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  1. Book ; Thesis: Immunregulatoren bei Autoimmunendokrinopathien

    Meyer, Gesine

    das AIRE-1 Gen und endogene Retroviren als Prädispositionsfaktoren

    2002  

    Author's details vorgelegt von Gesine Meyer
    Language German
    Size VI, 83 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2002
    HBZ-ID HT013584756
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Neue Aspekte der Glukokortikoidsubstitution bei Nebennierenrindeninsuffizienz.

    Kienitz, Tina / Meyer, Gesine

    Der Internist

    2021  Volume 63, Issue 1, Page(s) 12–17

    Abstract: Background: Appropriate glucocorticoid dose adjustment in specific situations significantly impacts quality of life and performance of patients with adrenal insufficiency. It is also pivotal for the prevention of adrenal crisis.: Objectives: ... ...

    Title translation New aspects of glucocorticoid substitution in adrenal insufficiency.
    Abstract Background: Appropriate glucocorticoid dose adjustment in specific situations significantly impacts quality of life and performance of patients with adrenal insufficiency. It is also pivotal for the prevention of adrenal crisis.
    Objectives: Improving medical care for patients with adrenal insufficiency.
    Materials and methods: Selective literature research focussing on the most recent studies.
    Results: Optimal glucocorticoid substitution aims at closely mimicking physiological fluctuations of cortisol levels. In recent years glucocorticoid preparations with modified pharmacokinetics have expanded the therapeutic arsenal. Adrenal crises occur with an incidence of 4.8-9.3 crises per 100 patient years. With a mortality of 0.5 per 100 patient years adrenal crisis is a life-threatening event. Therefore, it is of the utmost importance to adjust glucocorticoid dose in situations with increased cortisol demand in order to prevent as well as appropriately treat adrenal crisis.
    Conclusions: To prevent life-threatening adrenal crisis, patients, their families and medical staff require training.
    MeSH term(s) Acute Disease ; Adrenal Insufficiency/diagnosis ; Adrenal Insufficiency/drug therapy ; Glucocorticoids/adverse effects ; Humans ; Hydrocortisone ; Quality of Life
    Chemical Substances Glucocorticoids ; Hydrocortisone (WI4X0X7BPJ)
    Language German
    Publishing date 2021-12-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01209-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Vitrektomie zur Entfernung epimakulärer Membranen

    Meyer, Gesine

    1993  

    Author's details vorgelegt von Gesine Meyer
    Size [2], 36 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1993
    HBZ-ID HT004969279
    Database Catalogue ZB MED Medicine, Health

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  4. Article ; Online: Hormonal Gender Reassignment Treatment for Gender Dysphoria.

    Meyer, Gesine / Boczek, Ute / Bojunga, Jörg

    Deutsches Arzteblatt international

    2021  Volume 117, Issue 43, Page(s) 725–732

    Abstract: Background: No data are available at present on the prevalence of gender dysphoria (trans-identity) in Germany. On the basis of estimates from the Netherlands, it can be calculated that approximately 15 000 to 25 000 persons in Germany are affected. ... ...

