Article: Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders.
2023 Volume 14, Page(s) 1291115
Abstract: Communication between the immune and the nervous system is essential for human brain development and homeostasis. Disruption of this intricately regulated crosstalk can lead to neurodevelopmental, psychiatric, or neurodegenerative disorders. While animal ...
Abstract | Communication between the immune and the nervous system is essential for human brain development and homeostasis. Disruption of this intricately regulated crosstalk can lead to neurodevelopmental, psychiatric, or neurodegenerative disorders. While animal models have been essential in characterizing the role of neuroimmunity in development and disease, they come with inherent limitations due to species specific differences, particularly with regard to microglia, the major subset of brain resident immune cells. The advent of induced pluripotent stem cell (iPSC) technology now allows the development of clinically relevant models of the central nervous system that adequately reflect human genetic architecture. This article will review recent publications that have leveraged iPSC technology to assess neuro-immune interactions. First, we will discuss the role of environmental stressors such as neurotropic viruses or pro-inflammatory cytokines on neuronal and glial function. Next, we will review how iPSC models can be used to study genetic risk factors in neurological and psychiatric disorders. Lastly, we will evaluate current challenges and future potential for iPSC models in the field of neuroimmunity. |
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Language | English |
Publishing date | 2023-11-09 |
Publishing country | Switzerland |
Document type | Journal Article ; Review |
ZDB-ID | 2564218-2 |
ISSN | 1664-0640 |
ISSN | 1664-0640 |
DOI | 10.3389/fpsyt.2023.1291115 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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