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Book ; Online: Chapter Fishing and territory. Status and perspectives of Sardinia artisanal fisheries. The case of traditional fishery in Asinara Island MPA

Gazale, Vittorio / Tarricone, Ester / Carboni, Donatella / Messina, Giovanni

(Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques)

2022

Series title	Monitoring of Mediterranean Coastal Areas: Problems and Measurement Techniques
Keywords	The environment ; Marine Protected Area of Asinara Island ; Sardinia ; Fishing techniques and tools ; Small-scale fishing ; Artisanal fishing activities ; Traditional heritage
Language	English
Size	1 electronic resource (12 pages)
Publisher	Firenze University Press
Publishing place	Florence
Document type	Book ; Online
Note	English
HBZ-ID	HT030376240
ISBN	9791221500301
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Nuclear elongation during spermiogenesis depends on physical linkage of nuclear pore complexes to bundled microtubules by Drosophila Mst27D.

Li, Pengfei / Messina, Giovanni / Lehner, Christian F

PLoS genetics

2023 Volume 19, Issue 7, Page(s) e1010837

Abstract: Spermatozoa in animal species are usually highly elongated cells with a long motile tail attached to a head that contains the haploid genome in a compact and often elongated nucleus. In Drosophila melanogaster, the nucleus is compacted two hundred-fold ... ...

Abstract	Spermatozoa in animal species are usually highly elongated cells with a long motile tail attached to a head that contains the haploid genome in a compact and often elongated nucleus. In Drosophila melanogaster, the nucleus is compacted two hundred-fold in volume during spermiogenesis and re-modeled into a needle that is thirty-fold longer than its diameter. Nuclear elongation is preceded by a striking relocalization of nuclear pore complexes (NPCs). While NPCs are initially located throughout the nuclear envelope (NE) around the spherical nucleus of early round spermatids, they are later confined to one hemisphere. In the cytoplasm adjacent to this NPC-containing NE, the so-called dense complex with a strong bundle of microtubules is assembled. While this conspicuous proximity argued for functional significance of NPC-NE and microtubule bundle, experimental confirmation of their contributions to nuclear elongation has not yet been reported. Our functional characterization of the spermatid specific Mst27D protein now resolves this deficit. We demonstrate that Mst27D establishes physical linkage between NPC-NE and dense complex. The C-terminal region of Mst27D binds to the nuclear pore protein Nup358. The N-terminal CH domain of Mst27D, which is similar to that of EB1 family proteins, binds to microtubules. At high expression levels, Mst27D promotes bundling of microtubules in cultured cells. Microscopic analyses indicated co-localization of Mst27D with Nup358 and with the microtubule bundles of the dense complex. Time-lapse imaging revealed that nuclear elongation is accompanied by a progressive bundling of microtubules into a single elongated bundle. In Mst27D null mutants, this bundling process does not occur and nuclear elongation is abnormal. Thus, we propose that Mst27D permits normal nuclear elongation by promoting the attachment of the NPC-NE to the microtubules of the dense complex, as well as the progressive bundling of these microtubules.
MeSH term(s)	Male ; Animals ; Nuclear Pore/genetics ; Nuclear Pore/metabolism ; Drosophila/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Microtubules/metabolism ; Spermatogenesis/genetics ; Nuclear Envelope/genetics ; Nuclear Envelope/metabolism ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism
Chemical Substances	EB1 protein, Drosophila ; Microtubule-Associated Proteins ; Drosophila Proteins
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1010837
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division.

Prozzillo, Yuri / Santopietro, Maria Virginia / Messina, Giovanni / Dimitri, Patrizio

Cellular and molecular life sciences : CMLS

2023 Volume 80, Issue 12, Page(s) 365

Abstract: The aim of this review article is to focus on the unconventional roles of epigenetic players (chromatin remodelers and long non-coding RNAs) in cell division, beyond their well-characterized functions in chromatin regulation during cell differentiation ... ...