    Abstract Background: No data are available at present on the prevalence of gender dysphoria (trans-identity) in Germany. On the basis of estimates from the Netherlands, it can be calculated that approximately 15 000 to 25 000 persons in Germany are affected. Persons suffering from gender dysphoria often experience significant distress and have a strong desire for gender reassignment treatment.
    Methods: This review is based on pertinent publications retrieved by a selective search in the PubMed database employing the searching terms "transsexualism," "transgender," "gender incongruence," "gender identity disorder," "gender-affirming hormone therapy," and "gender dysphoria."
    Results: In view of its far-reaching consequences, some of which are irreversible, hormonal gender reassignment treatment should only be initiated after meticulous individual consideration, with the approval of the treating psychiatrist/psychotherapist and after extensive information of the patient by an experienced endo - crinologist. Before the treatment is begun, the patient must be extensively screened for risk factors. The contraindications include severe preexisting thromboembolic diseases (mainly if untreated), hormone-sensitive tumors, and uncontrolled pre - existing chronic diseases such as arterial hypertension and epilepsy. Finding an appropriate individual solution is the main objective even if contraindications are present. Male-to-female treatment is carried out with 17β-estradiol or 17β-estradiol valerate in combination with cyproterone acetate or spironolactone as an antiandrogen, female-to-male treatment with transdermal or intramuscular testosterone preparations. The treatment must be monitored permanently with clinical and laboratory follow-up as well as with gynecological and urological early-detection screening studies. Prospective studies and a meta-analysis (based on low-level evidence) have documented an improvement in the quality of life after gender reassignment treatment. Female-to-male gender-incongruent persons often have difficulty being accepted in a gynecological practice as a male patient.
    Concluzion: Further prospective studies for the quantification of the risks and benefits of hormonal treatment would be desirable. Potential interactions of the hormone preparations with other medications must always be considered.
    MeSH term(s) Female ; Gender Dysphoria/drug therapy ; Germany/epidemiology ; Humans ; Male ; Prospective Studies ; Quality of Life ; Sex Reassignment Surgery ; Transgender Persons ; Transsexualism
    Language English
    Publishing date 2021-02-09
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2020.0725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hypertensive crisis in a young man during micturition: contrast-enhanced ultrasound for diagnosis of paravesical paraganglioma.

    Meyer, Gesine

    Ultraschall in der Medizin (Stuttgart, Germany : 1980)

    2013  Volume 34, Issue 3, Page(s) 207–209

    MeSH term(s) Adolescent ; Contrast Media ; Diagnosis, Differential ; Humans ; Hypertension/etiology ; Hypertension/physiopathology ; Image Enhancement ; Male ; Metanephrine/blood ; Paraganglioma/complications ; Paraganglioma/diagnostic imaging ; Paraganglioma/physiopathology ; Phospholipids ; Sulfur Hexafluoride ; Ultrasonography, Doppler, Color ; Urinary Bladder Neoplasms/complications ; Urinary Bladder Neoplasms/diagnostic imaging ; Urinary Bladder Neoplasms/physiopathology ; Urination/physiology
    Chemical Substances Contrast Media ; Phospholipids ; contrast agent BR1 ; Metanephrine (5001-33-2) ; Sulfur Hexafluoride (WS7LR3I1D6)
    Language German
    Publishing date 2013-07-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 801064-x
    ISSN 1438-8782 ; 1439-0914 ; 1431-4894 ; 0172-4614
    ISSN (online) 1438-8782
    ISSN 1439-0914 ; 1431-4894 ; 0172-4614
    DOI 10.1055/s-0032-1319459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Retrospektive Betrachtung der thyreostatischen Therapie bei Patienten mit Morbus Basedow

    Schork-Gleser, Diana [Verfasser] / Meyer, Gesine [Akademischer Betreuer] / Meyer, Gesine [Gutachter] / Akker, Marjan van den [Gutachter]

    Identifikation von Risikofaktoren für ein Rezidiv und Empfehlung für die Dauer der thyreostatischen Therapie anhand des zeitlichen Verlaufs der TRAK

    2022  

    Author's details Diana Schork-Gleser ; Gutachter: Gesine Meyer, Marjan van den Akker ; Betreuer: Gesine Meyer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Addison-Krise – Risiko erkennen und rasch behandeln.

    Meyer, Gesine / Badenhoop, Klaus

    Deutsche medizinische Wochenschrift (1946)

    2018  Volume 143, Issue 6, Page(s) 392–396

    Abstract: An adrenal crisis (Addisonian crisis) is an acute life-threatening complication of adrenal insufficiency. It occurs when hydrocortisone demand is not met by supplementation in the context of an infection - often gastrointestinal, fever, trauma, acute ... ...

