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  1. Article ; Online: Monofilament threads in treatment of female hair loss.

    Metwalli, Mohamed / Khattab, Fathia M / Mandour, Samira

    The Journal of dermatological treatment

    2020  Volume 32, Issue 5, Page(s) 521–525

    Abstract: Background: Recently, thread treatment has been commonly used in Korean medicine for cosmetic reasons such as decreasing skin wrinkles. It was noted that an inserted thread caused constant stimulation, followed by assistance for connective tissue ... ...

    Abstract Background: Recently, thread treatment has been commonly used in Korean medicine for cosmetic reasons such as decreasing skin wrinkles. It was noted that an inserted thread caused constant stimulation, followed by assistance for connective tissue regeneration. However, its role in hair development has not yet been revealed.
    Objective: To perform a pilot study on the effect of monofilament threads scalp injections in women with female androgenetic alopecia.
    Materials and methods: This double-blind, multicenter, placebo-controlled study compared the effect of monofilament threads with that of saline as placebo. The endpoints were hair count and hair mass index (HMI), along with patient-opinion survey responses.
    Results: HMI or hair count has statistically significantly differed between the study and placebo groups. However, 73.3% of the treatment subjects (vs. 0% of the placebo subjects) experienced substantial improvement in hair loss, rate of hair loss, hair thickness, and ease of managing/styling hair, and 76.8% (vs. 18.4% of the placebo group) reported that their hair felt coarser or heavier after the treatment.
    Conclusion: Monofilament threads demonstrate highly statistically significant improvement in HMI or hair count in women female pattern hair loss. The patient survey results suggest a therapeutic advantage of monofilament threads as perceived by patients and according to hair count or HMI.
    MeSH term(s) Adult ; Alopecia/therapy ; Double-Blind Method ; Female ; Hair/growth & development ; Humans ; Pilot Projects ; Prospective Studies ; Scalp
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2019.1682499
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  2. Article ; Online: Combination of oral methotrexate and oral mini-pulse dexamethasone vs either agent alone in vitiligo treatment with follow up by dermoscope.

    ElGhareeb, Mohamed Ibrahim / Metwalli, Mohamed / AbdelMoneim, Nehal

    Dermatologic therapy

    2020  Volume 33, Issue 4, Page(s) e13586

    Abstract: This study aimed to compare the efficacy and safety of oral methotrexate (MTX) and oral mini-pulse (OMP) dexamethasone alone and in combination in the treatment of vitiligo. A total of 42 patients with vitiligo were included in the study. The patients ... ...

    Abstract This study aimed to compare the efficacy and safety of oral methotrexate (MTX) and oral mini-pulse (OMP) dexamethasone alone and in combination in the treatment of vitiligo. A total of 42 patients with vitiligo were included in the study. The patients were treated for three months and randomly assigned into three groups including 14 patients each: group A received oral MTX, group B received OMP dexamethasone, and group C received a combination of both. Follow-up was performed using digital photographs, Vitiligo European Task Force score, and dermoscopy. Disease extension significantly decreased in group C compared with that in groups A (P < .001) and B (P < .05). The frequency of intralesional pigmentation significantly increased (P < .05) in groups A and C and decreased (P < .05) in group B posttreatment noted using a dermoscope. Moreover, the frequency of micro-Koebner's phenomenon and starburst pattern significantly decreased (P < .05) in groups B and C and that of tapioca sago in group C only posttreatment.
    MeSH term(s) Administration, Oral ; Dexamethasone/adverse effects ; Follow-Up Studies ; Humans ; Methotrexate/adverse effects ; Treatment Outcome ; Vitiligo/diagnosis ; Vitiligo/drug therapy
    Chemical Substances Dexamethasone (7S5I7G3JQL) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13586
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  3. Article ; Online: Ruptured pancreaticoduodenal artery aneurysm presenting with duodenal obstruction

    Nakul Reddy, MD / Zeyad Ahmed Metwalli, MD

    Radiology Case Reports, Vol 14, Iss 5, Pp 568-

    2019  Volume 571

    Abstract: Visceral aneurysms of the pancreaticoduodenal arcades are rare. Although these aneurysms are often asymptomatic and identified incidentally on cross-sectional imaging, aneurysm rupture presents significant morbidity. Ruptured pancreaticoduodenal arcade ... ...

