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  1. Article ; Online: Carbohydrate knowledge, dietary guideline awareness, motivations and beliefs underlying low-carbohydrate dietary behaviours

    Chaitong Churuangsuk / Michael E. J. Lean / Emilie Combet

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 15

    Abstract: Abstract To explore the factors (including knowledge and attitude) influencing the decision to follow a low-carbohydrate diet (LCD) or not in a sample of the UK population. An online questionnaire was distributed electronically to adults who had either ... ...

    Abstract Abstract To explore the factors (including knowledge and attitude) influencing the decision to follow a low-carbohydrate diet (LCD) or not in a sample of the UK population. An online questionnaire was distributed electronically to adults who had either followed LCD or not (February–December 2019). Demographics and self-reported “LCD-status” (current, past and non-follower) were collected. Multivariable linear regression was used with carbohydrate knowledge, dietary guideline agreement and theory of planned behaviour (TPB) constructs (all as predictors) to explain the intention to follow a LCD (outcome). Respondents (n = 723, 71% women, median age 34; 85% white-ethnicity) were either following (n = 170, 24%) or had tried a LCD in the preceding 3 months (n = 184, 25%). Current followers had lower carbohydrate knowledge scores (1–2 point difference, scale − 11 to 11) than past and non-followers. A majority of current LCD followers disagreed with the EatWell guide recommendations “Base meals on potatoes, bread, rice and pasta, or other starchy carbohydrates. Choose whole grains where possible” (84%) and “Choose unsaturated oils and spreads and eat in small amounts such as vegetable, rapeseed, olive and sunflower oils” (68%) compared to past (37%, 10%, respectively) and non-followers (16%, 8%, respectively). Weight-loss ranked first as a motivation, and the internet was the most influencial source of information about LCDs. Among LCD-followers, 71% reported ≥ 5% weight loss, and over 80% did not inform their doctor, nurse, or dietitian about following a diet. Approximately half of LCD followers incorporated supplements to their diets (10% used multivitamin/mineral supplements), despite the restrictive nature of the diet. TPB constructs, carbohydrate knowledge, and guideline agreement explained 60% of the variance for the intention to follow a LCD. Attitude (std-β = 0.60), perceived behavioural control (std-β = 0.24) and subjective norm (std-β = 0.14) were positively associated with the intention to follow a LCD, while higher knowledge of carbohydrate, and agreeing with national dietary guidelines were both inversely associated (std-β = − 0.09 and − 0.13). The strongest primary reason behind UK adults’ following a LCD is to lose weight, facilitated by attitude, perceived behavioural control and subjective norm. Higher knowledge about carbohydrate and agreement with dietary guidelines are found among people who do not follow LCDs.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A novel decision model to predict the impact of weight management interventions

    Sandra Lopes / Henrik H. Meincke / Mark Lamotte / Anamaria‐Vera Olivieri / Michael E. J. Lean

    Obesity Science & Practice, Vol 7, Iss 3, Pp 269-

    The Core Obesity Model

    2021  Volume 280

    Abstract: Abstract Aims Models are needed to quantify the economic implications of obesity in relation to health outcomes and health‐related quality of life. This report presents the structure of the Core Obesity Model (COM) and compare its predictions with the UK ...

    Abstract Abstract Aims Models are needed to quantify the economic implications of obesity in relation to health outcomes and health‐related quality of life. This report presents the structure of the Core Obesity Model (COM) and compare its predictions with the UK clinical practice data. Materials and methods The COM is a Markov, closed‐cohort model, which expands on earlier obesity models by including prediabetes as a risk factor for type 2 diabetes (T2D), and sleep apnea and cancer as health outcomes. Selected outcomes predicted by the COM were compared with observed event rates from the Clinical Practice Research Datalink‐Hospital Episode Statistics (CPRD‐HES) study. The importance of baseline prediabetes prevalence, a factor not taken into account in previous economic models of obesity, was tested in a scenario analysis using data from the 2011 Health Survey of England. Results Cardiovascular (CV) event rates predicted by the COM were well matched with those in the CPRD‐HES study (7.8–8.5 per 1000 patient‐years across BMI groups) in both base case and scenario analyses (8.0–9.4 and 8.6–9.9, respectively). Rates of T2D were underpredicted in the base case (1.0–7.6 vs. 2.1–22.7) but increased to match those observed in CPRD‐HES for some BMI groups when a prospectively collected prediabetes prevalence was used (2.7–13.1). Mortality rates in the CPRD‐HES were consistently higher than the COM predictions, especially in higher BMI groups. Conclusions The COM predicts the occurrence of CV events and T2D with a good degree of accuracy, particularly when prediabetes is included in the model, indicating the importance of considering this risk factor in economic models of obesity.
    Keywords cost‐effectiveness ; health economics ; obesity therapy ; Internal medicine ; RC31-1245
    Subject code 796
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Supersize the label: The effect of prominent calorie labeling on sales

