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Article ; Online: Serum cytokines MCP-1 and GCS-F as potential biomarkers in pediatric inflammatory bowel disease.

Andrea Ott / Erol Tutdibi / Sybelle Goedicke-Fritz / Jakob Schöpe / Michael Zemlin / Nasenien Nourkami-Tutdibi

PLoS ONE, Vol 18, Iss 11, p e

2023 Volume 0288147

Abstract: Background Inflammatory bowel diseases (IBDs) with the subtypes ulcerative colitis (UC) and Crohn disease (CD), are chronic autoimmune inflammatory disorders of the gastrointestinal tract. Cytokines are associated with the development and progression in ... ...

Abstract	Background Inflammatory bowel diseases (IBDs) with the subtypes ulcerative colitis (UC) and Crohn disease (CD), are chronic autoimmune inflammatory disorders of the gastrointestinal tract. Cytokines are associated with the development and progression in pediatric IBD. We measured cytokine levels in pediatric IBD patients to assess their potential function as biomarkers in disease assessment. Method In this prospective cohort study, we enrolled 33 children with IBD. All patients were in stable remission for 3 months on enrollment. Patients who developed a relapse within six months after enrollment were classified as relapsers. Blood sampling was performed at enrolment and for relapsers in relapse and post-relapse. Serum concentrations of 14 cytokines, chemokines and growth factors (IL-1α, IL-1β, IL-6, IL-12p40, IP-10, TNF-α, IFN-γ, IL-10, IL-8, MIP-1α, MCP-1, MCP-3, G-CSF, GM-CSF) were measured simultaneously using multiplex bead-based sandwich immunoassay on Luminex 100 system. Results MCP-1 was significantly higher in CD patients compared to UC patients at each disease stage: stable remission (P<0.048), unstable remission (P<0.013), relapse (P<0.026) and post-relapse (P<0.024). G-CSF was significantly increased in UC patients developing a relapse and in post-relapse stage compared to UC patients in remission (P<0.02 and p<0.03, respectively). Conclusion MCP-1 showed potential as a diagnostic biomarker in CD patients independent of disease activity as it was able to discriminate between subtypes of pediatric IBD. In UC patients, G-CSF was significantly elevated in relapsers indicating its use and role as a potential prognostic biomarker.
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online ; Thesis: Die Auswirkungen von Vereinssport auf die subjektiv wahrgenommene Lebensqualität, das Ernährungsverhalten sowie den Konsum von Genussmitteln und leistungssteigernden Mitteln bei Kindern und Jugendlichen zwischen 12 und 20 Jahren

Arzideh, Roxana [Verfasser] / Michael, Zemlin [Akademischer Betreuer]

2022

Author's details	Roxana Arzideh ; Betreuer: Zemlin Michael
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Saarländische Universitäts- und Landesbibliothek
Publishing place	Saarbrücken
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Different populations of A(H1N1)pdm09 viruses in a patient with hemolytic-uremic syndrome

Yuguang Fu / Marianne Wedde / Sigrun Smola / Djin-Ye Oh / Thorsten Pfuhl / Jürgen Rissland / Michael Zemlin / Fidelis A. Flockerzi / Rainer M. Bohle / Andrea Thürmer / Susanne Duwe / Barbara Biere / Janine Reiche / Brunhilde Schweiger / Christin Mache / Thorsten Wolff / Georg Herrler / Ralf Dürrwald

International Journal of Medical Microbiology, Vol 314, Iss , Pp 151598- (2024)

2024

Abstract: Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized.A patient (age group 5–15 years) displaying symptoms of hemolytic uremic ... ...

Abstract	Respiratory viral infections may have different impacts ranging from infection without symptoms to severe disease or even death though the reasons are not well characterized.A patient (age group 5–15 years) displaying symptoms of hemolytic uremic syndrome died one day after hospitalization. qPCR, next generation sequencing, virus isolation, antigenic characterization, resistance analysis was performed and virus replication kinetics in well-differentiated airway cells were determined.Autopsy revealed hemorrhagic pneumonia as major pathological manifestation. Lung samples harbored a large population of A(H1N1)pdm09 viruses with the polymorphism H456H/Y in PB1 polymerase. The H456H/Y viruses replicated much faster to high viral titers than upper respiratory tract viruses in vitro. H456H/Y-infected air-liquid interface cultures of differentiated airway epithelial cells did reflect a more pronounced loss of ciliated cells. A different pattern of virus quasispecies was found in the upper airway samples where substitution S263S/F (HA1) was observed.The data support the notion that viral quasispecies had evolved locally in the lung to support high replicative fitness. This change may have initiated further pathogenic processes leading to rapid dissemination of inflammatory mediators followed by development of hemorrhagic lung lesions and fatal outcome.
Keywords	A(H1N1)pdm09 virus ; Fatal influenza ; S263S/F (HA1) and H456H/Y (PB1) mutations ; Microbiology ; QR1-502 ; Other systems of medicine ; RZ201-999
Language	English
Publishing date	2024-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dental Biofilm and Saliva Microbiome and Its Interplay with Pediatric Allergies

