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  1. AU="Michel Carles"
  2. AU="Haer, T."
  3. AU="Knapstein, Luke"
  4. AU="Zhao Ning"
  5. AU="Maiorka, Paulo César"
  6. AU="Dumolard, Anne"
  7. AU="Cheng-Zhong Zhang"
  8. AU="Song, Jiwu"
  9. AU="Terwilliger, Gordon"
  10. AU="Elhamzaoui, Hamza"
  11. AU="Béganton, Benoît"
  12. AU=Smith Zachary D.
  13. AU="Dotta, Federico"
  14. AU="Palmer, Andre"
  15. AU="Cai, Biao"
  16. AU="Leroux, Michel R"
  17. AU="Thomson, Jaidyn"
  18. AU="Novillo-Del Álamo, Blanca"
  19. AU="Deps, Patrícia D"

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  1. Artikel ; Online: COVID-19 patient experiences in prehospital pathways

    Patrick Peretti-Watel / Sébastien Cortaredona / Christian Pradier / Gaetan Gentile / Stéphanie Gentile / Philippe Brouqui / Michel Carles / Romain Lutaud / Lea Delorme / Juliette Mirouse / Manon Borg / Lucie Cattaneo / Didier Thery / Touitou Irit / Sophie Tardieu

    Family Medicine and Community Health, Vol 12, Iss

    a processual approach using life-events calendar method and state sequence analysis shows detrimental delays

    2024  Band 1

    Abstract: Objectives To our best knowledge, no study in France has comprehensively investigated the prehospital history of patients admitted for severe cases of COVID-19. ‘Patients’ voice is an excellent means to capture data on primary care pathways.We aimed to ... ...

    Abstract Objectives To our best knowledge, no study in France has comprehensively investigated the prehospital history of patients admitted for severe cases of COVID-19. ‘Patients’ voice is an excellent means to capture data on primary care pathways.We aimed to identify clusters of COVID-19 hospitalised patients with similar prehospital symptom sequences, and to test whether these clusters were associated with a higher risk of poor clinical outcomes.Design Cross-sectional online survey using life-event calendars.Setting All patients hospitalised for COVID-19 between September 2020 and May 2021 in the Infectious Disease Departments in Nice and in Marseilles in France.Participants 312 patients responded to the survey.Main outcome measures From the day of symptom onset to the day of hospitalisation, we defined a symptom sequence as the time-ordered vector of the successive symptom grades (grade 1, grade 2, grade 3). State sequence analysis with optimal matching was used to identify clusters of patients with similar symptom sequences. Multivariate logistic regressions were performed to test whether these clusters were associated with admission to intensive care unit (ICU) and COVID-19 sequelae after hospitalisation.Results Three clusters of symptom sequences were identified among 312 complete prehospital pathways. A specific group of patients (29%) experienced extended symptoms of severe COVID-19, persisting for an average duration of 7.5 days before hospitalisation. This group had a significantly higher probability of being admitted to ICU (adjusted OR 2.01). They were less likely to know a loved one who was a healthcare worker, and more likely to have a lower level of education. Similarly, this group of patients, who were more likely to have previously visited the emergency room without exhibiting severe symptoms at that time, may have been inclined to postpone reassessment when their health worsened.Their relatives played a decisive role in their hospitalisation.Conclusion and relevance This study highlights the negative ...
    Schlagwörter Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag BMJ Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Case Report

    Marion Louvois / Loïc Simon / Christelle Pomares / Pierre-Yves Jeandel / Elisa Demonchy / Michel Carles / Pascal Delaunay / Johan Courjon

    Frontiers in Medicine, Vol

    Autoimmune Hemolysis Anemia After Dihydroartemisinin and Piperaquine for Uncomplicated Plasmodium falciparum Malaria

    2022  Band 8

    Abstract: Malaria is still an endemic disease in Africa, with many imported cases in Europe. The standard treatment is intravenous artesunate for severe malaria and oral artemisinin-based combination therapy (ACT) for uncomplicated malaria. Delayed hemolytic ... ...

