LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 21

Search options

  1. Article: The Functional Medicine Approach to COVID-19: Primer on SARS-CoV-2 Testing.

    Messier, H / Evans, J M / Hanaway, P J

    Integrative medicine (Encinitas, Calif.)

    2020  Volume 19, Issue Suppl 1, Page(s) 44–53

    Abstract: The ability to accurately identify whether individuals are at risk for, infected with, or have an immune response to SARS-CoV-2 is essential to address the COVID-19 pandemic from both a personal, clinical and a public health perspective. We investigate ... ...

    Abstract The ability to accurately identify whether individuals are at risk for, infected with, or have an immune response to SARS-CoV-2 is essential to address the COVID-19 pandemic from both a personal, clinical and a public health perspective. We investigate the clinical value of testing for the presence of viral RNA (a surrogate for infection) and the presence of antibodies (a proxy for immunity) to gather data to protect both individual and public health. We define the limitations and the practical clinical application of viral and serologic testing.
    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2100529-1
    ISSN 1945-7081 ; 1546-993X
    ISSN (online) 1945-7081
    ISSN 1546-993X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Evidence Supporting a Phased Immuno-physiological Approach to COVID-19 From Prevention Through Recovery.

    Yanuck, S F / Pizzorno, J / Messier, H / Fitzgerald, K N

    Integrative medicine (Encinitas, Calif.)

    2020  Volume 19, Issue Suppl 1, Page(s) 8–35

    Abstract: This paper presents an evidence-based strategy for improving clinical outcomes in COVID-19. Recommendations are based on the phases of the disease, because optimal interventions for one phase may not be appropriate for a different phase. The four phases ... ...

    Abstract This paper presents an evidence-based strategy for improving clinical outcomes in COVID-19. Recommendations are based on the phases of the disease, because optimal interventions for one phase may not be appropriate for a different phase. The four phases addressed are: Prevention, Infection, Inflammation and Recovery. Underlying this phased approach is recognition of emerging evidence for two different components of pathophysiology, early infection and late stage severe complications. These two aspects of the disease suggest two different patterns of clinical emphasis that seem on the surface to be not entirely concordant. We describe the application of therapeutic strategies and appropriate tactics that address four main stages of disease progression for COVID-19. Emerging evidence in COVID-19 suggests that the SARS-CoV-2 virus may both evade the innate immune response and kill macrophages. Delayed innate immune response and a depleted population of macrophages can theoretically result in a blunted antigen presentation, delaying and diminishing activation of the adaptive immune response. Thus, one clinical strategy involves supporting patient innate and adaptive immune responses early in the time course of illness, with the goal of improving the timeliness, readiness, and robustness of both the innate and adaptive immune responses. At the other end of the disease pathology spectrum, risk of fatality in COVID-19 is driven by excessive and persistent upregulation of inflammatory mechanisms associated with cytokine storm. Thus, the second clinical strategy is to prevent or mitigate excessive inflammatory response to prevent the cytokine storm associated with high mortality risk. Clinical support for immune system pathogen clearance mechanisms involves obligate activation of immune response components that are inherently inflammatory. This puts the goals of the first clinical strategy (immune activation) potentially at odds with the goals of the second strategy(mitigation of proinflammatory effects). This creates a need for discernment about the time course of the illness and with that, understanding of which components of an overall strategy to apply at each phase of the time course of the illness. We review evidence from early observational studies and the existing literature on both outcomes and mechanisms of disease, to inform a phased approach to support the patient at risk for infection, with infection, with escalating inflammation during infection, and at risk of negative sequelae as they move into recovery.
    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2100529-1
    ISSN 1945-7081 ; 1546-993X
    ISSN (online) 1945-7081
    ISSN 1546-993X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: The Functional Medicine Approach to COVID-19: Primer on SARS-CoV-2 Testing

    Messier, H. / Evans, J. M. / Hanaway, P. J.

    Integrative Medicine

    Abstract: The ability to accurately identify whether individuals are at risk for, infected with, or have an immune response to SARS-CoV-2 is essential to address the COVID-19 pandemic from both a personal, clinical and a public health perspective We investigate ... ...

    Abstract The ability to accurately identify whether individuals are at risk for, infected with, or have an immune response to SARS-CoV-2 is essential to address the COVID-19 pandemic from both a personal, clinical and a public health perspective We investigate the clinical value of testing for the presence of viral RNA (a surrogate for infection) and the presence of antibodies (a proxy for immunity) to gather data to protect both individual and public health We define the limitations and the practical clinical application of viral and serologic testing
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #828676
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Evidence Supporting a Phased Immuno-physiological Approach to COVID-19 From Prevention Through Recovery

    Yanuck, S. F. / Pizzorno, J. / Messier, H. / Fitzgerald, K. N.

