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  1. AU="Michele Simeone"
  2. AU="Reynolds, Kimberly A"
  3. AU=Hua Cheng-Ge AU=Hua Cheng-Ge
  4. AU="Sorli, Luisa"
  5. AU=Ahmad Shah Adil Ishtiyaq
  6. AU="Bock, Thomas"
  7. AU=Chang Hyejung
  8. AU="Messer, Alison"
  9. AU="Samarzija, Miroslav"
  10. AU="Oh, Yun-Hee"
  11. AU="Ramos, Jairo"
  12. AU="Chauhan Kushwah, Vinita"
  13. AU="Winter, Katrin"
  14. AU="Berro, Julien"
  15. AU=Cummins Claire B.
  16. AU="Damholt, A"
  17. AU="Muthu, Santhosh Kumar"
  18. AU="Tysinger, Emma"
  19. AU=Covarrubias David
  20. AU="Dino Papeš"
  21. AU="Assis, Daniel Barbosa"
  22. AU="Lauquin, Guy J-M"

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  1. Artikel ; Online: Mental Health Interest and Its Prediction during the COVID-19 Pandemic Using Google Trends

    Magdalena Sycińska-Dziarnowska / Liliana Szyszka-Sommerfeld / Karolina Kłoda / Michele Simeone / Krzysztof Woźniak / Gianrico Spagnuolo

    International Journal of Environmental Research and Public Health, Vol 18, Iss 12369, p

    2021  Band 12369

    Abstract: This study aimed to analyze and predict interest in mental health-related queries created in Google Trends (GT) during the COVID-19 pandemic. The Google Trends tool collected data on the Google search engine interest and provided real-time surveillance. ... ...

    Abstract This study aimed to analyze and predict interest in mental health-related queries created in Google Trends (GT) during the COVID-19 pandemic. The Google Trends tool collected data on the Google search engine interest and provided real-time surveillance. Five key phrases: “depression”, “insomnia”, ”loneliness”, “psychologist”, and “psychiatrist”, were studied for the period from 25 September 2016 to 19 September 2021. The predictions for the upcoming trend were carried out for the period from September 2021 to September 2023 and were estimated by a hybrid five-component model. The results show a decrease of interest in the search queries “depression” and “loneliness” by 15.3% and 7.2%, respectively. Compared to the period under review, an increase of 5.2% in “insomnia” expression and 8.4% in the “psychiatrist” phrase were predicted. The expression “psychologist” is expected to show an almost unchanged interest. The upcoming changes in the expressions connected with mental health might be explained by vaccination and the gradual removal of social distancing rules. Finally, the analysis of GT can provide a timely insight into the mental health interest of a population and give a forecast for a short period trend.
    Schlagwörter mental health ; depression ; insomnia ; loneliness ; psychologist ; psychiatrist ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2021-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The Efficacy of Selected Sodium Hypochlorite Heating Methods for Increasing and Maintaining Its Intracanal Temperature—An Ex Vivo Study

    Roberto De Santis / Flavia Iaculli / Vincenzo Lodato / Vito Gallicchio / Michele Simeone / Gianrico Spagnuolo / Carlo Rengo

    Applied Sciences, Vol 12, Iss 891, p

    2022  Band 891

    Abstract: Background : Enhancement of the temperature of sodium hypochlorite (NaOCl) solution would increase its cleaning potential and decontamination of the root canal system. Therefore, the aim of the present in vitro investigation was to compare the efficacy ... ...

    Abstract Background : Enhancement of the temperature of sodium hypochlorite (NaOCl) solution would increase its cleaning potential and decontamination of the root canal system. Therefore, the aim of the present in vitro investigation was to compare the efficacy of different methods of NaOCl heating by evaluating the temperature profiles developed at different levels of the root canal system. Methods : Five thermocouples were applied at different levels of the root canal system of extracted human premolars. NaOCl solution was heated according to two methods: extraoral heating (50 °C, 60 °C, and 70 °C) using a magnetic hotplate heater and intracanal heating by F-06, XF-30/04, and ML-12 pluggers at 100 °C, 150 °C, and 180 °C. Results : The extraoral heating method was ineffective to produce a significant temperature increase at the root apex. Comparable results were obtained using the intracanal heating method through the ML-12 plugger that showed slightly better results only when set at 180 °C. On the other hand, negligible differences were observed in terms of temperature maintenance at several levels of the root between the F-06 and XF-30/04 pluggers, even though the time intervals were higher in case of XF-30/04. Conclusions : The intracanal heating method provided a better temperature persistence in the middle third of the root canal system. Conversely, extraoral heating was ineffective to produce a significant temperature increase at the apex of the root. Comparable results were obtained even using the ML-12 plugger.
    Schlagwörter endodontics ; heating ; irrigants ; root canal system ; sodium hypochlorite ; thermocouples ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 620
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: The Impact of Optogenetics on Regenerative Medicine

    Gianrico Spagnuolo / Fabio Genovese / Leonzio Fortunato / Michele Simeone / Carlo Rengo / Marco Tatullo

    Applied Sciences, Vol 10, Iss 1, p

    2019  Band 173

    Abstract: Optogenetics is a novel strategic field that combines light (opto-) and genetics (genetic) into applications able to control the activity of excitable cells and neuronal circuits. Using genetic manipulation, optogenetics may induce the coding of ... ...

