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Article ; Online: Comment on: Unsatisfactory quality of E. coli asparaginase biogenerics in India: Implications for clinical outcomes in acute lymphoblastic leukaemia.

Michalowski, Mariana Bohns / Cecconello, Daiane Keller

2021 Volume 68, Issue 11, Page(s) e29294

MeSH term(s)	Acute Disease ; Antineoplastic Agents/therapeutic use ; Asparaginase/therapeutic use ; Drugs, Generic/therapeutic use ; Escherichia coli/enzymology ; Humans ; India ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Therapeutic Equivalency
Chemical Substances	Antineoplastic Agents ; Drugs, Generic ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.29294
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Article ; Online: Epigenetics, hypersensibility and asthma: what do we know so far?

Lima, Douglas da Silva / de Morais, Rahuany Velleda / Rechenmacher, Ciliana / Michalowski, Mariana Bohns / Goldani, Marcelo Zubaran

Clinics (Sao Paulo, Brazil)

2023 Volume 78, Page(s) 100296

Abstract: In this review, we describe recent advances in understanding the relationship between epigenetic changes, especially DNA methylation (DNAm), with hypersensitivity and respiratory disorders such as asthma in childhood. It is clearly described that ... ...

Abstract	In this review, we describe recent advances in understanding the relationship between epigenetic changes, especially DNA methylation (DNAm), with hypersensitivity and respiratory disorders such as asthma in childhood. It is clearly described that epigenetic mechanisms can induce short to long-term changes in cells, tissues, and organs. Through the growing number of studies on the Origins of Health Development and Diseases, more and more data exist on how environmental and genomic aspects in early life can induce allergies and asthma. The lack of biomarkers, standardized assays, and access to more accessible tools for data collection and analysis are still a challenge for future studies. Through this review, the authors draw a panorama with the available information that can assist in the establishment of an epigenetic approach for the risk analysis of these pathologies.
MeSH term(s)	Humans ; Asthma/genetics ; Epigenesis, Genetic/genetics ; Hypersensitivity/genetics ; DNA Methylation ; Biomarkers/metabolism
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-12-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2182801-5
ISSN	1980-5322 ; 1807-5932
ISSN (online)	1980-5322
ISSN	1807-5932
DOI	10.1016/j.clinsp.2023.100296
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Zs.B 404: Show issues

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Article ; Online: From H1N1 to COVID-19: What we have seen in children with hemoglobinopathies.

Oliveira, Claudia de Melo / Soares, Victor Jablonski / Rechenmacher, Ciliana / Daudt, Liane Esteves / Michalowski, Mariana Bohns

Clinics (Sao Paulo, Brazil)

2022 Volume 77, Page(s) 100004

Abstract: This work aimed to better understand the impact of pandemics of respiratory viruses on children with hemoglobinopathies through a comprehensive review of the literature. MEDLINE, SCIELO, LILACS, and PUBMED were used as data sources to find articles ... ...

Abstract	This work aimed to better understand the impact of pandemics of respiratory viruses on children with hemoglobinopathies through a comprehensive review of the literature. MEDLINE, SCIELO, LILACS, and PUBMED were used as data sources to find articles without time period restrictions. Previous observations suggest that patients with hemoglobinopathies are a group especially susceptible to the complications of viral respiratory infections, with greater morbidity and mortality related to them. Within this context, this review found that, during the 2009 H1N1 pandemic, the risk of hospitalization in children and adults increased, especially in patients with a history of complications such as acute chest syndrome. In addition, the Coronavirus Disease 2019 (COVID-19) pandemic appears to have less repercussion among children with hemoglobinopathies compared to adults, similar to what is seen in the general population. In the H1N1 pandemic, patients with hemoglobinopathies behaved as a group more susceptible to complications, with increased morbidity and mortality. However, for COVID-19, the existing data to date on these patients do not show the same clinical impact. Thus, although these children deserve attention in case of infection due to their potential risks, they seem to have a favorable evolution.
MeSH term(s)	Adult ; COVID-19 ; Child ; Hemoglobinopathies/complications ; Hemoglobinopathies/epidemiology ; Humans ; Influenza A Virus, H1N1 Subtype ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2182801-5
ISSN	1980-5322 ; 1807-5932
ISSN (online)	1980-5322
ISSN	1807-5932
DOI	10.1016/j.clinsp.2021.100004
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Zs.B 404: Show issues

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Article ; Online: Monitoring asparaginase activity - Authors' reply.

