Article: Treatment of HIV-associated dyslipidemia: a role for omega-3 fatty acids.
2007 Volume 17, Issue 7, Page(s) 362–4, 367–73
Abstract: Both HIV and its treatment, particularly protease inhibitors, can cause lipidemia similar to that seen with the metabolic syndrome. The most notable effects are elevated triglyceride levels and decreased high-density lipoprotein cholesterol levels, with ... ...
Abstract | Both HIV and its treatment, particularly protease inhibitors, can cause lipidemia similar to that seen with the metabolic syndrome. The most notable effects are elevated triglyceride levels and decreased high-density lipoprotein cholesterol levels, with or without elevated low-density lipoprotein cholesterol (LDL-C) levels. Current recommendations by the National Cholesterol Education Program for HIV-infected persons focus on LDL-C as the primary target of therapy: after lifestyle modifications, statins should be used to lower LDL-C levels. Therapy with fibrates is recommended to lower triglyceride levels. However, omega-3 fatty acids can be an effective means of lowering triglyceride levels as well, particularly in patients with markedly elevated triglyceride levels. |
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MeSH term(s) | Antiretroviral Therapy, Highly Active ; Dyslipidemias/chemically induced ; Dyslipidemias/drug therapy ; Dyslipidemias/etiology ; Fatty Acids, Omega-3/therapeutic use ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Myocardial Infarction/chemically induced ; Myocardial Infarction/complications ; Protease Inhibitors/adverse effects ; Protease Inhibitors/therapeutic use ; Randomized Controlled Trials as Topic ; Risk Factors ; Triglycerides/blood |
Chemical Substances | Fatty Acids, Omega-3 ; Protease Inhibitors ; Triglycerides |
Language | English |
Publishing date | 2007-07 |
Publishing country | United States |
Document type | Journal Article ; Review |
ZDB-ID | 2039813-X |
ISSN | 1053-0894 |
ISSN | 1053-0894 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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