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Article ; Online: The Wernicke conundrum is misinterpreted.

Mesulam, Marsel / Thompson, Cynthia / Weintraub, Sandra / Rogalski, Emily

2022 Volume 146, Issue 4, Page(s) e21–e22

MeSH term(s)	Humans ; Wernicke Encephalopathy/diagnosis
Language	English
Publishing date	2022-12-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awac482
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Article: Primary progressive aphasia: A dementia of the language network.

Mesulam, Marsel

Dementia & neuropsychologia

2014 Volume 7, Issue 1, Page(s) 2–9

Abstract: Primary progressive aphasia (PPA) is a clinical syndrome diagnosed when three core criteria are met. First, there should be a language impairment (i.e., aphasia) that interferes with the usage or comprehension of words. Second, the neurological work-up ... ...

Abstract	Primary progressive aphasia (PPA) is a clinical syndrome diagnosed when three core criteria are met. First, there should be a language impairment (i.e., aphasia) that interferes with the usage or comprehension of words. Second, the neurological work-up should determine that the disease is neurodegenerative, and therefore progressive. Third, the aphasia should arise in relative isolation, without equivalent deficits of comportment or episodic memory. The language impairment can be fluent or non-fluent and may or may not interfere with word comprehension. Memory for recent events is preserved although memory scores obtained in verbally mediated tests may be abnormal. Minor changes in personality and behavior may be present but are not the leading factors that bring the patient to medical attention or that limit daily living activities. This distinctive clinical pattern is most conspicuous in the initial stages of the disease, and reflects a relatively selective atrophy of the language network, usually located in the left hemisphere. There are different clinical variants of PPA, each with a characteristic pattern of atrophy. The underlying neuropathological diseases are heterogeneous and can include Alzheimer's disease as well as frontotemporal lobar degeneration. The clinician's task is to recognize PPA and differentiate it from other neurodegenerative phenotypes, use biomarkers to surmise the nature of the underlying neuropathology, and institute the most fitting multimodal interventions.
Language	English
Publishing date	2014-04-03
Publishing country	Brazil
Document type	Journal Article
ISSN	1980-5764
ISSN	1980-5764
DOI	10.1590/s1980-57642013dn70100002
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Article ; Online: Cholinergic aspects of aging and Alzheimer's disease.

Mesulam, Marsel

Biological psychiatry

2012 Volume 71, Issue 9, Page(s) 760–761

MeSH term(s)	Aging/pathology ; Alzheimer Disease/pathology ; Cholinergic Neurons/pathology ; Female ; Humans ; Magnetic Resonance Imaging/psychology ; Male ; Neuroimaging/psychology ; Prosencephalon/pathology
Language	English
Publishing date	2012-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2012.02.025
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Article ; Online: The evolving landscape of human cortical connectivity: facts and inferences.

Mesulam, Marsel

NeuroImage

2011 Volume 62, Issue 4, Page(s) 2182–2189

Abstract: Human cognitive brain mapping is at a crossroads. On the one hand, it can access a rich data set of synaptic connectivity in the cerebral cortex of the monkey, an animal that lacks many of the complicated behaviors of interest. On the other hand, it is ... ...

Abstract	Human cognitive brain mapping is at a crossroads. On the one hand, it can access a rich data set of synaptic connectivity in the cerebral cortex of the monkey, an animal that lacks many of the complicated behaviors of interest. On the other hand, it is rapidly amassing an even richer data set on the functional map of the human cerebral cortex, but with relatively little hard data on underlying structural connectivity. This second point tends to be blurred in the current literature because of the multiple ways in which the term 'connection' is used in the context of the human brain. In some instances the term is used at a conceptual level, to designate a pathway that should be there if the behavior is to be performed. In other instances, it refers to the computational demonstration of a functional relationship, the structural basis of which is not necessarily known. A third usage is based on connections that are known to exist in the monkey and that are inferred to also exist in the human. The fourth and most direct usage involves connections structurally proven to exist in the human. These four usages have been invoked interchangeably to propose connectivistic mechanisms of human cognitive function. To enlarge the currently limited data set on structural connectivity is of considerable importance for conducting biologically more valid explorations of large-scale neurocognitive networks. This challenging goal will require histological laboratory investigations of the human brain to resume their former prominence and to play an increasingly more substantial role in brain mapping research.
MeSH term(s)	Brain/anatomy & histology ; Brain/physiology ; Brain Mapping/trends ; Humans ; Models, Neurological ; Neural Pathways/anatomy & histology ; Neural Pathways/physiology
Language	English
Publishing date	2011-12-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2011.12.033
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 7: Show issues

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Article ; Online: Defining neurocognitive networks in the BOLD new world of computed connectivity.