Abstract	The aim of this review article is to focus on the unconventional roles of epigenetic players (chromatin remodelers and long non-coding RNAs) in cell division, beyond their well-characterized functions in chromatin regulation during cell differentiation and development. In the last two decades, diverse experimental evidence has shown that subunits of SRCAP and p400/TIP60 chromatin remodeling complexes in humans relocate from interphase nuclei to centrosomes, spindle or midbody, with their depletion yielding an array of aberrant outcomes of mitosis and cytokinesis. Remarkably, this behavior is shared by orthologous subunits of the Drosophila melanogaster DOM/TIP60 complex, despite fruit flies and humans diverged over 700 million years ago. In short, the available data support the view that subunits of these complexes are a new class of moonlighting proteins, in that they lead a "double life": during the interphase, they function in chromatin regulation within the nucleus, but as the cell progresses through mitosis, they interact with established mitotic factors, thus becoming integral components of the cell division apparatus. By doing so, they contribute to ensuring the correct distribution of chromosomes in the two daughter cells and, when dysfunctional, can cause genomic instability, a condition that can trigger tumorigenesis and developmental diseases. Research over the past few years has unveiled a major contribution of long non-coding RNAs (lncRNAs) in the epigenetics regulation of gene expression which also impacts on cell division control. Here, we focus on possible structural roles of lncRNAs in the execution of cytokinesis: in particular, we suggest that specific classes of lncRNAs relocate to the midbody to form an architectural scaffold ensuring its proper assembly and function during abscission. Drawing attention to experimental evidence for non-canonical extranuclear roles of chromatin factors and lncRNAs has direct implications on important and novel aspects concerning both the epigenetic regulation and the evolutionary dynamics of cell division with a significant impact on differentiation, development, and diseases.
MeSH term(s)	Humans ; Animals ; Chromatin/genetics ; RNA, Long Noncoding/genetics ; Drosophila melanogaster/genetics ; Epigenesis, Genetic ; Mitosis/genetics ; Drosophila
Chemical Substances	Chromatin ; RNA, Long Noncoding
Language	English
Publishing date	2023-11-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-023-04949-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Serious games and eating behaviors: A systematic review of the last 5 years (2018-2022).

Limone, Pierpaolo / Messina, Giovanni / Toto, Giusi Antonia

Frontiers in nutrition

2022 Volume 9, Page(s) 978793

Abstract: Background: Serious game intervention has emerged over the years as a popular strategy for solving the problem of unhealthy eating behavior. This has prompted several scholars to explore its significant impact on eating behaviors, identifying its ... ...

Abstract	Background: Serious game intervention has emerged over the years as a popular strategy for solving the problem of unhealthy eating behavior. This has prompted several scholars to explore its significant impact on eating behaviors, identifying its positive effect on nutritional knowledge and eating behaviors. However, since this research field is yet nascent, an update in knowledge is required to further inform the real-world practice as an alternative intervention for instating healthy eating behavior. Therefore, this current research utilized a systematic review method to reveal the latest state of this concept of a serious game and eating behavior, to identify the position of the literature and shed light on under-researched and emerging areas by recommending future investigations. Method: To achieve the object of this research, four electronic databases- Science Direct, Web of Science (WoS), APA PsyclNFO, and Emerald- were searched using predefined keywords (search string) relating to the review topic. A total of 15,107 results were retrieved from the databases. After title, abstract, and full-text screening, 15 studies were included following inclusion criteria. Key findings: The result of this research demonstrated that various designs of serious games comprise an effective intervention for changing eating behavior in both children and adults and addressed the risks of childhood obesity and overweight. The findings also show that the design of the games is co-designed by different specialists such as a nutritionist, psychologist and developer, among others, as either single or multiple players. The effectiveness of the games was attributed to behavior techniques (BT), cognitive theories (CT), and socio-cognitive theories (SCT) of behavior change technique (BCT), incorporating an element of implicit learning in serious games. Feedback and reward were the most reported influencing strategies and self-reporting the evaluation approach. Conclusion: This research contributed significantly to the body of knowledge in the field of serious games as the most recent review of evidence in the research area. Evidence from 93.33% of the included studies confirmed the effectiveness of serious games in addressing eating behavior. This study concludes that serious games are an effective intervention for improving healthy eating behavior and decreasing unhealthy eating behavior and that various elements of behavior change techniques are essential components of implicit nutritional learning through the games. In addition, it is concluded that the risk of childhood obesity and overweight can be reduced or prevented by leveraging the strength of these games. The need for future research in this field was also pointed out by this study.
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.978793
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of the COVID-19 pandemic and the Russia-Ukraine war on stress and anxiety in students: A systematic review.