Nicole B. Arweiler / Vivien Rahmel / Bilal Alashkar Alhamwe / Fahd Alhamdan / Michael Zemlin / Sébastien Boutin / Alexander Dalpke / Harald Renz

Microorganisms, Vol 9, Iss 1330, p

2021 Volume 1330

Abstract: Little is known about the interplay and contribution of oral microorganisms to allergic diseases, especially in children. The aim of the clinical study was to associate saliva and dental biofilm microbiome with allergic disease, in particular with ... ...

Abstract	Little is known about the interplay and contribution of oral microorganisms to allergic diseases, especially in children. The aim of the clinical study was to associate saliva and dental biofilm microbiome with allergic disease, in particular with allergic asthma. In a single-center study, allergic/asthmatic children ( n = 15; AA-Chd; age 10.7 ± 2.9), atopic/allergic children ( n = 16; AT/AL-Chd; 11.3 ± 2.9), and healthy controls ( n = 15; CON-Chd; age 9.9 ± 2.2) were recruited. After removing adhering biofilms from teeth and collecting saliva, microbiome was analyzed by using a 16s-rRNA gene-based next-generation sequencing in these two mediums. Microbiome structure differed significantly between saliva and dental biofilms (β-diversity). Within the groups, the dental biofilm microbiome of AA-Chd and AT/AL-Chd showed a similar microbial fingerprint characterized by only a small number of taxa that were enriched or depleted (4) compared to the CON-Chd, while both diseased groups showed a stronger microbial shift compared to CON-Chd, revealing 14 taxa in AA-Chd and 15 taxa in AT/AL-Chd that were different. This could be the first note to the contribution of dental biofilm and its metabolic activity to allergic health or disease.
Keywords	dental biofilm ; saliva ; oral microbiome ; biofilm metabolism ; 16s-rRNA gene next-generation sequencing ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Contactless radar-based breathing monitoring of premature infants in the neonatal intensive care unit

Gabriel Beltrão / Regine Stutz / Franziska Hornberger / Wallace A. Martins / Dimitri Tatarinov / Mohammad Alaee-Kerahroodi / Ulrike Lindner / Lilly Stock / Elisabeth Kaiser / Sybelle Goedicke-Fritz / Udo Schroeder / Bhavani Shankar M. R. / Michael Zemlin

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 15

Abstract: Abstract Vital sign monitoring systems are essential in the care of hospitalized neonates. Due to the immaturity of their organs and immune system, premature infants require continuous monitoring of their vital parameters and sensors need to be directly ... ...

Abstract	Abstract Vital sign monitoring systems are essential in the care of hospitalized neonates. Due to the immaturity of their organs and immune system, premature infants require continuous monitoring of their vital parameters and sensors need to be directly attached to their fragile skin. Besides mobility restrictions and stress, these sensors often cause skin irritation and may lead to pressure necrosis. In this work, we show that a contactless radar-based approach is viable for breathing monitoring in the Neonatal intensive care unit (NICU). For the first time, different scenarios common to the NICU daily routine are investigated, and the challenges of monitoring in a real clinical setup are addressed through different contributions in the signal processing framework. Rather than just discarding measurements under strong interference, we present a novel random body movement mitigation technique based on the time-frequency decomposition of the recovered signal. In addition, we propose a simple and accurate frequency estimator which explores the harmonic structure of the breathing signal. As a result, the proposed radar-based solution is able to provide reliable breathing frequency estimation, which is close to the reference cabled device values most of the time. Our findings shed light on the strengths and limitations of this technology and lay the foundation for future studies toward a completely contactless solution for vital signs monitoring.
Keywords	Medicine ; R ; Science ; Q
Subject code	600
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Systemic Steroids in Preventing Bronchopulmonary Dysplasia (BPD)