Michalowski, Mariana Bohns / Daudt, Liane Esteves / Goldani, Marcelo Zubaran

The Lancet. Oncology

2018 Volume 19, Issue 11, Page(s) e576

MeSH term(s)	Antineoplastic Agents ; Asparaginase ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Chemical Substances	Antineoplastic Agents ; Asparaginase (EC 3.5.1.1)
Language	English
Publishing date	2018-11-01
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(18)30783-6
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Zs.A 5696: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of allogeneic stem cell transplantation in childhood and adolescence on quality of adulthood life: A case-control study.

de Oliveira da Silva, Priscila / Orlandini, Gabrielli Mottes / Paz, Alessandra / Dillenburg, Caroline Siviero / Michalowski, Mariana Bohns / Daudt, Liane Esteves

Pediatric transplantation

2022 Volume 26, Issue 7, Page(s) e14330

Abstract: Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with late complications that can impair the quality of life (QoL) of patients for years after transplant. The purpose of the present study was to determine the ... ...

Abstract	Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with late complications that can impair the quality of life (QoL) of patients for years after transplant. The purpose of the present study was to determine the difference in the QoL of adults that underwent allo-HSCT in childhood and adolescence compared with not transplanted adults. Methods: In this prospective case-control cross-sectional study, we included patients aged ≥18 years that received an allo-HSCT during childhood or adolescence and subsequently survived at least 2 years after transplantation. The control group consisted of blood donors matched for age and sex. QoL assessment was performed using the Short Form-36 (SF-36) Health Survey, Portuguese version 2. Results: Thirty-four transplanted patients and controls were included. 58.8% were male, and the median age at transplant was 13.5 years (range, 4-17 years). The median follow-up was 11.5 years (range, 2.0-23.0 years). The most common late effect was skeletally followed by endocrine complications. Patients with these late complications had the worst QOL in the following dimensions: physical functioning, role physical, bodily pain, general health, and mental health. When compared to the control group, patients had a lower score in two dimensions: physical functioning and role physical. Conclusions: Although skeletal and endocrine complications of transplant patients in childhood have an impact on physical functioning, most parameters of QoL of these patients in adulthood are similar to healthy individuals of the same age and gender. Early detection and long-term monitoring of late complications can prevent impairment of the QoL.
MeSH term(s)	Adolescent ; Adult ; Case-Control Studies ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Health Status ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Quality of Life
Language	English
Publishing date	2022-06-16
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.14330
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Zs.A 4947: Show issues

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Article ; Online: Antibiotic prophylaxis in acute childhood leukemia: What is known so far?

Dufrayer, Mauro Cesar / Monteiro, Yasmine Massaro Carneiro / Carlesse, Fabianne Altruda de Moraes Costa / Motta, Fabrizio / Daudt, Liane Esteves / Michalowski, Mariana Bohns

Hematology, transfusion and cell therapy

2022 Volume 45, Issue 4, Page(s) 473–482

Abstract: Introduction: The treatment of acute lymphoblastic leukemia (ALL) has evolved in recent decades, reaching an overall survival rate close to 90%. Currently, approximately 4% of patients with ALL die from secondary complications of chemotherapy. Among ... ...

Abstract	Introduction: The treatment of acute lymphoblastic leukemia (ALL) has evolved in recent decades, reaching an overall survival rate close to 90%. Currently, approximately 4% of patients with ALL die from secondary complications of chemotherapy. Among these complications, the most frequent is febrile neutropenia (FN). The treatment of acute myeloid leukemias (AMLs) is even more aggressive, being consequently related to a considerable amount of treatment-related toxicity with a high risk of severe infection and death. Method: In order to reduce the infection-related risks in these groups of patients, systemic antibacterial prophylaxis has emerged as a possible approach. Results: Antibiotic prophylaxis during neutropenia periods in those undergoing chemotherapy have .already been proven in adults with acute leukemias (ALs). Among the possible available therapeutic options for bacterial prophylaxis in children with cancer, fluoroquinolones emerged with the most amount of evidence. Within this class, levofloxacin became the best choice. Conclusion: Therefore, the use of levofloxacin seems to be indicated in very specific situations: in children who are known to be neutropenic for a long time, secondary to intensive chemotherapy; in children with AL undergoing chemotherapy to induce remission; or in children undergoing hematopoietic stem cell transplantation (HSCT). This article aims to describe recent evidence focusing on antibiotic prophylaxis in children with ALs.
Language	English
Publishing date	2022-11-21
Publishing country	Brazil
Document type	Journal Article ; Review
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2022.09.1279
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Article ; Online: Allergic reactions to asparaginase: retrospective cohort study in pediatric patients with acute lymphoid leukemia.