    Integr Med (Encinitas)

    Abstract: This paper presents an evidence-based strategy for improving clinical outcomes in COVID-19 Recommendations are based on the phases of the disease, because optimal interventions for one phase may not be appropriate for a different phase The four phases ... ...

    Abstract This paper presents an evidence-based strategy for improving clinical outcomes in COVID-19 Recommendations are based on the phases of the disease, because optimal interventions for one phase may not be appropriate for a different phase The four phases addressed are: Prevention, Infection, Inflammation and Recovery Underlying this phased approach is recognition of emerging evidence for two different components of pathophysiology, early infection and late stage severe complications These two aspects of the disease suggest two different patterns of clinical emphasis that seem on the surface to be not entirely concordant We describe the application of therapeutic strategies and appropriate tactics that address four main stages of disease progression for COVID-19 Emerging evidence in COVID-19 suggests that the SARS-CoV-2 virus may both evade the innate immune response and kill macrophages Delayed innate immune response and a depleted population of macrophages can theoretically result in a blunted antigen presentation, delaying and diminishing activation of the adaptive immune response Thus, one clinical strategy involves supporting patient innate and adaptive immune responses early in the time course of illness, with the goal of improving the timeliness, readiness, and robustness of both the innate and adaptive immune responses At the other end of the disease pathology spectrum, risk of fatality in COVID-19 is driven by excessive and persistent upregulation of inflammatory mechanisms associated with cytokine storm Thus, the second clinical strategy is to prevent or mitigate excessive inflammatory response to prevent the cytokine storm associated with high mortality risk Clinical support for immune system pathogen clearance mechanisms involves obligate activation of immune response components that are inherently inflammatory This puts the goals of the first clinical strategy (immune activation) potentially at odds with the goals of the second strategy(mitigation of proinflammatory effects) This creates a need for discernment about the time course of the illness and with that, understanding of which components of an overall strategy to apply at each phase of the time course of the illness We review evidence from early observational studies and the existing literature on both outcomes and mechanisms of disease, to inform a phased approach to support the patient at risk for infection, with infection, with escalating inflammation during infection, and at risk of negative sequelae as they move into recovery
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32425712
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: The Functional Medicine Approach to COVID-19: Virus-Specific Nutraceutical and Botanical Agents.

    Evans, J M / Luby, R / Lukaczer, D / Rountree, R / Stone, P M / Guilliams, T G / Yanuck, S / Messier, H / Ramsdell, K / Hanaway, P J

    Integrative medicine (Encinitas, Calif.)

    2020  Volume 19, Issue Suppl 1, Page(s) 34–42

    Abstract: As the novel infection with SARS-CoV-2 emerges, objective assessment of the scientific plausibility of nutraceutical and botanical interventions for prevention and treatment is important. We evaluate twelve such interventions with mechanisms of action ... ...

    Abstract As the novel infection with SARS-CoV-2 emerges, objective assessment of the scientific plausibility of nutraceutical and botanical interventions for prevention and treatment is important. We evaluate twelve such interventions with mechanisms of action that modulate the immune system, impair viral replication, and/or have been demonstrated to reduce severity of illness. These are examples of interventions that, mechanistically, can help protect patients in the presence of the prevalent and infectious SARS-CoV-2 virus. While there are limited studies to validate these agents to specifically prevent COVID-19, they have been chosen based upon their level of evidence for effectiveness and safety profiles, in the context of other viral infections. These agents are to be used in a patient-specific manner in concert with lifestyle interventions known to strengthen immune response (see related article in this issue of
    Keywords covid19
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2100529-1
    ISSN 1945-7081 ; 1546-993X
    ISSN (online) 1945-7081
    ISSN 1546-993X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Gut Microbiome Activity Contributes to Prediction of Individual Variation in Glycemic Response in Adults.

    Tily, Hal / Patridge, Eric / Cai, Ying / Gopu, Vishakh / Gline, Stephanie / Genkin, Matvey / Lindau, Haely / Sjue, Alisson / Slavov, Iordan / Perlina, Ally / Klitgord, Niels / Messier, Helen / Vuyisich, Momchilo / Banavar, Guruduth

    Diabetes therapy : research, treatment and education of diabetes and related disorders

    2021  Volume 13, Issue 1, Page(s) 89–111

    Abstract: Limiting postprandial glycemic response (PPGR) is an important intervention in reducing the risk of chronic metabolic diseases and has been shown to impart significant health benefits in people with elevated levels of blood sugar. In this study, we ... ...