Mesulam, Marsel

Neuron

2009 Volume 62, Issue 1, Page(s) 1–3

Abstract: Cognitive functions require the concerted activity of interconnected neuronal clusters that collectively form large-scale networks. In this issue, Seeley and colleagues use resting-state fluctuations of the BOLD signal to highlight the relevance of ... ...

Abstract	Cognitive functions require the concerted activity of interconnected neuronal clusters that collectively form large-scale networks. In this issue, Seeley and colleagues use resting-state fluctuations of the BOLD signal to highlight the relevance of networks to human brain function and dysfunction.
MeSH term(s)	Brain/blood supply ; Brain/physiology ; Brain Mapping ; Cognition/physiology ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods ; Models, Neurological ; Nerve Net/blood supply ; Nerve Net/physiology ; Neural Pathways/blood supply ; Neural Pathways/physiology
Language	English
Publishing date	2009-04-16
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2009.04.001
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 92: Show issues

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Article ; Online: Representation, inference, and transcendent encoding in neurocognitive networks of the human brain.

Mesulam, Marsel

Annals of neurology

2008 Volume 64, Issue 4, Page(s) 367–378

Abstract: The anatomical basis of conscious experience has traditionally been linked to sensory-fugal (inward) pathways that convey sensory information to progressively "higher" association cortices. Current thinking is emphasizing the importance of sensory-petal ... ...

Abstract	The anatomical basis of conscious experience has traditionally been linked to sensory-fugal (inward) pathways that convey sensory information to progressively "higher" association cortices. Current thinking is emphasizing the importance of sensory-petal pathways that run in the opposite (outward) direction. According to emerging views, many aspects of cognition may represent an iterative neural dialogue between sensory-fugal connections, which reflect the physical nature of ambient events, and sensory-petal connections, which infer the nature of the stimulus based on empirical accounts of past experience. These reciprocal pathways, embedded within the internally generated oscillations of the brain, are further modulated by top-down projections from high-order association cortices, most prominently located in prefrontal cortex. This set of top-down projections has the capacity to transcend experience-based representations and to insert internally generated priorities into the interpretation of ongoing events. The characteristically human capacity for resisting stimulus-bound responses and favoring novel interpretations may be linked to the influence of these top-down projections. The reciprocal sensory-processing pathways and their top-down modulations collectively define the conscious interpretation of experience.
MeSH term(s)	Brain/anatomy & histology ; Brain/physiology ; Cognition/physiology ; Humans ; Neural Pathways/anatomy & histology ; Neural Pathways/physiology ; Sensation/physiology
Language	English
Publishing date	2008-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.21534
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Zs.A 1370: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 478: Show issues

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Article ; Online: Primary progressive aphasia pathology.

Mesulam, Marsel

Annals of neurology

2008 Volume 63, Issue 1, Page(s) 124–125

MeSH term(s)	Alzheimer Disease/complications ; Alzheimer Disease/pathology ; Aphasia, Primary Progressive/classification ; Aphasia, Primary Progressive/diagnosis ; Aphasia, Primary Progressive/physiopathology ; Brain/pathology ; Brain/physiopathology ; Dementia/complications ; Dementia/pathology ; Diagnosis, Differential ; Hippocampus/pathology ; Hippocampus/physiopathology ; Humans ; Language ; Language Tests/standards ; Predictive Value of Tests ; Verbal Behavior/physiology
Language	English
Publishing date	2008-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.20940
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Zs.A 1370: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 478: Show issues

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Article: Imaging connectivity in the human cerebral cortex: the next frontier?

Mesulam, Marsel

Annals of neurology

2005 Volume 57, Issue 1, Page(s) 5–7

MeSH term(s)	Animals ; Cerebral Cortex/anatomy & histology ; Diagnostic Imaging/methods ; Humans ; Neural Pathways/anatomy & histology ; Staining and Labeling/methods
Language	English
Publishing date	2005-01
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.20368
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Zs.A 1370: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 478: Show issues

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Article: The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?

Mesulam, Marsel

Learning & memory (Cold Spring Harbor, N.Y.)