Battistel, Ana Paula / Rocha, Bruno Simas da / Santos, Maitê Telles Dos / Daudt, Liane Esteves / Michalowski, Mariana Bohns

Hematology, transfusion and cell therapy

2020 Volume 43, Issue 1, Page(s) 9–14

Abstract: Introduction: To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients.: Method: The study was performed based on retrospective data from patients under acute ... ...

Abstract	Introduction: To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients. Method: The study was performed based on retrospective data from patients under acute lymphoid leukemia treatment in a general university hospital located in southern Brazil. Information on patients who used ASP from 2010 to 2017 was collected. Allergic reactions were identified in electronic medical records. Results: Among the 98 patients included in the study, 16 (16.3 %) experienced an allergic reaction to native l-asparaginase (L-ASP). Of the 22 patients (22.4 %) that received only intravenous (IV) administration of l-ASP, 10 (62.5 %) had allergic reactions, while 48 patients (49 %) received intramuscular (IM) administration and 28 (28.6 %) received IV and IM administrations. The occurrence of allergic reactions differed between the groups (p <  0.001), and IV administration was associated with allergic reactions. Association was also observed between the severity of the reaction and the route of administration, with the IM route associated with grade 2 and IV route associated with grade 3. Occurrence of allergic reactions was higher when the commercial formulation of l-ASP, Leuginase®, was used (p =  0.0009 in the analysis per patient and p =  0.0003 in the analysis per administration). Conclusions: The IV administration and commercial Leuginase® presentation were associated with more allergic reactions in the study population, which corroborates the findings in the literature. The IV route was also associated with higher severity of reactions in the present study.
Language	English
Publishing date	2020-01-22
Publishing country	Brazil
Document type	Journal Article
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2019.10.007
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Article ; Online: The impact of COVID-19 in children with Sickle Cell Disease: Results of a multicentric registry.

Oliveira, Claudia de Melo / Soares, Victor Jablonski / Pellegrini Braga, Josefina Aparecida / Alcantara Bonilha, Thaís / Magalhães, Isis / Loggetto, Sandra Regina / Rechenmacher, Ciliana / Daudt, Liane Esteves / Michalowski, Mariana Bohns

PloS one

2023 Volume 18, Issue 4, Page(s) e0282423

Abstract: Objective: To analyze the outcomes of children with sickle cell disease (SCD) and COVID-19.: Method: A multicenter prospective study was conducted in five hematological centers from Central and Southeast Brazil, starting in April 2020. The variables ... ...

Abstract	Objective: To analyze the outcomes of children with sickle cell disease (SCD) and COVID-19. Method: A multicenter prospective study was conducted in five hematological centers from Central and Southeast Brazil, starting in April 2020. The variables recorded include clinical symptoms, diagnostic methods, therapeutic measures, and treatment sites. The clinical repercussions of the infection on the initial treatment and the overall prognosis were also evaluated. Results: Twenty-five unvaccinated children, aged 4 to 17 years, with SCD and a positive SARS-CoV-2 RT-PCR result participated in this study. Patients were classified as SCD types SS (n = 20, 80%) and SC (n = 5, 20%). Clinical characteristics and evolution were similar in both groups (p>0.05), except for the fetal hemoglobin value which was higher among the SC patients (p = 0.025). The most frequent symptoms were hyperthermia (72%) and cough (40%). Three children were admitted to the intensive care unit, all of whom were overweight/obese (p = 0.078). No deaths were observed. Conclusions: Although SCD leads to specific complications, the results found in this sample suggest that COVID-19 does not seem to carry an increased mortality risk in pediatric patients with this disease.
MeSH term(s)	Humans ; Child ; COVID-19/complications ; Prospective Studies ; SARS-CoV-2 ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/therapy ; Anemia, Sickle Cell/diagnosis ; Registries
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0282423
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Article ; Online: Safety of levofloxacin as an antibiotic prophylaxis in the induction phase of children newly diagnosed with acute lymphoblastic leukemia: an interim analysis of a randomized, open-label trial in Brazil.

Dufrayer, Mauro Cesar / Rechenmacher, Ciliana / Meneses, Clarice Franco / Monteiro, Yasmine Massaro Carneiro / Carlesse, Fabianne Altruda de Moraes Costa / Motta, Fabrizio / Daudt, Liane Esteves / Michalowski, Mariana Bohns

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

2023 Volume 27, Issue 2, Page(s) 102745

Abstract: Background: Despite high cure rates, treatment-related mortality in children with acute lymphoblastic leukemia (ALL) remains significant. About 4% of patients die during remission induction therapy and approximately two-thirds of treatment-related ... ...

