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Book ; Thesis: Untersuchungen an Zellkulturen von Nierenzellkarzinomen sowie ihren Chemotherapie-resistenten Tochterzellen unter Berücksichtigung des P-Glycoprotein 170 (MDR1-Gen-Produkt) und der Beta-1-Integrine VLA 1 - 6 (CD29, CD49 a - f)

Meyer, Nicolas

1999

Author's details	vorgelegt von Nicolas Meyer
Language	German
Size	61 Bl., Ill., graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hannover, Med. Hochsch., Diss., 2000
HBZ-ID	HT013009026
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: History of mood and anxiety disorders affects return to work and return to sports after rotator cuff repair.

Baltassat, Antoine / Riffault, Louis / Villatte, Guillaume / Meyer, Nicolas / Antoni, Maxime / Clavert, Philippe

Orthopaedics & traumatology, surgery & research : OTSR

2024 , Page(s) 103854

Abstract: Introduction: After rotator cuff repair (RCR), return to work and return to sports is affected by various psychosocial factors. The role of one of these factors - mood and anxiety disorders (MAD) - is still not clear. The primary objective of this study ...

Abstract	Introduction: After rotator cuff repair (RCR), return to work and return to sports is affected by various psychosocial factors. The role of one of these factors - mood and anxiety disorders (MAD) - is still not clear. The primary objective of this study was to determine the influence of prior MAD on the return to work and return to sports after RCR. Our hypothesis was that patients with a history of MAD would take longer to return to work and to sports after RCR, and the rate of return would be lower, than for patients without MAD. Materials and methods: This was a retrospective single-center study of patients who underwent arthroscopic RCR (distal supraspinatus tear). Patients who were employed and those who participated in sports before the surgery were included in the "working" and "sports" groups, respectively. The primary outcomes were the time to return to work and return to sports after surgery. The secondary outcomes were the ratio of patients returning to work and to sports at 3, 6 and 12 months; rate of return to same level of sports; need to change or stop working or sports. The effects of prior MAD on these various outcomes were determined using Bayesian multivariate analysis. Results: The "working" group consisted of 158 patients (of which 16.5% had MAD) and the "sports" group consisted of 118 patients (of which 17.8% had MAD). In those with a history of MAD, return to work was 21±11 weeks later and the return to sports was 17±8 weeks later than in those without MAD. There was a 98% probability that return to work or return to sports was delayed by at least 4 weeks in patients with history of MAD. The likelihood that patients with prior MAD who undergo RCR will completely abandon their sport was 2.8 times higher (OR=2.8 [1; 7.8]). Conclusion: We found a negative influence of prior MAD on the return to work and return to sports after RCR. Level of evidence: III; retrospective case-control study.
Language	English
Publishing date	2024-03-01
Publishing country	France
Document type	Journal Article
ISSN	1877-0568
ISSN (online)	1877-0568
DOI	10.1016/j.otsr.2024.103854
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Radial neck osteolysis after radial head replacement: Functional impact and risk factors.

Antoni, Maxime / Bruyere, Alexandra / Meyer, Nicolas / Clavert, Philippe

Orthopaedics & traumatology, surgery & research : OTSR

2022 Volume 109, Issue 5, Page(s) 103291

Abstract: Introduction: Onset of radial neck osteolysis (RNO) has been reported after radial head replacement (RHR), but data are sparse regarding impact and risk factors. We therefore conducted a retrospective study, 1) to quantify RNO after RHR, 2) to assess ... ...

