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Article ; Online: Novel, Selective, and Developable Dopamine D

Micheli, Fabrizio

2017 Volume 12, Issue 16, Page(s) 1254–1260

Abstract: This Minireview describes a presentation made at the XXIV National Meeting in Medicinal Chemistry (NMMC) held in Perugia (Italy), September 11-14, 2016. It relates to the discovery of novel templates of the so-called "amino" region of dopamine ... ...

Abstract	This Minireview describes a presentation made at the XXIV National Meeting in Medicinal Chemistry (NMMC) held in Perugia (Italy), September 11-14, 2016. It relates to the discovery of novel templates of the so-called "amino" region of dopamine D
MeSH term(s)	Dopamine Antagonists/chemistry ; Dopamine Antagonists/metabolism ; Drug Design ; Heptanes/chemistry ; Heptanes/metabolism ; Humans ; Morpholines/chemistry ; Morpholines/metabolism ; Protein Binding ; Pyrroles/chemistry ; Pyrroles/metabolism ; Receptors, Dopamine D2/chemistry ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3/antagonists & inhibitors ; Receptors, Dopamine D3/metabolism ; Structure-Activity Relationship
Chemical Substances	Dopamine Antagonists ; Heptanes ; Morpholines ; Pyrroles ; Receptors, Dopamine D2 ; Receptors, Dopamine D3 ; morpholine (8B2ZCK305O)
Language	English
Publishing date	2017-08-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.201700148
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Article ; Online: Exploring multiple stressor effects with Ecopath, Ecosim, and Ecospace: Research designs, modeling techniques, and future directions.

Stock, A / Murray, C C / Gregr, E J / Steenbeek, J / Woodburn, E / Micheli, F / Christensen, V / Chan, K M A

The Science of the total environment

2023 Volume 869, Page(s) 161719

Abstract: Understanding the cumulative effects of multiple stressors is a research priority in environmental science. Ecological models are a key component of tackling this challenge because they can simulate interactions between the components of an ecosystem. ... ...

Abstract	Understanding the cumulative effects of multiple stressors is a research priority in environmental science. Ecological models are a key component of tackling this challenge because they can simulate interactions between the components of an ecosystem. Here, we ask, how has the popular modeling platform Ecopath with Ecosim (EwE) been used to model human impacts related to climate change, land and sea use, pollution, and invasive species? We conducted a literature review encompassing 166 studies covering stressors other than fishing mostly in aquatic ecosystems. The most modeled stressors were physical climate change (60 studies), species introductions (22), habitat loss (21), and eutrophication (20), using a range of modeling techniques. Despite this comprehensive coverage, we identified four gaps that must be filled to harness the potential of EwE for studying multiple stressor effects. First, only 12% of studies investigated three or more stressors, with most studies focusing on single stressors. Furthermore, many studies modeled only one of many pathways through which each stressor is known to affect ecosystems. Second, various methods have been applied to define environmental response functions representing the effects of single stressors on species groups. These functions can have a large effect on the simulated ecological changes, but best practices for deriving them are yet to emerge. Third, human dimensions of environmental change - except for fisheries - were rarely considered. Fourth, only 3% of studies used statistical research designs that allow attribution of simulated ecosystem changes to stressors' direct effects and interactions, such as factorial (computational) experiments. None made full use of the statistical possibilities that arise when simulations can be repeated many times with controlled changes to the inputs. We argue that all four gaps are feasibly filled by integrating ecological modeling with advances in other subfields of environmental science and in computational statistics.
MeSH term(s)	Humans ; Ecosystem ; Research Design ; Models, Theoretical ; Introduced Species ; Climate Change
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.161719
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Article ; Online: Size-dependent vulnerability to herbivory in a coastal foundation species.

Ng, Crystal A / Micheli, Fiorenza

Oecologia

2020 Volume 193, Issue 1, Page(s) 199–209

Abstract: Ecologists have long wondered how plants and algae persist under constant herbivory, and studies have shown that factors like chemical defense and morphology can protect these species from consumption. However, grazers are also highly diverse and exert ... ...

