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  1. Article ; Online: Is Left Atrial Appendage Occlusion Safe and Effective in Octogenarians?

    Rodés-Cabau, Josep / Mesnier, Jules

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 5, Page(s) 677–679

    MeSH term(s) Aged, 80 and over ; Humans ; Octogenarians ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CT-FFR in the TAVR Work-Up: Optimizing the Gatekeeper.

    Mesnier, Jules / Rodés-Cabau, Josep

    JACC. Cardiovascular interventions

    2022  Volume 15, Issue 11, Page(s) 1150–1152

    MeSH term(s) Computed Tomography Angiography ; Coronary Angiography ; Coronary Artery Disease ; Coronary Stenosis ; Fractional Flow Reserve, Myocardial ; Humans ; Predictive Value of Tests ; Tomography, X-Ray Computed ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2022-05-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2022.04.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6669: Show issues Location:
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  3. Article ; Online: Vascular Access Site for TAVR: Use the Approach You Master Best.

    Mesnier, Jules / Collet, Jean Philippe

    JACC. Cardiovascular interventions

    2020  Volume 13, Issue 12, Page(s) 1469–1470

    MeSH term(s) Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Fluoroscopy ; Humans ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.04.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Evolving Indications of Transcatheter Aortic Valve Replacement-Where Are We Now, and Where Are We Going.

    Mesnier, Jules / Panagides, Vassili / Nuche, Jorge / Rodés-Cabau, Josep

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: Indications for transcatheter aortic valve replacement (TAVR) have steadily increased over the last decade since the first trials including inoperable or very high risk patients. Thus, TAVR is now the most common treatment of aortic valve stenosis in ... ...

    Abstract Indications for transcatheter aortic valve replacement (TAVR) have steadily increased over the last decade since the first trials including inoperable or very high risk patients. Thus, TAVR is now the most common treatment of aortic valve stenosis in elderly patients (vs. surgical aortic valve replacement -SAVR-). In this review, we summarize the current indications of TAVR and explore future directions in which TAVR indications can expand.
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11113090
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  5. Article ; Online: Relevance of medical information obtained from ChatGPT: Are large language models friends or foes?

    Mesnier, Jules / Suc, Gaspard / Sayah, Neila / Abtan, Jérémie / Steg, Philippe Gabriel

    Archives of cardiovascular diseases

    2023  Volume 116, Issue 10, Page(s) 485–486

    Language English
    Publishing date 2023-09-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2408778-6
    ISSN 1875-2128 ; 1875-2136
    ISSN (online) 1875-2128
    ISSN 1875-2136
    DOI 10.1016/j.acvd.2023.07.009
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  6. Article ; Online: Device profile of the SAPIEN 3 transcatheter heart valve in low-risk patients with aortic stenosis: overview of its safety and efficacy.

    Alperi, Alberto / Mesnier, Jules / Panagides, Vassili / Rodés-Cabau, Josep

    Expert review of medical devices

    2021  Volume 18, Issue 9, Page(s) 815–821

    Abstract: Introduction: Transcatheter aortic valve replacement (TAVR) has become a treatment of reference for patients with symptomatic severe aortic stenosis, and the balloon-expandable SAPIEN 3 and SAPIEN 3 Ultra transcatheter heart valve systems are two of the ...

    Abstract Introduction: Transcatheter aortic valve replacement (TAVR) has become a treatment of reference for patients with symptomatic severe aortic stenosis, and the balloon-expandable SAPIEN 3 and SAPIEN 3 Ultra transcatheter heart valve systems are two of the most broadly used worldwide. Lately, TAVR has progressively expanded toward the treatment of low-risk patients.
    Areas covered: In this review we aimed to describe the main characteristics of the SAPIEN 3 valve, and to delineate the main clinical findings regarding the safety and efficacy associated with this THV system in low-risk patients undergoing TAVR.
    Expert opinion: The approval of THV systems for use in low-risk patients has been a significant step forward in expanding current TAVR indications. Along with procedural refinement and growing operator experience, device iterations implemented in new-generation THV systems have played a vital role in the successful spread of TAVR. The availability of SAPIEN 3 represented an inflection point, as it allows for a predictable positioning and safer navigability while dramatically decreasing the rate of residual paravalvular leakage compared to previous balloon-expandable systems. However, some unresolved issues remain like the relatively high rates of conduction disturbances and the uncertainty about valve performance in the long-term. Future studies are warranted.
    MeSH term(s) Aortic Valve/surgery ; Aortic Valve Stenosis/surgery ; Heart Valve Prosthesis ; Humans ; Prosthesis Design ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-08-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2021.1969915
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    Zs.A 6424: Show issues Location:
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  7. Article ; Online: Percutaneous Coronary Intervention Pre-TAVR: Current State of the Evidence.

