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  1. Article ; Online: The Sustainability of Ohanami Cherry Blossom Festivals as a Cultural Icon

    Emi Moriuchi / Michael Basil

    Sustainability, Vol 11, Iss 6, p

    2019  Volume 1820

    Abstract: Background: One important form of sustainability is the continuation of culture and cultural practices. This study examined the case of Japanese Ohanami or cherry blossom festivals. Historically, Ohanami focused on the cherry blossom as a symbol of ... ...

    Abstract Background: One important form of sustainability is the continuation of culture and cultural practices. This study examined the case of Japanese Ohanami or cherry blossom festivals. Historically, Ohanami focused on the cherry blossom as a symbol of spring’s arrival, where communal aspects, consumption of sake and seasonal foods, painting or photography, and pilgrimages to sacred sites were used to celebrate the ephemeral aspects of blossoms, spring, and life. Methods: This study examines how cherry blossom festivals are celebrated and understood and how these celebrations are changing. Results: Current celebrations demonstrate several forces are changing this celebration. The changes in cherry blossom festivals are seen in four areas (bonding, cultural continuity, marketing exploitation, and cultural symbolism). Cherry blossom festivals are also observed overseas—at first glance this suggests its continuity, however, the ways in which Ohanami is observed raise concerns about the accuracy of this cultural practice. Conclusion: Ohanami celebrations are celebrated both in Japan and overseas, and although their practice continues, the nature of the cultural celebrations are changing.
    Keywords holiday ; cultural celebrations ; culture ; Hanami ; place attributes ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 390
    Language English
    Publishing date 2019-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book: Cardiovascular disorders

    Gravanis, Michael Basil

    pathogenesis and pathophysiology

    1993  

    Author's details Michael B. Gravanis
    Keywords Cardiovascular Diseases / etiology ; Cardiovascular Diseases / physiopathology ; Kardiovaskuläre Krankheit
    Subject Herz-Kreislauf-Krankheit ; Herz-Kreislauf-Erkrankung ; Kardiovaskuläres System ; Cardiovasculäre Krankheit ; Kardiovaskuläre Krankheiten
    Language English
    Size XIII, 576 S. : zahlr. Ill., graph. Darst.
    Publisher Mosby
    Publishing place St. Louis u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT004942670
    ISBN 0-8016-6336-9 ; 978-0-8016-6336-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 2029 order for loan Magazin

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  3. Article: Oxidative Stress is a shared characteristic of ME/CFS and Long COVID.

    Shankar, Vishnu / Wilhelmy, Julie / Curtis, Ellis J / Michael, Basil / Cervantes, Layla / Mallajosyula, Vamsee A / Davis, Ronald W / Snyder, Michael / Younis, Shady / Robinson, William H / Shankar, Sadasivan / Mischel, Paul S / Bonilla, Hector / Davis, Mark M

    bioRxiv : the preprint server for biology

    2024  

    Abstract: More than 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition, wherein patients of all ages report fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis / chronic ... ...

    Abstract More than 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition, wherein patients of all ages report fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). With no current treatments or reliable diagnostic markers, there is an urgent need to define the molecular underpinnings of these conditions. By studying bioenergetic characteristics of peripheral blood lymphocytes in over 16 healthy controls, 15 ME/CFS, and 15 LC, we find both ME/CFS and LC donors exhibit signs of elevated oxidative stress, relative to healthy controls, especially in the memory subset. Using a combination of flow cytometry, bulk RNA-seq analysis, mass spectrometry, and systems chemistry analysis, we also observed aberrations in ROS clearance pathways including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage. Critically, these changes in redox pathways show striking sex-specific trends. While females diagnosed with ME/CFS exhibit higher total ROS and mitochondrial calcium levels, males with an ME/CFS diagnosis have normal ROS levels, but larger changes in lipid oxidative damage. Further analyses show that higher ROS levels correlates with hyperproliferation of T cells in females, consistent with the known role of elevated ROS levels in the initiation of proliferation. This hyperproliferation of T cells can be attenuated by metformin, suggesting this FDA-approved drug as a possible treatment, as also suggested by a recent clinical study of LC patients. Thus, we report that both ME/CFS and LC are mechanistically related and could be diagnosed with quantitative blood cell measurements. We also suggest that effective, patient tailored drugs might be discovered using standard lymphocyte stimulation assays.
    Language English
    Publishing date 2024-05-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.05.04.592477
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: The sanctuary of Demeter at Eleusis