Abstract	Ecologists have long wondered how plants and algae persist under constant herbivory, and studies have shown that factors like chemical defense and morphology can protect these species from consumption. However, grazers are also highly diverse and exert varying top-down control over primary producers depending on traits such as body size. Moreover, susceptibility of plants and algae to herbivory may vary across life stages and size classes, with juveniles potentially the most vulnerable. Here, we focus on diverse grazing communities within giant kelp forests and compared consumption on two size classes of juvenile giant kelp (Macrocystis pyrifera) across four herbivore species ranging in size. We also integrated field and literature densities to estimate impacts on populations of juvenile kelp. We found that purple sea urchins, a species known for exerting strong control over adult M. pyrifera, had weak per capita impact on microscopic kelp, on par with a much smaller crustacean species. While urchin consumption increased with macroscopic juvenile kelp, it never surpassed the smaller brown turban snail, suggesting that feeding morphology, in addition to herbivore body size, is a predictor of consumption at these small size classes. The smaller herbivores also occurred in high densities in the field, increasing their predicted population-level impacts on juvenile kelp compared to urchins and perhaps other larger, but less abundant, herbivores. This study highlights the variation in species' roles within an herbivore guild and the importance of age-related changes in grazing vulnerability to better understand herbivore control on plant and algae population dynamics.
MeSH term(s)	Ecosystem ; Forests ; Herbivory ; Kelp ; Macrocystis
Language	English
Publishing date	2020-04-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123369-5
ISSN	1432-1939 ; 0029-8549
ISSN (online)	1432-1939
ISSN	0029-8549
DOI	10.1007/s00442-020-04655-3
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Article ; Online: Short-term effects of hypoxia are more important than effects of ocean acidification on grazing interactions with juvenile giant kelp (Macrocystis pyrifera).

Ng, Crystal A / Micheli, Fiorenza

Scientific reports

2020 Volume 10, Issue 1, Page(s) 5403

Abstract: Species interactions are crucial for the persistence of ecosystems. Within vegetated habitats, early life stages of plants and algae must survive factors such as grazing to recover from disturbances. However, grazing impacts on early stages, especially ... ...

Abstract	Species interactions are crucial for the persistence of ecosystems. Within vegetated habitats, early life stages of plants and algae must survive factors such as grazing to recover from disturbances. However, grazing impacts on early stages, especially under the context of a rapidly changing climate, are largely unknown. Here we examine interaction strengths between juvenile giant kelp (Macrocystis pyrifera) and four common grazers under hypoxia and ocean acidification using short-term laboratory experiments and field data of grazer abundances to estimate population-level grazing impacts. We found that grazing is a significant source of mortality for juvenile kelp and, using field abundances, estimate grazers can remove on average 15.4% and a maximum of 73.9% of juveniles per m
MeSH term(s)	Biomass ; Ecosystem ; Food Chain ; Hydrogen-Ion Concentration ; Hypoxia/physiopathology ; Kelp/physiology ; Macrocystis/physiology ; Seawater
Language	English
Publishing date	2020-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-62294-3
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Article ; Online: Short- and long-term impacts of variable hypoxia exposures on kelp forest sea urchins.

Low, Natalie H N / Micheli, Fiorenza

Scientific reports

2020 Volume 10, Issue 1, Page(s) 2632

Abstract: Climate change is altering the intensity and variability of environmental stress that organisms and ecosystems experience, but effects of changing stress regimes are not well understood. We examined impacts of constant and variable sublethal hypoxia ... ...

Abstract	Climate change is altering the intensity and variability of environmental stress that organisms and ecosystems experience, but effects of changing stress regimes are not well understood. We examined impacts of constant and variable sublethal hypoxia exposures on multiple biological processes in the sea urchin Strongylocentrotus purpuratus, a key grazer in California Current kelp forests, which experience high variability in physical conditions. We quantified metabolic rates, grazing, growth, calcification, spine regeneration, and gonad production under constant, 3-hour variable, and 6-hour variable exposures to sublethal hypoxia, and compared responses for each hypoxia regime to normoxic conditions. Sea urchins in constant hypoxia maintained baseline metabolic rates, but had lower grazing, gonad development, and calcification rates than those in ambient conditions. The sublethal impacts of variable hypoxia differed among biological processes. Spine regrowth was reduced under all hypoxia treatments, calcification rates under variable hypoxia were intermediate between normoxia and constant hypoxia, and gonad production correlated negatively with continuous time under hypoxia. Therefore, exposure variability can differentially modulate the impacts of sublethal hypoxia, and may impact sea urchin populations and ecosystems via reduced feeding and reproduction. Addressing realistic, multifaceted stressor exposures and multiple biological responses is crucial for understanding climate change impacts on species and ecosystems.
MeSH term(s)	Animals ; Calcification, Physiologic ; Cell Hypoxia ; Climate Change ; Ecosystem ; Food Chain ; Kelp/physiology ; Oxygen/metabolism ; Oxygen Consumption ; Reproduction ; Sea Urchins/cytology ; Sea Urchins/growth & development ; Sea Urchins/physiology
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2020-02-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-59483-5
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Article ; Online: Exploring climate-induced sex-based differences in aquatic and terrestrial ecosystems to mitigate biodiversity loss.