    Title translation Addisonian Crisis - Risk Assessment and Appropriate Treatment.
    Abstract An adrenal crisis (Addisonian crisis) is an acute life-threatening complication of adrenal insufficiency. It occurs when hydrocortisone demand is not met by supplementation in the context of an infection - often gastrointestinal, fever, trauma, acute psychological or physical stress. Symptoms of weakness, nausea, muscle/joint pain and drowsiness may develop out of robust health within few hours. If overlooked, treated too late, with insufficient dose or route of application, there exists a considerable risk of mortality. Treatment consists of immediate parenteral hydrocortisone (100 mg bolus) and subsequent continuous infusion until the underlying precipitating cause is cured and/or when regular supplementation can be continued. Physicians and nurses must not underestimate the condition, since diagnosis and treatment must not be delayed. Patients, relatives and spouses need to be trained in prevention and early recognition through educational programs and emergency cards.
    MeSH term(s) Addison Disease/diagnosis ; Addison Disease/epidemiology ; Addison Disease/therapy ; Anti-Inflammatory Agents/therapeutic use ; Humans ; Hydrocortisone/therapeutic use ; Risk Assessment
    Chemical Substances Anti-Inflammatory Agents ; Hydrocortisone (WI4X0X7BPJ)
    Language German
    Publishing date 2018-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/s-0043-111729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Increasing normality-persisting barriers: Current socio-demographic characteristics of 350 individuals diagnosed with gender dysphoria.

    Meyer, Gesine / Mayer, Moritz / Mondorf, Antonia / Herrmann, Eva / Bojunga, Jörg

    Clinical endocrinology

    2020  Volume 92, Issue 3, Page(s) 241–246

    Abstract: Introduction: The number of individuals requesting medical treatment for gender dysphoria has increased significantly within the past years. Our purpose was to examine current biographic and socio-demographic characteristics and aspects of legal gender ... ...

    Abstract Introduction: The number of individuals requesting medical treatment for gender dysphoria has increased significantly within the past years. Our purpose was to examine current biographic and socio-demographic characteristics and aspects of legal gender reassignment.
    Design: Medical files from n = 350 individuals of a German Endocrine outpatient clinic were collected from 2009 to 2017 and analysed retrospectively.
    Results: Ratio of transwomen to transmen equates to 1:1.89 with a remarkable increase of transmen by the year 2013, showing a reversal of gender distribution compared with previous studies for the first time. Use of illegal substances or self-initiated hormone therapy was rare (4.6 and 2.1%). Satisfaction with gender-affirming hormone therapy was significantly higher in transmen than in transwomen (100% vs 96.2%, P = .005). Use of antidepressants declined significantly after onset of hormone treatment in transmen (13% vs 7%; P = .007). The number of individuals with a graduation diploma was only about half as high as in the general population (14.3% vs 27.3%), whereas unemployment rate was more than twice as high (14% vs 6.9%). Median latency between application for legal gender reassignment and definitive court decision was 9 months.
    Conclusions: Our data provide possible indications for a decline of psychosocial burden in individuals diagnosed with gender dysphoria over the last years. However, affected individuals are still limited in their occupational and financial opportunities as well as by a complex and expensive procedure of legal gender reassignment in Germany.
    MeSH term(s) Adolescent ; Adult ; Communication Barriers ; Cost of Illness ; Female ; Gender Dysphoria/economics ; Gender Dysphoria/epidemiology ; Gender Dysphoria/psychology ; Gender Dysphoria/therapy ; Germany/epidemiology ; Health Services Accessibility/economics ; Health Services Accessibility/statistics & numerical data ; Humans ; Male ; Middle Aged ; Occupations/economics ; Occupations/statistics & numerical data ; Patient Satisfaction/economics ; Patient Satisfaction/statistics & numerical data ; Retrospective Studies ; Sex Reassignment Procedures/economics ; Sex Reassignment Procedures/psychology ; Sex Reassignment Procedures/statistics & numerical data ; Socioeconomic Factors ; Transgender Persons/psychology ; Transgender Persons/statistics & numerical data ; Transsexualism/economics ; Transsexualism/epidemiology ; Transsexualism/psychology ; Transsexualism/therapy ; Young Adult
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 121745-8
    ISSN 1365-2265 ; 0300-0664
    ISSN (online) 1365-2265
    ISSN 0300-0664
    DOI 10.1111/cen.14140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Shear Wave Elastography Reveals a High Prevalence of NAFLD-related Fibrosis even in Type 1 Diabetes.

