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  1. Article ; Online: Inherited ADAMTS13 deficiency: Unique presentation and treatment.

    Michaels, Lisa A

    Pediatric blood & cancer

    2008  Volume 51, Issue 3, Page(s) 445; author reply 446

    MeSH term(s) ADAM Proteins/deficiency ; ADAM Proteins/genetics ; ADAMTS13 Protein ; Adolescent ; Cognition Disorders/etiology ; Disease Management ; Humans ; Male ; Purpura, Thrombotic Thrombocytopenic/complications ; Purpura, Thrombotic Thrombocytopenic/etiology
    Chemical Substances ADAM Proteins (EC 3.4.24.-) ; ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87)
    Language English
    Publishing date 2008-09
    Publishing country United States
    Document type Case Reports ; Letter ; Comment
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.21636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1131: Show issues Location:
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  2. Article ; Online: Safety and efficacy of BAY 94-9027, an extended-half-life factor VIII, during minor surgical procedures in patients with severe haemophilia A.

    Santagostino, Elena / Lalezari, Shadan / Reding, Mark T / Ducore, Jonathan / Ng, Heng Joo / Poulsen, Lone H / Michaels, Lisa A / Linardi, Camila

    Haemophilia : the official journal of the World Federation of Hemophilia

    2021  Volume 27, Issue 4, Page(s) e559–e562

    MeSH term(s) Factor VIII/therapeutic use ; Half-Life ; Hemophilia A/drug therapy ; Humans ; Minor Surgical Procedures ; Polyethylene Glycols ; Treatment Outcome
    Chemical Substances BAY 94-9027 ; Polyethylene Glycols (3WJQ0SDW1A) ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2021-05-03
    Publishing country England
    Document type Letter
    ZDB-ID 1229713-6
    ISSN 1365-2516 ; 1351-8216 ; 1355-0691
    ISSN (online) 1365-2516
    ISSN 1351-8216 ; 1355-0691
    DOI 10.1111/hae.14319
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    Zs.A 4249: Show issues Location:
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    Zs.MO 450: Show issues

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  3. Article: A response to: laboratory testing for thrombophilia in pediatric patients.

    Michaels, Lisa A

    Thrombosis and haemostasis

    2003  Volume 89, Issue 1, Page(s) 204–205

    MeSH term(s) Child ; Clinical Laboratory Techniques ; Genetic Testing/standards ; Humans ; Practice Guidelines as Topic ; Thrombophilia/diagnosis ; Thrombophilia/genetics
    Language English
    Publishing date 2003-01
    Publishing country Germany
    Document type Comment ; Letter
    ZDB-ID 518294-3
    ISSN 0340-6245
    ISSN 0340-6245
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    Uh III Zs.192: Show issues Location:
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  4. Article ; Online: Safety and efficacy of BAY 94-9027, an extended-half-life factor VIII, during surgery in patients with severe hemophilia A: Results of the PROTECT VIII clinical trial.

    Santagostino, Elena / Lalezari, Shadan / Reding, Mark T / Ducore, Jonathan / Ng, Heng Joo / Poulsen, Lone H / Michaels, Lisa A / Linardi, Camila C G

    Thrombosis research

    2019  Volume 183, Page(s) 13–19

    Abstract: Introduction: Ensuring hemostasis during invasive procedures is a challenge in patients with severe hemophilia A. This analysis evaluated efficacy and safety of BAY 94-9027, an extended-half-life recombinant factor VIII (FVIII), in the surgical setting.! ...

