Giovanni / Saia, Valentina / Falcou, Anne / Biraschi, Francesco / Zini, Andrea / Simonetti, Luigi / Riva, Letizia / Bigliardi, Guido / Vallone, Stefano / Nencini, Patrizia / Limbucci, Nicola / Diomedi, Marina / Da Ros, Valerio / Longoni, Marco / Ruggiero, Maria / Tassinari, Tiziana / Allegretti, Luca / Cerrato, Paolo /
    Rubino, Elisa / Bergui, Mauro / Cavallo, Roberto / Naldi, Andrea / Comelli, Chiara / Cappellari, Manuel / Zivelonghi, Cecilia / Plebani, Mauro / De Vito, Alessandro / Merli, Nicola / Saletti, Andrea / Musolino, Rosa Fortunata / Ferraù, Ludovica / Vinci, Sergio Lucio / Sacco, Simona / Orlandi, Berardino / De Santis, Federica / Filauri, Pietro / Ruiz, Luigi / Sepe, Federica Nicoletta / Gallesio, Ivan / Petruzzellis, Marco / Chiumarulo, Luigi / Sangalli, Davide / Salmaggi, Andrea / Filizzolo, Marco / Moller, Jessica / Melis, Maurizio / Comelli, Simone / Magoni, Mauro / Gilberti, Nicola / Gasparotti, Roberto / Invernizzi, Paolo / Pavia, Marco / Pinto, Vincenza / Laspada, Salvatore / Marcheselli, Simona / Ajello, Daniele / Viaro, Federica / Baracchini, Claudio / Causin, Francesco / Giannini, Nicola / Caselli, Maria Chiara / Mancuso, Michelangelo / Cosottini, Mirco / Scoditti, Umberto / Menozzi, Roberto / Russo, Monia / Amistá, Pietro / Napoletano, Rosa / Romano, Daniele Giuseppe / Tassi, Rossana / Bracco, Sandra / Carimati, Federico / Versino, Maurizio / Giorgianni, Andrea / De Boni, Antonella / Fasano, Antonio / Barbarini, Leonardo / Paladini, Adriana / Franchini, Enrica / Dall'Ora, Elisa / Comai, Alessio / Giovanni, Frisullo / Pedicelli, Alessandro / Sallustio, Fabrizio / Casetta, Ilaria / Fainardi, Enrico / Mangiafico, Salvatore / Toni, Danilo

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2023  Volume 44, Issue 10, Page(s) 3577–3585

    Abstract: Background: Heart failure (HF) is the second most important cardiac risk factor for stroke after atrial fibrillation (AF). Few data are available on mechanical thrombectomy (MT) in acute ischemic stroke (AIS) patients with HF.: Methods: The source of ...

    Abstract Background: Heart failure (HF) is the second most important cardiac risk factor for stroke after atrial fibrillation (AF). Few data are available on mechanical thrombectomy (MT) in acute ischemic stroke (AIS) patients with HF.
    Methods: The source of data is the multicentre Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS). All AIS patients ≥ 18 years receiving MT were categorised in two groups: HF and no-HF. Baseline clinical and neuroradiological findings on admission were analysed.
    Results: Of 8924 patients, 642 (7.2%) had HF. Compared to the no-HF group, HF patients had higher prevalence of cardiovascular risk factors. Rate of complete recanalisation (TICI 2b-3) was 76.9% in HF vs 78.1% in no-HF group (p = 0.481). Rate of symptomatic intracerebral haemorrhage at 24-h non-contrast computed tomography (NCCT) was 7.6% in HF vs 8.3% in no-HF patients (p = 0.520). At 3 months, 36.4% of HF patients and 48.2% of no-HF patients (p < 0.001) had mRS 0-2, and mortality was, respectively, 30.7% and 18.5% (p < 0.001). In multivariate logistic regression, HF was independently associated with mortality at 3 months (OR 1.53, 1.24-1.88 95% CI, p < 0.001). In multivariate ordinal regression, HF patients had a probability of transitioning to a higher mRS level of 1.23 (1.05-1.44 95% CI, p = 0.012). The propensity score analysis of two groups matched for age, sex, and NIHSS at admission yielded the same results.
    Conclusion: MT is safe and effective in HF patients with AIS. Patients with HF and AIS suffered from higher 3-month mortality and unfavourable outcome regardless of acute treatments.
    MeSH term(s) Humans ; Ischemic Stroke/etiology ; Thrombectomy/adverse effects ; Treatment Outcome ; Stroke/epidemiology ; Stroke/surgery ; Heart Failure/complications ; Registries ; Retrospective Studies ; Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Brain Ischemia/epidemiology ; Endovascular Procedures/adverse effects
    Language English
    Publishing date 2023-05-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-023-06830-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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