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Book ; Thesis: Inhibition of Rac1 GTPase downregulates vascular endothelial growth factor receptor-2 expression by suppressing Sp1-dependent DNA binding in human endothelial cells

Michailidou, Despina

2009

Author's details	vorgelegt von Despina Michailidou
Subject code	612.01
Language	English
Size	VI, 86 S. : Ill., graph. Darst., 21 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Frankfurt (Main), Univ., Diss., 2010
HBZ-ID	HT016651376
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Risk of venous and arterial thromboembolism in patients with giant cell arteritis and/or polymyalgia rheumatica: A Veterans Health Administration population-based study in the United States.

Michailidou, Despina / Zhang, Tianyu / Stamatis, Pavlos / Ng, Bernard

Journal of internal medicine

2022 Volume 291, Issue 5, Page(s) 665–675

Abstract: Background: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are systemic inflammatory diseases that primarily affect elderly women.: Objectives: To compare the risk of thromboembolic events and retinal vascular occlusions in GCA and/or ... ...

Abstract	Background: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are systemic inflammatory diseases that primarily affect elderly women. Objectives: To compare the risk of thromboembolic events and retinal vascular occlusions in GCA and/or PMR with that in osteoarthritis (OA), evaluating a veteran-based population. Methods: A total of 1535 patients with GCA, 10,265 with PMR, and 1203 with overlapping disease, as well as 39,009 age- and sex-matched patients with OA were identified in this retrospective study. The incidence rate ratios (IRRs) of pulmonary embolism (PE), deep venous thrombosis (DVT), arterial thromboembolism, central retinal artery occlusion, and central retinal vein occlusion were calculated and examined over time. The cumulative incidence was plotted and hazard ratios (HRs) of thromboembolic events were calculated, adjusting for independent risk factors of thromboembolism. Results: Patients with GCA and overlapping disease exhibited higher IRRs for all thromboembolic events compared to patients with OA. Patients with GCA had a higher risk of developing DVT and retinal vascular occlusions than those with overlapping disease (HR: 2.01, 95% confidence interval [CI]: 1.35-2.99, p < 0.001; HR: 2.37, 95% CI: 1.23-4.53, p = 0.009, respectively) or PMR alone (HR: 1.89, 95% CI: 1.50-2.41, p < 0.001; HR: 4.68, 95% CI: 3.10-7.07, p < 0.001, respectively). Patients with GCA had a higher risk of developing PE than those with PMR (HR: 1.55, 95% CI: 1.1-2.18, p = 0.01). Conclusion: The risk of thromboembolic events differs between GCA, PMR, and overlapping diseases. Our findings may help predict the risk of thromboembolic events based on disease phenotype.
MeSH term(s)	Aged ; Female ; Giant Cell Arteritis/complications ; Giant Cell Arteritis/epidemiology ; Giant Cell Arteritis/genetics ; Humans ; Polymyalgia Rheumatica/complications ; Polymyalgia Rheumatica/epidemiology ; Polymyalgia Rheumatica/genetics ; Retrospective Studies ; Thromboembolism ; United States/epidemiology ; Veterans Health
Language	English
Publishing date	2022-01-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13446
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Article: Resolution of accelerated nodulosis with upadacitinib in a patient with systemic lupus erythematosus and Jaccoud's arthropathy.

Michailidou, Despina / Long, Thomas H / Argenyi, Zsolt B / Noss, Erika H

Clinical and experimental rheumatology

2022 Volume 41 Suppl 135, Issue 9, Page(s) 11–12

MeSH term(s)	Humans ; Joint Diseases ; Heterocyclic Compounds, 3-Ring ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy
Chemical Substances	upadacitinib (4RA0KN46E0) ; Heterocyclic Compounds, 3-Ring
Language	English
Publishing date	2022-02-18
Publishing country	Italy
Document type	Letter
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
DOI	10.55563/clinexprheumatol/hkokxs
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Article: Pathogenesis of giant cell arteritis with focus on cellular populations.

Stamatis, Pavlos / Turesson, Carl / Michailidou, Despina / Mohammad, Aladdin J

Frontiers in medicine

2022 Volume 9, Page(s) 1058600

Abstract: Giant cell arteritis (GCA), the most common non-infectious vasculitis, mainly affects elderly individuals. The disease usually affects the aorta and its main supra-aortic branches causing both general symptoms of inflammation and specific ischemic ... ...