Abstract	Introduction: Onset of radial neck osteolysis (RNO) has been reported after radial head replacement (RHR), but data are sparse regarding impact and risk factors. We therefore conducted a retrospective study, 1) to quantify RNO after RHR, 2) to assess clinical and radiological impact, and 3) to identify risk factors. Hypothesis: RNO prevalence is high, but functional impact is limited. Material and method: A single-center retrospective study included all patients undergoing RHR for acute radial head fracture between 2008 and 2017: 53 patients, with a mean age of 53.8±15.7 years [range, 21-85 years]. At a minimum 2 years' follow-up, patients were assessed clinically on joint range of motion and Mayo Elbow Performance Score (MEPS) and radiologically on standard radiographs. Associations between RNO and various parameters were assessed. Results: At a mean 46.7±19.8 months' follow-up [range, 24-84 months], RNO was found in 54.7% of cases (29/53), with mean 4.0 ±2.8mm distal extension [range, 1.2-13.4mm], corresponding to 13.4±7.3% of stem height [range, 2.7-27.7%]. RNO at last follow-up was not significantly associated with reduced flexion-extension (121.9° versus 114.0°; p=0.11), pronation-supination (152.6° versus 138.3°; p=0.25) or MEPS (84.7 versus 84.8; p=0.97), or with higher rates of postoperative complications (11/29 (37.9%) versus 7/24 (29.2%); p=0.782) or surgical revision (11/29 (37.9%) versus 10/24 (41.7%); p=0.503). RNO was significantly associated with cementless fixation (19/29 (65.5%) versus 7/24 (29.2%); p=0.01), unipolar prosthesis (21/29 (72.4%) versus 7/24 (29.2%); p=0.002), high filling-ratio, whether proximal (88% versus 77%; p=0.002), middle (84% versus 75%; p=0.007) or distal (69% versus 59%; p=0.032), and shorter radial stem (33.2mm versus 46.3mm; p=0.011). No demographic parameters showed significant association with RNO at last follow-up. Conclusion: RNO was frequent after RHR, but without clinical or radiological impact in the present series. The risk factors identified here argue for involvement of stress shielding. Level of evidence: IV, cohort study.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Elbow ; Osteolysis ; Cohort Studies ; Retrospective Studies ; Treatment Outcome ; Elbow Joint/diagnostic imaging ; Elbow Joint/surgery ; Radius Fractures/diagnostic imaging ; Radius Fractures/surgery ; Risk Factors ; Range of Motion, Articular
Language	English
Publishing date	2022-04-22
Publishing country	France
Document type	Journal Article
ISSN	1877-0568
ISSN (online)	1877-0568
DOI	10.1016/j.otsr.2022.103291
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Implementation of an enhanced recovery program for complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a referral center

Charleux-Muller Diane / Fabacher Thibaut / Romain Benoit / Meyer Nicolas / Brigand Cécile / Delhorme Jean-Baptiste

Pleura and Peritoneum, Vol 8, Iss 1, Pp 11-

a case control prospective study

2023 Volume 18

Abstract: Current recommendations regarding enhanced recovery programs (ERPs) after complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are based on a low level of evidence. The aim of this study is to evaluate the effect of ...

Abstract	Current recommendations regarding enhanced recovery programs (ERPs) after complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are based on a low level of evidence. The aim of this study is to evaluate the effect of implementing an adapted ERP for CCRS and HIPEC in a referral center.
Keywords	enhanced recovery after surgery (eras) ; enhanced recovery programs ; hyperthermic intraperitoneal chemotherapy (hipec) ; peritoneal carcinomatosis ; Medicine ; R ; Specialties of internal medicine ; RC581-951
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of a reduced iodine load with deep learning reconstruction on abdominal MDCT.

Ludes, Gaspard / Ohana, Mickael / Labani, Aissam / Meyer, Nicolas / Moliére, Sébastien / Roy, Catherine

Medicine

2023 Volume 102, Issue 35, Page(s) e34579

Abstract: To evaluate the impact of a reduced iodine load using deep learning reconstruction (DLR) on the hepatic parenchyma compared to conventional iterative reconstruction (hybrid IR) and its consequence on the radiation dose and image quality. This ... ...