Limone, Pierpaolo / Toto, Giusi Antonia / Messina, Giovanni

Frontiers in psychiatry

2022 Volume 13, Page(s) 1081013

Abstract: Background: The outbreak of the COVID-19 pandemic at the end of 2019 and the Russian-Ukrainian war in February 2022 created restrictions and uncertainties that affected the general population's mental health. One of the affected groups was students. ... ...

Abstract	Background: The outbreak of the COVID-19 pandemic at the end of 2019 and the Russian-Ukrainian war in February 2022 created restrictions and uncertainties that affected the general population's mental health. One of the affected groups was students. This systematic review summarizes the current literature on the prevalence, outcomes, and interventions for stress and anxiety among university, college, graduate, or postsecondary populations. Methods: A systematic literature search was performed on PubMed, Web of Science, Scopus, Embase, Cochrane Library, CINAHL, PsychInfo, and ProQuest, following PRISMA guidelines. Specific inclusion and exclusion criteria were applied, and screening was performed to identify the definitive studies. Results: The prevalence of anxiety was relatively high, ranging from 88.9 to 13.63%, and the prevalence of stress ranged from 56 to 28.14%. The predictors of stress and anxiety included young age, gender being female, STEM course, loneliness, low academic level in school, urban lockdown, confinement, having a preexisting disease, having relatives or friends infected with COVID-19, and proximity to a COVID-19 zone. The predictors of stress included gender being female, living with family, living in a household with many people, being confined rather than having the freedom to relocate, proximity to confirmed cases of COVID-19, lack of access to materials on COVID-19, preexisting mental disorders, and lack of knowledge on the preventable nature of COVID-19. The sources of anxiety among the university students identified in the study included academics, postponement of graduation, cancelation or disruption of planned events, inability to achieve goals, and finances. In addition, the students used trauma-focused, forward-focused, task-oriented, emotion-oriented, and avoidance-oriented coping strategies. Conclusion: The included studies showed that stress and anxiety increased during the pandemic and the war, with gender and uncertainty playing a critical role. The studies provide insights into the widespread use of problem-focused and task-focused coping strategies despite their impact on increasing stress and anxiety.
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2022.1081013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential Protective Effects of Spirulina (

Mallamaci, Rosanna / Storelli, Maria Maddalena / Barbarossa, Alexia / Messina, Giovanni / Valenzano, Anna / Meleleo, Daniela

International journal of molecular sciences

2023 Volume 24, Issue 23

Abstract: ... ...

Abstract	Spirulina
MeSH term(s)	Humans ; Mercury/toxicity ; Cadmium/toxicity ; Spirulina ; Lead/pharmacology ; Neuroblastoma ; Metals, Heavy/toxicity ; Cell Line, Tumor ; Cell Survival
Chemical Substances	Mercury (FXS1BY2PGL) ; Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Metals, Heavy
Language	English
Publishing date	2023-12-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242317076
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Polysomnographic study in pediatric neurofibromatosis type 1.

Carotenuto, Marco / Messina, Giovanni / Esposito, Maria / Santoro, Claudia / Iacono, Diego / Spruyt, Karen

Frontiers in neurology

2023 Volume 14, Page(s) 1213430

Abstract: Background: Neurofibromatosis type 1 (NF1) is a genetic disease that alters neurodevelopment. We aimed to analyze the sleep macrostructure of a sample of children affected by NF1 without neurocognitive co-morbidities and MRI reports of unidentified ... ...

Abstract	Background: Neurofibromatosis type 1 (NF1) is a genetic disease that alters neurodevelopment. We aimed to analyze the sleep macrostructure of a sample of children affected by NF1 without neurocognitive co-morbidities and MRI reports of unidentified bright objects (UBOs). Methods: A 100 pre-pubertal children participated in the cross-sectional study: 50 subjects were children diagnosed with NF1 and 50 subjects were typically developing healthy children (TDC). All participants underwent polysomnographic evaluation through which conventional sleep parameters were collected: Total sleep time (TST), Sleep latency (SOL), first REM latency (FRL), number of stage shifts/h (SS/h), number of awakenings/h (AWN/h), wake after sleep onset (WASO%), sleep efficiency percentage (SE%), percentage of sleep time spent in sleep stages 1 (N1%) and 2 (N2%), slow-wave sleep (N3%), and REM sleep (REM%). Additionally, nocturnal respiratory events such as apnea/hypopnea index (AHI), oxygen desaturation index (ODI), and periodic limb movement index (PLMI) were recorded. Results: Neurofibromatosis type 1 children showed a reduction in sleep duration parameters (TST; Conclusion: The data showed that the sleep macrostructure differs between NF1 and TDC children. These findings suggest that the evaluation of sleep may provide useful support in corroborating the diagnosis and offers additional therapeutic management perspectives in NF1 and genetic neurodevelopmental disorders in general.
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1213430
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of