    Abstract Malaria is still an endemic disease in Africa, with many imported cases in Europe. The standard treatment is intravenous artesunate for severe malaria and oral artemisinin-based combination therapy (ACT) for uncomplicated malaria. Delayed hemolytic anemia (DHA) after intravenous artesunate has been extensively described, and guidelines recommend biological monitoring until 1 month after the end of the treatment. A link with an autoimmune process is still unsure. Nevertheless, cases with positive direct antiglobulin test (DAT) have been reported. Conversely, DHA is not recognized as an adverse effect of oral ACT. Previously, only few cases of DHA occurring after oral ACT without intravenous artesunate administration have been reported. We report the case of a 42-year-old man returning from Togo. He was treated with dihydroartemisinin/piperaquine combination for uncomplicated Plasmodium falciparum malaria, with low parasitemia. Nine days after the end of the treatment, the patient developed hemolytic anemia with positive DAT. Eventually, the patient recovered after corticotherapy. After excluding common causes of autoimmune hemolytic anemia, we considered that dihydroartemisinin/piperaquine treatment was involved in this side effect.
    Schlagwörter hemolytic anemia ; malaria ; artemisinin-based combination ; artemisinin derivatives ; autoimmune ; direct antiglobulin test ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Critical care medicine in the French Territories in the Americas

    Hatem Kallel / Dabor Resiere / Stéphanie Houcke / Didier Hommel / Jean Marc Pujo / Frederic Martino / Michel Carles / Hossein Mehdaoui

    Revista Panamericana de Salud Pública, Vol 45, Iss 46, Pp 1-

    Current situation and prospects

    2021  Band 7

    Abstract: Hospitals in the French Territories in the Americas (FTA) work according to international and French standards. This paper aims to describe different aspects of critical care in the FTA. For this, we reviewed official information about population size ... ...

    Abstract Hospitals in the French Territories in the Americas (FTA) work according to international and French standards. This paper aims to describe different aspects of critical care in the FTA. For this, we reviewed official information about population size and intensive care unit (ICU) bed capacity in the FTA and literature on FTA ICU specificities. Persons living in or visiting the FTA are exposed to specific risks, mainly severe road traffic injuries, envenoming, stab or ballistic wounds, and emergent tropical infectious diseases. These diseases may require specific knowledge and critical care management. However, there are not enough ICU beds in the FTA. Indeed, there are 7.2 ICU beds/100 000 population in Guadeloupe, 7.2 in Martinique, and 4.5 in French Guiana. In addition, seriously ill patients in remote areas regularly have to be transferred, most often by helicopter, resulting in a delay in admission to intensive care. The COVID-19 crisis has shown that the health care system in the FTA is unready to face such an epidemic and that intensive care bed capacity must be increased. In conclusion, the critical care sector in the FTA requires upgrading of infrastructure, human resources, and equipment as well as enhancement of multidisciplinary care. Also needed are promotion of training, research, and regional and international medical and scientific cooperation.
    Schlagwörter critical care ; tropical medicine ; french guiana ; guadeloupe ; martinique ; Medicine ; R ; Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 650
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag Pan American Health Organization
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Sciatic nerve block or not for outpatient total knee arthroplasty? Study protocol for a randomized controlled trial

    Laurie Tran / Melissa Barthelemy / Pascal Boileau / Marc Raucoules-Aime / Michel Carles / Christophe Trojani

    Trials, Vol 20, Iss 1, Pp 1-

    2019  Band 8

    Abstract: Abstract Background The number of patients operated on for total knee arthroplasty (TKA) is growing worldwide. Outpatient surgery is defined by a length of stay (LOS) in the hospital of less than 12 h. This can be limited for TKA, with the efficient ... ...