    Abstract Visceral aneurysms of the pancreaticoduodenal arcades are rare. Although these aneurysms are often asymptomatic and identified incidentally on cross-sectional imaging, aneurysm rupture presents significant morbidity. Ruptured pancreaticoduodenal arcade aneurysms typically present with abdominal pain, hemorrhagic shock, or gastrointestinal bleeding. A 72-year-old male presented with nausea and vomiting and was found to have imaging evidence of duodenal obstruction. This was due to a duodenal intramural hematoma caused by a ruptured submucosal aneurysm supplied by a branch of the inferior pancreaticoduodenal artery in the presence of median arcuate ligament compression of the celiac artery. This was subsequently treated with endovascular embolization with clinical improvement in duodenal obstruction. This case illustrates an unusual presentation of a ruptured pancreaticoduodenal arcade aneurysm. Keywords: Pancreaticoduodenal artery aneurysm, Duodenal stenosis, Duodenal obstruction
    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2019-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  4. Article: Topical liquiritin improves melasma.

    Amer, M / Metwalli, M

    International journal of dermatology

    2000  Volume 39, Issue 4, Page(s) 299–301

    Abstract: Twenty women with a clinical diagnosis of melasma were treated with liquiritin cream on one side of the face and with a vehicle cream on the other side twice daily for 4 weeks. Patients were advised to avoid sun exposure and/or used topical sunscreen ... ...

    Abstract Twenty women with a clinical diagnosis of melasma were treated with liquiritin cream on one side of the face and with a vehicle cream on the other side twice daily for 4 weeks. Patients were advised to avoid sun exposure and/or used topical sunscreen during the entire period of treatment. Inclusion criteria included an age range from 18 to 40 years and bilateral and symmetrical idiopathic epidermal melasma. Exclusion criteria included patients with dermal melasma (differentiated by Wood's light), melasma with pregnancy, and patients currently receiving hormone replacement therapy. Melasma pigmentary intensity was rated on a five-point scale in relation to the patient's normal facial skin (1, no difference; 2, slightly more pigmented; 3, moderately more pigmented; 4, markedly more pigmented; and 5, intensely more pigmented). The size of the lesions was measured directly using a millimeter grid scale. Ratings and measurements were made prior to treatment and at each of the follow-up visits (after 2, 4, 6, 8, and 10 weeks). Clinical evaluation was performed at week 4; the overall response was rated as excellent, good, fair, or poor. Color photographs were taken at the start and at week 4 of the study. Side-effects were observed and treated.
    MeSH term(s) Administration, Topical ; Adolescent ; Adult ; Female ; Glycyrrhetinic Acid/therapeutic use ; Humans ; Melanosis/drug therapy ; Melanosis/pathology ; Ointments ; Treatment Outcome
    Chemical Substances Ointments ; Glycyrrhetinic Acid (P540XA09DR)
    Language English
    Publishing date 2000-04
    Publishing country England
    Document type Clinical Trial ; Controlled Clinical Trial ; Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1046/j.1365-4362.2000.00943.x
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  5. Article: Cutaneous vasculitis in western Africa.

    Amer, M / Metwalli, M

    Clinics in dermatology

    1999  Volume 17, Issue 6, Page(s) 655–658

    MeSH term(s) Africa, Western/epidemiology ; Female ; Humans ; Incidence ; Male ; Risk Factors ; Skin Diseases, Vascular/epidemiology ; Skin Diseases, Vascular/etiology ; Vasculitis/epidemiology ; Vasculitis/etiology
    Language English
    Publishing date 1999-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1064149-x
    ISSN 0738-081X
    ISSN 0738-081X
    DOI 10.1016/s0738-081x(99)00070-x
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  6. Article: Topical hydroquinone in the treatment of some hyperpigmentary disorders.