Gissi, Elena / Schiebinger, Londa / Hadly, Elizabeth A / Crowder, Larry B / Santoleri, Rosalia / Micheli, Fiorenza

Nature communications

2023 Volume 14, Issue 1, Page(s) 4787

MeSH term(s)	Ecosystem ; Biodiversity
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40316-8
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Article: Pathogenesis-related protein 10 in resistance to biotic stress: progress in elucidating functions, regulation and modes of action.

Lopes, Natasha Dos Santos / Santos, Ariana Silva / de Novais, Diogo Pereira Silva / Pirovani, Carlos Priminho / Micheli, Fabienne

Frontiers in plant science

2023 Volume 14, Page(s) 1193873

Abstract: Introduction: The Family of pathogenesis-related proteins 10 (PR-10) is widely distributed in the plant kingdom. PR-10 are multifunctional proteins, constitutively expressed in all plant tissues, playing a role in growth and development or being induced ...

Abstract	Introduction: The Family of pathogenesis-related proteins 10 (PR-10) is widely distributed in the plant kingdom. PR-10 are multifunctional proteins, constitutively expressed in all plant tissues, playing a role in growth and development or being induced in stress situations. Several studies have investigated the preponderant role of PR-10 in plant defense against biotic stresses; however, little is known about the mechanisms of action of these proteins. This is the first systematic review conducted to gather information on the subject and to reveal the possible mechanisms of action that PR-10 perform. Methods: Therefore, three databases were used for the article search: PubMed, Web of Science, and Scopus. To avoid bias, a protocol with inclusion and exclusion criteria was prepared. In total, 216 articles related to the proposed objective of this study were selected. Results: The participation of PR-10 was revealed in the plant's defense against several stressor agents such as viruses, bacteria, fungi, oomycetes, nematodes and insects, and studies involving fungi and bacteria were predominant in the selected articles. Studies with combined techniques showed a compilation of relevant information about PR-10 in biotic stress that collaborate with the understanding of the mechanisms of action of these molecules. The up-regulation of PR-10 was predominant under different conditions of biotic stress, in addition to being more expressive in resistant varieties both at the transcriptional and translational level. Discussion: Biological models that have been proposed reveal an intrinsic network of molecular interactions involving the modes of action of PR-10. These include hormonal pathways, transcription factors, physical interactions with effector proteins or pattern recognition receptors and other molecules involved with the plant's defense system. Conclusion: The molecular networks involving PR-10 reveal how the plant's defense response is mediated, either to trigger susceptibility or, based on data systematized in this review, more frequently, to have plant resistance to the disease.
Language	English
Publishing date	2023-07-04
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1193873
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Article: Evaluation of Lumbar Adhesiolysis Using a Radiofrequency Catheter During Epiduroscopy in the Treatment of Failed Back Surgery Syndrome (FBSS).

Gazzeri, Roberto / Tribuzi, Susanna / Leoni, Matteo Luigi Giuseppe / Micheli, Fabrizio / Occhigrossi, Felice

Surgical technology international

2023 Volume 43

Abstract: Failed back surgery syndrome (FBSS) is a complication of spinal surgery that results in severe and disabling back/leg pain. Epiduroscopy is a percutaneous minimally invasive surgical technique used in the treatment of lumbar radicular pain that enables ... ...