    Abstract Abstract Background The number of patients operated on for total knee arthroplasty (TKA) is growing worldwide. Outpatient surgery is defined by a length of stay (LOS) in the hospital of less than 12 h. This can be limited for TKA, with the efficient management of pain and perioperative complications, such as blood loss, affecting a safe hospital discharge. Outpatient TKA with a suitable protocol, including multimodal measures, could improve the success rate of this procedure. Among the main measures, single-shot sciatic nerve block in association with continuous femoral nerve block for pain control needs to be evaluated in outpatient TKA. Furthermore, to promote the safety of the postoperative period and to accelerate rehabilitation, patients who undergo ambulatory TKA could be discharged to a rehabilitation center on the day of surgery to screen adverse events and to optimize the rehabilitation process. This study is designed to assess the benefits of sciatic nerve block in postoperative pain relief for outpatient TKA. Methods/design This randomized prospective controlled study will be conducted in the knee unit of the teaching hospital of the Nice university and will include 40 patients undergoing primary unilateral outpatient TKA, discharged the day of surgery to a private rehabilitation center for enhanced recovery after surgery, after a hospital stay of less than 12 h. Before surgery, all patients will receive a continuous femoral nerve block with 2 mg/ml ropivacaine 20 ml, and then patients will be randomly assigned to receive or not receive a single-shot sciatic nerve block with 2 mg/ml ropivacaine, 20 ml. The primary outcome measure is the success rate of outpatient TKA. This rate is defined by patients discharged from the hospital to a rehabilitation center the day of surgery with no re-hospitalization due to insufficient pain control before the fifth postoperative day. Secondary outcomes include the incidence of major and minor adverse events during the first five postoperative days and measurement of the quality of recovery using the Knee injury and Osteoarthritis Outcome Score and the new International Knee Society scores plus the Quality of Recovery-40 questionnaire. Discussion The assessment of anesthesia and rehabilitation protocols enabling major orthopedic surgery, such as TKA, is necessary. This randomized controlled study will address the hypothesis that a suitable multimodal protocol including sciatic nerve block could improve pain control and thus improve the success rate of outpatient TKA. Trial registration EudraCT, 2016-000226-19. Registered on 15 April 2016.
    Schlagwörter Total knee arthroplasty ; Outpatient procedure ; Sciatic nerve block ; Randomized controlled study ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Emergence of Lyme Disease on the French Riviera, a Retrospective Survey

    Jacques Sevestre / Antoine Benichou / Vanessa Rio / Pascal Delaunay / Géraldine Gonfrier / Cécile Martaresche / Virginie Carlo / Sarah Nakam / Véronique Mondain / Michel Carles / Pierre Yves Jeandel / Jacques Durant

    Frontiers in Medicine, Vol

    2022  Band 9

    Abstract: BackgroundThe French Riviera has been declared free of Lyme Borreliosis (LB) for years. Many patients are referred for presumed LB, sometimes with atypical clinical signs and/or doubtful serology, calling the diagnosis into question.MethodsPatients were ... ...

    Abstract BackgroundThe French Riviera has been declared free of Lyme Borreliosis (LB) for years. Many patients are referred for presumed LB, sometimes with atypical clinical signs and/or doubtful serology, calling the diagnosis into question.MethodsPatients were assessed for LB diagnosis, depending on clinical presentation, laboratory findings, and further examination by other medical professionals.ResultsAmong 255 patients, 45 (18%) were classified as confirmed LB cases [including 28 ongoing LB (10%) and 17 past LB (8%)], and for 210 (82%) a Lyme borreliosis diagnosis was ruled out. Among ongoing LB, 56% had been exposed to or bitten by ticks, exclusively in rural locations of the Alpes-Maritimes. As a result of the diagnostic procedure, 132 (52%) patients had been treated. An alternative diagnosis was established for 134 (52%) patients, covering a wide range of conditions, including mainly psychological (28%) and neurological conditions (25%) or inflammatory and systemic diseases (22%).ConclusionsOur results strongly suggest the endemicity of LB in the Alpes-Maritimes region. Confirmed LB accounted for 18% of patients while 52% were diagnosed with other conditions.
    Schlagwörter Lyme ; Borrelia ; French Riviera ; borreliosis ; Ixodes ricinus ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Humoral and cellular responses after a third dose of SARS-CoV-2 BNT162b2 vaccine in patients with lymphoid malignancies

    Daniel Re / Barbara Seitz-Polski / Vesna Brglez / Michel Carles / Daisy Graça / Sylvia Benzaken / Stéphane Liguori / Khaled Zahreddine / Margaux Delforge / Béatrice Bailly-Maitre / Benjamin Verrière / Emmanuel Chamorey / Jérôme Barrière

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Band 9

    Abstract: Vaccination is effective in preventing severe COVID-19 symptoms. Here the authors monitor patients with hematopoietic malignancy to find the third dose of the mRNA vaccine, BNT162b2, only boosts the humoral immunity in those showing responses to 2nd dose ...