    Nikolaou, Charoula K / Livia Demkova / Michael E.J. Lean / Michael McPartland

    Nutrition. 2017 Mar., v. 35

    2017  

    Abstract: Calorie labeling has been suggested as an antiobesity measure; however, evidence on its effects is scarce and formatting guidance not well defined. The aim of this study was to test the effects of prominent calorie labeling on sales of the labeled items ... ...

    Abstract Calorie labeling has been suggested as an antiobesity measure; however, evidence on its effects is scarce and formatting guidance not well defined. The aim of this study was to test the effects of prominent calorie labeling on sales of the labeled items.Prominent calorie labels were posted in front of two popular items for a period of 1 mo. Sales were recorded for 2 mo consecutively, before and during labeling.Muffins sales (the higher-calorie item) fell by 30%, whereas sales of scones rose by 4%, a significant difference (χ2 = 10.258; P = 0.0014).Calorie labeling is effective when noticed. Wider adoption of calorie labeling for all food businesses and strengthening legislation with formatting guidelines should be the next step in public health policy.
    Keywords guidelines ; health policy ; nutrition labeling ; sales
    Language English
    Dates of publication 2017-03
    Size p. 112-113.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2016.11.006
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Validity of predictive equations to estimate RMR in females with varying BMI

    George Thom / Konstantinos Gerasimidis / Eleni Rizou / Hani Alfheeaid / Nick Barwell / Eirini Manthou / Sadia Fatima / Jason M. R. Gill / Michael E. J. Lean / Dalia Malkova

    Journal of Nutritional Science, Vol

    2020  Volume 9

    Abstract: Estimation of RMR using prediction equations is the basis for calculating energy requirements. In the present study, RMR was predicted by Harris–Benedict, Schofield, Henry, Mifflin–St Jeor and Owen equations and measured by indirect calorimetry in 125 ... ...

    Abstract Estimation of RMR using prediction equations is the basis for calculating energy requirements. In the present study, RMR was predicted by Harris–Benedict, Schofield, Henry, Mifflin–St Jeor and Owen equations and measured by indirect calorimetry in 125 healthy adult women of varying BMI (17–44 kg/m2). Agreement between methods was assessed by Bland–Altman analyses and each equation was assessed for accuracy by calculating the percentage of individuals predicted within ± 10 % of measured RMR. Slopes and intercepts of bias as a function of average RMR (mean of predicted and measured RMR) were calculated by regression analyses. Predictors of equation bias were investigated using univariate and multivariate linear regression. At group level, bias (the difference between predicted and measured RMR) was not different from zero only for Mifflin–St Jeor (0 (sd 153) kcal/d (0 (sd 640) kJ/d)) and Henry (8 (sd 163) kcal/d (33 (sd 682) kJ/d)) equations. Mifflin–St Jeor and Henry equations were most accurate at the individual level and predicted RMR within 10 % of measured RMR in 71 and 66 % of participants, respectively. For all equations, limits of agreement were wide, slopes of bias were negative, and intercepts of bias were positive and significantly (P < 0⋅05) different from zero. Increasing age, height and BMI were associated with underestimation of RMR, but collectively these variables explained only 15 % of the variance in estimation bias. Overall accuracy of equations for prediction of RMR is low at the individual level, particularly in women with low and high RMR. The Mifflin–St Jeor equation was the most accurate for this dataset, but prediction errors were still observed in about one-third of participants.
    Keywords RMR ; Prediction equations ; Mifflin–St Jeor equations ; Henry equations ; Schofield equations ; Harris–Benedict equations ; Owen equations ; Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Subject code 518
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Validity of predictive equations to estimate RMR in females with varying BMI - CORRIGENDUM