Abstract	Giant cell arteritis (GCA), the most common non-infectious vasculitis, mainly affects elderly individuals. The disease usually affects the aorta and its main supra-aortic branches causing both general symptoms of inflammation and specific ischemic symptoms because of the limited blood flow due to arterial structural changes in the inflamed arteries. The pathogenesis of the GCA is complex and includes a dysregulated immune response that affects both the innate and the adaptive immunity. During the last two decades several studies have investigated interactions among antigen-presenting cells and lymphocytes, which contribute to the formation of the inflammatory infiltrate in the affected arteries. Toll-like receptor signaling and interactions through the VEGF-Notch-Jagged1 pathway are emerging as crucial events of the aberrant inflammatory response, facilitating among others the migration of inflammatory cells to the inflamed arteries and their interactions with the local stromal milieu. The increased use of checkpoint inhibitors in cancer immunotherapy and their immune-related adverse events has fed interest in the role of checkpoint dysfunction in GCA, and recent studies suggest a dysregulated check point system which is unable to suppress the inflammation in the previously immune-privileged arteries, leading to vasculitis. The role of B-cells is currently reevaluated because of new reports of considerable numbers of plasma cells in inflamed arteries as well as the formation of artery tertiary lymphoid organs. There is emerging evidence on previously less studied cell populations, such as the neutrophils, CD8+ T-cells, T regulatory cells and tissue residing memory cells as well as for stromal cells which were previously considered as innocent bystanders. The aim of this review is to summarize the evidence in the literature regarding the cell populations involved in the pathogenesis of GCA and especially in the context of an aged, immune system.
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.1058600
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Article ; Online: Role of Neutrophils in Systemic Vasculitides.

Michailidou, Despina / Mustelin, Tomas / Lood, Christian

Frontiers in immunology

2020 Volume 11, Page(s) 619705

Abstract: Neutrophils and neutrophil extracellular traps (NETs) contribute to the pathogenesis of many autoimmune diseases, including vasculitis. Though neutrophils, and NETs, can break self-tolerance by being a source of autoantigens for autoantibodies in anti- ... ...

Abstract	Neutrophils and neutrophil extracellular traps (NETs) contribute to the pathogenesis of many autoimmune diseases, including vasculitis. Though neutrophils, and NETs, can break self-tolerance by being a source of autoantigens for autoantibodies in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, playing a key role in driving the autoimmune response, the role of neutrophils and NETs in large vessel vasculitis, including giant cell arteritis (GCA), is not well understood. In this review, we summarize the current insight into molecular mechanisms contributing to neutrophil-mediated pathology in small and medium vessel vasculitis, as well as provide potential translational perspectives on how neutrophils, and NETs, may partake in large vessel vasculitis, a rare disease entity of unclear pathogenesis.
MeSH term(s)	Extracellular Traps/immunology ; Humans ; Neutrophils/immunology ; Neutrophils/pathology ; Systemic Vasculitis/immunology ; Systemic Vasculitis/pathology
Language	English
Publishing date	2020-12-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.619705
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Article ; Online: Allergic Aspects of IgG4-Related Disease: Implications for Pathogenesis and Therapy.

Michailidou, Despina / Schwartz, Daniella Muallem / Mustelin, Tomas / Hughes, Grant C

Frontiers in immunology

2021 Volume 12, Page(s) 693192

Abstract: IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same ... ...

Abstract	IgG4-related disease (IgG4-RD) is a rare systemic fibroinflammatory disease frequently associated with allergy. The pathogenesis of IgG4-RD is poorly understood, and effective therapies are limited. However, IgG4-RD appears to involve some of the same pathogenic mechanisms observed in allergic disease, such as T helper 2 (Th2) and regulatory T cell (Treg) activation, IgG4 and IgE hypersecretion, and blood/tissue eosinophilia. In addition, IgG4-RD tissue fibrosis appears to involve activation of basophils and mast cells and their release of alarmins and cytokines. In this article, we review allergy-like features of IgG4-RD and highlight targeted therapies for allergy that have potential in treating patients with IgG4-RD.
MeSH term(s)	Alarmins/metabolism ; Animals ; Cytokines/metabolism ; Fibrosis ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/metabolism ; Hypersensitivity/physiopathology ; Immune System/immunology ; Immune System/metabolism ; Immune System/physiopathology ; Immunoglobulin E/metabolism ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Immunoglobulin G4-Related Disease/immunology ; Immunoglobulin G4-Related Disease/metabolism ; Immunoglobulin G4-Related Disease/physiopathology ; Signal Transduction
Chemical Substances	Alarmins ; Cytokines ; Immunoglobulin G ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2021-07-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.693192
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Article ; Online: Large Vessel Vasculitis in a Young Woman with EIF2AK4-associated Pulmonary Capillary Hemangiomatosis/Pulmonary Veno-Occlusive Disease.

Michailidou, Despina / Chen, Delphine L / Collins, Bridget F / George, Marjorie P / Montani, David / Rayner, Samuel G / Sirisak, Chanprasert / Leary, Peter J

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 5, Page(s) e29–e31

Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202212-2260IM
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Article ; Online: Association of blood biomarkers and autoimmunity with immune related adverse events in patients with cancer treated with immune checkpoint inhibitors.

Michailidou, Despina / Khaki, Ali Raza / Morelli, Maria Pia / Diamantopoulos, Leonidas / Singh, Namrata / Grivas, Petros

Scientific reports

2021 Volume 11, Issue 1, Page(s) 9029

Abstract: Patients with cancer treated with immune checkpoint inhibitors (ICIs) develop immune related adverse events (irAEs), however biomarkers are lacking. We hypothesized that clinicopathologic and laboratory factors would be associated with irAE risk and ... ...

