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  1. Article ; Online: Role of tomosynthesis in breast imaging going forward.

    Michell, M J / Batohi, B

    Clinical radiology

    2018  Volume 73, Issue 4, Page(s) 358–371

    Abstract: Digital breast tomosynthesis (DBT) is a modified mammographic technique that overcomes some of the limitations of full-field digital mammography (2DDM) by eliminating the effect of overlapping breast tissue. In the UK, DBT is utilised in both the ... ...

    Abstract Digital breast tomosynthesis (DBT) is a modified mammographic technique that overcomes some of the limitations of full-field digital mammography (2DDM) by eliminating the effect of overlapping breast tissue. In the UK, DBT is utilised in both the symptomatic setting and in breast screening assessment clinics. A literature search was conducted from 2010-2017 to ensure that the most recent developments in DBT technology, clinical applications, and assessment of its usefulness in breast screening were reviewed. Technological advances in DBT include the addition of synthetic 2D mammograms, which are generated from the DBT data set, and the use of DBT to guide vacuum-assisted biopsy and excisions. The units from each vendor vary in several aspects, which are detailed in this article. DBT improves diagnostic accuracy and reader confidence when identifying benign and malignant lesions. It has also been shown to be more accurate than 2DDM in assessing tumour size and in the assessment of multifocal tumours. In the screening setting, retrospective reader studies have shown that the addition of DBT to 2DDM showed equivalent or an improvement in sensitivity and specificity when compared to 2DDM alone. Many of these trials showed an increase in invasive cancer detection and a reduction in recall rates. Large prospective randomised controlled trials conducted in Europe and North America will evaluate effectiveness, practicalities, and cost implications of utilising DBT in routine breast screening practice.
    MeSH term(s) Breast/diagnostic imaging ; Breast Neoplasms/diagnostic imaging ; Early Detection of Cancer/methods ; Early Detection of Cancer/trends ; Female ; Humans ; Mammography/methods ; Mammography/trends ; Sensitivity and Specificity
    Language English
    Publishing date 2018-02-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391227-9
    ISSN 1365-229X ; 0009-9260
    ISSN (online) 1365-229X
    ISSN 0009-9260
    DOI 10.1016/j.crad.2018.01.001
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    Ue I Zs.201: Show issues Location:
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  2. Article ; Online: Breast screening review--a radiologist's perspective.

    Michell, M J

    The British journal of radiology

    2012  Volume 85, Issue 1015, Page(s) 845–847

    Abstract: Recently published articles in the lay press and scientific journals have questioned the value of breast screening, and have raised concerns about both possible harmful effects and the information provided for females when they receive their screening ... ...

    Abstract Recently published articles in the lay press and scientific journals have questioned the value of breast screening, and have raised concerns about both possible harmful effects and the information provided for females when they receive their screening invitation. A review of data from screening trials and the process for providing information for the public on screening has been announced by Professor Sir Mike Richards, National Clinical Director for Cancer. What are the major issues involved and what expectations should radiologists and other members of the screening team have of the review?
    MeSH term(s) Adult ; Age Factors ; Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/prevention & control ; Female ; Health Education/organization & administration ; Humans ; Mammography/adverse effects ; Mammography/methods ; Mass Screening/organization & administration ; Middle Aged ; Physician's Role ; Program Evaluation ; Radiology/standards ; Radiology/trends ; Risk Assessment ; United Kingdom
    Language English
    Publishing date 2012-06-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr/21332901
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  3. Article: Doing it by distance: the option for busy health professionals.

    Michell, M

    Australian nursing journal (July 1993)

    2000  Volume 8, Issue 5, Page(s) 35

    MeSH term(s) Education, Distance/organization & administration ; Education, Nursing, Continuing/organization & administration ; Health Personnel/education ; Humans ; Inservice Training/organization & administration ; Time Factors
    Language English
    Publishing date 2000-11
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1176954-3
    ISSN 1320-3185
    ISSN 1320-3185
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    Zs.A 3921: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Wireless Breast Localization Using Radio-frequency Identification Tags: The First Reported European Experience in Breast Cancer.

    Wazir, Umar / Tayeh, Salim / Perry, Nicholas / Michell, Michael / Malhotra, Anmol / Mokbel, Kefah

    In vivo (Athens, Greece)

    2020  Volume 34, Issue 1, Page(s) 233–238

    Abstract: Background/aim: Wire-guided localisation (WGL) has been the mainstay for localisation of clinically occult breast lesions before excision. However, it has restrictive scheduling requirements, and causes patient discomfort. This has prompted the ... ...