    Kosmopulos, Michael Basil

    : the Bronze age

    (The Archaeological Society at Athens library ; 295)

    2014  

    Author's details Michael B. Cosmopoulos
    Series title The Archaeological Society at Athens library ; 295
    Language English
    Size XIX, 478 S, Ill., graph. Darst., Kt
    Publisher Ē en Athēnais Archaiologikē Etaireia
    Publishing place Athens
    Document type Book
    ISBN 9786185047160 ; 6185047160
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book: The sanctuary of Demeter at Eleusis

    Kosmopulos, Michael Basil

    : the Bronze age

    (The Archaeological Society at Athens library ; 296)

    2014  

    Author's details Michael B. Cosmopoulos
    Series title The Archaeological Society at Athens library ; 296
    Language English
    Size VII, 288, 50, 82 S, Ill
    Publisher Ē en Athēnais Archaiologikē Etaireia
    Publishing place Athens
    Document type Book
    ISBN 9786185047177 ; 6185047179
    Database Former special subject collection: coastal and deep sea fishing

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  6. Book: The sanctuary of Demeter at Eleusis

    Kosmopulos, Michael Basil

    the Bronze age

    (The Archaeological Society at Athens Library ; ...)

    2014  

    Author's details Michael B. Cosmopoulos
    Series title The Archaeological Society at Athens Library
    ...
    Language English
    Publisher Ē en Athēnais Archaiologikē Etaireia
    Publishing place Athens
    Document type Book
    ISBN 9786185047153 ; 6185047152
    Database Former special subject collection: coastal and deep sea fishing

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

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  7. Article ; Online: Oxidative Stress is a shared characteristic of ME/CFS and Long COVID

    Shankar, Vishnu / Wilhelmy, Julie / Curtis, Ellis J. / Michael, Basil / Cervantes, Layla / Mallajosyula, Vamsee A. / Davis, Ronald W. / Snyder, Michael / Younis, Shady / Robinson, William H. / Shankar, Sadasivan / Mischel, Paul S. / Bonilla, Hector / Davis, Mark M.

    bioRxiv

    Abstract: More than 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition, wherein patients of all ages report fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis/chronic ... ...

    Abstract More than 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition, wherein patients of all ages report fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). With no current treatments or reliable diagnostic markers, there is an urgent need to define the molecular underpinnings of these conditions. By studying bioenergetic characteristics of peripheral blood lymphocytes in over 16 healthy controls, 15 ME/CFS, and 15 LC, we find both ME/CFS and LC donors exhibit signs of elevated oxidative stress, relative to healthy controls, especially in the memory subset. Using a combination of flow cytometry, bulk RNA-seq analysis, mass spectrometry, and systems chemistry analysis, we also observed aberrations in ROS clearance pathways including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage. Critically, these changes in redox pathways show striking sex-specific trends. While females diagnosed with ME/CFS exhibit higher total ROS and mitochondrial calcium levels, males with an ME/CFS diagnosis have normal ROS levels, but larger changes in lipid oxidative damage. Further analyses show that higher ROS levels correlates with hyperproliferation of T cells in females, consistent with the known role of elevated ROS levels in the initiation of proliferation. This hyperproliferation of T cells can be attenuated by metformin, suggesting this FDA-approved drug as a possible treatment, as also suggested by a recent clinical study of LC patients. Thus, we report that both ME/CFS and LC are mechanistically related and could be diagnosed with quantitative blood cell measurements. We also suggest that effective, patient tailored drugs might be discovered using standard lymphocyte stimulation assays.
    Keywords covid19
    Language English
    Publishing date 2024-05-05
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2024.05.04.592477
    Database COVID19

    Full text online

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  8. Article ; Online: Oxidative Stress is a shared characteristic of ME/CFS and Long COVID

    Shankar, Vishnu / Wilhelmy, Julie / Michael, Basil / Cervantes, Layla / Mallajosyula, Vamsee / Davis, Ronald / Snyder, Michael / Younis, Shady / Robinson, William H / Shankar, Sadasivan / Mischel, Paul / Bonilla, Hector / Davis, Mark

    bioRxiv

    Abstract: More than 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition, wherein patients of all ages report fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis/chronic ... ...

