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  1. Book ; Online: L'innovation thérapeutique : évolution et tendances

    Meunier, Bernard

    2015  

    Abstract: L'innovation thérapeutique n'est pas à la hauteur des espoirs qu'ont laissé entrevoir, ces vingt dernières années, les progrès fulgurants de la biologie moléculaire, de la génétique ou encore de la bio-informatique. Si certains domaines, comme la ... ...

    Abstract L'innovation thérapeutique n'est pas à la hauteur des espoirs qu'ont laissé entrevoir, ces vingt dernières années, les progrès fulgurants de la biologie moléculaire, de la génétique ou encore de la bio-informatique. Si certains domaines, comme la cancérologie, ont largement bénéficié de ces avancées, pour d'autres, l'innovation est au point mort. Nous avons trop peu d'exemples de réussite dans l'innovation thérapeutique en France pour nous abstenir d'une profonde réflexion sur la création des..
    Size 1 electronic resource ( p.)
    Publisher Collège de France
    Document type Book ; Online
    Note French ; Open Access
    HBZ-ID HT020092126
    ISBN 9782213686912 ; 9782722604247 ; 2213686912 ; 2722604248
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Conference proceedings: DNA and RNA cleavers and chemotherapy of cancer and viral diseases

    Meunier, Bernard

    [proceedings of the NATO Advanced Research Workshop on DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases, Toulouse, France, September 11 - 14, 1995]

    (NATO ASI series : Series C, Mathematical and physical sciences ; 479)

    1996  

    Event/congress Advanced Research Workshop on DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases (1995, Toulouse)
    Author's details ed. by Bernhard Meunier
    Series title NATO ASI series : Series C, Mathematical and physical sciences ; 479
    NATO ASI series
    NATO ASI series ; Series C, Mathematical and physical sciences
    Collection NATO ASI series
    NATO ASI series ; Series C, Mathematical and physical sciences
    Keywords DNA / chemistry / congresses ; RNA / chemistry / congresses ; Antineoplastic Agents / chemistry / congresses ; Antiviral Agents / chemistry / congresses ; Neoplasms / drug therapy / congresses ; Virus Diseases / drug therapy / congresses ; Cytostatikum ; Molekularpharmakologie
    Subject Zytostatikum ; Cancerotoxischer Stoff ; Carcinostatikum ; Krebsmittel ; Antineoplastikum ; Anticarcinogen ; Antikarzinogen ; Anticancerogen ; Antineoplastisches Mittel
    Language English
    Size XXV, 372 S. : Ill., graph. Darst.
    Publisher Kluwer Acad. Publ
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT007169335
    ISBN 0-7923-4025-6 ; 978-0-7923-4025-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 269 order for loan Magazin

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  3. Article ; Online: Covid-19, ou quand le manque d’antiviraux efficaces devient un problème mondial

    Meunier, Bernard

    ISSN: 0151-9093 ; EISSN: 2105-2409 ; L'Actualité Chimique ; https://hal.archives-ouvertes.fr/hal-02547542 ; L'Actualité Chimique, Société chimique de France, 2020, 451, pp.1-5

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [CHIM.COOR]Chemical Sciences/Coordination chemistry ; covid19
    Language French
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Covid-19, ou quand le manque d’antiviraux efficaces devient un problème mondial

    Meunier, Bernard

    ISSN: 0151-9093 ; EISSN: 2105-2409 ; L'Actualité Chimique ; https://hal.archives-ouvertes.fr/hal-02547542 ; L'Actualité Chimique, Société chimique de France, 2020, 451, pp.1-5

    2020  

    Abstract: International ... ...

    Abstract International audience
    Keywords [CHIM.COOR]Chemical Sciences/Coordination chemistry ; covid19
    Language French
    Publisher HAL CCSD
    Publishing country fr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: How to Define a Nanozyme.

    Robert, Anne / Meunier, Bernard

    ACS nano

    2022  Volume 16, Issue 5, Page(s) 6956–6959

    Abstract: Over the past 15 years, many articles have considered "nanozymes" as ferromagnetic nanoparticles having an "intrinsic peroxidase-like activity" in the presence of hydrogen peroxide. However, the definition and the catalytic activity of these nanozymes ... ...

    Abstract Over the past 15 years, many articles have considered "nanozymes" as ferromagnetic nanoparticles having an "intrinsic peroxidase-like activity" in the presence of hydrogen peroxide. However, the definition and the catalytic activity of these nanozymes have been questioned. The present Perspective reports the main criteria that are essential to classify a nanoparticle as a nanozyme. It is important to consider that not all nanoparticles able to generate hydroxyl radicals in the presence of hydrogen peroxide without catalytic activity can be registered as nanozymes.
    MeSH term(s) Hydrogen Peroxide ; Nanoparticles ; Catalysis
    Chemical Substances Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.2c02966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Age and Alzheimer's Disease.

    Meunier, Bernard

    Nutrients

    2016  Volume 8, Issue 6

    Abstract: A recent review article published in Nutrients by Brewer [1] attracted the attention of the readers on the role of copper toxicity as major factor in Alzheimer's disease.[ ... ]. ...