Prozzillo, Yuri / Fattorini, Gaia / Ferreri, Diego / Leo, Manuela / Dimitri, Patrizio / Messina, Giovanni

Cells

2023 Volume 12, Issue 10

Abstract: ATP-dependent chromatin remodeling complexes are involved in nucleosome sliding and eviction and/or the incorporation of histone variants into chromatin to facilitate several cellular and biological processes, including DNA transcription, replication and ...

Abstract	ATP-dependent chromatin remodeling complexes are involved in nucleosome sliding and eviction and/or the incorporation of histone variants into chromatin to facilitate several cellular and biological processes, including DNA transcription, replication and repair. The DOM/TIP60 chromatin remodeling complex of
MeSH term(s)	Animals ; Humans ; Male ; Adenosine Triphosphate/metabolism ; Chromatin/metabolism ; Drosophila/metabolism ; Drosophila melanogaster/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Meiosis/genetics ; Nucleosomes/metabolism
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Chromatin ; Drosophila Proteins ; Histone Acetyltransferases (EC 2.3.1.48) ; Nucleosomes ; Tip60 protein, Drosophila (EC 2.3.1.48) ; dom protein, Drosophila
Language	English
Publishing date	2023-05-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12101348
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Epigenetic Silencing of P-Element Reporter Genes Induced by Transcriptionally Active Domains of Constitutive Heterochromatin in Drosophila melanogaster

Messina, Giovanni / Celauro, Emanuele / Marsano, Renè Massimiliano / Prozzillo, Yuri / Dimitri, Patrizio

Genes (Basel). 2022 Dec. 21, v. 14, no. 1

2022

Abstract: Reporter genes inserted via P-element integration into different locations of the Drosophila melanogaster genome have been routinely used to monitor the functional state of chromatin domains. It is commonly thought that P-element-derived reporter genes ... ...

Abstract	Reporter genes inserted via P-element integration into different locations of the Drosophila melanogaster genome have been routinely used to monitor the functional state of chromatin domains. It is commonly thought that P-element-derived reporter genes are subjected to position effect variegation (PEV) when transposed into constitutive heterochromatin because they acquire heterochromatin-like epigenetic modifications that promote silencing. However, sequencing and annotation of the D. melanogaster genome have shown that constitutive heterochromatin is a genetically and molecularly heterogeneous compartment. In fact, in addition to repetitive DNAs, it harbors hundreds of functional genes, together accounting for a significant fraction of its entire genomic territory. Notably, most of these genes are actively transcribed in different developmental stages and tissues, irrespective of their location in heterochromatin. An open question in the genetic and molecular studies on PEV in D. melanogaster is whether functional heterochromatin domains, i.e., heterochromatin harboring active genes, are able to silence reporter genes therein transposed or, on the contrary, can drive their expression. In this work, we provide experimental evidence showing that strong silencing of the Pw⁺ reporters is induced even when they are integrated within or near actively transcribed loci in the pericentric regions of chromosome 2. Interestingly, some Pw⁺ reporters were found insensitive to the action of a known PEV suppressor. Two of them are inserted within Yeti, a gene expressed in the deep heterochromatin of chromosome 2 which carries active chromatin marks. The difference sensitivity to suppressors-exhibited Pw⁺ reporters supports the view that different epigenetic regulators or mechanisms control different regions of heterochromatin. Together, our results suggest that there may be more complexity regarding the molecular mechanisms underlying PEV.
Keywords	Drosophila melanogaster ; epigenetics ; genes ; genomics ; heterochromatin ; transcription (genetics)
Language	English
Dates of publication	2022-1221
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14010012
Database	NAL-Catalogue (AGRICOLA)

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Article: Update on coronavirus disease 2019 (COVID-19)

Santantonio, Teresa A. / Messina, Giovanni

Open Neurol. J.

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #143156
Database	COVID19

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