Noura Zayat / Patrick Truffert / Elodie Drumez / Alain Duhamel / Julien Labreuche / Michael Zemlin / David Milligan / Rolf F. Maier / Pierre-Henri Jarreau / Héloïse Torchin / Jennifer Zeitlin / Alexandra Nuytten / On behalf of the EPICE Research Group

International Journal of Environmental Research and Public Health, Vol 19, Iss 5600, p

Neurodevelopmental Outcome According to the Risk of BPD in the EPICE Cohort

2022 Volume 5600

Abstract: Background: Postnatal steroids (PNS) have been used to prevent bronchopulmonary dysplasia (BPD) in preterm infants but have potential adverse effects on neurodevelopment. These effects might be modulated by their risk of BPD. We aimed to compare patients’ ...

Abstract	Background: Postnatal steroids (PNS) have been used to prevent bronchopulmonary dysplasia (BPD) in preterm infants but have potential adverse effects on neurodevelopment. These effects might be modulated by their risk of BPD. We aimed to compare patients’ neurodevelopment with PNS treatment according to their risk of BPD in a European cohort. Methods: We developed a prediction model for BPD to classify infants born between 24 + 0 and 29 + 6 weeks of gestation in three groups and compared patients’ neurological outcome at two years of corrected age using the propensity score (PS) method. Results: Of 3662 neonates included in the analysis, 901 (24.6%) were diagnosed with BPD. Our prediction model for BPD had an area under the ROC curve of 0.82. In the group with the highest risk of developing BPD, PNS were associated with an increased risk of gross motor impairment: OR of 1.95 after IPTW adjustment (95% CI 1.18 to 3.24, p = 0.010). This difference existed regardless of the type of steroid used. However, there was an increased risk of cognitive anomalies for patients treated with dexa/betamethasone that was no longer observed with hydrocortisone. Conclusions: This study suggests that PNS might be associated with an increased risk of gross motor impairment regardless of the group risk for BPD. Further randomised controlled trials exploring the use of PNS to prevent BPD should include a risk-based evaluation of neurodevelopmental outcomes. This observation still needs to be confirmed in a randomised controlled trial.
Keywords	neurodevelopmental outcome ; bronchopulmonary dysplasia ; preterm birth ; post natal steroid therapy ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Attenuated asthma phenotype in mice with a fetal-like antigen receptor repertoire

Regine Stutz / Christopher Meyer / Elisabeth Kaiser / Sybelle Goedicke-Fritz / Harry W. Schroeder / Robert Bals / Christoph Haertel / Tobias Rogosch / Sebastian Kerzel / Michael Zemlin

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 11

Abstract: Abstract We hypothesized that the scarcity of N-nucleotides might contribute to the inability of the neonate to mount a robust allergic immune response. To test this, we used terminal deoxyribunucleotidyl Transferase deficient (TdT−/−) mice, which ... ...

Abstract	Abstract We hypothesized that the scarcity of N-nucleotides might contribute to the inability of the neonate to mount a robust allergic immune response. To test this, we used terminal deoxyribunucleotidyl Transferase deficient (TdT−/−) mice, which express “fetal-like” T cell receptor and immunoglobulin repertoires with largely germline-encoded CDR3 regions. Intraperitoneal sensitization was followed by aerosol provocation with either PBS or the allergen OVA in both TdT−/− mice and wild-type mice to develop allergic respiratory inflammation. The effects of this procedure were investigated by lung function test, immunological analysis of serum and brochoalveolar lavage. The local TH2 cytokine milieu was significantly attenuated in TdT−/− mice. Within this group, the induction of total IgE levels was also significantly reduced after sensitization. TdT−/− mice showed a tendency toward reduced eosinophilic inflow into the bronchial tubes, which was associated with the elimination of respiratory hyperreactivity. In conclusion, in a murine model of allergic airway inflammation, the expression of fetal-like antigen receptors was associated with potent indications of a reduced ability to mount an asthma phenotype. This underlines the importance of somatically-generated antigen-receptor repertoire diversity in type one allergic immune responses and suggests that the fetus may be protected from allergic responses, at least in part, by controlling N addition.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Insights from circulating microRNAs in cardiovascular entities in turner syndrome patients.