    Abstract Vaccination is effective in preventing severe COVID-19 symptoms. Here the authors monitor patients with hematopoietic malignancy to find the third dose of the mRNA vaccine, BNT162b2, only boosts the humoral immunity in those showing responses to 2nd dose vaccination but can induce an independent T-cell response in a fraction of seronegative patients.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France

    Johan Courjon / Julie Contenti / Elisa Demonchy / Jacques Levraut / Pascal Barbry / Géraldine Rios / Jean Dellamonica / David Chirio / Caroline Bonnefoy / Valérie Giordanengo / Michel Carles

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 6

    Abstract: Abstract The variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (Southeast of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this area. A high incidence rate together ... ...

    Abstract Abstract The variant 20I/501Y.V1, associated to a higher risk of transmissibility, emerged in Nice city (Southeast of France, French Riviera) during January 2021. The pandemic has resumed late December 2020 in this area. A high incidence rate together with a fast turn-over of the main circulating variants, provided us the opportunity to analyze modifications in clinical profile and outcome traits. We performed an observational study in the University hospital of Nice from December 2020 to February 2021. We analyzed data of sequencing of SARS-CoV-2 from the sewage collector and PCR screening from all positive samples at the hospital. Then, we described the characteristics of all COVID-19 patients admitted in the emergency department (ED) (n = 1247) and those hospitalized in the infectious diseases ward or ICU (n = 232). The UK-variant was absent in this area in December, then increasingly spread in January representing 59% of the PCR screening performed mid-February. The rate of patients over 65 years admitted to the ED decreased from 63 to 50% (p = 0.001). The mean age of hospitalized patients in the infectious diseases ward decreased from 70.7 to 59.2 (p < 0.001) while the proportion of patients without comorbidity increased from 16 to 42% (p = 0.007). Spread of the UK-variant in the Southeast of France affects younger and healthier patients.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag Nature Portfolio
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Protrusión acetabular en la artroplastia total de cadera

    Rafael Roque Benítez / Michel Carles Hirtenfeld

    Revista Cubana de Ortopedia y Traumatología, Vol 26, Iss 2, Pp 110-

    2012  Band 118

    Abstract: Introducción: la presencia de protrusión acetabular en un paciente que va a ser sometido a una artroplastia total de cadera indica un incremento de la dificultad de la intervención, toda vez que el tratamiento requiere la reconstrucción del defecto ... ...

    Abstract Introducción: la presencia de protrusión acetabular en un paciente que va a ser sometido a una artroplastia total de cadera indica un incremento de la dificultad de la intervención, toda vez que el tratamiento requiere la reconstrucción del defecto cavitario. Objetivo: evaluar los resultados del tratamiento de la protrusión acetabular con injerto óseo de la pared medial acetabular, en conjunción con una artroplastia total de cadera con componente acetabular no cementado. Métodos: estudio descriptivo, prospectivo y longitudinal en 38 pacientes que recibieron injerto óseo de la pared medial acetabular, en conjunción con una artroplastia total de cadera con componente acetabular no cementado, de enero de 2008 a diciembre de 2010. Se utilizó injerto autólogo en 23 pacientes y homólogo de banco en 15. Los pacientes se siguieron por examen físico y rayos X, realizados a las 4 semanas, a las 12 semanas, a los 6 meses y 1 año posterior a la cirugía. Resultados: todos los tipos de injerto aparentaron incorporase dentro del mismo período de aproximadamente 3 meses. Ningún paciente mostró progresión de la protrusión durante la etapa de consolidación del injerto o posterior. La puntuación en la escala de Harris mejoró de una media preoperatoria de 38 (22-55) a una media posoperatoria de 89 (80-95). Conclusión: la reconstrucción de la cavidad acetabular, con la utilización de injerto en la pared medial y componente acetabular no cementado, proporciona sustrato óseo suficiente para prolongar la vida útil de la artroplastia.
    Schlagwörter artroplastia total de cadera ; protrusión acetabular ; injerto óseo ; Surgery ; RD1-811 ; Medicine ; R
    Sprache Spanisch
    Erscheinungsdatum 2012-12-01T00:00:00Z
    Verlag Editorial Ciencias Médicas
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Three New Cases of Melioidosis, Guadeloupe, French West Indies

