Article ; Online: Response to intranasal
Frontiers in allergy
2023 Volume 4, Page(s) 1046684
Abstract: Justification: We have previously documented that in individuals with chronic rhinosinusitis (CRS) refractory to surgery, intranasal application of live : Method: Epithelial brushings collected prospectively as a sub-study of the : Results: ... ...
Abstract | Justification: We have previously documented that in individuals with chronic rhinosinusitis (CRS) refractory to surgery, intranasal application of live Method: Epithelial brushings collected prospectively as a sub-study of the Results: Differentially identified transcripts and pathways were assessed for the overall population and the clinical phenotypes of CRSwNP and CRSsNP. Patterns of response to treatment were similar across all groups, implicating pathways for the regulation of immunity and epithelial cell regulation. These resemble the patterns of improvement observed following successful treatment with endoscopic sinus surgery or azithromycin. Conclusion: Gene expression profiling following the application of live bacteria to the diseased sinus epithelium highlights the implication of multiple components of the inflammation-microbiome-epithelial barrier axis implicated in CRS. These effects appear to involve both epithelial restoration and modulation of innate and adaptive immunity, supporting the potential interest of targeting the sinus epithelium and the microbiome as potential CRS therapies. |
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Language | English |
Publishing date | 2023-03-15 |
Publishing country | Switzerland |
Document type | Journal Article |
ISSN | 2673-6101 |
ISSN (online) | 2673-6101 |
DOI | 10.3389/falgy.2023.1046684 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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