    Meyer, Gesine / Dauth, Nina / Grimm, Matthias / Herrmann, Eva / Bojunga, Joerg / Friedrich-Rust, Mireen

    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

    2021  Volume 130, Issue 8, Page(s) 532–538

    Abstract: Background: The association between type 2 diabetes mellitus (T2DM) and advanced stages of non-alcoholic fatty liver disease is well known. Some studies indicate a relevant prevalence also in type 1 diabetes mellitus (T1DM), but so far there is only ... ...

    Abstract Background: The association between type 2 diabetes mellitus (T2DM) and advanced stages of non-alcoholic fatty liver disease is well known. Some studies indicate a relevant prevalence also in type 1 diabetes mellitus (T1DM), but so far there is only limited data.
    Objective: To determine the prevalence of non-alcoholic fatty liver disease (NAFLD)-related liver fibrosis in individuals with T1DM and compare to those with type 2 diabetes.
    Methods: Diabetic patients from a single diabetes care centre were screened for liver fibrosis by sonographic shear wave elastography (SWE). In addition, all patients received laboratory evaluation including non-alcoholic fatty liver fibrosis score and Fibrosis-4 Index.
    Results: Three hundred and forty patients were included in the study, of these, 310 received SWE. Overall 254 patients (93 with type 1 and 161 with type 2 diabetes) had reliable measurements and were included in the final analysis. In patients with type 1 diabetes, the prevalence of NAFLD-related liver fibrosis was 16-21%, depending on the method of detection. Significant liver fibrosis was observed in 30-46% of patients with type 2 diabetes.
    Conclusions: Our data revealed an unexpectedly high prevalence of NAFLD-related liver fibrosis in patients with type 1 diabetes. To our knowledge, this is one of the first studies using SWE to diagnose advanced NAFLD in type 1 diabetes in a non-preselected cohort. Considering the findings of our study, regular screening for hepatic complications must be recommended for all diabetic patients, even for those with type 1 diabetes.
    MeSH term(s) Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnostic imaging ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/diagnostic imaging ; Diabetes Mellitus, Type 2/epidemiology ; Elasticity Imaging Techniques/methods ; Humans ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/epidemiology ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/epidemiology ; Prevalence
    Language English
    Publishing date 2021-11-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1225416-2
    ISSN 1439-3646 ; 0947-7349
    ISSN (online) 1439-3646
    ISSN 0947-7349
    DOI 10.1055/a-1666-0431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Addison-Krise – Risiko erkennen und rasch behandeln

    Meyer, Gesine / Badenhoop, Klaus

    DMW - Deutsche Medizinische Wochenschrift

    2018  Volume 143, Issue 06, Page(s) 392–396

    Abstract: An adrenal crisis (Addisonian crisis) is an acute life-threatening complication of adrenal insufficiency. It occurs when hydrocortisone demand is not met by supplementation in the context of an infection – often gastrointestinal, fever, trauma, acute ... ...

    Abstract An adrenal crisis (Addisonian crisis) is an acute life-threatening complication of adrenal insufficiency. It occurs when hydrocortisone demand is not met by supplementation in the context of an infection – often gastrointestinal, fever, trauma, acute psychological or physical stress. Symptoms of weakness, nausea, muscle/joint pain and drowsiness may develop out of robust health within few hours. If overlooked, treated too late, with insufficient dose or route of application, there exists a considerable risk of mortality. Treatment consists of immediate parenteral hydrocortisone (100 mg bolus) and subsequent continuous infusion until the underlying precipitating cause is cured and/or when regular supplementation can be continued. Physicians and nurses must not underestimate the condition, since diagnosis and treatment must not be delayed. Patients, relatives and spouses need to be trained in prevention and early recognition through educational programs and emergency cards.
    Keywords Nebenniereninsuffizienz ; autoimmun polyglanduläres Syndrom ; Kortisolmangel ; adrenal insufficiency ; autoimmune polyglandular syndrome ; cortisol deficiency
    Language German
    Publishing date 2018-03-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/s-0043-111729
    Database Thieme publisher's database

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