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Book ; Thesis: Inhibition of Rac1 GTPase downregulates vascular endothelial growth factor receptor-2 expression by suppressing Sp1-dependent DNA binding in human endothelial cells

Michailidou, Despina

2009

Author's details	vorgelegt von Despina Michailidou
Subject code	612.01
Language	English
Size	VI, 86 S. : Ill., graph. Darst., 21 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Frankfurt (Main), Univ., Diss., 2010
HBZ-ID	HT016651376
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Risk of venous and arterial thromboembolism in patients with giant cell arteritis and/or polymyalgia rheumatica: A Veterans Health Administration population-based study in the United States.

Michailidou, Despina / Zhang, Tianyu / Stamatis, Pavlos / Ng, Bernard

Journal of internal medicine

2022 Volume 291, Issue 5, Page(s) 665–675

Abstract: Background: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are systemic inflammatory diseases that primarily affect elderly women.: Objectives: To compare the risk of thromboembolic events and retinal vascular occlusions in GCA and/or ... ...

Abstract	Background: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are systemic inflammatory diseases that primarily affect elderly women. Objectives: To compare the risk of thromboembolic events and retinal vascular occlusions in GCA and/or PMR with that in osteoarthritis (OA), evaluating a veteran-based population. Methods: A total of 1535 patients with GCA, 10,265 with PMR, and 1203 with overlapping disease, as well as 39,009 age- and sex-matched patients with OA were identified in this retrospective study. The incidence rate ratios (IRRs) of pulmonary embolism (PE), deep venous thrombosis (DVT), arterial thromboembolism, central retinal artery occlusion, and central retinal vein occlusion were calculated and examined over time. The cumulative incidence was plotted and hazard ratios (HRs) of thromboembolic events were calculated, adjusting for independent risk factors of thromboembolism. Results: Patients with GCA and overlapping disease exhibited higher IRRs for all thromboembolic events compared to patients with OA. Patients with GCA had a higher risk of developing DVT and retinal vascular occlusions than those with overlapping disease (HR: 2.01, 95% confidence interval [CI]: 1.35-2.99, p < 0.001; HR: 2.37, 95% CI: 1.23-4.53, p = 0.009, respectively) or PMR alone (HR: 1.89, 95% CI: 1.50-2.41, p < 0.001; HR: 4.68, 95% CI: 3.10-7.07, p < 0.001, respectively). Patients with GCA had a higher risk of developing PE than those with PMR (HR: 1.55, 95% CI: 1.1-2.18, p = 0.01). Conclusion: The risk of thromboembolic events differs between GCA, PMR, and overlapping diseases. Our findings may help predict the risk of thromboembolic events based on disease phenotype.
MeSH term(s)	Aged ; Female ; Giant Cell Arteritis/complications ; Giant Cell Arteritis/epidemiology ; Giant Cell Arteritis/genetics ; Humans ; Polymyalgia Rheumatica/complications ; Polymyalgia Rheumatica/epidemiology ; Polymyalgia Rheumatica/genetics ; Retrospective Studies ; Thromboembolism ; United States/epidemiology ; Veterans Health
Language	English
Publishing date	2022-01-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13446
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Article: Pathogenesis of giant cell arteritis with focus on cellular populations.

Stamatis, Pavlos / Turesson, Carl / Michailidou, Despina / Mohammad, Aladdin J

Frontiers in medicine

2022 Volume 9, Page(s) 1058600

Abstract: Giant cell arteritis (GCA), the most common non-infectious vasculitis, mainly affects elderly individuals. The disease usually affects the aorta and its main supra-aortic branches causing both general symptoms of inflammation and specific ischemic ... ...

Abstract	Giant cell arteritis (GCA), the most common non-infectious vasculitis, mainly affects elderly individuals. The disease usually affects the aorta and its main supra-aortic branches causing both general symptoms of inflammation and specific ischemic symptoms because of the limited blood flow due to arterial structural changes in the inflamed arteries. The pathogenesis of the GCA is complex and includes a dysregulated immune response that affects both the innate and the adaptive immunity. During the last two decades several studies have investigated interactions among antigen-presenting cells and lymphocytes, which contribute to the formation of the inflammatory infiltrate in the affected arteries. Toll-like receptor signaling and interactions through the VEGF-Notch-Jagged1 pathway are emerging as crucial events of the aberrant inflammatory response, facilitating among others the migration of inflammatory cells to the inflamed arteries and their interactions with the local stromal milieu. The increased use of checkpoint inhibitors in cancer immunotherapy and their immune-related adverse events has fed interest in the role of checkpoint dysfunction in GCA, and recent studies suggest a dysregulated check point system which is unable to suppress the inflammation in the previously immune-privileged arteries, leading to vasculitis. The role of B-cells is currently reevaluated because of new reports of considerable numbers of plasma cells in inflamed arteries as well as the formation of artery tertiary lymphoid organs. There is emerging evidence on previously less studied cell populations, such as the neutrophils, CD8+ T-cells, T regulatory cells and tissue residing memory cells as well as for stromal cells which were previously considered as innocent bystanders. The aim of this review is to summarize the evidence in the literature regarding the cell populations involved in the pathogenesis of GCA and especially in the context of an aged, immune system.
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.1058600
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Resolution of accelerated nodulosis with upadacitinib in a patient with systemic lupus erythematosus and Jaccoud's arthropathy.