2004 Volume 11, Issue 1, Page(s) 43–49

Abstract: A profound loss of cortical cholinergic innervation is a nearly invariant feature of advanced Alzheimer's disease (AD). The temporal course of this lesion and its relationship to other aspects of the disease have not yet been fully clarified. Despite ... ...

Abstract	A profound loss of cortical cholinergic innervation is a nearly invariant feature of advanced Alzheimer's disease (AD). The temporal course of this lesion and its relationship to other aspects of the disease have not yet been fully clarified. Despite assertions to the contrary, a review of the evidence suggests that a perturbation of cholinergic innervation is likely to be present even in the very early stages of AD. This cholinergic lesion is unlikely to be a major determinant of the clinical symptoms or of the neuropathological lesions. Nonetheless, it almost certainly contributes to the severity of the cognitive and behavioral deficits, especially in the areas of memory and attention. The cholinergic lesion may also influence the progression of the neuropathological process through complex interactions with amyloidogenesis, tau phosphorylation and neuroplasticity.
MeSH term(s)	Acetylcholine/metabolism ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Animals ; Attention ; Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Cholinergic Fibers/pathology ; Disease Progression ; Humans ; Memory ; Neurofibrillary Tangles/pathology ; Neuronal Plasticity ; Phosphorylation ; Plaque, Amyloid/pathology
Chemical Substances	Acetylcholine (N9YNS0M02X)
Language	English
Publishing date	2004-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	1204777-6
ISSN	1549-5485 ; 1072-0502
ISSN (online)	1549-5485
ISSN	1072-0502
DOI	10.1101/lm.69204
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Article ; Online: Communication Bridge™-2 (CB2): an NIH Stage 2 randomized control trial of a speech-language intervention for communication impairments in individuals with mild to moderate primary progressive aphasia.

Roberts, Angela C / Rademaker, Alfred W / Salley, Elizabeth Ann / Mooney, Aimee / Morhardt, Darby / Fried-Oken, Melanie / Weintraub, Sandra / Mesulam, Marsel / Rogalski, Emily

Trials

2022 Volume 23, Issue 1, Page(s) 487

Abstract: Background: Primary progressive aphasia (PPA) is a clinical dementia syndrome. Impairments in language (speaking, reading, writing, and understanding) are the primary and persistent symptoms. These impairments progress insidiously and devastate ... ...

Abstract	Background: Primary progressive aphasia (PPA) is a clinical dementia syndrome. Impairments in language (speaking, reading, writing, and understanding) are the primary and persistent symptoms. These impairments progress insidiously and devastate communication confidence, participation, and quality of life for persons living with PPA. Currently, there are no effective disease modifying treatments for PPA. Speech-language interventions hold promise for mitigating communication challenges and language symptoms. However, evidence regarding their efficacy in PPA is of low quality and there are currently no rigorous randomized trials. Method: Communication Bridge™-2 (CB2) is a Stage 2, superiority, single-blind, randomized, parallel group, active-control, behavioral clinical trial delivered virtually within a telehealth service delivery model to individuals with PPA. Ninety carefully characterized participants with clinically confirmed PPA will be randomized to one of two speech-language intervention arms: (1) Communication Bridge™ a dyadic intervention based in communication participation therapy models that incorporates salient training stimuli or (2) the control intervention a non-dyadic intervention based in impairment therapy models addressing word retrieval and language production that incorporates fixed stimuli. The superiority of Communication Bridge™ over the Control arm will be evaluated using primary outcomes of communication confidence and participation. Other outcomes include accuracy for trained words and scripts. Participants complete two therapy blocks over a 12-month period. Outcomes will be measured at baseline, at each therapy block, and at 12 months post enrollment. Discussion: The CB2 trial will supply Level 2 evidence regarding the efficacy of the Communication Bridge™ intervention delivered in a telehealth service delivery model for individuals with mild to moderate PPA. An important by-product of the CB2 trial is that these data can be used to evaluate the efficacy of speech-language interventions delivered in both trial arms for persons with PPA. The impact of these data should not be overlooked as they will yield important insights examining why interventions work and for whom, which will advance effectiveness trials for speech-language interventions in PPA. Trial registration: ClinicalTrials.gov NCT03371706 . Registered prospectively on December 13, 2017.
MeSH term(s)	Aphasia, Primary Progressive/diagnosis ; Aphasia, Primary Progressive/therapy ; Communication ; Communication Disorders ; Humans ; Quality of Life ; Single-Blind Method ; Speech
Language	English
Publishing date	2022-06-13
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06162-7
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