Article ; Online: Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis.
2021 Volume 23, Issue 4
Abstract: Di (2‑ethylhexyl) phthalate (DEHP), an environmental pollutant, is widely used as a plasticizer and causes serious pollution in the ecological environment. As previously reported, exposure to DEHP may cause thyroid dysfunction of the hypothalamic‑ ... ...
| Abstract | Di (2‑ethylhexyl) phthalate (DEHP), an environmental pollutant, is widely used as a plasticizer and causes serious pollution in the ecological environment. As previously reported, exposure to DEHP may cause thyroid dysfunction of the hypothalamic‑pituitary‑thyroid (HPT) axis. However, the underlying role of DEHP remains to be elucidated. The present study performed intragastrical administration of DEHP (150, 300 and 600 mg/kg) once a day for 90 consecutive days. DEHP‑stimulated oxidative stress increased the thyroid follicular cavity diameter and caused thyrocyte oedema. Furthermore, DEHP exposure altered mRNA and protein levels. Thus, DEHP may perturb TH homeostasis by affecting biosynthesis, biotransformation, bio‑transportation, receptor levels and metabolism through disruption of the HPT axis and activation of the thyroid‑stimulating hormone (TSH)/TSH receptor signaling pathway. These results identified the formerly unappreciated endocrine‑disrupting activities of phthalates and the molecular mechanisms of DEHP‑induced thyrotoxicity. |
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| MeSH term(s) | Animals ; Diethylhexyl Phthalate/toxicity ; Environmental Pollutants/toxicity ; Gene Expression Regulation/drug effects ; Homeostasis/drug effects ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/growth & development ; Hypothalamo-Hypophyseal System/metabolism ; Male ; Organ Size/drug effects ; Oxidative Stress/drug effects ; Plasticizers/toxicity ; Rats, Wistar ; Receptors, Thyrotropin/genetics ; Receptors, Thyrotropin/metabolism ; Receptors, Thyrotropin-Releasing Hormone/genetics ; Receptors, Thyrotropin-Releasing Hormone/metabolism ; Signal Transduction/drug effects ; Thyroid Gland/drug effects ; Thyroid Gland/growth & development ; Thyroid Gland/metabolism ; Thyroid Hormones/blood ; Thyroid Hormones/metabolism ; Thyroid Nuclear Factor 1/genetics ; Thyroid Nuclear Factor 1/metabolism ; Thyrotropin, beta Subunit/genetics ; Thyrotropin, beta Subunit/metabolism ; Rats |
| Chemical Substances | Environmental Pollutants ; Plasticizers ; Receptors, Thyrotropin ; Receptors, Thyrotropin-Releasing Hormone ; Thyroid Hormones ; Thyroid Nuclear Factor 1 ; Thyrotropin, beta Subunit ; Diethylhexyl Phthalate (C42K0PH13C) |
| Language | English |
| Publishing date | 2021-03-02 |
| Publishing country | Greece |
| Document type | Journal Article |
| ZDB-ID | 2469505-1 |
| ISSN | 1791-3004 ; 1791-2997 |
| ISSN (online) | 1791-3004 |
| ISSN | 1791-2997 |
| DOI | 10.3892/mmr.2021.11930 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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