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  1. Book ; Thesis: Retrospektive Analyse mikrobiologischer Befunde bei Patienten mit Peritonsillarabszess unter Berücksichtigung klinischer Aspekte

    Meyer, Maria Christine

    2022  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Maria Christine Meyer
    Language German
    Size XI, 94 Seiten, Diagramme, 21 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2022
    Note Zusammenfassung auf Deutsch und Englisch
    HBZ-ID HT030011804
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 D 149 order for loan Magazin

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  2. Book ; Online ; Thesis: Charakterisierung des Proteins Peter Pan in HeLa-Zellen

    Meyer, Maria Theresia [Verfasser]

    2021  

    Author's details Maria Theresia Meyer
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universität Ulm
    Publishing place Ulm
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article ; Online: Effects of the mineralocorticoid receptor antagonist eplerenone in experimental autoimmune encephalomyelitis.

    Alvarez Quintero, Guido S / Lima, Analia / Roig, Paulina / Meyer, Maria / de Kloet, E R / De Nicola, Alejandro F / Garay, Laura I

    The Journal of steroid biochemistry and molecular biology

    2024  Volume 238, Page(s) 106461

    Abstract: There is growing evidence indicating that mineralocorticoid receptor (MR) expression influences a wide variety of functions in metabolic and immune response. The present study explored if antagonism of the MR reduces neuroinflammation in the spinal cord ... ...

    Abstract There is growing evidence indicating that mineralocorticoid receptor (MR) expression influences a wide variety of functions in metabolic and immune response. The present study explored if antagonism of the MR reduces neuroinflammation in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE). Eplerenone (EPLE) (100 mg/kg dissolved in 30% 2-hydroxypropyl-β-cyclodextrin) was administered intraperitoneally (i.p.) daily from EAE induction (day 0) until sacrificed on day 17 post-induction. The MR blocker (a) significantly decreased the inflammatory parameters TLR4, MYD88, IL-1β, and iNOS mRNAs; (b) attenuated HMGB1, NLRP3, TGF-β mRNAs, microglia, and aquaporin4 immunoreaction without modifying GFAP. Serum IL-1β was also decreased in the EAE+EPLE group. Moreover, EPLE treatment prevented demyelination and improved clinical signs of EAE mice. Interestingly, MR was decreased and GR remained unchanged in EAE mice while EPLE treatment restored MR expression, suggesting that a dysbalanced MR/GR was associated with the development of neuroinflammation. Our results indicated that MR blockage with EPLE attenuated inflammation-related spinal cord pathology in the EAE mouse model of Multiple Sclerosis, supporting a novel therapeutic approach for immune-related diseases.
    MeSH term(s) Mice ; Animals ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Eplerenone/pharmacology ; Eplerenone/therapeutic use ; Mineralocorticoid Receptor Antagonists/pharmacology ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Neuroinflammatory Diseases ; Spinal Cord/pathology ; Mice, Inbred C57BL
    Chemical Substances Eplerenone (6995V82D0B) ; Mineralocorticoid Receptor Antagonists
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2024.106461
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 708: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Early Signs of Neuroinflammation in the Postnatal Wobbler Mouse Model of Amyotrophic Lateral Sclerosis.

    Meyer, Maria / Lima, Analia / Deniselle, Maria Claudia Gonzalez / De Nicola, Alejandro F

    Cellular and molecular neurobiology

    2022  Volume 43, Issue 5, Page(s) 2149–2163

    Abstract: The Wobbler mouse is an accepted model of sporadic amyotrophic lateral sclerosis. The spinal cord of clinically symptomatic animals (3-5 months old) shows vacuolar motoneuron degeneration, inflammation, and gliosis accompanied by motor impairment. ... ...