Masood Abu-Halima / Felix Sebastian Oberhoffer / Mohammed Abd El Rahman / Anna-Maria Jung / Michael Zemlin / Tilman R Rohrer / Mustafa Kahraman / Andreas Keller / Eckart Meese / Hashim Abdul-Khaliq

PLoS ONE, Vol 15, Iss 4, p e

2020 Volume 0231402

Abstract: BACKGROUND:Turner syndrome (TS) is a chromosomal disorder, in which a female is partially or entirely missing one of the two X chromosomes, with a prevalence of 1:2500 live female births. The present study aims to identify a circulating microRNA (miRNA) ... ...

Abstract	BACKGROUND:Turner syndrome (TS) is a chromosomal disorder, in which a female is partially or entirely missing one of the two X chromosomes, with a prevalence of 1:2500 live female births. The present study aims to identify a circulating microRNA (miRNA) signature for TS patients with and without congenital heart disease (CHD). METHODS:Microarray platform interrogating 2549 miRNAs were used to detect the miRNA abundance levels in the blood of 33 TS patients and 14 age-matched healthy volunteer controls (HVs). The differentially abundant miRNAs between the two groups were further validated by RT-qPCR. RESULTS:We identified 60 differentially abundant miRNA in the blood of TS patients compared to HVs, from which, 41 and 19 miRNAs showed a higher and a lower abundance levels in TS patients compared to HVs, respectively. RT-qPCR confirmed the significantly higher abundance levels of eight miRNAs namely miR-374b-5p, miR-199a-5p, miR-340-3p, miR-125b-5p, miR-30e-3p, miR-126-3p, miR-5695, and miR-26b-5p in TS patients as compared with the HVs. The abundance level of miR-5695 was higher in TS patients displaying CHD as compared to TS patients without CHD (p = 0.0265; log2-fold change 1.99); whereas, the abundance level of miR-126-3p was lower in TS patients with congenital aortic valve disease (AVD) compared to TS patients without BAV (p = 0.0139, log2-fold change 1.52). The clinical feature statistics revealed that miR-126-3p had a significant correlation with sinotubular junction Z-score (r = 0.42; p = 0.0154). CONCLUSION:The identified circulating miRNAs signature for TS patients with manifestations associated with cardiovascular diseases provide new insights into the molecular mechanism of TS that may guide the development of novel diagnostic approaches.
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of postconceptional age on universal newborn hearing screening in NICU-babies

Jochen Müller-Mazzotta / Michael Zemlin / Roswitha Berger / Holger Hanschmann

Audiology Research, Vol 2, Iss 1, Pp e1-e

2012 Volume 1

Abstract: The feasibility of universal newborn hearing screening (UNHS) using automated auditory brainstem response (AABR) devices in the neonatal intensive care unit (NICU) is already well demonstrated. The aim of this study was to find out whether the ... ...

Abstract	The feasibility of universal newborn hearing screening (UNHS) using automated auditory brainstem response (AABR) devices in the neonatal intensive care unit (NICU) is already well demonstrated. The aim of this study was to find out whether the postconceptional age (PCA) of the babies at the time of the AABR measurement has an influence on the measuring results and to determine the earliest time point for a reliable hearing screening in preterm neonates. Hearing screening measurements of 634 neonates (NICU-Babies) were included. We had complete data for 577 of these babies. The babies were born between 24 and 42 weeks of gestation in the years 2007-2008 and were screened in the Neonatal Unit of the Marburg University hospital. In this group, the hearing screening had been performed at or after 32 weeks of PCA. The AABR measurements showed a specificity of 93.9% (babies tested between 32 and 34 weeks of PCA), 95.8% (tested between 35 and 37 weeks), 95.9% (tested between 38 and 40 weeks of PCA) and 92.1% (tested after 40 weeks of PCA). Hearing screening yields reliable results at 32 weeks PCA. Therefore, an UNHS can be already performed before term without risking a higher rate of false positive results. However, individual factors such as cardiorespiratory and temperature stability of the baby should be considered.
Keywords	universal newborn hearing screening ; neonatal intensive care unit ; automated auditory brainstem response ; postconceptional age. ; Otorhinolaryngology ; RF1-547 ; Medicine ; R
Subject code	390
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correction to

Daniel Ebrahimi-Fakhari / Lilian Lisa Mann / Martin Poryo / Norbert Graf / Rüdiger von Kries / Beate Heinrich / Darius Ebrahimi-Fakhari / Marina Flotats-Bastardas / Ludwig Gortner / Michael Zemlin / Sascha Meyer

Orphanet Journal of Rare Diseases, Vol 14, Iss 1, Pp 1-

Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national, prospective surveillance study

2019 Volume 1

Abstract: ...

Abstract	.
Keywords	Medicine ; R
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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