Abstract	Patients with cancer treated with immune checkpoint inhibitors (ICIs) develop immune related adverse events (irAEs), however biomarkers are lacking. We hypothesized that clinicopathologic and laboratory factors would be associated with irAE risk and overall survival (OS) in this population. In a retrospective study of patients treated with ICIs we collected clinicopathologic, laboratory, irAEs and outcomes data. The association between baseline blood biomarkers, clinicopathologic features and irAEs was assessed by logistic regression adjusting for age, sex, smoking, cancer type, performance status, concomitant other systemic therapy, history of autoimmune disease (AD), chronic infection and pre-existing systemic steroid use (regardless of dose). Optimal cutoff values of biomarkers were identified by recursive partitioning analysis. 470 patients were identified; 156 (33%) developed irAEs, which were associated with baseline absolute lymphocyte count > 2.6 k/ul (adjusted [a]OR: 4.30), absolute monocyte count > 0.29 k/ul (aOR: 2.34) and platelet count > 145 k/ul (aOR: 2.23), neutrophil to lymphocyte ratio (NLR) ≤ 5.3 (aOR: 2.07) and monocyte to lymphocyte ratio (MLR) ≤ 0.73 (aOR: 2.96), as well as platelet to lymphocyte ratio ≤ 534 (aOR: 5.05). Patients with pre-existing AD (aOR: 2.57), family history of AD (aOR: 5.98), and ICI combination (aOR: 2.00) had higher odds of irAEs. Baseline NLR ≤ 5.3 (aHR: 0.68), MLR ≤ 0.73 (aHR: 0.43), PLT > 145 (aHR: 0.48) and PLR ≤ 534 (aHR: 0.48) were associated with longer OS. irAEs were associated with autoimmune history, ICI combination and baseline laboratory measurements. Lower NLR, MLR and PLR may have favorable prognostic value. Our hypothesis-generating findings require validation in larger prospective studies.
MeSH term(s)	Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Autoimmunity ; Biomarkers, Tumor/blood ; Blood Cell Count ; Cohort Studies ; Female ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Survival Analysis
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2021-04-27
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-88307-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An Unusual Case of Proximal Limb Muscle Weakness.

Michailidou, Despina / Chung, Sarah / Andrews, James S / Starkebaum, Gordon A / Chew, Felix S / Latimer, Caitlin S

Arthritis & rheumatology (Hoboken, N.J.)

2021 Volume 73, Issue 3, Page(s) 541

MeSH term(s)	Computed Tomography Angiography ; Edema/diagnostic imaging ; Edema/pathology ; Female ; Glucocorticoids/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Muscle Weakness/etiology ; Polyarteritis Nodosa/complications ; Polyarteritis Nodosa/diagnostic imaging ; Polyarteritis Nodosa/drug therapy ; Polyarteritis Nodosa/pathology ; Quadriceps Muscle/blood supply ; Quadriceps Muscle/diagnostic imaging ; Quadriceps Muscle/pathology
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.41626
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Article ; Online: Predictive models for thromboembolic events in giant cell arteritis: A US veterans health administration population-based study.

Michailidou, Despina / Zhang, Tianyu / Kuderer, Nicole M / Lyman, Gary H / Diamantopoulos, Andreas P / Stamatis, Pavlos / Ng, Bernard

Frontiers in immunology

2022 Volume 13, Page(s) 997347

Abstract: Giant cell arteritis (GCA) that affects older patients is an independent risk factor for thromboembolic events. The objective of this study was to identify predictive factors for thromboembolic events in patients with GCA and develop quantitative ... ...

Abstract	Giant cell arteritis (GCA) that affects older patients is an independent risk factor for thromboembolic events. The objective of this study was to identify predictive factors for thromboembolic events in patients with GCA and develop quantitative predictive tools (prognostic nomograms) for pulmonary embolism (PE) and deep venous thrombosis (DVT). A total of 13,029 patients with a GCA diagnosis were included in this retrospective study. We investigated potential predictors of PE and DVT using univariable and multivariable Cox regression models. Nomograms were then constructed based on the results of our Cox models. We also assessed the accuracy and predictive ability of our models by using calibration curves and cross-validation concordance index. Age, inpatient status at the time of initial diagnosis of GCA, number of admissions before diagnosis of GCA, and Charlson comorbidity index were each found to be independent predictive factors of thromboembolic events. Prognostic nomograms were then prepared based on these predictors with promising prognostic ability. The probability of developing thromboembolic events over an observation period of 5 years was estimated by with time-to-event analysis using the method of Kaplan and Meier, after stratifying patients based on predicted risk. The concordance index of the time-to-event analysis for both PE and DVT was > 0.61, indicating a good predictive performance. The proposed nomograms, based on specific predictive factors, can accurately estimate the probability of developing PE or DVT among patients with GCA.
MeSH term(s)	Humans ; Giant Cell Arteritis/complications ; Giant Cell Arteritis/epidemiology ; Retrospective Studies ; Veterans Health ; Thromboembolism/epidemiology ; Thromboembolism/etiology ; Research Design ; Pulmonary Embolism/epidemiology ; Pulmonary Embolism/etiology
Language	English
Publishing date	2022-11-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.997347
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