    Abstract More than 65 million individuals worldwide are estimated to have Long COVID (LC), a complex multisystemic condition, wherein patients of all ages report fatigue, post-exertional malaise, and other symptoms resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). With no current treatments or reliable diagnostic markers, there is an urgent need to define the molecular underpinnings of these conditions. By studying bioenergetic characteristics of peripheral blood lymphocytes in over 16 healthy controls, 15 ME/CFS, and 15 LC, we find both ME/CFS and LC donors exhibit signs of elevated oxidative stress, relative to healthy controls, especially in the memory subset. Using a combination of flow cytometry, bulk RNA-seq analysis, mass spectrometry, and systems chemistry analysis, we also observed aberrations in ROS clearance pathways including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage. Critically, these changes in redox pathways show striking sex-specific trends. While females diagnosed with ME/CFS exhibit higher total ROS and mitochondrial calcium levels, males with an ME/CFS diagnosis have normal ROS levels, but larger changes in lipid oxidative damage. Further analyses show that higher ROS levels correlates with hyperproliferation of T cells in females, consistent with the known role of elevated ROS levels in the initiation of proliferation. This hyperproliferation of T cells can be attenuated by metformin, suggesting this FDA-approved drug as a possible treatment, as also suggested by a recent clinical study of LC patients. Thus, we report that both ME/CFS and LC are mechanistically related and could be diagnosed with quantitative blood cell measurements. We also suggest that effective, patient tailored drugs might be discovered using standard lymphocyte stimulation assays.
    Keywords covid19
    Language English
    Publishing date 2024-05-05
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2024.05.04.592477
    Database COVID19

    Full text online

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  9. Book: Cardiovascular pathophysiology

    Gravanis, Michael Basil

    1987  

    Author's details Michael Basil Gravanis
    Keywords Cardiovascular Diseases / physiopathology
    Size XVII, 478 S. : zahlr. Ill. u. graph. Darst.
    Edition 1. [Dr.]
    Publisher McGraw-Hill
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003023380
    ISBN 0-07-024131-7 ; 978-0-07-024131-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1987 A 3237 order for loan Magazin

    Order via subito

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  10. Article ; Online: Multi-omics microsampling for the profiling of lifestyle-associated changes in health.

    Shen, Xiaotao / Kellogg, Ryan / Panyard, Daniel J / Bararpour, Nasim / Castillo, Kevin Erazo / Lee-McMullen, Brittany / Delfarah, Alireza / Ubellacker, Jessalyn / Ahadi, Sara / Rosenberg-Hasson, Yael / Ganz, Ariel / Contrepois, Kévin / Michael, Basil / Simms, Ian / Wang, Chuchu / Hornburg, Daniel / Snyder, Michael P

    Nature biomedical engineering

    2023  Volume 8, Issue 1, Page(s) 11–29

    Abstract: Current healthcare practices are reactive and use limited physiological and clinical information, often collected months or years apart. Moreover, the discovery and profiling of blood biomarkers in clinical and research settings are constrained by ... ...

    Abstract Current healthcare practices are reactive and use limited physiological and clinical information, often collected months or years apart. Moreover, the discovery and profiling of blood biomarkers in clinical and research settings are constrained by geographical barriers, the cost and inconvenience of in-clinic venepuncture, low sampling frequency and the low depth of molecular measurements. Here we describe a strategy for the frequent capture and analysis of thousands of metabolites, lipids, cytokines and proteins in 10 μl of blood alongside physiological information from wearable sensors. We show the advantages of such frequent and dense multi-omics microsampling in two applications: the assessment of the reactions to a complex mixture of dietary interventions, to discover individualized inflammatory and metabolic responses; and deep individualized profiling, to reveal large-scale molecular fluctuations as well as thousands of molecular relationships associated with intra-day physiological variations (in heart rate, for example) and with the levels of clinical biomarkers (specifically, glucose and cortisol) and of physical activity. Combining wearables and multi-omics microsampling for frequent and scalable omics may facilitate dynamic health profiling and biomarker discovery.
    MeSH term(s) Multiomics ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-022-00999-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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