Michailidou, Despina / Long, Thomas H / Argenyi, Zsolt B / Noss, Erika H

Clinical and experimental rheumatology

2022 Volume 41 Suppl 135, Issue 9, Page(s) 11–12

MeSH term(s)	Humans ; Joint Diseases ; Heterocyclic Compounds, 3-Ring ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy
Chemical Substances	upadacitinib (4RA0KN46E0) ; Heterocyclic Compounds, 3-Ring
Language	English
Publishing date	2022-02-18
Publishing country	Italy
Document type	Letter
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/hkokxs
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Book: The inexorable evolution of financialisation

Michailidou, Domna

financial crises in emerging markets

2015

Abstract: Since the 2007 financial crisis, discussion on issues related to the size, spread and frequency of financial crises has captivated a wide variety of audiences. Why has the world economy experienced such an increase in financial transactions and private ... ...

Author's details	Domna Michailidou, Teaching Fellow,School of Public Policy, University College London, UK
Abstract	"Since the 2007 financial crisis, discussion on issues related to the size, spread and frequency of financial crises has captivated a wide variety of audiences. Why has the world economy experienced such an increase in financial transactions and private and public indebtedness since the 1980s? How have middle-income developing countries suddenly become a part of this dynamic? And, most importantly, how has the topic of financial crises been featured in households' daily discussions in both developed and developing parts of the world? Domna Michailidou addresses the questions above through exploring the inexorable evolution of financialisation into financial crisis through the examination of three countries: Mexico, Brazil and South Korea. Concentrating on emerging economies, and especially choosing three very different economies that all experienced financial crises in the 1990s, this book explores what lessons can be learnt regarding financial fragility, volatility and failure in the wake of capital market liberalisation. "--
Keywords	Debts, Public ; Financial crises ; International finance ; Developing countries
Language	English
Size	pages cm
Publisher	Palgrave Macmillan
Publishing place	London
Document type	Book
ISBN	9781137553638 ; 1137553634
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Role of Neutrophils in Systemic Vasculitides.

Michailidou, Despina / Mustelin, Tomas / Lood, Christian

Frontiers in immunology

2020 Volume 11, Page(s) 619705

Abstract: Neutrophils and neutrophil extracellular traps (NETs) contribute to the pathogenesis of many autoimmune diseases, including vasculitis. Though neutrophils, and NETs, can break self-tolerance by being a source of autoantigens for autoantibodies in anti- ... ...

Abstract	Neutrophils and neutrophil extracellular traps (NETs) contribute to the pathogenesis of many autoimmune diseases, including vasculitis. Though neutrophils, and NETs, can break self-tolerance by being a source of autoantigens for autoantibodies in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, playing a key role in driving the autoimmune response, the role of neutrophils and NETs in large vessel vasculitis, including giant cell arteritis (GCA), is not well understood. In this review, we summarize the current insight into molecular mechanisms contributing to neutrophil-mediated pathology in small and medium vessel vasculitis, as well as provide potential translational perspectives on how neutrophils, and NETs, may partake in large vessel vasculitis, a rare disease entity of unclear pathogenesis.
MeSH term(s)	Extracellular Traps/immunology ; Humans ; Neutrophils/immunology ; Neutrophils/pathology ; Systemic Vasculitis/immunology ; Systemic Vasculitis/pathology
Language	English
Publishing date	2020-12-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.619705
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy.

Michailidou, Despina / Schwartz, Daniella Muallem / Mustelin, Tomas / Hughes, Grant C

Frontiers in immunology

2021 Volume 12, Page(s) 693192

Abstract: IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same ... ...

Abstract	IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same pathogenic mechanisms observed in allergic disease, such as T helper 2 (Th2) and regulatory T cell (Treg) activation, IgG4 and IgE hypersecretion, and blood/tissue eosinophilia. In addition, IgG4-RD tissue fibrosis appears to involve activation of basophils and mast cells and their release of alarmins and cytokines. In this article, we review allergy-like features of IgG4-RD and highlight targeted therapies for allergy that have potential in treating patients with IgG4-RD.
MeSH term(s)	Alarmins/metabolism ; Animals ; Cytokines/metabolism ; Fibrosis ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/metabolism ; Hypersensitivity/physiopathology ; Immune System/immunology ; Immune System/metabolism ; Immune System/physiopathology ; Immunoglobulin E/metabolism ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Immunoglobulin G4-Related Disease/immunology ; Immunoglobulin G4-Related Disease/metabolism ; Immunoglobulin G4-Related Disease/physiopathology ; Signal Transduction
Chemical Substances	Alarmins ; Cytokines ; Immunoglobulin G ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2021-07-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.693192
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Civil war, contested sovereignty and the limits of global health partnerships: A case study of the Syrian polio outbreak in 2013.