    Keller, Lukas S / Panagides, Vassili / Mesnier, Jules / Nuche, Jorge / Rodés-Cabau, Josep

    Current cardiology reports

    2022  Volume 24, Issue 8, Page(s) 1011–1020

    Abstract: Purpose of review: This review intends to give an up-to-date overview of the current state of evidence in the treatment of coronary artery disease (CAD) in patients undergoing transcatheter aortic valve replacement (TAVR), focusing on percutaneous ... ...

    Abstract Purpose of review: This review intends to give an up-to-date overview of the current state of evidence in the treatment of coronary artery disease (CAD) in patients undergoing transcatheter aortic valve replacement (TAVR), focusing on percutaneous coronary interventions (PCI) pre-TAVR.
    Recent findings: The recently published ACTIVATION trial is the 1st randomized trial comparing coronary revascularization (PCI) versus medical treatment in patients with significant CAD undergoing TAVR. With the caveat of several major limitations of the trial, the results of this study raised the question about the appropriateness of the common practice to routinely revascularize coronary stenosis before TAVR. Aortic valve stenosis is the most common valvular heart disease among the elderly and it often co-occurs with CAD. TAVR is increasingly considered an alternative to surgical aortic valve replacement not only in the elderly population but also in younger and lower-risk patients. The impact of co-existing CAD on clinical outcomes as well as the optimal timing of PCI in TAVR candidates is still unclear and the subject of ongoing randomized trials. Meanwhile, it is common practice in many centers to routinely perform invasive coronary angiography and PCI for significant coronary disease as part of the TAVR workup. While computed tomography angiography has emerged as a possible alternative to the invasive coronary angiography in patients with low pre-test probability for CAD, the value of functional invasive assessment of coronary lesions in the pre-TAVR setting has still to be clarified. Also, there is an increasing interest in the clinical relevance and optimal management of the potentially challenging coronary access post-TAVR, requiring further research.
    MeSH term(s) Aged ; Aortic Valve/surgery ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/surgery ; Coronary Artery Disease/complications ; Coronary Artery Disease/surgery ; Humans ; Percutaneous Coronary Intervention/methods ; Risk Factors ; Transcatheter Aortic Valve Replacement/methods ; Treatment Outcome
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-022-01717-1
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    Zs.A 5524: Show issues Location:
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  8. Article: Transcatheter Mitral Valve Replacement Using Transcatheter Aortic Valve or Dedicated Devices: Current Evidence and Future Prospects.

    Quentin, Victor / Mesnier, Jules / Delhomme, Clémence / Sayah, Neila / Guedeney, Paul / Barthélémy, Olivier / Suc, Gaspard / Collet, Jean-Philippe

    Journal of clinical medicine

    2023  Volume 12, Issue 21

    Abstract: Transcatheter mitral valve replacement (TMVR) is a novel and evolving field dedicated to addressing the therapeutic challenges posed by patients at high surgical risk with mitral valve disease. TMVR can be categorized into two distinct fields based on ... ...

    Abstract Transcatheter mitral valve replacement (TMVR) is a novel and evolving field dedicated to addressing the therapeutic challenges posed by patients at high surgical risk with mitral valve disease. TMVR can be categorized into two distinct fields based on the type of device and its specific indications: TMVR with transcatheter aortic valves (TAV) and TMVR with dedicated devices. Similar to aortic stenosis, TMVR with TAV requires a rigid support structure to secure the valve in place. As a result, it is indicated for patients with failing bioprothesis or surgical rings or mitral valve disease associated with severe mitral annular calcification (MAC), which furnishes the necessary foundation for valve anchoring. While TMVR with TAV has shown promising outcomes in valve-in-valve procedures, its effectiveness remains more contentious in valve-in-ring or valve-in-MAC procedures. Conversely, TMVR with dedicated devices seeks to address native mitral regurgitation, whether accompanied by MAC or not, providing an alternative to Transcatheter Edge-to-Edge Repair (TEER) when TEER is not feasible or expected to yield unsatisfactory results. This emerging field is gradually surmounting technical challenges, including anchoring a valve in a non-calcified annulus and transitioning from the transapical route to the transeptal approach. Numerous devices are presently undergoing clinical trials. This review aims to furnish an overview of the supporting evidence for TMVR using TAV in each specific indication (valve-in-valve, valve-in-ring, valve-in-MAC). Subsequently, we will discuss the anticipated benefits of TMVR with dedicated devices over TEER, summarize the characteristics and clinical results of TMVR systems currently under investigation, and outline future prospects in this field.
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12216712
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  9. Article ; Online: Antithrombotic Management After Left Atrial Appendage Closure: Current Evidence and Future Perspectives.