    Abstract Background/aim: Wire-guided localisation (WGL) has been the mainstay for localisation of clinically occult breast lesions before excision. However, it has restrictive scheduling requirements, and causes patient discomfort. This has prompted the development of various wireless alternatives. In this prospective study we shall evaluate the role of radiation-free wireless localisation using a radiofrequency identification (RFID) tag and a hand-held reader (LOCalizer™) in the management of occult breast lesions.
    Patients and methods: This technique was evaluated in a prospective cohort of 10 patients. The evaluation focused on: i) successful deployment, ii) identification and retrieval, iii) the status of surgical margins and need for re-operation, iv) resected specimen weight, v) marker migration rates (>5mm), and vi) acceptance by patients, radiologists and surgeons.
    Results: RFID tags (n=11) were deployed under ultrasound guidance pre-operatively to localise occult breast lesions in 10 patients. The mean time for deployment of the RFID tag was 5.4 min (range=2-20). The mean distance from the lesion was 0.45 mm (range=0-3). The mean duration for retrieval was 10.2 min (range=6-20). Mean specimen weight was 19.6 g for malignant lesions (range=4.5-42). All tags were identified, and none had migrated. There were no positive margins, re-operations, nor complications. Patient feedback was highly positive. Both radiologists and surgeons rated the LOCalizer™ technique as better than WGL.
    Conclusion: Our study demonstrates that wireless localisation using RFID is an effective and time-efficient alternative to WGL, with low margin positivity and re-operation rates, and high patient, radiologist and surgeon acceptance.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/surgery ; Female ; Humans ; Middle Aged ; Prognosis ; Prospective Studies ; Radio Frequency Identification Device/methods ; Wireless Technology/instrumentation
    Language English
    Publishing date 2020-01-13
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.11765
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    Zs.A 2288: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Expanded phenotypic and hematologic abnormalities beyond bone marrow failure in MECOM-associated syndromes.

    Lozano Chinga, Michell M / Bertuch, Alison A / Afify, Zeinab / Dollerschell, Kaylee / Hsu, Joanne I / John, Tami D / Rao, Emily S / Rowe, Robert Grant / Sankaran, Vijay G / Shimamura, Akiko / Williams, David A / Nakano, Taizo A

    American journal of medical genetics. Part A

    2023  Volume 191, Issue 7, Page(s) 1826–1835

    Abstract: The MECOM gene encodes multiple protein isoforms that are essential for hematopoietic stem cell self-renewal and maintenance. Germline MECOM variants have been associated with congenital thrombocytopenia, radioulnar synostosis and bone marrow failure; ... ...

    Abstract The MECOM gene encodes multiple protein isoforms that are essential for hematopoietic stem cell self-renewal and maintenance. Germline MECOM variants have been associated with congenital thrombocytopenia, radioulnar synostosis and bone marrow failure; however, the phenotypic spectrum of MECOM-associated syndromes continues to expand and novel pathogenic variants continue to be identified. We describe eight unrelated patients who add to the previously known phenotypes and genetic defects of MECOM-associated syndromes. As each subject presented with unique MECOM variants, the series failed to demonstrate clear genotype-to-phenotype correlation but may suggest a role for additional modifiers that affect gene expression and subsequent phenotype. Recognition of the expanded hematologic and non-hematologic clinical features allows for rapid molecular diagnosis, early identification of life-threatening complications, and improved genetic counseling for families. A centralized international publicly accessible database to share annotated MECOM variants would advance their clinical interpretation and provide a foundation to perform functional MECOM studies.
    MeSH term(s) Humans ; Bone Marrow Diseases/diagnosis ; Bone Marrow Diseases/genetics ; Syndrome ; Bone Marrow Failure Disorders ; Pancytopenia ; Transcription Factors/genetics ; Hematologic Diseases ; Phenotype ; MDS1 and EVI1 Complex Locus Protein/genetics
    Chemical Substances Transcription Factors ; MECOM protein, human ; MDS1 and EVI1 Complex Locus Protein
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2108614-X
    ISSN 1552-4833 ; 0148-7299 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 0148-7299 ; 1552-4825
    DOI 10.1002/ajmg.a.63208
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    Zs.A 1376/A: Show issues Location:
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  6. Article ; Online: Uncomplicated percutaneous IVC filter removal following implantation time of 6033 days

    Hans Michell, MD / Gregory Johnston, MD / Christopher S Morris, MD

    Radiology Case Reports, Vol 15, Iss 7, Pp 1078-

    2020  Volume 1082

    Abstract: Pulmonary embolism (PE) is a major cause of morbidity and mortality in the United States and usually occurs secondary to venous thromboembolism. Inferior vena cava (IVC) filters are minimally invasive intravascular devices placed in patients who are at ... ...