Abstract	Failed back surgery syndrome (FBSS) is a complication of spinal surgery that results in severe and disabling back/leg pain. Epiduroscopy is a percutaneous minimally invasive surgical technique used in the treatment of lumbar radicular pain that enables both direct visualization of epidural adhesions in patients with FBSS and the mechanical release of fibrotic scars in the epidural space. Although the use of a balloon catheter during epiduroscopy can usually remove adhesions between the dura and the vertebrae, in the thickest areas of fibrosis, the use of a catheter with a molecular quantum resonance radiofrequency generator may resect hard epidural fibrotic obstructions. The aim of this study was to evaluate the efficacy and safety of this radiofrequency catheter in the treatment of severe epidural fibrotic scars. Ninety-three patients with FBSS were enrolled in this study. In 49 cases, a thick area of fibrosis was visualized during epiduroscopy and the use of a balloon catheter could not remove the fibrotic scars. In all of these cases, we used a molecular quantum resonance radiofrequency catheter to remove dense fibrotic areas. Intraoperatively during epiduroscopy, we could directly visualize lysis of the fibrotic scars. Immediately after the procedure and at 1-month and 6-month follow-up, the patients reported significant pain reduction. Pain reduction and patient satisfaction were also reported at 12 months in all but 5 cases. This study found a clinically relevant reduction of pain at 1 and 6 months after epiduroscopy in patients with FBSS. The use of a radiofrequency catheter is safe and effective in resection of hard and thick epidural scars.
Language	English
Publishing date	2023-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225512-9
ISSN	1090-3941
ISSN	1090-3941
DOI	10.52198/23.STI.43.NS1714
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Article ; Online: Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus.

Vissani, Matteo / Micheli, Federico / Pecchioli, Guido / Ramat, Silvia / Mazzoni, Alberto

Annals of clinical and translational neurology

2022 Volume 9, Issue 4, Page(s) 552–557

Abstract: Impulsive-compulsive behaviors (ICB) are over-represented in Parkinson's disease (PD) patients. Neurons in the ventral subthalamic nucleus (STN) might play a predominant role in the modulation of impulsivity. We characterized the firing regularity of 742 ...

Abstract	Impulsive-compulsive behaviors (ICB) are over-represented in Parkinson's disease (PD) patients. Neurons in the ventral subthalamic nucleus (STN) might play a predominant role in the modulation of impulsivity. We characterized the firing regularity of 742 subthalamic neurons from 24 PD patients (12 ICB+ and 12 ICB-) in an OFF medication state. We computed the firing regularity in the dorsal and ventral STN regions, and we compared their performance in discriminating ICB patients. Regularity of ventral neurons in ICB+ patients is higher and supports a significant discrimination between the two cohorts. These results substantiate a ventral location of neurons involved in impulsivity.
MeSH term(s)	Deep Brain Stimulation ; Humans ; Impulsive Behavior/physiology ; Neurons ; Parkinson Disease/complications ; Subthalamic Nucleus/physiology
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2740696-9
ISSN	2328-9503 ; 2328-9503
ISSN (online)	2328-9503
ISSN	2328-9503
DOI	10.1002/acn3.51530
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Article ; Online: Exploiting multivalency and cooperativity of gold nanoparticles for binding phosphatidylinositol (3,4,5)-trisphosphate at sub-nanomolar concentrations.

Della Sala, Flavio / Ceresara, Elisa / Micheli, Fabrizio / Fontana, Stefano / Prins, Leonard J / Scrimin, Paolo

Organic & biomolecular chemistry

2023 Volume 21, Issue 4, Page(s) 743–747

Abstract: Cationic, monolayer-protected gold nanoparticles provide a multivalent charged surface and a hydrophobic monolayer that synergistically contribute to the binding of phosphatidylinositol (3,4,5)-trisphosphate, a relevant biomarker. The observed ... ...

Abstract	Cationic, monolayer-protected gold nanoparticles provide a multivalent charged surface and a hydrophobic monolayer that synergistically contribute to the binding of phosphatidylinositol (3,4,5)-trisphosphate, a relevant biomarker. The observed dissociation constant is in the picomolar region, providing the possibility of using these gold nanoparticles for the selective extraction of this molecule from biological fluids.
MeSH term(s)	Gold/chemistry ; Metal Nanoparticles/chemistry ; Hydrophobic and Hydrophilic Interactions
Chemical Substances	Gold (7440-57-5)
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob02088b
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