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  1. Article ; Online: Now that the door is open: an update on ischemic stroke pharmacotherapeutics for the neurointerventionalist.

    Fraser, Justin F / Pahwa, Shivani / Maniskas, Michael / Michas, Christopher / Martinez, Mesha / Pennypacker, Keith R / Dornbos, David

    Journal of neurointerventional surgery

    2024  Volume 16, Issue 4, Page(s) 425–428

    Abstract: The last 10 years have seen a major shift in management of large vessel ischemic stroke with changes towards ever-expanding use of reperfusion therapies (intravenous thrombolysis and mechanical thrombectomy). These strategies 'open the door' to acute ... ...

    Abstract The last 10 years have seen a major shift in management of large vessel ischemic stroke with changes towards ever-expanding use of reperfusion therapies (intravenous thrombolysis and mechanical thrombectomy). These strategies 'open the door' to acute therapeutics for ischemic tissue, and we should investigate novel therapeutic approaches to enhance survival of recently reperfused brain. Key insights into new approaches have been provided through translational research models and preclinical paradigms, and through detailed research on ischemic mechanisms. Additional recent clinical trials offer exciting salvos into this new strategy of pairing reperfusion with neuroprotective therapy. This pairing strategy can be employed using drugs that have shown neuroprotective efficacy; neurointerventionalists can administer these during or immediately after reperfusion therapy. This represents a crucial moment when we emphasize reperfusion, and have the technological capability along with the clinical trial experience to lead the way in multiprong approaches to stroke treatment.
    MeSH term(s) Humans ; Ischemic Stroke/drug therapy ; Brain Ischemia/drug therapy ; Stroke/drug therapy ; Thrombolytic Therapy ; Thrombectomy ; Treatment Outcome ; Fibrinolytic Agents/therapeutic use
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/jnis-2022-019293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6845: Show issues Location:
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  2. Article: Synthesis of Functionalized Phenanthrenes via Regioselective Oxidative Radical Cyclization

    Pati, Kamalkishore / Michas Christopher / Allenger David / Piskun Ilya / Coutros Peter S / Gomes Gabriel dos Passos / Alabugin Igor V

    Journal of organic chemistry. 2015 Dec. 04, v. 80, no. 23

    2015  

    Abstract: The majority of Sn-mediated cyclizations are reductive and, thus, cannot give a fully conjugated product. This is a limitation in the application of Sn-mediated radical cascades for the preparation of fully conjugated molecules. In this work, we report ... ...

    Abstract The majority of Sn-mediated cyclizations are reductive and, thus, cannot give a fully conjugated product. This is a limitation in the application of Sn-mediated radical cascades for the preparation of fully conjugated molecules. In this work, we report an oxidatively terminated Bu₃Sn-mediated cyclization of an alkyne where AIBN, the commonly used initiator, takes on a new function as an oxidative agent. Sn-mediated radical transformation of biphenyl aryl acetylenes into functionalized phenanthrenyl stannanes can be initiated via two potentially equilibrating vinyl radicals, one of which can be trapped by the fast 6-endoclosure at the biphenyl moiety in good to excellent yields. The efficient preparation of Sn-substituted phenanthrenes opens access to convenient building blocks for the construction of larger polyaromatics.
    Keywords alkynes ; cyclization reactions ; free radicals ; moieties ; organic chemistry ; phenanthrenes ; regioselectivity
    Language English
    Dates of publication 2015-1204
    Size p. 11706-11717.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021%2Facs.joc.5b01014
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Synthesis of Functionalized Phenanthrenes via Regioselective Oxidative Radical Cyclization.

    Pati, Kamalkishore / Michas, Christopher / Allenger, David / Piskun, Ilya / Coutros, Peter S / Gomes, Gabriel Dos Passos / Alabugin, Igor V

    The Journal of organic chemistry

    2015  Volume 80, Issue 23, Page(s) 11706–11717

    Abstract: The majority of Sn-mediated cyclizations are reductive and, thus, cannot give a fully conjugated product. This is a limitation in the application of Sn-mediated radical cascades for the preparation of fully conjugated molecules. In this work, we report ... ...

    Abstract The majority of Sn-mediated cyclizations are reductive and, thus, cannot give a fully conjugated product. This is a limitation in the application of Sn-mediated radical cascades for the preparation of fully conjugated molecules. In this work, we report an oxidatively terminated Bu3Sn-mediated cyclization of an alkyne where AIBN, the commonly used initiator, takes on a new function as an oxidative agent. Sn-mediated radical transformation of biphenyl aryl acetylenes into functionalized phenanthrenyl stannanes can be initiated via two potentially equilibrating vinyl radicals, one of which can be trapped by the fast 6-endoclosure at the biphenyl moiety in good to excellent yields. The efficient preparation of Sn-substituted phenanthrenes opens access to convenient building blocks for the construction of larger polyaromatics.
    Language English
    Publishing date 2015-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.5b01014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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