    Abstract Introduction: Ensuring hemostasis during invasive procedures is a challenge in patients with severe hemophilia A. This analysis evaluated efficacy and safety of BAY 94-9027, an extended-half-life recombinant factor VIII (FVIII), in the surgical setting.
    Materials and methods: Patients participating in an open-label BAY 94-9027 clinical trial who underwent major surgery were included in the analysis. Investigator/surgeon assessment of hemostasis during surgery was the primary outcome. In addition, information about FVIII use, FVIII levels during perioperative period, bleeding complications and FVIII inhibitor development were collected.
    Results: Data were analyzed for 26 major surgeries (orthopedic, n = 21) in 20 patients aged 13-61 years. BAY 94-9027 provided effective hemostasis during all procedures. FVIII levels 6-8 h post preoperative infusion and prior to the first follow-up infusion were in the range expected to maintain protection in the major surgery setting. The median time from preoperative infusion to the first follow-up infusion (the first infusion administered after the preoperative infusion) was 12.33 (3.6-49.9) h. No intraoperative bleeding complications occurred, and no new inhibitors developed following any surgery.
    Conclusions: The results of the study demonstrate that BAY 94-9027 was efficacious and well tolerated in the treatment of patients undergoing major surgeries. Advantages of BAY 94-9027 include the potential for less frequent infusion and reduced factor consumption, which should simplify the management of patients during major surgery.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Coagulants/pharmacology ; Coagulants/therapeutic use ; Factor VIII/pharmacology ; Factor VIII/therapeutic use ; Female ; Hemophilia A/drug therapy ; Hemophilia A/pathology ; Humans ; Male ; Middle Aged ; Polyethylene Glycols/pharmacology ; Polyethylene Glycols/therapeutic use ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Treatment Outcome ; Young Adult
    Chemical Substances BAY 94-9027 ; Coagulants ; Recombinant Proteins ; Polyethylene Glycols (3WJQ0SDW1A) ; Factor VIII (9001-27-8)
    Language English
    Publishing date 2019-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2019.08.023
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    Zs.A 863: Show issues Location:
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  5. Article: Risk of thrombosis with anomalies of the inferior vena cava and inherited thrombophilia.

    Bruins, Benjamin / Michaels, Lisa A

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2008  Volume 9, Issue 11, Page(s) 1187, author reply 1187–8

    MeSH term(s) Adolescent ; Antithrombin III Deficiency/complications ; Humans ; Risk Assessment ; Risk Factors ; Vascular Malformations/complications ; Vena Cava, Inferior/abnormalities ; Venous Thrombosis/etiology ; Young Adult
    Language English
    Publishing date 2008-11
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0b013e328306f324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5210: Show issues Location:
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    Zs.MO 559: Show issues

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  6. Article: Helicobacter pylori in children with chronic idiopathic thrombocytopenic purpura: are the obstacles in the way typical in pediatric hematology?

    Kühne, Thomas / Michaels, Lisa A

    Journal of pediatric hematology/oncology

    2008  Volume 30, Issue 1, Page(s) 2–3

    MeSH term(s) Adult ; Antigens, Bacterial/immunology ; Child ; Child, Preschool ; Chronic Disease ; Cytokines/immunology ; Female ; Gastrointestinal Diseases/drug therapy ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/etiology ; Gastrointestinal Diseases/immunology ; Gastrointestinal Diseases/microbiology ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Helicobacter Infections/immunology ; Helicobacter pylori ; Humans ; Male ; Molecular Mimicry/immunology ; Platelet Count ; Platelet Membrane Glycoproteins/immunology ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Purpura, Thrombocytopenic, Idiopathic/epidemiology ; Purpura, Thrombocytopenic, Idiopathic/etiology ; Purpura, Thrombocytopenic, Idiopathic/immunology ; Purpura, Thrombocytopenic, Idiopathic/microbiology ; von Willebrand Factor/immunology
    Chemical Substances Antigens, Bacterial ; Cytokines ; Platelet Membrane Glycoproteins ; von Willebrand Factor
    Language English
    Publishing date 2008-01
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0b013e31815bcdcd
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    Zs.A 1537: Show issues Location:
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  7. Article: A response to: Laboratory testing for thrombophilia in pediatric patients

    Michaels, Lisa A.

    Thrombosis and Haemostasis

    2003  Volume 89, Issue 01, Page(s) 204–205

    Language English
    Publishing date 2003-01-01
    Publisher Schattauer GmbH
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/s-0037-1613563
    Database Thieme publisher's database

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    Zs.MO 433: Show issues

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  8. Article ; Online: An unusual presentation of May-Thurner syndrome in a pediatric patient with a pelvic kidney.

    Eng, Jeffrey M / Walor, David M / Michaels, Lisa A / Weiss, Aaron R

    Journal of pediatric urology

    2013  Volume 9, Issue 1, Page(s) e72–5

    Abstract: We report a case of an adolescent who presented with a deep vein thrombosis (DVT) and clinical findings consistent with May-Thurner Syndrome. Specific imaging demonstrated direct compression of the left common iliac vein by an overlying pelvic kidney. ... ...