    Amer, M / Metwalli, M

    International journal of dermatology

    1998  Volume 37, Issue 6, Page(s) 449–450

    MeSH term(s) Adolescent ; Adult ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Hydroquinones/therapeutic use ; Hyperpigmentation/drug therapy ; Male ; Middle Aged ; Treatment Outcome
    Chemical Substances Dermatologic Agents ; Hydroquinones ; hydroquinone (XV74C1N1AE)
    Language English
    Publishing date 1998-06
    Publishing country England
    Document type Clinical Trial ; Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1046/j.1365-4362.1998.00499.x
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  7. Article: Environmental dermatology: an overview.

    Amer, M / Metwalli, M

    Clinics in dermatology

    1998  Volume 16, Issue 1, Page(s) 23–25

    MeSH term(s) Air Pollutants/adverse effects ; Causality ; Environmental Exposure/adverse effects ; Humans ; Risk Assessment ; Skin Diseases/diagnosis ; Skin Diseases/epidemiology ; Skin Diseases/etiology ; Socioeconomic Factors
    Chemical Substances Air Pollutants
    Language English
    Publishing date 1998-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1064149-x
    ISSN 0738-081X
    ISSN 0738-081X
    DOI 10.1016/s0738-081x(97)00166-1
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  8. Article: Skin diseases and enzymatic antioxidant activity among workers exposed to pesticides.

    Amer, M / Metwalli, M / Abu el-Magd, Y

    Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit

    2002  Volume 8, Issue 2-3, Page(s) 363–373

    Abstract: In this study, 150 workers exposed to pesticides and 50 healthy control subjects were given clinical and dermatological examinations, patch tests, tests of liver and renal function, complete blood count, blood sugar and urinalysis. Activity of the ... ...

    Abstract In this study, 150 workers exposed to pesticides and 50 healthy control subjects were given clinical and dermatological examinations, patch tests, tests of liver and renal function, complete blood count, blood sugar and urinalysis. Activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and glutathione reductase was also evaluated. Dermatological findings were positive in 78%, 76% and 54% of workers exposed to organophosphates, pyrethroids and carbamate pesticides respectively. The patch test was positive in 70% of workers exposed to pyrethroids and 64% exposed to carbamate pesticides. Liver enzyme levels were generally increased in workers while antioxidant enzyme activity was significantly decreased in all workers compared with the controls.
    MeSH term(s) Adult ; Age Distribution ; Analysis of Variance ; Antioxidants/metabolism ; Carbaryl/poisoning ; Case-Control Studies ; Chemical Industry ; Dermatitis, Occupational/enzymology ; Dermatitis, Occupational/epidemiology ; Dermatitis, Occupational/etiology ; Diazinon/poisoning ; Egypt/epidemiology ; Glutathione Peroxidase/blood ; Glutathione Reductase/blood ; Humans ; Kidney Function Tests ; Lipid Peroxidation ; Liver Function Tests ; Male ; Middle Aged ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; Occupational Exposure/statistics & numerical data ; Pesticides/poisoning ; Pyrethrins/poisoning ; Skin Absorption ; Skin Tests ; Superoxide Dismutase/blood ; Time Factors ; Urban Health/statistics & numerical data
    Chemical Substances Antioxidants ; Pesticides ; Pyrethrins ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Reductase (EC 1.8.1.7) ; Carbaryl (R890C8J3N1) ; Diazinon (YUS1M1Q929)
    Language English
    Publishing date 2002-03
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 1291071-5
    ISSN 1687-1634 ; 1020-3397
    ISSN (online) 1687-1634
    ISSN 1020-3397
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  9. Book ; Online: Skin diseases and enzymatic antioxidant activity among workers exposed to pesticides

    Amer, M. / Metwalli, M. / Abu El Magd, Y.

    2002  

    Abstract: 363-373 ... In this study, 150 workers exposed to pesticides and 50 healthy control subjects were given clinical and dermatological examinations, patch tests, tests of liver and renal function, complete blood count, blood sugar and urinalysis. Activity of ... ...

