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  1. Article ; Online: Preliminary

    Hadda, Zebiri / Hélène, Van Den Berghe / Tom, Paunet / Aurélie, Wolf-Mandroux / Audrey, Bethry / Hubert, Taillades / Noël, Yohan Jean / Pirot, Nelly / Catherine, Botteron / Michel, Chammas / Pierre-Emmanuel, Chammas / Xavier, Garric

    Biomaterials science

    2022  Volume 10, Issue 7, Page(s) 1776–1786

    Abstract: Peritendinous adhesions are complications known to occur up to 6 weeks after surgery and cause chronic pain and disability. Anti-adhesion barriers are currently the best option for prevention. In a previous study, we designed two biodegradable membranes, ...

    Abstract Peritendinous adhesions are complications known to occur up to 6 weeks after surgery and cause chronic pain and disability. Anti-adhesion barriers are currently the best option for prevention. In a previous study, we designed two biodegradable membranes, D-PACO1 and D-PACO
    MeSH term(s) Achilles Tendon/pathology ; Achilles Tendon/surgery ; Animals ; Polyesters ; Polymers ; Rats ; Tissue Adhesions/prevention & control ; Wound Healing
    Chemical Substances Polyesters ; Polymers
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d1bm01150b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Preliminary in vivo study of biodegradable PLA–PEU–PLA anti-adhesion membranes in a rat Achilles tendon model of peritendinous adhesions

    Hadda, Zebiri / Hélène, Van Den Berghe / Tom, Paunet / Aurélie, Wolf-Mandroux / Audrey, Bethry / Hubert, Taillades / Noël, Yohan Jean / Pirot, Nelly / Catherine, Botteron / Michel, Chammas / Pierre-Emmanuel, Chammas / Xavier, Garric

    Biomaterials science. 2022 Mar. 29, v. 10, no. 7

    2022  

    Abstract: Peritendinous adhesions are complications known to occur up to 6 weeks after surgery and cause chronic pain and disability. Anti-adhesion barriers are currently the best option for prevention. In a previous study, we designed two biodegradable membranes, ...

    Abstract Peritendinous adhesions are complications known to occur up to 6 weeks after surgery and cause chronic pain and disability. Anti-adhesion barriers are currently the best option for prevention. In a previous study, we designed two biodegradable membranes, D-PACO1 and D-PACO₂, based on new triblock copolymers and conducted in vitro evaluations. The membranes maintained filmogenic integrity, had degradation rates that promoted anti-adhesion and were biocompatible, suggesting their safe and effective use as anti-adhesion devices. To test this hypothesis, we conducted a preliminary in vivo study in a rat model of peritendinous adhesions and evaluated the membranes’ degradation rates, tendon healing and anti-adhesion effect compared to non-surgical and surgical control groups 2 and 10 weeks after surgery. Macroscopic evaluation showed membranes were effective in reducing the extent and severity of adhesions. Membranes acted as physical barriers at 2 weeks and underwent a complete or significant biodegradation at 10 weeks. D-PACO₂ had a longer degradation rate compared to D-PACO1, was more effective in reducing adhesions and is expected to be more effective in promoting tendon healing. The tendency of D-PACO1 to promote tendon healing while D-PACO₂ did not interfere with healing highlights the need to redesign the porosity of the D-PACO membranes for optimal nutrient diffusion, while maintaining their anti-adhesion effect and clinical usability. Preliminary findings revealed that adhesions form beyond the 6 weeks cited in the literature. In this study, adhesion formation continued for up to 10 weeks, underlining the need to increase the experimental period and sample size of future experiments evaluating anti-adhesion membranes.
    Keywords Achilles tendon ; adhesion ; animal models ; biocompatible materials ; biodegradability ; biodegradation ; composite polymers ; pain ; porosity ; rats ; sample size ; surgery
    Language English
    Dates of publication 2022-0329
    Size p. 1776-1786.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d1bm01150b
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Carpal tunnel syndrome - Part II (treatment)

    Michel Chammas / Jorge Boretto / Lauren Marquardt Burmann / Renato Matta Ramos / Francisco Santos Neto / Jefferson Braga Silva

    Revista Brasileira de Ortopedia, Vol 49, Iss 5, Pp 437-

    2014  Volume 445

    Abstract: The treatments for non-deficit forms of carpal tunnel syndrome (CTS) are corticoid infiltration and/or a nighttime immobilization brace. Surgical treatment, which includes sectioning the retinaculum of the flexors (retinaculotomy), is indicated in cases ... ...

    Abstract The treatments for non-deficit forms of carpal tunnel syndrome (CTS) are corticoid infiltration and/or a nighttime immobilization brace. Surgical treatment, which includes sectioning the retinaculum of the flexors (retinaculotomy), is indicated in cases of resistance to conservative treatment in deficit forms or, more frequently, in acute forms. In minimally invasive techniques (endoscopy and mini-open), and even though the learning curve is longer, it seems that functional recovery occurs earlier than in the classical surgery, but with identical long-term results. The choice depends on the surgeon, patient, severity, etiology and availability of material. The results are satisfactory in close to 90% of the cases. Recovery of strength requires four to six months after regression of the pain of pillar pain type. This surgery has the reputation of being benign and has a complication rate of 0.2–0.5%.
    Keywords sÍndrome do túnel do carpo/fisiopatologia ; sÍndrome do túnel do carpo/etiologia ; sÍndrome do túnel do carpo/cirurgia ; Endoscopia ; Medicine ; R ; Orthopedic surgery ; RD701-811
    Subject code 616
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher Sociedade Brasileira de Ortopedia e Traumatologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Carpal tunnel syndrome - Part I (anatomy, physiology, etiology and diagnosis)

    Michel Chammas / Jorge Boretto / Lauren Marquardt Burmann / Renato Matta Ramos / Francisco Carlos dos Santos Neto / Jefferson Braga Silva

    Revista Brasileira de Ortopedia, Vol 49, Iss 5, Pp 429-

    2014  Volume 436

    Abstract: Carpal tunnel syndrome (CTS) is defined by compression of the median nerve in the wrist. It is the commonest of the compressive syndromes and its most frequent cause is idiopathic. Even though spontaneous regression is possible, the general rule is that ... ...