    Abstract The Wobbler mouse is an accepted model of sporadic amyotrophic lateral sclerosis. The spinal cord of clinically symptomatic animals (3-5 months old) shows vacuolar motoneuron degeneration, inflammation, and gliosis accompanied by motor impairment. However, data are not conclusive concerning pathological changes appearing early after birth. To answer this question, we used postnatal day (PND) 6 genotyped Wobbler pups to determine abnormalities of glia and neurons at this early age period in the spinal cord. We found astrogliosis, microgliosis with morphophenotypic changes pointing to active ameboid microglia, enhanced expression of the proinflammatory markers TLR4, NFkB, TNF, and inducible nitric oxide synthase. The astrocytic enzyme glutamine synthase and the glutamate-aspartate transporter GLAST were also reduced in PND 6 Wobbler pups, suggesting excitotoxicity due to impaired glutamate homeostasis. At the neuronal level, PND 6 Wobblers showed swollen soma, increased choline acetyltransferase immunofluorescence staining, and low expression of the neuronal nuclear antigen NeuN. However, vacuolated motoneurons, a typical signature of older clinically symptomatic Wobbler mice, were absent in the spinal cord of PND 6 Wobblers. The results suggest predominance of neuroinflammation and abnormalities of microglia and astrocytes at this early period of Wobbler life, accompanied by some neuronal changes. Data support the non-cell autonomous hypothesis of the Wobbler disorder, and bring useful information with regard to intervening molecular inflammatory mechanisms at the beginning stage of human motoneuron degenerative diseases.
    MeSH term(s) Humans ; Animals ; Mice ; Infant ; Amyotrophic Lateral Sclerosis ; Neuroinflammatory Diseases ; Motor Neurons ; Inflammation ; Neuroglia ; Disease Models, Animal ; Gliosis ; Spinal Cord ; Mice, Neurologic Mutants
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 283404-2
    ISSN 1573-6830 ; 0272-4340
    ISSN (online) 1573-6830
    ISSN 0272-4340
    DOI 10.1007/s10571-022-01294-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1727: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Validating the use of lyophilized natural organic matter as background material in GAC rapid small-scale column tests.

    Abulikemu, Gulizhaer / Speth, Thomas F / Vogt, Jeffrey A / Meyer, Maria / Hong, Ying / Pressman, Jonathan G

    Journal of water process engineering

    2022  Volume 47

    Abstract: Utilities often test the effectiveness of different granular activated carbons (GACs) to determine which is most advantageous for their system. For surface water systems, in particular, the seasonal and annual variability of natural organic matter (NOM) ... ...

    Abstract Utilities often test the effectiveness of different granular activated carbons (GACs) to determine which is most advantageous for their system. For surface water systems, in particular, the seasonal and annual variability of natural organic matter (NOM) in the source water makes it difficult to benchmark the effectiveness of GACs over multiple contract periods. This study produced stable, lyophilized NOM from the filtered water (FW), i.e., the influent to GAC contactors, which was then reconstituted (Recon) and tested against the FW itself in parallel rapid small-scale column tests (RSSCTs). The results demonstrated nearly identical NOM breakthrough profiles. RSSCTs conducted with both FW and Recon were shown to simulate the full-scale contactor performance well, while similar RSSCTs with regenerated GAC yielded a slightly earlier breakthrough, possibly due to the changes in GAC characteristics during regeneration and grinding. RSSCTs evaluating the removal of microcystin-LR (MC-LR) in the presence of background NOM contained in FW and Recon showed slightly different results, possibly due to the difference in chloride concentrations of these two waters. This work validates that reconstituted lyophilized NOM can be used as a source water surrogate for GAC evaluations when the constituent of interest is NOM, and potentially for other constituents depending upon the influence of additional inorganic constituents that were not evaluated as part of this study.
    Language English
    Publishing date 2022-06-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2214-7144
    ISSN (online) 2214-7144
    DOI 10.1016/j.jwpe.2022.102773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Thesis: Langzeitverlaufsbeobachtung von Patienten mit Erregungsbildungsstörungen des Herzens