    Mesnier, Jules / Cepas-Guillén, Pedro / Freixa, Xavier / Flores-Umanzor, Eduardo / Hoang Trinh, Kim / O'Hara, Gilles / Rodés-Cabau, Josep

    Circulation. Cardiovascular interventions

    2023  Volume 16, Issue 5, Page(s) e012812

    Abstract: Left atrial appendage closure is an alternative to chronic oral anticoagulation to prevent embolic events related to nonvalvular atrial fibrillation. After device implantation, antithrombotic treatment is prescribed to prevent device-related thrombosis, ... ...

    Abstract Left atrial appendage closure is an alternative to chronic oral anticoagulation to prevent embolic events related to nonvalvular atrial fibrillation. After device implantation, antithrombotic treatment is prescribed to prevent device-related thrombosis, a dreadful complication associated with an increased risk of ischemic events. However, the optimal antithrombotic treatment after left atrial appendage closure, effective on both device-related thrombus prevention and bleeding risk mitigation, remains to be determined. In more than 10 years experience with left atrial appendage closure, a wide range of antithrombotic treatments have been used, mostly in observational studies. In this review, we analyzed the body of evidence for each antithrombotic regimen after left atrial appendage closure to provide tools to guide the physician choice and describe future perspectives in the field.
    MeSH term(s) Humans ; Stroke/diagnosis ; Stroke/etiology ; Stroke/prevention & control ; Anticoagulants/adverse effects ; Fibrinolytic Agents/adverse effects ; Atrial Appendage ; Treatment Outcome ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Thrombosis/etiology ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants ; Fibrinolytic Agents
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.122.012812
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    Zs.A 6746: Show issues Location:
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  10. Article ; Online: Sex differences and outcomes in surgical infective endocarditis.

    Leterrier, Juliette / Iung, Bernard / de Tymoski, Christian / Deconinck, Laurene / Para, Marylou / Duval, Xavier / Provenchere, Sophie / Mesnier, Jules / Delhomme, Clemence / Haviari, Skerdi / Urena, Marina / Suc, Gaspard

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2024  Volume 65, Issue 4

    Abstract: Background: Cardiac surgery for infective endocarditis (IE) is associated with significant hospital mortality, and female sex may be associated with worse outcomes. However, the impact of sex on the presenting characteristics, management, and outcomes ... ...

    Abstract Background: Cardiac surgery for infective endocarditis (IE) is associated with significant hospital mortality, and female sex may be associated with worse outcomes. However, the impact of sex on the presenting characteristics, management, and outcomes of patients operated on for acute infective endocarditis (IE) has not been adequately studied.
    Objectives: The goal of our study was to analyse differences in management and outcome of IE between women and men who undergo surgery.
    Methods: Clinical data of 717 patients undergoing cardiac surgery for IE between December 2005 and December 2019 were prospectively collected. Sex-related postoperative outcomes including in-hospital mortality were recorded. Univariable and multivariable analyses were performed to identify potential sex-related determinant of in-hospital mortality.
    Results: In all, 532 male patients (74.2%) and 185 female patients (25.8%) underwent surgery for IE. At baseline, women had more frequent mitral regurgitation with 63 patients (34.1%) than men with 135 patients (25.4%) (P = 0.002). Female sex was associated with higher in-hospital mortality (23.2% versus 17.3%, P = 0.049). However, multivariable analysis revealed age (P < 0.01), antibiotics < 7 days before surgery (P = 0.01) and staphylococcal IE (P < 0.01) but not female sex (P = 0.99) as independent determinants of hospital mortality.
    Conclusions: In this study of patients operated-on for IE, female sex was associated with more severe manifestations of IE and significantly higher in-hospital mortality. However, after multivariable analysis, initial presentation, but not sex, seemed to determine clinical outcomes.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Hospital Mortality ; Sex Factors ; Aged ; Cardiac Surgical Procedures/mortality ; Cardiac Surgical Procedures/adverse effects ; Endocarditis/surgery ; Endocarditis/mortality ; Treatment Outcome ; Retrospective Studies ; Risk Factors ; Prospective Studies
    Language English
    Publishing date 2024-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezae114
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