    Abstract Optogenetics is a novel strategic field that combines light (opto-) and genetics (genetic) into applications able to control the activity of excitable cells and neuronal circuits. Using genetic manipulation, optogenetics may induce the coding of photosensitive ion channels on specific neurons: this non-invasive technology combines several approaches that allow users to achieve improved optical control and higher resolution. This technology can be applied to optical systems already present in the clinical-diagnostic field, and it has also excellent effects on biological investigations and on therapeutic strategies. Recently, several biomedical applications of optogenetics have been investigated, such as applications in ophthalmology, in bone repairing, in heart failure recovery, in post-stroke recovery, in tissue engineering, and regenerative medicine (TERM). Nevertheless, the most promising and developed applications of optogenetics are related to dynamic signal coding in cell physiology and neurological diseases. In this review, we will describe the state of the art and future insights on the impact of optogenetics on regenerative medicine.
    Schlagwörter optogenetics ; regenerative medicine ; biomedical applications ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 621
    Sprache Englisch
    Erscheinungsdatum 2019-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Positively charged polymers modulate the fate of human mesenchymal stromal cells via ephrinB2/EphB4 signaling

    Ilenia De Luca / Anna Di Salle / Nicola Alessio / Sabrina Margarucci / Michele Simeone / Umberto Galderisi / Anna Calarco / Gianfranco Peluso

    Stem Cell Research, Vol 17, Iss 2, Pp 248-

    2016  Band 255

    Abstract: Understanding the mechanisms by which mesenchymal stromal cells (MSCs) interact with the physical properties (e.g. topography, charge, ζ-potential, and contact angle) of polymeric surfaces is essential to design new biomaterials capable of regulating ... ...

    Abstract Understanding the mechanisms by which mesenchymal stromal cells (MSCs) interact with the physical properties (e.g. topography, charge, ζ-potential, and contact angle) of polymeric surfaces is essential to design new biomaterials capable of regulating stem cell behavior. The present study investigated the ability of two polymers (pHM1 and pHM3) with different positive surface charge densities to modulate the differentiation of MSCs into osteoblast-like phenotype via cell-cell ephrinB2/EphB4 signaling. Although pHM1 promoted the phosphorylation of EphB4, leading to cell differentiation, pHM3, characterized by a high positive surface charge density, had no significant effect on EphB4 activation or MSCs differentiation. When the MSCs were cultured on pHM1 in the presence of a forward signaling blocking peptide, the osteoblast differentiation was compromised. Our results demonstrated that the ephrinB2/EphB4 interaction was required for MSCs differentiation into an osteoblast-like phenotype and that the presence of a high positive surface charge density altered this interaction.
    Schlagwörter Cationic polymers ; MSCs differentiation ; Cell-cell ephrinB2/EphB4 signaling ; Regenerative medicine ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 500 ; 571
    Sprache Englisch
    Erscheinungsdatum 2016-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Direct restoration modalities of fractured central maxillary incisors: A multi-levels validated finite elements analysis with in vivo strain measurements.

    Davide, Apicella / Raffaella, Aversa / Marco, Tatullo / Michele, Simeone / Syed, Jamaluddin / Massimo, Marrelli / Marco, Ferrari / Antonio, Apicella

    Dental materials : official publication of the Academy of Dental Materials

    2015  Band 31, Heft 12, Seite(n) e289–305

    Abstract: Objective: To quantify the influence of fracture geometry and restorative materials rigidity on the stress intensity and distribution of restored fractured central maxillary incisors (CMI) with particular investigation of the adhesive interfaces. ... ...

    Abstract Objective: To quantify the influence of fracture geometry and restorative materials rigidity on the stress intensity and distribution of restored fractured central maxillary incisors (CMI) with particular investigation of the adhesive interfaces. Ancillary objectives are to present an innovative technology to measure the in vivo strain state of sound maxillary incisors and to present the collected data.
    Methods: A validation experimental biomechanics approach has been associated to finite element analysis. FEA models consisted of CMI, periodontal ligament and the corresponding alveolar bone process. Three models were created representing different orientation of the fracture planes. Three different angulations of the fracture plane in buccal-palatal direction were modeled: the fracture plane perpendicular to the long axis in the buccal-palatal direction (0°); the fracture plane inclined bucco-palatally in apical-coronal direction (-30°); the fracture plane inclined palatal-buccally in apical-coronal direction (+30°). First set of computing runs was performed for in vivo FE-model validation purposes. In the second part, a 50N force was applied on the buccal aspect of the CMI models. Ten patients were selected and subjected to the strain measurement of CMI under controlled loading conditions.
    Results: The main differences were noticed in the middle and incisal thirds of incisors crowns, due to the presence of the incisal portion restoration. The stress intensity in -30° models is increased in the enamel structure close to the restoration, due to a thinning of the remaining natural tissues. The rigidity of the restoring material slightly reduces such phenomenon. -30° model exhibits the higher interfacial stress in the adhesive layer with respect to +30° and 0° models. The lower stress intensity was noticed in the 0° models, restoration material rigidity did not influenced the interfacial stress state in 0° models. On the contrary, material rigidity influenced the interfacial stress state in +30° and -30° models, higher rigidity restoring materials exhibits lower interfacial stress with respect to low rigidity materials.
    Significance: Fracture planes inclined palatal-buccally in apical-coronal direction (+30°) reduce the interfacial stress intensity and natural tissues stress intensity with respect to the other tested configurations.
    Mesh-Begriff(e) Adolescent ; Adult ; Computer-Aided Design ; Dental Restoration, Permanent/methods ; Dental Stress Analysis ; Female ; Finite Element Analysis ; Humans ; Incisor/injuries ; Male ; Maxilla ; Tensile Strength ; Tooth Fractures/therapy
    Sprache Englisch
    Erscheinungsdatum 2015-12
    Erscheinungsland England
    Dokumenttyp Clinical Trial ; Journal Article
    ZDB-ID 605995-8
    ISSN 1879-0097 ; 0109-5641
    ISSN (online) 1879-0097
    ISSN 0109-5641
    DOI 10.1016/j.dental.2015.09.016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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