    Abstract We report a case of an adolescent who presented with a deep vein thrombosis (DVT) and clinical findings consistent with May-Thurner Syndrome. Specific imaging demonstrated direct compression of the left common iliac vein by an overlying pelvic kidney. The patient's history and clinical presentation is detailed. The discussion focuses on the potential implications for care and management of a patient with an ectopic left pelvic kidney.
    MeSH term(s) Adolescent ; Anticoagulants/therapeutic use ; Humans ; Kidney/diagnostic imaging ; Kidney Diseases/diagnostic imaging ; Kidney Diseases/etiology ; Male ; May-Thurner Syndrome/complications ; May-Thurner Syndrome/diagnostic imaging ; May-Thurner Syndrome/drug therapy ; Phlebography ; Ultrasonography ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/drug therapy ; Venous Thrombosis/etiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2013-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2012.08.014
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    Zs.A 6387: Show issues Location:
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  9. Article: Pediatric clinical research in benign hematology: a dilemma?

    Kühne, Thomas / Michaels, Lisa A

    Journal of pediatric hematology/oncology

    2005  Volume 27, Issue 12, Page(s) 637–638

    MeSH term(s) Adolescent ; Age Factors ; Child ; Child, Preschool ; Evidence-Based Medicine ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/therapeutic use ; Hematology/trends ; Humans ; Infant ; Pediatrics/trends ; Practice Guidelines as Topic ; Research/economics ; Research/trends ; Research Support as Topic ; Thromboembolism/drug therapy ; Thromboembolism/epidemiology ; Venous Thrombosis/drug therapy ; Venous Thrombosis/epidemiology
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2005-12-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/01.mph.0000194020.33215.bf
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  10. Article ; Online: Patient-reported experience of bleeding events in haemophilia.

    Flood, Emuella / Pocoski, Jennifer / Michaels, Lisa A / McCoy, Anne / Beusterien, Kathleen / Sasanè, Rahul

    European journal of haematology

    2014  Volume 93 Suppl 75, Page(s) 19–28

    Abstract: Background: Patients with haemophilia experience bleeds because of absent or reduced clotting factor. The study objective was to understand the bleeding experience from the patients' perspective.: Materials and methods: Individuals with moderate/ ... ...

    Abstract Background: Patients with haemophilia experience bleeds because of absent or reduced clotting factor. The study objective was to understand the bleeding experience from the patients' perspective.
    Materials and methods: Individuals with moderate/severe haemophilia participated in interviews and were asked to describe their most recent bleeding experience, including symptoms, signs of onset, impacts, when bleeding stopped and treatment effectiveness. Interview transcripts were analysed using a thematic analysis involving the coding of transcripts to identify key concepts and themes.
    Results: Twenty males [10 adults, mean age = 41 (19-52); 10 adolescents, mean age = 13 (12-17)] with moderate (n = 5) or severe (n = 15) haemophilia participated. Symptoms signalling bleed onset included pain, swelling, stiffness, tingling/numbness and/or warmth. Participants reported feeling anger and frustration due to the unpredictable nature, pain and inconvenience of the episode. Adults sometimes reported delaying treatment due to inconvenience or cost; adolescents generally treated right away. Reported bleed severity was influenced by pain level, speed of symptom progression, location, continued use of the affected area, recurrence in same location of recent bleed and treatment delay. Participants reported that it was 'easy' to know when the bleed had stopped. Participants reported that symptoms might linger for days before they returned back to 'normal'.
    Conclusions: This qualitative study details the substantial impact of an acute bleed from the patient perspective. Given that treatment was reported to be delayed in part due to inconvenience, more convenient treatment options could help reduce delays in treating bleeds and thereby minimise bleed-related impacts. Clinical studies in haemophilia should include validated patient-reported measurements of acute symptoms and bleed severity to comprehensively assess the bleeding event.
    MeSH term(s) Adolescent ; Adult ; Child ; Cross-Sectional Studies ; Hemophilia A/complications ; Hemorrhage/etiology ; Hemorrhage/psychology ; Humans ; Male ; Middle Aged ; Self Disclosure ; Young Adult
    Language English
    Publishing date 2014-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.12329
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