    Abstract Carpal tunnel syndrome (CTS) is defined by compression of the median nerve in the wrist. It is the commonest of the compressive syndromes and its most frequent cause is idiopathic. Even though spontaneous regression is possible, the general rule is that the symptoms will worsen. The diagnosis is primarily clinical, from the symptoms and provocative tests. Elec-troneuromyographic examination may be recommended before the operation or in cases of occupational illnesses.
    Keywords Sindrome do túnel do carpo/fisiopatologia ; Sindrome do túnel do carpo/etiologia ; Sindrome do túnel do carpo/diagnóstico ; Nervo mediano ; Medicine ; R ; Orthopedic surgery ; RD701-811
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher Sociedade Brasileira de Ortopedia e Traumatologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Changes in Mass and Performance in Rabbit Muscles after Muscle Damage with or without Transplantation of Primary Satellite Cells

    Ramzi Boubaker El Andalousi / Paul-André Daussin / Jean-Paul Micallef / Colette Roux / Jean Nougues / Michel Chammas / Yves Reyne / Francis Bacou

    Cell Transplantation, Vol

    2002  Volume 11

    Abstract: Changes in morphology, metabolism, myosin heavy chain gene expression, and functional performances in damaged rabbit muscles with or without transplantation of primary satellite cells were investigated. For this purpose, we damaged bilaterally the fast ... ...

    Abstract Changes in morphology, metabolism, myosin heavy chain gene expression, and functional performances in damaged rabbit muscles with or without transplantation of primary satellite cells were investigated. For this purpose, we damaged bilaterally the fast muscle tibialis anterior (TA) with either 1.5 or 2.6 ml cardiotoxin 10–5 M injections. Primary cultures of satellite cells were autotransplanted unilaterally 5 days after muscle degeneration. Two months postoperation, the masses of damaged TAs, with or without transplantation, were significantly larger than those of the controls. Furthermore, damaged transplanted muscles weighed significantly more than damaged muscles only. The increase in muscle mass was essentially due to increased fiber size. These results were independent of the quantity of cardiotoxin injected into the muscles. Maximal forces were similar in control and 2.6 ml damaged TAs with or without satellite cell transfer. In contrast, 1.5 ml damaged TAs showed a significant decrease in maximal forces that reached the level of controls after transplantation of satellite cells. Fatigue resistance was similar in control and 1.5 ml damaged TAs independently of satellite cell transfer. Fatigue index was significantly higher in 2.6 ml damaged muscles with or without cell transplantation. These changes could be explained in part by muscle metabolism, which shifted towards oxidative activities, and by gene expression of myosin heavy chain isoforms, which presented an increase in type IIa and a decrease in type I and IIb in all damaged muscles with or without cell transfer. Under our experimental conditions, these results show that muscle damage rather than satellite cell transplantation changes muscle metabolism, myosin heavy chain isoform gene expression, and, to a lesser extent, muscle contractile properties. In contrast, muscle weight and fiber size are increased both by muscle damage and by satellite cell transfer.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2002-03-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Transplantation of Adipose Tissue-Derived Stromal Cells Increases Mass and Functional Capacity of Damaged Skeletal Muscle

    Francis Bacou / Ramzi Boubaker El Andalousi / Paul-André Daussin / Jean-Paul Micallef / Jonathan M. Levin / Michel Chammas / Louis Casteilla / Yves Reyne / Jean Nouguès

    Cell Transplantation, Vol

    2004  Volume 13

    Abstract: The regenerating skeletal muscle environment is capable of inducing uncommitted progenitors to terminally differentiate. The aim of this work was to determine whether adipose tissue-derived stromal cells were able to participate in muscle regeneration ... ...

    Abstract The regenerating skeletal muscle environment is capable of inducing uncommitted progenitors to terminally differentiate. The aim of this work was to determine whether adipose tissue-derived stromal cells were able to participate in muscle regeneration and to characterize the effect on muscle mass and functional capacities after transplantation of these cells. Adipose tissue stromal cells labeled with Adv cyto LacZ from 3-day-old primary cultures (SVF1) were autotransplanted into damaged tibialis anterior muscles. Fifteen days later, β-galactosidase staining of regenerated fibers was detected, showing participation of these cells in muscle regeneration. Two months after SVF1 cell transfer, muscles were heavier, showed a significantly larger fiber section area, and developed a significantly higher maximal force compared with damaged control muscles. These results are similar to those previously obtained after satellite cell transplantation. However, SVF1 transfer also generated a small amount of adipose tissue localized along the needle course. To minimize these adipose contaminants, we transferred cells from 7-day-old secondary cultures of the SVF1, containing only a small proportion of already engaged preadipocytes (SVF2). Under these conditions, no adipose tissue was observed in regenerated muscle but there was also no effect on muscle performances compared with damaged control muscles. This result provides further evidence for the existence of progenitor cells in the stromal fraction of freshly isolated adipose tissue cells, which, under our conditions, keep some of their pluripotent properties in primary cultures.
    Keywords Medicine ; R
    Subject code 610 ; 571
    Language English
    Publishing date 2004-03-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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