    Abstract Limiting postprandial glycemic response (PPGR) is an important intervention in reducing the risk of chronic metabolic diseases and has been shown to impart significant health benefits in people with elevated levels of blood sugar. In this study, we collected gut microbiome activity data by assessing the metatranscriptome, and we measured the glycemic responses of 550 adults who consumed more than 30,000 meals, collectively, from omnivore or vegetarian/gluten-free diets. We demonstrate that gut microbiome activity, anthropometric factors, and food macronutrients modulate individual variation in glycemic response. We employ two predictive models, including a mixed-effects linear regression model (R = 0.77) and a gradient boosting machine model (R
    Language English
    Publishing date 2021-11-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2566702-6
    ISSN 1869-6961 ; 1869-6953
    ISSN (online) 1869-6961
    ISSN 1869-6953
    DOI 10.1007/s13300-021-01174-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: The Functional Medicine Approach to COVID-19: Virus-Specific Nutraceutical and Botanical Agents

    Evans, J. M. / Luby, R. / Lukaczer, D. / Rountree, R. / Stone, P. M. / Guilliams, T. G. / Yanuck, S. / Messier, H. / Ramsdell, K. / Hanaway, P. J.

    Integrative Medicine

    Abstract: As the novel infection with SARS-CoV-2 emerges, objective assessment of the scientific plausibility of nutraceutical and botanical interventions for prevention and treatment is important We evaluate twelve such interventions with mechanisms of action ... ...

    Abstract As the novel infection with SARS-CoV-2 emerges, objective assessment of the scientific plausibility of nutraceutical and botanical interventions for prevention and treatment is important We evaluate twelve such interventions with mechanisms of action that modulate the immune system, impair viral replication, and/or have been demonstrated to reduce severity of illness These are examples of interventions that, mechanistically, can help protect patients in the presence of the prevalent and infectious SARS-CoV-2 virus While there are limited studies to validate these agents to specifically prevent COVID-19, they have been chosen based upon their level of evidence for effectiveness and safety profiles, in the context of other viral infections These agents are to be used in a patient-specific manner in concert with lifestyle interventions known to strengthen immune response (see related article in this issue of IMCJ)
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #824816
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: A Robust Metatranscriptomic Technology for Population-Scale Studies of Diet, Gut Microbiome, and Human Health.

    Hatch, Andrew / Horne, James / Toma, Ryan / Twibell, Brittany L / Somerville, Kalie M / Pelle, Benjamin / Canfield, Kinga P / Genkin, Matvey / Banavar, Guruduth / Perlina, Ally / Messier, Helen / Klitgord, Niels / Vuyisich, Momchilo

    International journal of genomics

    2019  Volume 2019, Page(s) 1718741

    Abstract: A functional readout of the gut microbiome is necessary to enable precise control of the gut microbiome's functions, which support human health and prevent or minimize a wide range of chronic diseases. Stool metatranscriptomic analysis offers a ... ...

    Abstract A functional readout of the gut microbiome is necessary to enable precise control of the gut microbiome's functions, which support human health and prevent or minimize a wide range of chronic diseases. Stool metatranscriptomic analysis offers a comprehensive functional view of the gut microbiome, but despite its usefulness, it has rarely been used in clinical studies due to its complexity, cost, and bioinformatic challenges. This method has also received criticism due to potential intrasample variability, rapid changes, and RNA degradation. Here, we describe a robust and automated stool metatranscriptomic method, called Viomega, which was specifically developed for population-scale studies. Viomega includes sample collection, ambient temperature sample preservation, total RNA extraction, physical removal of ribosomal RNAs (rRNAs), preparation of directional Illumina libraries, Illumina sequencing, taxonomic classification based on a database of >110,000 microbial genomes, and quantitative microbial gene expression analysis using a database of ~100 million microbial genes. We applied this method to 10,000 human stool samples and performed several small-scale studies to demonstrate sample stability and consistency. In summary, Viomega is an inexpensive, high-throughput, automated, and accurate sample-to-result stool metatranscriptomic technology platform for large-scale studies and a wide range of applications.
    Language English
    Publishing date 2019-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2711883-6
    ISSN 2314-4378 ; 2314-436X
    ISSN (online) 2314-4378
    ISSN 2314-436X
    DOI 10.1155/2019/1718741
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: A novel POU domain protein which binds to the T-cell receptor beta enhancer.

    Messier, H / Brickner, H / Gaikwad, J / Fotedar, A

    Molecular and cellular biology

    1993  Volume 13, Issue 9, Page(s) 5450–5460

    Abstract: POU domain proteins have been implicated in the regulation of a number of lineage-specific genes. Among the first POU domain proteins described were the immunoglobulin octamer-binding proteins Oct-1 and Oct-2. It was therefore of special interest when we ...