Abstract	To evaluate the impact of a reduced iodine load using deep learning reconstruction (DLR) on the hepatic parenchyma compared to conventional iterative reconstruction (hybrid IR) and its consequence on the radiation dose and image quality. This retrospective monocentric intraindividual comparison study included 66 patients explored at the portal phase using different multidetector computed tomography parameters: Group A, hybrid IR algorithm (hybrid IR) and a nonionic low-osmolality contrast agent (350 mgI/mL); Group B, DLR algorithm (DLR) and a nonionic iso-osmolality contrast agent (270 mgI/mL). We recorded the attenuation of the liver parenchyma, image quality, and radiation dose parameters. The mean hounsfield units (HU) value of the liver parenchyma was significantly lower in group B, at 105.9 ± 10.9 HU versus 118.5 ± 14.6 HU in group A. However, the 90%IC of mean liver attenuation in the group B (DLR) was between 100.8 HU and 109.3 HU. The signal-to-noise ratio of the liver parenchyma was significantly higher on DLR images, increasing by 56%. However, for both the contrast-to-noise ratio (CNR) and CNR liver/PV no statistical difference was found, even if the CNR liver/PV ratio was slightly higher for group A. The mean dose-length product and computed tomography dose index volume values were significantly lower with DLR, corresponding to a radiation dose reduction of 36% for the DLR. Using a DLR algorithm for abdominal multidetector computed tomography with a low iodine load can provide sufficient enhancement of the liver parenchyma up to 100 HU in addition to the advantages of a higher image quality, a better signal-to-noise ratio and a lower radiation dose.
MeSH term(s)	Humans ; Multidetector Computed Tomography ; Contrast Media ; Deep Learning ; Retrospective Studies ; Iodine
Chemical Substances	Contrast Media ; Iodine (9679TC07X4)
Language	English
Publishing date	2023-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034579
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Article ; Online: Implementation of an enhanced recovery program for complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a referral center: a case control prospective study.

Charleux-Muller, Diane / Fabacher, Thibaut / Romain, Benoit / Meyer, Nicolas / Brigand, Cécile / Delhorme, Jean-Baptiste

Pleura and peritoneum

2023 Volume 8, Issue 1, Page(s) 11–18

Abstract: Objectives: Current recommendations regarding enhanced recovery programs (ERPs) after complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are based on a low level of evidence. The aim of this study is to evaluate ... ...

Abstract	Objectives: Current recommendations regarding enhanced recovery programs (ERPs) after complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are based on a low level of evidence. The aim of this study is to evaluate the effect of implementing an adapted ERP for CCRS and HIPEC in a referral center. Methods: We conducted a study with a prospective group of 44 patients (post-ERP group) who underwent CCRS with HIPEC between July 2016 and June 2018, the period during which ERP was implemented. This group was compared to a second retrospective group of 21 patients who underwent CCRS with HIPEC between June 2015 and June 2016, during which ERP was not yet implemented (pre-ERP group). Results: The ERP compliance rate was 65% in the post-ERP group. The hospital length of stay (HLS) was shorter in the post-ERP group: 24.9 days (IQR 11-68, pre-ERP group) vs. 16.1 days (IQR 6-45, post-ERP group), as was the major morbidity rate (pre-ERP group=33.3% vs. post-ERP group=20.5%). The nasogastric tube, urinary catheter and abdominal drains were all retrieved faster in the post-ERP group. Conclusions: The implementation of an adapted ERP after CCRS with HIPEC procedures reduces morbidity and shortens the HLS.
Language	English
Publishing date	2023-01-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2861909-2
ISSN	2364-768X ; 2364-7671
ISSN (online)	2364-768X
ISSN	2364-7671
DOI	10.1515/pp-2022-0133
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increased operative time has a negative impact on clinical outcome in arthroscopic rotator cuff repair.

