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  1. Article ; Online: SARS-CoV-2 serology in 4000 health care and administrative staff across seven sites in Lombardy, Italy

    Maria Teresa Sandri / Elena Azzolini / Valter Torri / Sara Carloni / Chiara Pozzi / Michela Salvatici / Michele Tedeschi / Massimo Castoldi / Alberto Mantovani / Maria Rescigno

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 14

    Abstract: Abstract Lombardy is the Italian region most affected by COVID-19. We tested the presence of plasma anti-SARS-CoV-2 IgG antibodies in 3985 employees across 7 healthcare facilities in areas of Lombardy with different exposure to the SARS-CoV-2 epidemic. ... ...

    Abstract Abstract Lombardy is the Italian region most affected by COVID-19. We tested the presence of plasma anti-SARS-CoV-2 IgG antibodies in 3985 employees across 7 healthcare facilities in areas of Lombardy with different exposure to the SARS-CoV-2 epidemic. Subjects filled a questionnaire to self-report on COVID-19 symptoms, comorbidities, smoking, regular or remote working, and the exposure to COVID-infected individuals. We show that the number of individuals exposed to the virus depended on the geographical location of the facility, ranging between 3 and 43%, consistent with the spatial variation of COVID-19 incidence in Lombardy, and correlated with family interactions. We observed a higher prevalence of females than males positive for IgG, however the level of antibodies was similar, suggesting a comparable magnitude of the anti-spike antibody response. IgG positivity among smokers was lower (7.4% vs 13.5%) although without difference in IgG plasma levels. We observed 11.9% of IgG positive asymptomatic individuals and another 23.1% with one or two symptoms. Interestingly, among the IgG positive population, 81.2% of subjects with anosmia/dysgeusia and fever were SARS-CoV-2 infected, indicating that these symptoms are strongly associated to COVID-19. In conclusion, the frequency of IgG positivity and SARS-CoV-2 infection is dependent on the geographical exposure to the virus and primarily to family rather than hospital exposure.
    Keywords Medicine ; R ; Science ; Q
    Subject code 360
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Association between Cardiac Troponin I and Mortality in Patients with COVID-19

    Michela, Salvatici / Barbara, Barbieri / Cioffi, Sara Maria Giulia / Morenghi, Emanuela / Leone, Francesco Paolo / Maura, Federica / Moriello, Giuseppe / Sandri, Maria Teresa

    Biomarkers

    2020  , Page(s) 1–22

    Keywords Clinical Biochemistry ; Biochemistry ; Health, Toxicology and Mutagenesis ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1324372-x
    ISSN 1354-750X
    ISSN 1354-750X
    DOI 10.1080/1354750x.2020.1831609
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Circulating MicroRNAs as Potential Predictors of Anthracycline-Induced Troponin Elevation in Breast Cancer Patients

    Sonia Gioffré / Mattia Chiesa / Daniela Maria Cardinale / Veronica Ricci / Chiara Vavassori / Carlo Maria Cipolla / Serge Masson / Maria Teresa Sandri / Michela Salvatici / Fabio Ciceri / Roberto Latini / Lidia Irene Staszewsky / Giulio Pompilio / Gualtiero I. Colombo / Yuri D’Alessandra

    Journal of Clinical Medicine, Vol 9, Iss 1418, p

    Diverging Effects of Doxorubicin and Epirubicin

    2020  Volume 1418

    Abstract: Anthracyclines are anti-neoplastic drugs presenting cardiotoxicity as a side effect. Cardiac troponins (cTn) and echocardiography are currently used to assess cardiac damage and dysfunction, but early biomarkers identifying patients in need of preventive ...

    Abstract Anthracyclines are anti-neoplastic drugs presenting cardiotoxicity as a side effect. Cardiac troponins (cTn) and echocardiography are currently used to assess cardiac damage and dysfunction, but early biomarkers identifying patients in need of preventive treatments remain a partially met need. Circulating microRNAs (miRNAs) represent good candidates, so we investigated their possible roles as predictors of troponin elevation upon anthracycline treatment. Eighty-eight female breast cancer patients administered with doxorubicin (DOX) or epirubicin (EPI) were divided into four groups basing on drug type and cTn positive (cTn+) or negative (cTn−) levels: DOX cTn−, DOX cTn+, EPI cTn− and EPI cTn+. Blood was collected at baseline, during treatment, and at follow-up. We identified plasma miRNAs of interest by OpenArray screening and single assay validation. Our results showed miR-122-5p, miR-499a-5p and miR-885-5p dysregulation in DOX patients at T0, identifying a signature separating, with good accuracy, DOX cTn− from DOX cTn+. No miRNAs showed differential expression in EPI subjects. Conversely, an anthracycline-mediated modulation (regardless of cTn) was observed for miR-34a-5p, -122-5p and -885-5p. Our study indicates specific circulating miRNAs as possible prediction markers for cardiac troponin perturbation upon anthracycline treatment. Indeed, our findings hint at the possible future use of plasma miRNAs to predict the cardiac responsiveness of patients to different anticancer agents.
    Keywords microRNA ; anthracyclines ; biomarkers ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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