Abstract	Background: Despite high cure rates, treatment-related mortality in children with acute lymphoblastic leukemia (ALL) remains significant. About 4% of patients die during remission induction therapy and approximately two-thirds of treatment-related deaths are due to infectious complications. Methods: From May 2021 to June 2022, children aged one through 18 years, with a recent diagnosis of ALL, admitted to three pediatric oncology centers in Brazil, were enrolled in this multicenter, open-label, randomized, phase 3 clinical trial. Eligible patients were randomly divided into two groups, based on a 1:1 allocation ratio, to receive, or not, levofloxacin as a prophylactic agent during the induction phase. All patients were treated according to the IC-BFM 2009 chemotherapy protocol. Primary endpoints were carbapenemase-producing Enterobacteriaceae (CPE) colonization, Clostridioides difficile diarrhea, and other adverse events related to the use of levofloxacin. The secondary endpoint was febrile neutropenia during induction. The median follow-up was 289 days. Results: Twenty patients were included in this trial, 10 in each group (control and levofloxacin). Mild adverse reactions related to levofloxacin were observed in three patients (30%). Three patients had Clostridioides difficile diarrhea, two in the levofloxacin group and one in the control group (p > 0.99). Only one patient presented colonization by CPE. This patient belonged to the levofloxacin group (p > 0.99). Nine patients presented febrile neutropenia, five in the control group and four in the levofloxacin intervention group (p > 0.99), one patient died due to febrile neutropenia. Conclusion: The use of levofloxacin was shown to be safe in the induction phase in children with de novo ALL. The use of this medication did not increase the rate of colonization by CPE nor the rate of diarrhea by C. difficile. All adverse reactions were mild and remitted either spontaneously or after switching medicine administration from oral to intravenous route.
MeSH term(s)	Humans ; Child ; Adolescent ; Levofloxacin/adverse effects ; Antibiotic Prophylaxis/methods ; Anti-Bacterial Agents/adverse effects ; Clostridioides difficile ; Brazil ; Febrile Neutropenia/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Diarrhea/complications ; Diarrhea/drug therapy
Chemical Substances	Levofloxacin (6GNT3Y5LMF) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-02-05
Publishing country	Brazil
Document type	Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	2041400-6
ISSN	1678-4391 ; 1413-8670
ISSN (online)	1678-4391
ISSN	1413-8670
DOI	10.1016/j.bjid.2023.102745
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Zs.A 5633: Show issues

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Article: Flow cytometry as a diagnostic tool in neuroblastoma

Furlanetto, Gislaine / Spagnol, Fabiane / Alegretti, Ana Paula / Farias, Mariela Granero / Soares, Victor Jablonski / Daudt, Liane Esteves / Loss, Jiseh Fagundes / Scroferneker, Maria Lúcia / Michalowski, Mariana Bohns

Journal of immunological methods. 2021 Nov., v. 498

2021

Abstract: In recent years, there has been an expansion in the use of flow cytometry (FC) immunophenotyping in the diagnosis and monitoring of childhood solid neoplasms. Neuroblastoma (NB), in turn, is the most common extracranial solid tumor in childhood. In the ... ...

Abstract	In recent years, there has been an expansion in the use of flow cytometry (FC) immunophenotyping in the diagnosis and monitoring of childhood solid neoplasms. Neuroblastoma (NB), in turn, is the most common extracranial solid tumor in childhood. In the present study, we sought to compare FC and anatomopathological examination (PA) / immunohistochemistry (IHC) of children diagnosed or suspected with NB. The median age was 59 months (minimum 0; maximum 325 months), of these 12 were male (57.1%, 12/21). Forty-eight samples (27 bone marrow (BM), 10 peripheral blood (PB), 8 primary tumors (PT) and 2 liver nodules (HN) and 1 rib fragment (RF)) from 21 patients were evaluated. Twenty-nine samples were from patients with clinical suspicion while 19 samples were from patients with previously confirmed diagnosis. Thirteen samples (7 BM, 5 PT and 1 HN) presented NB when analyzed in FC while 8 (3 BM and 5 PT) samples were positive for NB in the PA/IHC. They were concordant in 88.9% of the cases. No NB cells were identified in any PB. Considering the PA as the gold standard, the FC obtained a sensitivity of 100%, a specificity of 86%, a positive predictive value of 67% and a negative predictive value of 100%. This study demonstrates that FC can be used as a methodology for diagnosis and assessment of NB involvement. In addition, FC has the advantage of allowing a quick diagnosis and accurate classification of the disease, and can also assist in monitoring the treatment.
Keywords	blood ; bone marrow ; childhood ; diagnostic techniques ; flow cytometry ; immunohistochemistry ; immunophenotyping ; liver ; males ; neoplasms
Language	English
Dates of publication	2021-11
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2021.113135
Database	NAL-Catalogue (AGRICOLA)

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