    Meyer, Brigitte

    1999  

    Author's details vorgelegt von Brigitte Meyer
    Language German
    Size 56 S., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lübeck, Med. Univ., Diss., 1999
    HBZ-ID HT013059181
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 D 1545 order for loan Magazin

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  7. Book ; Thesis: Therapeutisches Vorgehen bei Salmonellen-Enteritiden Erwachsener

    Meyer, Maria

    1980  

    Author's details vorlegt von Maria Meyer
    Size 54 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 1980
    HBZ-ID HT000272396
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    80 D 2384 order for loan Magazin

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  8. Article ; Online: Testosterone Reduces Myelin Abnormalities in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis.

    Esperante, Ivan J / Meyer, Maria / Banzan, Carolina / Kruse, Maria Sol / Lima, Analia / Roig, Paulina / Guennoun, Rachida / Schumacher, Michael / De Nicola, Alejandro F / Gonzalez Deniselle, Maria Claudia

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron degenerative disease that is associated with demyelination. ... ...

    Abstract Amyotrophic lateral sclerosis (ALS) is a fatal motoneuron degenerative disease that is associated with demyelination. The
    MeSH term(s) Animals ; Mice ; Myelin Sheath/metabolism ; Myelin Sheath/drug effects ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Male ; Disease Models, Animal ; Testosterone/pharmacology ; Spinal Cord/metabolism ; Spinal Cord/drug effects ; Spinal Cord/pathology ; Excitatory Amino Acid Transporter 2/metabolism ; Excitatory Amino Acid Transporter 2/genetics ; Microglia/drug effects ; Microglia/metabolism ; Microglia/pathology
    Chemical Substances Testosterone (3XMK78S47O) ; Excitatory Amino Acid Transporter 2
    Language English
    Publishing date 2024-04-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Awareness of alcohol as a risk factor for cancer: A population-based cross-sectional study among 3000 Danish men and women.

    Thomsen, Karen Linding / Christensen, Anne Sofie Plum / Meyer, Maria Kristine Hagelskær

    Preventive medicine reports

    2020  Volume 19, Page(s) 101156

    Abstract: Alcohol increases the risk of several cancer types. However, awareness of the link between alcohol and cancer is estimated to be low in Denmark. The objective of this study was to examine awareness of alcohol as a risk factor for cancer in the Danish ... ...

    Abstract Alcohol increases the risk of several cancer types. However, awareness of the link between alcohol and cancer is estimated to be low in Denmark. The objective of this study was to examine awareness of alcohol as a risk factor for cancer in the Danish population. 3000 Danish men and women aged 18-74 years, who are nationally representative participated in a cross-sectional study. Open and closed-ended questions were used to assess unprompted and prompted cancer awareness in relation to the respondents' demographic profile, alcohol consumption and use of tobacco. Unprompted, 22.2% of respondents were aware of the link between alcohol and cancer, whereas prompted 44.8% were aware of this. When prompted about specific cancer types, 39.5% were aware of the fact that alcohol increases the risk of liver cancer and only 9.6% were aware of the link between alcohol and breast cancer. Being aware of the link between alcohol and cancer was associated with being female, having a higher level of education, living in the Capital Region of Denmark, as well as being a non-smoker. There were no statistical significant associations between awareness of alcohol as a risk factor for cancer and the respondents' age, marital status and alcohol consumption. Conclusively, the study confirms a rather low public awareness of the link between alcohol and cancer in the Danish population, especially regarding certain cancer types such as breast cancer. There is a continued need to inform the public about the relationship between alcohol and cancer.
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2020.101156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: Untersuchung des Einflusses der Mensch-Hund-Beziehung nach Roberto Marchesini auf das Verhalten des Hundes

    Meyer, Maria

    2008  

    Author's details vorgelegt von Maria Meyer geb. Pagano Scorcio
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Tierärztliche Hochsch., Diss--Hannover, 2008
    Database Special collection on veterinary medicine and general parasitology

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