Kennedy, Jonathan / Michailidou, Domna

Health policy and planning

2017 Volume 32, Issue 5, Page(s) 690–698

Abstract: States and the World Health Organization (WHO), an international organization that is mandated to respect the sovereignty of its member states, are still the leading actors in global health. This paper explores how this discrepancy inhibits the ability ... ...

Abstract	States and the World Health Organization (WHO), an international organization that is mandated to respect the sovereignty of its member states, are still the leading actors in global health. This paper explores how this discrepancy inhibits the ability of global health partnerships to implement programmes in conflict-affected areas that are under the de facto control of rebel organizations. We concentrate on a single crucial case, the polio outbreak in Syria in 2013, analysing a variety of qualitative data-twenty semi-structured interviews with key actors, official documents, and media reports-in order to investigate the events that preceded and followed this event. The WHO's mandate to respect the Syrian government's sovereignty inhibited its ability to prevent, identify and contain the outbreak because the Assad regime refused it permission to operate in rebel-controlled areas. The polio outbreak was identified and contained by organizations operating outside the United Nations (UN) system that disregarded the Syrian government's sovereignty claims and cooperated with the militants. Thus, we identify a serious problem with so-called global health partnerships in which nation states and international organizations remain key actors. Such initiatives function well in situations where there is a capable state that is concerned with the welfare of its citizens and has exclusivity of jurisdiction over its territory. But they can encounter difficulties in areas where rebels challenge the state's sovereignty. Although the response to the Syrian polio outbreak was ultimately effective, it was reactive, ad hoc, slow and relied on personnel who had little experience. Global health partnerships would be more effective in conflict-affected areas if they put in place proactive and institutionalized plans to implement their programmes in regions outside government control.
MeSH term(s)	Disease Outbreaks/prevention & control ; Epidemiological Monitoring ; Global Health/legislation & jurisprudence ; Humans ; Immunization Programs/legislation & jurisprudence ; Poliomyelitis/epidemiology ; Poliomyelitis/prevention & control ; Syria/epidemiology ; Warfare ; World Health Organization
Language	English
Publishing date	2017-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	632896-9
ISSN	1460-2237 ; 0268-1080
ISSN (online)	1460-2237
ISSN	0268-1080
DOI	10.1093/heapol/czw148
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Article: Stress, Professional Burnout, and Employee Efficiency in the Greek National Organization for the Provision of Health Services.

Vlassi, Alexandra / Vitkos, Evangelos / Michailidou, Despoina / Lykoudis, Panagis M / Kioroglou, Lambrini / Kyrgidis, Athanassios / Tilaveridis, Ioannis / Dardavesis, Theodoros

Clinics and practice

2023 Volume 13, Issue 6, Page(s) 1541–1548

Abstract: Background: Workplace stress and burnout in the Greek healthcare system had been considered severe even before the high pressure of the COVID-19 pandemic. We aimed to investigate occupational quality of life and burnout effects on workplace errors among ...

Abstract	Background: Workplace stress and burnout in the Greek healthcare system had been considered severe even before the high pressure of the COVID-19 pandemic. We aimed to investigate occupational quality of life and burnout effects on workplace errors among the administrative staff in the Greek healthcare system. Methods: We enrolled 120 administrative healthcare employee participants between April and May 2019. Occupational burnout was assessed using the Maslach Burnout Inventory-Human Services Survey and the Hospital Anxiety and Depression Scale. Findings: Inadequate staffing, a low sense of well-being, exhaustion, and low family income were associated with workplace errors. Increased workload and staff shortages were associated with occupation related quality of life. Conclusions: Targeted interventions supporting healthcare staff mental health are warranted. Application to practice: Wellness and professional burnout can affect professional efficiency and are associated with workplace errors in the healthcare sector. Targeted interventions are warranted to support the mental health of healthcare staff during work and to prevent incidents of post-traumatic stress. Shortages of staffing may lead to an increase in the cost of the provided services.
Language	English
Publishing date	2023-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2605724-4
ISSN	2039-7283 ; 2039-7275
ISSN (online)	2039-7283
ISSN	2039-7275
DOI	10.3390/clinpract13060135
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Article ; Online: Large Vessel Vasculitis in a Young Woman with EIF2AK4-associated Pulmonary Capillary Hemangiomatosis/Pulmonary Veno-Occlusive Disease.

Michailidou, Despina / Chen, Delphine L / Collins, Bridget F / George, Marjorie P / Montani, David / Rayner, Samuel G / Sirisak, Chanprasert / Leary, Peter J

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 5, Page(s) e29–e31

Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202212-2260IM
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