    Abstract POU domain proteins have been implicated in the regulation of a number of lineage-specific genes. Among the first POU domain proteins described were the immunoglobulin octamer-binding proteins Oct-1 and Oct-2. It was therefore of special interest when we identified a novel lymphoid POU domain protein in Southwestern (DNA-protein) screens of T-cell lambda gt11 libraries. This novel POU protein, TCF beta 1, binds in a sequence-specific manner to a critical motif in the T-cell receptor (TCR) beta enhancer. Sequence analysis revealed that TCF beta 1 represents a new class of POU domain proteins which are distantly related to other POU proteins. TCF beta 1 is encoded by multiple exons whose organization is distinct from that of other POU domain proteins. The expression of TCF beta 1 in a tissue-restricted manner and its ability to bind to multiple motifs in the TCR beta enhancer support a role in regulating TCR beta gene expression. The expression of TCF beta 1 in both B and T cells and the ability of recombinant TCF beta 1 to bind octamer and octamer-related motifs suggest that TCF beta 1 has additional roles in lymphoid cell function. The ability of TCF beta 1 to transactivate in a sequence-specific manner is consistent with a role for regulating lymphoid gene expression.
    MeSH term(s) Amino Acid Sequence ; Base Sequence ; Binding, Competitive ; Cloning, Molecular ; Consensus Sequence ; DNA Mutational Analysis ; DNA-Binding Proteins/metabolism ; Enhancer Elements, Genetic ; Exons ; Genes ; Genes, Homeobox ; Humans ; Molecular Sequence Data ; Oligodeoxyribonucleotides/chemistry ; POU Domain Factors ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Sequence Alignment ; Structure-Activity Relationship ; Tissue Distribution ; Transcriptional Activation
    Chemical Substances DNA-Binding Proteins ; Oligodeoxyribonucleotides ; POU Domain Factors ; POU6F1 protein, human ; Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 1993-09
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/mcb.13.9.5450-5460.1993
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Shedding of microparticles by myofibroblasts as mediator of cellular cross-talk during normal wound healing.

    Moulin, Véronique J / Mayrand, Dominique / Messier, Hugo / Martinez, Maria Carmen / Lopez-Vallé, Carlos A / Genest, Hervé

    Journal of cellular physiology

    2010  Volume 225, Issue 3, Page(s) 734–740

    Abstract: Interactions between cells are a crucial mechanism to correctly heal a wounded tissue. Myofibroblasts have a central role during healing but their means to communicate with other cells is unknown. Microparticles (MP) have demonstrated a potential role as ...

    Abstract Interactions between cells are a crucial mechanism to correctly heal a wounded tissue. Myofibroblasts have a central role during healing but their means to communicate with other cells is unknown. Microparticles (MP) have demonstrated a potential role as mediators of cellular interactions during various diseases. We have analyzed the production of MP by normal (Wmyo) and pathological (hypertrophic scar, Hmyo) myofibroblasts and human dermal fibroblasts (Fb) when treated with serum or plasma as examples of body fluids. We have shown that the presence of these body fluids induced a very significant increase in MP production by Wmyo while no MP production was denoted for Hmyo and Fb. These effects were at least due to thermally sensitive protein(s) with a molecular mass >30 kDa. Furthermore, the increase in MP production was not linked to an increase in apoptotic Wmyo. MP characterization showed that VEGF and FGF2 were present in MP and that endothelial and (myo)fibroblast cell growth can be stimulated by MP treatment. We postulated that MP production by myofibroblasts could modulate mesenchymal cell growth and angiogenesis during normal healing.
    MeSH term(s) Adult ; Apoptosis ; Cell Communication ; Cell Proliferation ; Cell-Derived Microparticles/metabolism ; Cell-Derived Microparticles/pathology ; Cells, Cultured ; Cicatrix, Hypertrophic/metabolism ; Cicatrix, Hypertrophic/pathology ; Fibroblast Growth Factor 2/blood ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Granulation Tissue/metabolism ; Granulation Tissue/pathology ; Humans ; Molecular Weight ; Phenotype ; Protein Denaturation ; Skin/metabolism ; Skin/pathology ; Vascular Endothelial Growth Factor A/blood ; Wound Healing ; Young Adult
    Chemical Substances VEGFA protein, human ; Vascular Endothelial Growth Factor A ; Fibroblast Growth Factor 2 (103107-01-3)
    Language English
    Publishing date 2010-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.22268
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top