    George Thom / Konstantinos Gerasimidis / Eleni Rizou / Hani Alfheeaid / Nick Barwell / Eirini Manthou / Sadia Fatima / Jason M. R. Gill / Michael E. J. Lean / Dalia Malkova

    Journal of Nutritional Science, Vol

    2020  Volume 9

    Keywords Nutrition. Foods and food supply ; TX341-641 ; Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Beyond BMI: How to Capture Influences from Body Composition in Health Surveys

    Peeters, Anna / Emma Gearon / Michael E. J. Lean / Stephanie Tanamas / Yasmin Al-Gindan

    Current nutrition reports. 2016 Dec., v. 5, no. 4

    2016  

    Abstract: Population monitoring of health risks is critical for resource allocation and planning of health services and preventive interventions. It also enables identification of population groups and regional areas where need may be greater. To support these ... ...

    Abstract Population monitoring of health risks is critical for resource allocation and planning of health services and preventive interventions. It also enables identification of population groups and regional areas where need may be greater. To support these functions, population monitoring needs to be accurate and reliable over time. With increasing prevalence of obesity over time, the need to monitor high risk adiposity is recognised internationally. Body composition is regularly monitored in population health surveys globally, primarily to identify high risk adiposity as an important contributor to future disease burden. Body mass index, a composite of height and weight, is the most commonly used population indicator of high risk adiposity, but its correlation with body fat is relatively poor. Many population surveys also collect waist and hip circumference, with a minority collecting further indicators such as skinfold thickness, bioelectrical impedance and dual-energy X-ray absorptiometry. Here, we review the advantages and disadvantages of the body composition indicators currently used in population health surveys and reflect on how the information from such indicators could be optimised. Our focus is on the use of indicators to identify those at increased metabolic health risk associated with excess body fat. We conclude that while most current indicators have reasonable correlation with body fat when tested, they have only been validated in small, specific samples that cannot be compared and are likely to have limited use over time as populations change demographically and in their body composition. Future population monitoring of high risk adiposity requires a more systematic analysis of which combined indicators from population health surveys will provide the best estimation of excess body fat and future cardio-metabolic risk across all adult ages, both sexes and a wide range of ethnicities.
    Keywords adiposity ; adults ; bioelectrical impedance ; body mass index ; burden of disease ; dual-energy X-ray absorptiometry ; health services ; health surveys ; hips ; monitoring ; nutrition ; obesity ; planning ; resource allocation ; risk ; skinfold thickness ; waist
    Language English
    Dates of publication 2016-12
    Size p. 286-294.
    Publishing place Springer US
    Document type Article
    Note Review
    ISSN 2161-3311
    DOI 10.1007/s13668-016-0183-5
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Personalized Health, eLearning, and mHealth Interventions to Improve Nutritional Status

    Gasch, Margarete / Bhone M. Kyaw / Charoula K. Nikolaou / Gerard J. Dunleavy / Michael E. J. Lean

    Current nutrition reports. 2016 Dec., v. 5, no. 4

    2016  

    Abstract: Personalised health through nutrition has been made possible by recent advances in technology. We ran a search strategy in July 2016 to identify all existing studies on mobile/eLearning randomized controlled interventions designed to improve diet, ... ...