    Abstract A recent review article published in Nutrients by Brewer [1] attracted the attention of the readers on the role of copper toxicity as major factor in Alzheimer's disease.[...].
    MeSH term(s) Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease/blood ; Alzheimer Disease/chemically induced ; Alzheimer Disease/diagnosis ; Copper/blood ; Copper/toxicity ; Humans ; Life Expectancy
    Chemical Substances Copper (789U1901C5)
    Language English
    Publishing date 2016-06-16
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu8060372
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Specific Copper(II) Chelator TDMQ20 Is Efficient for the Treatment of Wilson's Disease in Mice.

    Zhu, Yingshan / Tang, Ying / Huang, Lan / Nguyen, Michel / Liu, Yan / Robert, Anne / Meunier, Bernard

    Pharmaceutics

    2023  Volume 15, Issue 12

    Abstract: 1) Background: In patients with Wilson's disease, the deficiency of the copper carrier ATP7B causes the accumulation of copper in the liver, brain and various other organs. Lifelong treatment is therefore mandatory, using copper chelators to increase ... ...

    Abstract (1) Background: In patients with Wilson's disease, the deficiency of the copper carrier ATP7B causes the accumulation of copper in the liver, brain and various other organs. Lifelong treatment is therefore mandatory, using copper chelators to increase the excretion of copper and to avoid life-threatening damage. The clinically used reference drug, D-penicillamine, exhibit numerous adverse effects, especially a frequent severe and irreversible neurological worsening, mainly due to its lack of metal selectivity; (2) Methods: A new tetradentate ligand based on an 8-aminoquinoline entity, named TDMQ20, which is highly selective for copper compared with other metal ions, is evaluated in "toxic milk" TX mice as an oral treatment of this Wilson's disease murine model; (3) Results: The concentration of copper in the liver of "toxic milk" TX mice decreased and the fecal excretion of copper increased upon oral treatment with TDMQ20. Both effects are dose-dependent, and more pronounced than those of D-penicillamine; (4) Conclusions: The TDMQ20 copper chelator is more efficient than the reference drug D-penicillamine for the treatment of a Wilson's disease murine model. Pharmacological data obtained with TDMQ20 on the TX mouse model strongly support the selection of this ligand as a drug candidate for this genetic disease.
    Language English
    Publishing date 2023-12-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15122719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Does chemistry have a future in therapeutic innovations?

    Meunier, Bernard

    Angewandte Chemie (International ed. in English)

    2012  Volume 51, Issue 35, Page(s) 8702–8706

    MeSH term(s) Biopharmaceutics/trends ; Chemistry, Pharmaceutical/trends ; Drug Discovery/trends ; Drug Industry/trends ; Humans ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/economics
    Chemical Substances Small Molecule Libraries
    Language English
    Publishing date 2012-08-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201202506
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  9. Article ; Online: Comment on "A Propensity Score Matched Analysis of Open Versus Minimally Invasive Transthoracic Esophagectomy in the Netherlands".

    Meunier, Bernard / Bergeat, Damien

    Annals of surgery

    2018  Volume 269, Issue 4, Page(s) e55–e56

    MeSH term(s) Carcinoma, Squamous Cell/surgery ; Esophageal Neoplasms/surgery ; Esophagectomy ; Humans ; Netherlands ; Propensity Score
    Language English
    Publishing date 2018-06-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000002868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.35/1: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Gluteal Propeller Perforator Flaps: A Paradigm Shift in Abdominoperineal Amputation Reconstruction.

    Chrelias, Theodoros / Berkane, Yanis / Rousson, Etienne / Uygun, Korkut / Meunier, Bernard / Kartheuser, Alex / Watier, Eric / Duisit, Jérôme / Bertheuil, Nicolas

    Journal of clinical medicine

    2023  Volume 12, Issue 12

    Abstract: Abdominoperineal amputation (AAP) is a gold standard procedure treating advanced abdominal and pelvic cancers. The defect resulting from this extensive surgery must be reconstructed to avoid complications, such as infection, dehiscence, delayed healing, ... ...

    Abstract Abdominoperineal amputation (AAP) is a gold standard procedure treating advanced abdominal and pelvic cancers. The defect resulting from this extensive surgery must be reconstructed to avoid complications, such as infection, dehiscence, delayed healing, or even death. Several approaches can be chosen depending on the patient. Muscle-based reconstructions are a reliable solution but are responsible for additional morbidity for these fragile patients. We present and discuss our experience in AAP reconstruction using gluteal-artery-based propeller perforator flaps (G-PPF) in a case series. Between January 2017 and March 2021, 20 patients received G-PPF reconstruction in two centers. Either superior gluteal artery (SGAP)- or inferior artery (IGAP)-based perforator flaps were performed depending on the best configuration. Preoperative, intraoperative, and postoperative data were collected. A total of 23 G-PPF were performed-12 SGAP and 11 IGAP flaps. Final defect coverage was achieved in 100% of cases. Eleven patients experienced at least one complication (55%), amongst whom six patients (30%) had delayed healing, and three patients (15%) had at least one flap complication. One patient underwent a new surgery at 4 months for a perineal abscess under the flap, and three patients died from disease recurrence. Gluteal-artery-based propeller perforator flaps are an effective and modern surgical procedure for AAP reconstruction. Their mechanic properties, in addition to their low morbidity, make them an optimal technique for this purpose; however, technical skills are needed, and closer surveillance with patient compliance is critical to ensure success. G-PPF should be widely used in specialized centers and considered a modern alternative to muscle-based reconstructions.
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12124014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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