Article ; Online: Pegcetacoplan treatment for geographic atrophy due to age-related macular degeneration: a plain language summary of the FILLY study.
2022 Volume 14, Issue 13, Page(s) 995–1006
Abstract: What is this summary about?: This is a summary of a publication about the FILLY study, which was published in : What happened in the filly study?: The FILLY study included participants with GA and tested how well pegcetacoplan worked compared to a ... ...
Abstract | What is this summary about?: This is a summary of a publication about the FILLY study, which was published in What happened in the filly study?: The FILLY study included participants with GA and tested how well pegcetacoplan worked compared to a sham injection (an injection that looks like the study treatment but does not have any medicine in it). The study also looked at how safe it was in adults with GA. What were the results?: The main questions the researchers wanted to answer were: What do the results of the study mean?: Overall, results from this study showed that participants who received pegcetacoplan had slower growth of GA lesions than participants who received the sham injection. After the participants had stopped receiving pegcetacaoplan, the effect of the treatment seemed to be reduced. Pegcetacoplan did not change how well the participants could see during their vision tests in this trial. ClinicalTrials.gov NCT number: NCT02503332. |
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MeSH term(s) | Animals ; Complement C3/therapeutic use ; Complement Inactivating Agents/therapeutic use ; Female ; Geographic Atrophy/complications ; Geographic Atrophy/drug therapy ; Horses ; Humans ; Language ; Macular Degeneration/complications ; Macular Degeneration/drug therapy ; Peptides, Cyclic ; Visual Acuity |
Chemical Substances | Complement C3 ; Complement Inactivating Agents ; Peptides, Cyclic ; pegcetacoplan (TO3JYR3BOU) |
Language | English |
Publishing date | 2022-07-21 |
Publishing country | England |
Document type | Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Comment |
ZDB-ID | 2495964-9 |
ISSN | 1750-7448 ; 1750-743X |
ISSN (online) | 1750-7448 |
ISSN | 1750-743X |
DOI | 10.2217/imt-2022-0078 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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