    Abstract 363-373

    In this study, 150 workers exposed to pesticides and 50 healthy control subjects were given clinical and dermatological examinations, patch tests, tests of liver and renal function, complete blood count, blood sugar and urinalysis. Activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and glutathione reductase was also evaluated. Dermatological findings were positive in 78%, 76% and 54% of workers exposed to organophosphates, pyrethroids and carbamate pesticides respectively. The patch test was positive in 70% of workers exposed to pyrethroids and 64% exposed to carbamate pesticides. Liver enzyme levels were generally increased in workers while antioxidant enzyme activity was significantly decreased in all workers compared with the controls
    Keywords Age Distribution ; Antioxidants ; Carbaryl ; Case-Control Studies ; Chemical Industry ; Dermatitis ; Occupational ; Glutathione Peroxidase ; Glutathione Reductase ; Liver Function Tests ; Skin Absorption ; Superoxide Dismutase ; Pesticides
    Language English
    Document type Book ; Online
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  10. Article: Spectrophotometric determination of nizatidine and ranitidine through charge transfer complex formation.

    Walash, M / Sharaf-El Din, M / Metwalli, M E-S / RedaShabana, M

    Archives of pharmacal research

    2004  Volume 27, Issue 7, Page(s) 720–726

    Abstract: Two Spectrophotometric procedures are presented for the determination of two commonly used H2-receptor antagonists, nizatidine (I) and ranitidine hydrochloride (II). The methods are based mainly on charge transfer complexation reaction of these drugs ... ...

    Abstract Two Spectrophotometric procedures are presented for the determination of two commonly used H2-receptor antagonists, nizatidine (I) and ranitidine hydrochloride (II). The methods are based mainly on charge transfer complexation reaction of these drugs with either p-chloranilic acid (rho-CA) or 2, 3 dichloro-5, 6-dicyanoquinone (DDQ). The produced colored products are quantified spectrophotometrically at 515 and 467 nm in chloranilic acid and DDQ methods, respectively. The molar ratios for the reaction products and the optimum assay conditions were studied. The methods determine the cited drugs in concentration ranges of 20-200 and 20-160 microg/mL for nizatidine and ranges of 20-240 and 20-140 microg/mL for ranitidine with chloranilic acid and DDQ methods, respectively. A more detailed investigation of the complexes formed was made with respect to their composition, association constant, molar absorptivity and free energy change. The proposed procedures were successfully utilized in the determination of the drugs in pharmaceutical preparations. The standard addition method was applied by adding nizatidine and ranitidine to the previously analyzed tablets or capsules. The recovery of each drug was calculated by comparing the concentration obtained from the spiked mixtures with those of the pure drug. The results of analysis of commercial tablets and the recovery study (standard addition method) of the cited drugs suggested that there is no interference from any excipients, which are present in tablets or capsules. Statistical comparison of the results was performed with regard to accuracy and precision using student's t-test and F-ratio at 95% confidence level. There is no significant difference between the reported and proposed methods with regard to accuracy and precision.
    MeSH term(s) Anti-Ulcer Agents/analysis ; Benzoquinones/chemistry ; Capsules ; Chemical Phenomena ; Chemistry, Physical ; Indicators and Reagents ; Nizatidine/analysis ; Ranitidine/analysis ; Reference Standards ; Reproducibility of Results ; Solutions ; Spectrophotometry, Ultraviolet ; Tablets
    Chemical Substances Anti-Ulcer Agents ; Benzoquinones ; Capsules ; Indicators and Reagents ; Solutions ; Tablets ; dichlorodicyanobenzoquinone (1H5KD39UH7) ; Ranitidine (884KT10YB7) ; Nizatidine (P41PML4GHR) ; chloranilic acid (YJ8L3BB7Y4)
    Language English
    Publishing date 2004-07-21
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 447623-2
    ISSN 1976-3786 ; 0253-6269
    ISSN (online) 1976-3786
    ISSN 0253-6269
    DOI 10.1007/bf02980138
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