    Abstract Personalised health through nutrition has been made possible by recent advances in technology. We ran a search strategy in July 2016 to identify all existing studies on mobile/eLearning randomized controlled interventions designed to improve diet, nutrition and/or body weight in adults, at individual or community level. A total of 22 studies met the inclusion and exclusion criteria for inclusion. Most studies found that integrations of technology for delivering and personalizing interventions on diet/nutrition and/or body weight were effective in reducing body-weight in overweight/obese populations (n = 8), preventing weight gain n = 4) and improving certain dietary habits (n = 10). The low cost of eHealth/mHealth interventions and their potential to reach large, sometimes hard-to-reach young population sectors makes them attractive targets for upscaling.
    Keywords adults ; diet ; eating habits ; nutritional status ; overweight ; weight gain
    Language English
    Dates of publication 2016-12
    Size p. 295-306.
    Publishing place Springer US
    Document type Article
    Note Review
    ISSN 2161-3311
    DOI 10.1007/s13668-016-0184-4
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism

    Pereira-Caro, Gema / Jose Manuel Moreno-Rojas / Nicoletta Brindani / Daniele Del Rio / Michael E. J. Lean / Yukihiko Hara / Alan Crozier

    Journal of agricultural and food chemistry. 2017 July 5, v. 65, no. 26

    2017  

    Abstract: Data obtained with in vitro fecal incubations and a feeding study indicate black tea theaflavin and its galloyl derivatives are not absorbed in detectable amounts in either the upper or lower gastrointestinal tract. The theaflavin skeleton is ... ...

    Abstract Data obtained with in vitro fecal incubations and a feeding study indicate black tea theaflavin and its galloyl derivatives are not absorbed in detectable amounts in either the upper or lower gastrointestinal tract. The theaflavin skeleton is comparatively resistant to degradation by colonic bacteria with a 67% recovery being obtained after a 24 h incubation, which yielded 21 phenolic and aromatic catabolites. The theaflavin galloyl moiety was removed by the microbiota, and the released gallic acid further transformed to 3-O- and 4-O-methyl gallic acids, pyrogallol-1-sulfate and pyrogallol-2-sulfate, which were excreted in urine in amounts equivalent to 94% of intake. The main urinary product potentially derived from breakdown of the theaflavin skeleton was 3-(4′-hydroxyphenyl)propionic acid. A number of the colonic catabolites originating from gallic acid and theaflavins has been reported to be bioactive in ex vivo and in vitro models with a variety of potential modes of action.
    Keywords absorption ; bioavailability ; black tea ; gallic acid ; gastrointestinal system ; intestinal microorganisms ; mechanism of action ; metabolism ; metabolites ; models ; moieties ; propionic acid ; theaflavins ; urine
    Language English
    Dates of publication 2017-0705
    Size p. 5365-5374.
    Publishing place American Chemical Society, Books and Journals Division
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.7b01707
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study

    Overman, Margot J / Neil Pendleton / Terence W. O’Neill / Gyorgy Bartfai / Felipe F. Casanueva / Joseph D. Finn / Gianni Forti / Giulia Rastrelli / Aleksander Giwercman / Thang S. Han / Ilpo T. Huhtaniemi / Krzysztof Kula / Michael E. J. Lean / Margus Punab / David M. Lee / Elon S. Correa / Tomas Ahern / Sabine M. P. Verschueren / Leen Antonio /
    Evelien Gielen / Martin K. Rutter / Dirk Vanderschueren / Frederick C. W. Wu / Jos Tournoy

    European journal of nutrition. 2017 Sept., v. 56, no. 6

    2017  

    Abstract: PURPOSE: Although lower levels of vitamin D have been related to poor cognitive functioning and dementia in older adults, evidence from longitudinal investigations is inconsistent. The objective of this study was to determine whether 25-hydroxyvitamin D [ ...