    Bénédicte Melot / Sylvaine Bastian / Nathalie Dournon / Eric Valade / Olivier Gorgé / Anne Le Fleche / Charlotte Idier / Mireille Vernier / Elisabeth Fernandes / Bruno Hoen / Sébastien Breurec / Michel Carles

    Emerging Infectious Diseases, Vol 26, Iss 3, Pp 617-

    2020  Band 619

    Abstract: Melioidosis has been detected in the Caribbean, and an increasing number of cases has been reported in the past few decades, but only 2 cases were reported in Guadeloupe during the past 20 years. We describe 3 more cases that occurred during 2016–2017 ... ...

    Abstract Melioidosis has been detected in the Caribbean, and an increasing number of cases has been reported in the past few decades, but only 2 cases were reported in Guadeloupe during the past 20 years. We describe 3 more cases that occurred during 2016–2017 and examine arguments for increasing endemicity.
    Schlagwörter melioidosis ; Burkholderia pseudomallei ; endemicity ; Caribbean ; Guadeloupe ; French West Indies ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag Centers for Disease Control and Prevention
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Salivary detection of COVID-19

    Jacques Boutros / Jonathan Benzaquen / Charles Hugo Marquette / Marius Ilié / Mickelina Labaky / Didier Benchetrit / Thibaut Lavrut / Sylvie Leroy / Richard Chemla / Michel Carles / Virginie Tanga / Charlotte Maniel / Olivier Bordone / Maryline Allégra / Virginie Lespinet / Julien Fayada / Jennifer Griffonnet / Véronique Hofman / Paul Hofman

    ERJ Open Research, Vol 7, Iss

    clinical performance of oral sponge sampling for SARS-CoV-2 testing

    2021  Band 4

    Abstract: Background The current diagnostic standard for coronavirus disease 2019 (COVID-19) is reverse transcriptase-polymerase chain reaction (RT-PCR) testing with nasopharyngeal (NP) swabs. The invasiveness and need for trained personnel make the NP technique ... ...

    Abstract Background The current diagnostic standard for coronavirus disease 2019 (COVID-19) is reverse transcriptase-polymerase chain reaction (RT-PCR) testing with nasopharyngeal (NP) swabs. The invasiveness and need for trained personnel make the NP technique unsuited for repeated community-based mass screening. We developed a technique to collect saliva in a simple and easy way with the sponges that are usually used for tamponade of epistaxis. This study was carried out to validate the clinical performance of oral sponge (OS) sampling for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. Methods Over a period of 22 weeks, we collected prospectively 409 paired NP and OS samples from consecutive subjects presenting to a public community-based free screening centre. Subjects were referred by their attending physician because of recent COVID-19 symptoms (n = 147) or by the contact tracing staff of the French public health insurance because they were considered as close contacts of a laboratory-confirmed COVID-19 case (n = 262). Results In symptomatic subjects, RT-PCR SARS-CoV-2 testing with OS showed a 96.5% (95% CI: 89.6–94.8) concordance with NP testing, and a 93.2% (95% CI: 89.1–97.3) sensitivity when using the IdyllaTM platform and a sensitivity of 76.3% (95% CI: 69.4–83.2) on the Synlab Barla laboratory platform. In close contacts the NP-OS concordance (93.8%, 95% CI: 90.9–96.7) and OS sensitivity (71.9%, 95% CI: 66.5–77.3) were slightly lower. Conclusion These results strongly suggest that OS testing is a straightforward, low-cost and high-throughput sampling method that can be used for frequent RT-PCR testing of COVID-19 patients and mass screening of populations.
    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag European Respiratory Society
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