Thery, Charles / Antoni, Maxime / Dujeux, Clément / Eichler, David / Meyer, Nicolas / Clavert, Philippe

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

2023 Volume 33, Issue 7, Page(s) 2865–2871

Abstract: Background: Few data are available about the impact of operative time on outcome of rotator cuff repair.: Aim: The aim of this study was to evaluate the impact of operative time on clinical outcome and tendon healing after arthroscopic rotator cuff ... ...

Abstract	Background: Few data are available about the impact of operative time on outcome of rotator cuff repair. Aim: The aim of this study was to evaluate the impact of operative time on clinical outcome and tendon healing after arthroscopic rotator cuff repair. Methods: Patients operated on for distal supraspinatus tear in our institution between 2012 and 2018 were included retrospectively. Operative time, from skin incision until skin closure, was extracted from medical files. For statistical analysis, operative time was treated as a quantitative variable. Endpoints were clinical outcome (Constant score, range of motion), tendon healing (on CT or MRI) and complications at 1 year. The significance threshold was set at p = 0.05. Results: A total of 219 Patients, with a mean age of 54.6 years (range 40-70 years), were included. Mean operative time 44.9 min (range 14-140 min). Significant correlations (p < 0.05) were found for Constant score and external rotation at 1 year: increasing operative time by 1 min led to a decrease in Constant score of 0.115 points, or 6.9 points for a 60-min increase (p = 0.0167) and a decrease in external rotation of 0.134°, or 8.04° for a 60-min increase (p = 0.0214). No significant correlations were found for anterior elevation at 1 year (p = 0.2577), tendon healing at 1 year (p = 0.295) or onset of complications during follow-up (p = 0.193). Discussion: The minimal clinically important difference in Constant score in patients undergoing rotator cuff surgery is between 6 and 10 points. An increase of more than 60 min in operative time significantly impacted clinical outcome of arthroscopic distal supraspinatus repair, but not tendon healing. Level of evidence: Level III: Retrospective Cohort Design. Therapeutic Study.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Rotator Cuff/diagnostic imaging ; Rotator Cuff/surgery ; Retrospective Studies ; Operative Time ; Treatment Outcome ; Rotator Cuff Injuries/surgery ; Magnetic Resonance Imaging ; Arthroscopy/adverse effects ; Range of Motion, Articular
Language	English
Publishing date	2023-03-06
Publishing country	France
Document type	Journal Article
ZDB-ID	1231084-0
ISSN	1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
ISSN (online)	1432-1068
ISSN	1633-8065 ; 0948-4817 ; 0940-3264
DOI	10.1007/s00590-023-03487-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: History of mood and anxiety disorders does not affect the outcomes of arthroscopic rotator cuff repair.

Dujeux, Clément / Antoni, Maxime / Thery, Charles / Eichler, David / Meyer, Nicolas / Clavert, Philippe

Orthopaedics & traumatology, surgery & research : OTSR

2023 Volume 109, Issue 7, Page(s) 103550

Abstract: Background: A pre-existing mood and anxiety disorder (MAD) is often present in patients with rotator cuff pathology, but its presumed negative effect on the outcomes has not been demonstrated.: Aim of study and hypothesis: The primary objective of ... ...

