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  1. AU="Meyers, Amanda"
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  1. Article: Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010.

    Ramirez-Medina, Elizabeth / Rai, Ayushi / Espinoza, Nallely / Spinard, Edward / Silva, Ediane / Burton, Leeanna / Clark, Jason / Meyers, Amanda / Valladares, Alyssa / Velazquez-Salinas, Lauro / Gay, Cyril G / Gladue, Douglas P / Borca, Manuel V

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 4

    Abstract: We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G). As reported, ASFV-G-Δ9GL/ΔUK induces ... ...

    Abstract We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G). As reported, ASFV-G-Δ9GL/ΔUK induces protection, while intramuscularly (IM), administered at doses of 10
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13040319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Deletion of the EP402R Gene from the Genome of African Swine Fever Vaccine Strain ASFV-G-∆I177L Provides the Potential Capability of Differentiating between Infected and Vaccinated Animals.

    Borca, Manuel V / Ramirez-Medina, Elizabeth / Espinoza, Nallely / Rai, Ayushi / Spinard, Edward / Velazquez-Salinas, Lauro / Valladares, Alyssa / Silva, Ediane / Burton, Leeanna / Meyers, Amanda / Clark, Jason / Wu, Ping / Gay, Cyril G / Gladue, Douglas P

    Viruses

    2024  Volume 16, Issue 3

    Abstract: The African swine fever virus (ASFV) mutant ASFV-G-∆I177L is a safe and efficacious vaccine which induces protection against the challenge of its parental virus, the Georgia 2010 isolate. Although a genetic DIVA (differentiation between infected and ... ...

    Abstract The African swine fever virus (ASFV) mutant ASFV-G-∆I177L is a safe and efficacious vaccine which induces protection against the challenge of its parental virus, the Georgia 2010 isolate. Although a genetic DIVA (differentiation between infected and vaccinated animals) assay has been developed for this vaccine, still there is not a serological DIVA test for differentiating between animals vaccinated with ASFV-G-∆I177L and those infected with wild-type viruses. In this report, we describe the development of the ASFV-G-∆I177L mutant having deleted the
    MeSH term(s) Swine ; Animals ; African Swine Fever Virus ; African Swine Fever ; Viral Vaccines/genetics ; Sus scrofa ; Virulence ; Vaccines, Synthetic/genetics ; Vaccines, Attenuated/genetics ; Recombinant Proteins/genetics ; Gene Deletion
    Chemical Substances Viral Vaccines ; Vaccines, Synthetic ; Vaccines, Attenuated ; Recombinant Proteins
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge.

    Borca, Manuel V / Rai, Ayushi / Espinoza, Nallely / Ramirez-Medina, Elizabeth / Spinard, Edward / Velazquez-Salinas, Lauro / Valladares, Alyssa / Silva, Ediane / Burton, Leeanna / Meyers, Amanda / Gay, Cyril G / Gladue, Douglas P

    Viruses

    2023  Volume 15, Issue 10

    Abstract: ASFV vaccine candidate ASFV-G-ΔI177L has been shown to be highly efficacious in inducing protection against challenges with the parental virus, the Georgia 2010 isolate, as well as against field strains isolated from Vietnam. ASFV-G-ΔI177L has been shown ...

    Abstract ASFV vaccine candidate ASFV-G-ΔI177L has been shown to be highly efficacious in inducing protection against challenges with the parental virus, the Georgia 2010 isolate, as well as against field strains isolated from Vietnam. ASFV-G-ΔI177L has been shown to produce protection even when used at low doses (10
    MeSH term(s) Swine ; Animals ; African Swine Fever ; African Swine Fever Virus ; Viral Vaccines ; Viral Proteins/genetics ; Sus scrofa ; Macrophages ; Cell Line
    Chemical Substances Viral Vaccines ; Viral Proteins
    Language English
    Publishing date 2023-10-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15102064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Evaluation of the Deletion of the African Swine Fever Virus Gene

    Ramirez-Medina, Elizabeth / Velazquez-Salinas, Lauro / Rai, Ayushi / Espinoza, Nallely / Valladares, Alyssa / Silva, Ediane / Burton, Leeanna / Spinard, Edward / Meyers, Amanda / Risatti, Guillermo / Calvelage, Sten / Blome, Sandra / Gladue, Douglas P / Borca, Manuel V

    Viruses

    2023  Volume 15, Issue 10

    Abstract: African swine fever virus (ASFV) is a structurally complex, double-stranded DNA virus, which causes African swine fever (ASF), a contagious disease affecting swine. ASF is currently affecting pork production in a large geographical region, including ... ...

    Abstract African swine fever virus (ASFV) is a structurally complex, double-stranded DNA virus, which causes African swine fever (ASF), a contagious disease affecting swine. ASF is currently affecting pork production in a large geographical region, including Eurasia and the Caribbean. ASFV has a large genome, which harbors more than 160 genes, but most of these genes' functions have not been experimentally characterized. One of these genes is the
    MeSH term(s) Swine ; Animals ; African Swine Fever Virus ; African Swine Fever ; Georgia ; Virulence/genetics ; Gene Deletion ; Sus scrofa ; Virus Replication ; DNA-Directed DNA Polymerase/genetics
    Chemical Substances DNA-Directed DNA Polymerase (EC 2.7.7.7)
    Language English
    Publishing date 2023-10-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15102134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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