    Institution The EMAS Study Group
    Abstract PURPOSE: Although lower levels of vitamin D have been related to poor cognitive functioning and dementia in older adults, evidence from longitudinal investigations is inconsistent. The objective of this study was to determine whether 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)₂D] levels are associated with specified measures of cognitive decline in ageing men. METHODS: The European Male Ageing Study (EMAS) followed 3369 men aged 40–79 over 4.4 years. 25(OH)D levels at baseline were measured by radioimmunoassay, and 1,25(OH)₂D levels were obtained with liquid chromatography–tandem mass spectrometry. Visuoconstructional abilities, visual memory, and processing speed at baseline and follow-up were assessed using the Rey–Osterrieth Complex Figure Test (ROCF), Camden Topographical Recognition Memory (CTRM), and the Digit Symbol Substitution Test (DSST). RESULTS: Following attritions, a total of 2430 men with a mean (SD) age of 59.0 (10.6) were included in the analyses. At baseline, the mean 25(OH)D concentration was 64.6 (31.5) nmol/l, and mean 1,25(OH)₂D level was 59.6 (16.6) pmol/l. In age-adjusted linear regression models, high 25(OH)D concentrations were associated with a smaller decline in the DSST (β = 0.007, p = 0.020). Men with low 25(OH)D levels (<50 nmol/l) showed a greater decline in the CTRM compared to men with higher (≥75 nmol/l) levels (β = −0.41, p = 0.035). However, these associations disappeared after adjusting for confounders such as depressive symptoms, BMI, and comorbidities. There was no indication of a relationship between 1,25(OH)₂D and decline in cognitive subdomains. CONCLUSION: We found no evidence for an independent association between 25(OH)D or 1,25(OH)₂D levels and visuoconstructional abilities, visual memory, or processing speed over on average 4.4 years in this sample of middle-aged and elderly European men.
    Keywords body mass index ; cognition ; comorbidity ; dementia ; elderly ; liquid chromatography ; males ; memory ; men ; mental depression ; radioimmunoassays ; regression analysis ; tandem mass spectrometry
    Language English
    Dates of publication 2017-09
    Size p. 2093-2103.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-016-1247-4
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men.

    Kate L Holliday / Stephen R Pye / Wendy Thomson / Steven Boonen / Herman Borghs / Dirk Vanderschueren / Evelien Gielen / Ilpo T Huhtaniemi / Judith E Adams / Kate A Ward / Gyorgy Bartfai / Felipe Casanueva / Joseph D Finn / Gianni Forti / Aleksander Giwercman / Thang S Han / Krzysztof Kula / Fernand Labrie / Michael E J Lean /
    Neil Pendleton / Margus Punab / Frederick C W Wu / Terence W O'Neill

    PLoS ONE, Vol 6, Iss 7, p e

    2011  Volume 22037

    Abstract: Genome-wide association studies (GWAS) have identified 6q25, which incorporates the oestrogen receptor α gene (ESR1), as a quantitative trait locus for areal bone mineral density (BMD(a)) of the hip and lumbar spine. The aim of this study was to ... ...

    Abstract Genome-wide association studies (GWAS) have identified 6q25, which incorporates the oestrogen receptor α gene (ESR1), as a quantitative trait locus for areal bone mineral density (BMD(a)) of the hip and lumbar spine. The aim of this study was to determine the influence of this locus on other bone health outcomes; calcaneal ultrasound (QUS) parameters, radial peripheral quantitative computed tomography (pQCT) parameters and markers of bone turnover in a population sample of European men.Eight single nucleotide polymorphisms (SNP) in the 6q25 locus were genotyped in men aged 40-79 years from 7 European countries, participating in the European Male Ageing Study (EMAS). The associations between SNPs and measured bone parameters were tested under an additive genetic model adjusting for centre using linear regression.2468 men, mean (SD) aged 59.9 (11.1) years had QUS measurements performed and bone turnover marker levels measured. A subset of 628 men had DXA and pQCT measurements. Multiple independent SNPs showed significant associations with BMD using all three measurement techniques. Most notably, rs1999805 was associated with a 0.10 SD (95%CI 0.05, 0.16; p = 0.0001) lower estimated BMD at the calcaneus, a 0.14 SD (95%CI 0.05, 0.24; p = 0.004) lower total hip BMD(a), a 0.12 SD (95%CI 0.02, 0.23; p = 0.026) lower lumbar spine BMD(a) and a 0.18 SD (95%CI 0.06, 0.29; p = 0.003) lower trabecular BMD at the distal radius for each copy of the minor allele. There was no association with serum levels of bone turnover markers and a single SNP which was associated with cortical density was also associated with cortical BMC and thickness.Our data replicate previous associations found between SNPs in the 6q25 locus and BMD(a) at the hip and extend these data to include associations with calcaneal ultrasound parameters and radial volumetric BMD.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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