Abstract	Background: A pre-existing mood and anxiety disorder (MAD) is often present in patients with rotator cuff pathology, but its presumed negative effect on the outcomes has not been demonstrated. Aim of study and hypothesis: The primary objective of this study was to evaluate how a history of MAD affects the clinical outcomes 1 year after arthroscopic rotator cuff repair (RCR). The secondary objectives were to evaluate how a history of MAD affects tendon healing, analgesic consumption and the occurrence of complications. Materials and methods: The study population consisted of 219 patients (mean age 54.5±6.6 years) who underwent arthroscopic repair for a distal supraspinatus tendon tear, with 17% (38/219) presenting an history of MAD (depression, unspecified mood disorder, anxiety, and bipolar disorder). Using univariate and multivariate analyses, the joint range of motion, Constant score, analgesic consumption, occurrence of complications during the first postoperative year and tendon healing at 1 year (MRI or CT arthrography) were compared between the two groups (with or without MAD). Results: The Constant score was lower preoperatively in patients with history of MAD (-4 points, p=.04) but there were no significant differences between the two groups at the various postoperative follow-up time points (p>.05). No significant difference was found between the two groups of patients in their analgesic consumption at the various postoperative time points (p>.05), tendon healing at 1 year (p=.17) or the occurrence of postoperative complications (p=.59). Discussion/conclusion: Pre-existing MAD had no effect on the clinical outcomes after arthroscopic RCR at 1 year and no effect on tendon healing, analgesic consumption or the occurrence of complications in our study population. Level of evidence: III; retrospective case-control study.
MeSH term(s)	Humans ; Middle Aged ; Rotator Cuff/surgery ; Retrospective Studies ; Case-Control Studies ; Anxiety Disorders ; Treatment Outcome ; Rotator Cuff Injuries/surgery ; Arthroscopy ; Magnetic Resonance Imaging ; Range of Motion, Articular ; Analgesics
Chemical Substances	Analgesics
Language	English
Publishing date	2023-01-13
Publishing country	France
Document type	Journal Article
ISSN	1877-0568
ISSN (online)	1877-0568
DOI	10.1016/j.otsr.2023.103550
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neoadjuvant in Situ and Systemic Immunotherapy with Lymph Node Cryoablation in Resectable Stage III Melanoma Metastasis: a Proof-of-Concept Study.

Braud, Antoine / Auloge, Pierre / Meyer, Nicolas / Bouvrais, Caroline / Gharbi, Mousselim / Lang, Hervé / Gangi, Afshin / Lipsker, Dan

Cardiovascular and interventional radiology

2024

Abstract: Purpose: Complete lymph node dissection is the recommended treatment for clinically detectable lymph nodes in stage III melanoma. This surgery is associated with substantial morbidity. We hypothesize that combining percutaneous imaging-guided ... ...

Abstract	Purpose: Complete lymph node dissection is the recommended treatment for clinically detectable lymph nodes in stage III melanoma. This surgery is associated with substantial morbidity. We hypothesize that combining percutaneous imaging-guided cryoablation of locoregional lymph nodes metastases with neoadjuvant in situ and systemic immunotherapy could allow disease control and evaluate the feasibility of this combination in this proof-of-concept study. Methods: We enrolled 15 patients with stage IIIB/IIIC melanoma. Patients were treated as follows: a single 240 mg flat dose infusion of nivolumab on day 1, cryoablation under local anesthesia using CT on day 2, and a single intralesional injection of 10-20 mg of ipilimumab into the lymphadenopathy treated by cryotherapy on day 3. Five-eight weeks after this procedure, complete lymph node dissection was performed according to routine care. The primary outcome measure of this study was feasibility, measured as the number of failures (i.e., inability to complete the entire procedure). Results: The procedure was carried out successfully in 15 out of 15 patients with an observed number of failures of 0. The Bayesian analysis showed an estimated failure rate of 4.2% [0.2-20.6]. Eight patients (53%) had adverse events secondary to either immunotherapy or cryotherapy. Grade 3/4 events occurred in three patients, but all resolved quickly and patients could proceed to surgery as scheduled. Eight patients (53%) had a pathological complete or near complete response. Conclusion: Combining percutaneous cryotherapy with in situ ipilimumab and systemic nivolumab for stage III resectable melanoma is feasible with tolerable toxicity.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-024-03699-9
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Article ; Online: Post Hoc Bayesian Analyses.

Ferreira, David / Meyer, Nicolas

JAMA

2019 Volume 321, Issue 16, Page(s) 1632

MeSH term(s)	Bayes Theorem ; Dyspnea ; Extracorporeal Membrane Oxygenation ; Humans ; Probability ; Respiratory Distress Syndrome, Adult
Language	English
Publishing date	2019-04-22
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2019.1194
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