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  1. Article ; Online: Effect of osteoarthritis and its surgical treatment on patients' quality of life: a longitudinal study.

    Mezey, Gyöngyi Anna / Paulik, Edit / Máté, Zsuzsanna

    BMC musculoskeletal disorders

    2023  Volume 24, Issue 1, Page(s) 537

    Abstract: Background: Osteoarthritis (OA) is one of the primary causes of pain and disability worldwide leading to patients having some of the worst health-related quality of life (QOL). The purpose of our study was to investigate the progression of the generic ... ...

    Abstract Background: Osteoarthritis (OA) is one of the primary causes of pain and disability worldwide leading to patients having some of the worst health-related quality of life (QOL). The purpose of our study was to investigate the progression of the generic and disease-specific QOL of osteoarthritic patients going through total hip or knee replacement surgery and the factors that might alter the effect of surgery on QOL.
    Methods: A longitudinal study was performed based on data collected from 120 OA patients who filled in the short version of the WHO's generic measure of quality of life (WHOQOL-BREF) and the disease-specific Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) before and after surgery.
    Results: Domains related to physical health status showed relatively lower scores in patients before surgery. Patients reported a significant increase of QOL after surgery in the WHOQOL-BREF physical domain, especially if they were from the younger group (< 65 years, p = 0.022) or had a manual job (p = 0.008). Disease-specific QOL outcome results indicate that overall patients gained significantly better QOL in all domains of the WOMAC score. Patients with hip OA seemed to have the most benefit of their operation as they reported better outcome in WOMAC pain (p = 0.019), stiffness (p = 0.010), physical function domains (p = 0.011) and total score (p = 0.007) compared to knee OA patients.
    Conclusion: There was a statistically significant improvement in all domains concerning physical functions in the study population. Patients also reported significant improvement in the social relationship domain, which indicates that OA itself as well as its management might have a profound effect on patients' life beyond the reduction of their pain.
    MeSH term(s) Humans ; Quality of Life ; Longitudinal Studies ; Health Status ; Osteoarthritis, Knee/surgery ; Pain
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-023-06662-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Factors Influencing Pain Management of Patients with Osteoarthritis: A Cross-Sectional Study.

    Mezey, Gyöngyi Anna / Máté, Zsuzsanna / Paulik, Edit

    Journal of clinical medicine

    2022  Volume 11, Issue 5

    Abstract: Background: Osteoarthritis (OA) is a complex disease associated with chronic pain. Many patients treat their joint pain at a symptomatic level with over-the-counter (OTC) pain medications, often without the knowledge of their physicians. The aim of this ...

    Abstract Background: Osteoarthritis (OA) is a complex disease associated with chronic pain. Many patients treat their joint pain at a symptomatic level with over-the-counter (OTC) pain medications, often without the knowledge of their physicians. The aim of this study was to provide physicians with data about osteoarthritic patients' habits of pain management and to examine the explanatory factors of various ways of self-treatment.
    Methods: A cross-sectional study involving 189 patients with hip or knee OA and scheduled for joint replacement surgery was carried out. Participants filled out a self-administered questionnaire consisting of the Western Ontario and McMaster Universities Osteoarthritis Index and questions about their methods of alleviating pain.
    Results: 2.6% of patients did not use anything to alleviate their pain, while 63% practiced a non-pharmacological method. Diclofenac was the most frequently used drug, followed by ibuprofen. Profession had the greatest impact on medication habits; patients doing manual work were significantly more likely to take OTC non-steroidal anti-inflammatory drugs and use topical analgesics.
    Conclusions: Patients utilized a wide variety of pain management techniques. They seemed to use well-known painkillers, even if their side effects were less desirable. Such patients require comprehensive pain management, including educational and behavioural interventions, complemented by topical and oral medication.
    Language English
    Publishing date 2022-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11051352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Relative performance of various biomaterials used for maxillary sinus augmentation: A Bayesian network meta-analysis.

    Trimmel, Bálint / Gede, Noémi / Hegyi, Péter / Szakács, Zsolt / Mezey, Gyöngyi Anna / Varga, Eszter / Kivovics, Márton / Hanák, Lilla / Rumbus, Zoltán / Szabó, György

    Clinical oral implants research

    2021  Volume 32, Issue 2, Page(s) 135–153

    Abstract: Objectives: To assess the histomorphometric outcomes obtained in randomized clinical trials (RCTs) with different biomaterials used for maxillary sinus augmentation (MSA).: Materials and methods: A search of the existing medical literature until ... ...

    Abstract Objectives: To assess the histomorphometric outcomes obtained in randomized clinical trials (RCTs) with different biomaterials used for maxillary sinus augmentation (MSA).
    Materials and methods: A search of the existing medical literature until October 1, 2019, was performed. Inclusion criteria were (a) RCTs assessing a two-stage MSA from the lateral approach using autologous bone or biomaterials for grafting and (b) reported histomorphometric outcomes based on crestal bone core biopsy samples. The Bayesian method was used to perform pairwise meta-analyses and network meta-analysis (NMA). The primary outcome, the new bone percentage (NB %), was calculated as mean differences with 95% credible intervals. The interventions were ranked by their posterior probability by calculating the surface under the cumulative ranking curve values.
    Results: Thirty-four RCTs (842 MSAs) were included in the analysis with a normal healing period (5-8 months). All comparisons were presented in a league table. On the basis of the ranking probability, the most effective bone grafting material for NB% was bovine xenograft + bone marrow concentrate (BMC) (81%), followed by bovine xenograft + platelet-rich plasma (PRP) (77%), bioactive glass ceramic + autologous bone 1:1 (70%), nanocrystalline hydroxyapatite in silica gel (70%), and bioactive glass ceramic (70%). Autologous bone graft alone took the twelfth position with 57%.
    Conclusion: Within the limitations of the present NMA, the analysis did not confirm autologous bone alone as the gold standard for MSA and showed superiority of composite grafts such as bovine xenograft + BMC after 5-8 months of healing.
    MeSH term(s) Animals ; Biocompatible Materials ; Bone Substitutes ; Bone Transplantation ; Cattle ; Maxilla ; Maxillary Sinus ; Network Meta-Analysis ; Sinus Floor Augmentation
    Chemical Substances Biocompatible Materials ; Bone Substitutes
    Language English
    Publishing date 2021-01-06
    Publishing country Denmark
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 1067626-0
    ISSN 1600-0501 ; 0905-7161
    ISSN (online) 1600-0501
    ISSN 0905-7161
    DOI 10.1111/clr.13690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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