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  1. Article ; Online: Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States.

    Mezue, Kenechukwu / Driggin, Elissa

    Journal of cardiac failure

    2023  Volume 29, Issue 8, Page(s) 1173–1174

    MeSH term(s) Humans ; Genetic Variation/genetics ; Heart Failure/epidemiology ; Heart Failure/genetics ; Heart Failure, Diastolic/epidemiology ; Heart Failure, Diastolic/genetics ; Intercellular Adhesion Molecule-1/genetics ; United States/epidemiology
    Chemical Substances Intercellular Adhesion Molecule-1 (126547-89-5) ; ICAM1 protein, human
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2023.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4340: Show issues Location:
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  2. Article ; Online: Molecular Imaging in Acute Aortic Syndrome: Lighting a Path to Better Risk Assessment.

    Tawakol, Ahmed / Mezue, Kenechukwu N

    JACC. Cardiovascular imaging

    2022  Volume 15, Issue 7, Page(s) 1305–1307

    MeSH term(s) Fluorodeoxyglucose F18 ; Humans ; Lighting ; Molecular Imaging/methods ; Positron-Emission Tomography/methods ; Predictive Value of Tests ; Radiopharmaceuticals ; Risk Assessment
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2491503-8
    ISSN 1876-7591 ; 1936-878X
    ISSN (online) 1876-7591
    ISSN 1936-878X
    DOI 10.1016/j.jcmg.2022.04.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Reply: Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk.

    Mezue, Kenechukwu / Abohashem, Shady / Osborne, Michael T / Tawakol, Ahmed

    Journal of the American College of Cardiology

    2023  Volume 82, Issue 23, Page(s) e227–e228

    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Risk Factors ; Alcohol Drinking/adverse effects ; Causality ; Heart Disease Risk Factors
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2023.09.825
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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  4. Article ; Online: Fluid Restriction Recommendations in Heart Failure: Dry as a Bone or Quench Your Thirst?

    Merlo, Aurelie / Mezue, Kenechukwu / Ambrosy, Andrew P

    Journal of cardiac failure

    2022  Volume 28, Issue 10, Page(s) 1531–1533

    MeSH term(s) Heart Failure/diagnosis ; Heart Failure/therapy ; Humans ; Thirst
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2022.07.054
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  5. Article: The increasing burden of hypertension in Nigeria - can a dietary salt reduction strategy change the trend?

    Mezue, Kenechukwu

    Perspectives in public health

    2014  Volume 134, Issue 6, Page(s) 346–352

    Abstract: Developing countries face a dual challenge of both communicable and non-communicable disease - 80% of deaths from cardiovascular disease occur in low and middle-income countries. Hypertension ranks highest as an attributable cause of mortality in both ... ...

    Abstract Developing countries face a dual challenge of both communicable and non-communicable disease - 80% of deaths from cardiovascular disease occur in low and middle-income countries. Hypertension ranks highest as an attributable cause of mortality in both developed and developing countries. The prevalence of hypertension is rising rapidly in Nigeria, from 11% two decades ago to about 30% in recent times. This review explores salt reduction in the diet at the population-wide level as a means of reducing the burden of hypertension in Nigeria. The evidence behind this strategy is explored, methods of how this goal was achieved in other countries are investigated and recommendations on how it could be accomplished in the Nigerian context are considered. There are suggestions that if salt reductions are effectively implemented on a population-wide basis, it will have an impact on morbidity and mortality as large as that which the provision of drains and safe water had in the 19(th) century.
    MeSH term(s) Cost-Benefit Analysis ; Diet ; Diet, Sodium-Restricted/economics ; Diet, Sodium-Restricted/methods ; Food Industry/standards ; Health Promotion/methods ; Humans ; Hypertension/epidemiology ; Hypertension/prevention & control ; Nigeria/epidemiology ; Prevalence ; Risk Factors ; Sodium, Dietary
    Chemical Substances Sodium, Dietary
    Language English
    Publishing date 2014-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2478358-4
    ISSN 1757-9147 ; 1757-9139
    ISSN (online) 1757-9147
    ISSN 1757-9139
    DOI 10.1177/1757913913499658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 423: Show issues Location:
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  6. Article: Clinical Biochemistry of Serum Troponin.

    Gokhan, Ilhan / Dong, Weilai / Grubman, Daniel / Mezue, Kenechukwu / Yang, David / Wang, Yanting / Gandhi, Parul U / Kwan, Jennifer M / Hu, Jiun-Ruey

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Accurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS). Knowledge of the molecular characteristics of the ... ...

    Abstract Accurate measurement and interpretation of serum levels of troponin (Tn) is a central part of the clinical workup of a patient presenting with chest pain suspicious for acute coronary syndrome (ACS). Knowledge of the molecular characteristics of the troponin complex and test characteristics of troponin measurement assays allows for a deeper understanding of causes of false positive and false negative test results in myocardial injury. In this review, we discuss the molecular structure and functions of the constituent proteins of the troponin complex (TnT, TnC, and TnI); review the different isoforms of Tn and where they are from; survey the evolution of clinical Tn assays, ranging from first-generation to high-sensitivity (hs); provide a primer on statistical interpretation of assay results based on different clinical settings; and discuss potential causes of false results. We also summarize the advances in technologies that may lead to the development of future Tn assays, including the development of point of care assays and wearable Tn sensors for real-time continuous measurement.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14040378
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  7. Article ; Online: Social determinants and cardiovascular care: A focus on vulnerable populations and the Jamaica experience.

    Madu, Ernest / Mezue, Kenechukwu / Madu, Kristofer

    FASEB bioAdvances

    2021  Volume 3, Issue 4, Page(s) 266–274

    Abstract: The concept of social determinants of health (SDOH) describes the complex interplay of social, economic, cultural, and environmental forces that influence health and illness and result in health inequities in society. In cardiovascular disease (CVD), ... ...

    Abstract The concept of social determinants of health (SDOH) describes the complex interplay of social, economic, cultural, and environmental forces that influence health and illness and result in health inequities in society. In cardiovascular disease (CVD), SDOH play a significant role in contributing to the severe morbidity and mortality that various cardiovascular diseases inflict on our societies. The components of SDOH include wealth/income, employment status, education, social interactions/support, access to medical care (including mental health services), housing, transportation, physical environment (including availability of green space, water/sanitation, air pollution, noise pollution), work environment, access to good nutrition, social and community networks, access to technology and data, exposure to crime/social disorder/violence, exposure to adverse law enforcement/bad governance, and cultural norms. Leveraging reliable SDOH data is critical to addressing healthcare needs of the community. At-risk populations must be connected to the appropriate resources needed to overcome these barriers to access to achieve better health outcomes. This review explores this theme with a focus on several vulnerable populations and offers possible strategies to reduce these inequalities. The Heart Institute of the Caribbean (HIC) was founded in 2005 to improve access to quality medical and cardiovascular services, made available to everyone regardless of their socioeconomic status. HIC has encountered and learned to navigate a myriad structural, institutional, socio-economic, cultural, and behavioral barriers to appropriate CVD care for vulnerable populations in Jamaica and the wider Caribbean. The successes attained and the lessons learned by HIC can be replicated in other nations to address social determinants that impede cardiovascular and medical care in vulnerable populations and may alleviate the access gap in high-quality care in developing countries and in underserved and marginalized communities in developed countries.
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 2573-9832
    ISSN (online) 2573-9832
    DOI 10.1096/fba.2020-00116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: PET myocardial perfusion imaging in superior vena cava syndrome.

    Mezue, Kenechukwu / Chow, David / Tawakol, Ahmed / Fakhri, Georges El / Osborne, Michael T

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2022  Volume 30, Issue 4, Page(s) 1720–1724

    MeSH term(s) Humans ; Superior Vena Cava Syndrome/diagnostic imaging ; Myocardial Perfusion Imaging ; Vena Cava, Superior/diagnostic imaging
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-022-03033-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4121: Show issues Location:
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  9. Article ; Online: Directly Observed Therapy: A Possible Tool to Tackle Medication Nonadherence in the CVD Epidemic.

    Mezue, Kenechukwu / Rangaswami, Janani

    Journal of the American College of Cardiology

    2017  Volume 69, Issue 24, Page(s) 3009

    MeSH term(s) Cardiovascular Diseases ; Directly Observed Therapy ; Humans ; Medication Adherence ; Time Factors
    Language English
    Publishing date 2017-03-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2017.02.076
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  10. Article ; Online: Focused cardiac ultrasound in pregnancy.

    Edwards, Paul / Anyaogu, Chinyere / Mezue, Kenechukwu / Baugh, Dainia / Goha, Ahmed / Egbuche, Obiora / Nunura, Felix / Madu, Ernest

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2023  Volume 71, Issue 2, Page(s) 81–91

    Abstract: Cardiac disease in pregnancy is an important cause of maternal morbidity and mortality. In many high-income countries, acquired cardiac disease is now the largest cause of maternal mortality. Given its prevalence in low- and middle-income countries ( ... ...

    Abstract Cardiac disease in pregnancy is an important cause of maternal morbidity and mortality. In many high-income countries, acquired cardiac disease is now the largest cause of maternal mortality. Given its prevalence in low- and middle-income countries (LMICs), rheumatic heart disease is the most common cause of cardiac disease in pregnancy worldwide and is associated with poor maternal outcome. The diagnosis of cardiac disease in pregnancy is often delayed resulting in excess maternal morbidity and mortality. Maternal mortality review committees have suggested that prompt recognition and treatment of heart disease in pregnancy may improve maternal outcome. Given the similarities between symptoms of normal pregnancy and those of cardiac disease, the clinical diagnosis of heart disease in pregnancy is challenging with echocardiography being the primary diagnostic modality. Focused cardiac ultrasound (FOCUS) at the point of care provides supplemental data to the history and physical examination and has been demonstrated to permit early diagnosis and improvement in the management of cardiac disease in emergency medicine, intensive care, and anesthesia. It has also been demonstrated to be useful in surveillance for rheumatic heart disease in LMICs. The use of FOCUS may allow earlier and more accurate diagnosis of cardiac disease in pregnancy with the potential to decrease morbidity and mortality in both developed and developing countries.
    MeSH term(s) Pregnancy ; Female ; Humans ; Rheumatic Heart Disease ; Echocardiography ; Morbidity ; Prevalence ; Income ; Pregnancy Outcome
    Language English
    Publishing date 2023-01-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1177/10815589221142195
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    Zs.A 307: Show issues Location:
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