    Abstract Pulmonary embolism (PE) is a major cause of morbidity and mortality in the United States and usually occurs secondary to venous thromboembolism. Inferior vena cava (IVC) filters are minimally invasive intravascular devices placed in patients who are at increased risk for venous thromboembolism leading to PE, however, has a contraindication to medical anticoagulation therapy. The longest reported case of a retrievable IVC filter has remained in place and successfully removed in a living patient has been 4753 days (13 years). We present a case of an uneventful, successful IVC removal with a dwell time of 6033 days (16 years).
    Keywords IVC ; IVC filter retrieval ; Interventional radiology ; Pulmonary embolism ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  7. Article ; Online: The Use of Magnetic Seeds and Radiofrequency Identifier Tags in Breast Surgery for Non-palpable Lesions.

    Tayeh, Salim / Gera, Ritika / Perry, Nicholas / Michell, Michael / Malhotra, Anmol / Mokbel, Kefah

    Anticancer research

    2019  Volume 40, Issue 1, Page(s) 315–321

    Abstract: Background: Wire-guided localisation (WGL) remains the most widely used technique to guide surgical excision of non-palpable breast lesions worldwide. However, recent technological advances have led to the advent of less invasive radiation-free ... ...

    Abstract Background: Wire-guided localisation (WGL) remains the most widely used technique to guide surgical excision of non-palpable breast lesions worldwide. However, recent technological advances have led to the advent of less invasive radiation-free localisation methods to overcome the limitations of WGL.
    Patients and methods: This study prospectively evaluated the role of two radiation-free non-wire localisation methods. Magnetic seeds (n=16) and radiofrequency tags (n=6) were deployed under imaging guidance to guide the surgical excision in 19 consecutive patients.
    Results: The identification/retrieval and migration rates were 100% and 4.5%, respectively. Twenty-one out of 22 (95.5%) cases had clear surgical margins and no complications were observed. All radiologists and the surgeon rated these methods as being much better than wire localisation. Patient satisfaction data were recorded using a linear visual analogue scale (n=10/19). The mean score was 9.7/10 (range=8-10).
    Conclusion: Our study provides further evidence that radiation-free wireless breast localisation is an effective alternative to WGL.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Humans ; Magnetic Phenomena ; Mastectomy ; Middle Aged ; Radio Frequency Identification Device
    Language English
    Publishing date 2019-12-14
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.13955
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    Zs.A 1642: Show issues Location:
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  8. Article ; Online: Uncomplicated percutaneous IVC filter removal following implantation time of 6033 days

    Hans Michell, MD / Gregory P. Johnston, MD / Christopher S. Morris, MD

    Radiology Case Reports, Vol 15, Iss 9, Pp 1719-

    2020  Volume 1725

    Abstract: Most patients have a time limited indication for inferior vena cava filtration. When the indication has expired, a retrievable inferior vena cava filter should be removed percutaneously, unless the risks of retrieval outweigh the benefits. Over time, ... ...

    Abstract Most patients have a time limited indication for inferior vena cava filtration. When the indication has expired, a retrievable inferior vena cava filter should be removed percutaneously, unless the risks of retrieval outweigh the benefits. Over time, long term indwelling inferior vena cava filters may experience complications, such as strut penetration, migration, thrombosis, tilt, fracture, and inferior vena cava stenosis. Long term indwelling retrievable inferior vena cava filters may become embedded in the wall of the inferior vena cava, making percutaneous retrieval difficult. However, this is not always the case, and they also may be easily and safely removed using simple techniques. We present a case of a long term indwelling retrievable inferior vena cava filter that was easily removed using simple techniques, 16.5 years after placement.
    Keywords Retrievable inferior vena cava filter ; Removal IVC filter ; IVC filter complications ; Gunther-Tulip IVC filter ; IVC filter strut penetration ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Bland embolization of a ruptured hepatoblastoma with massive intraperitoneal hemorrhage

    Nariman Nezami, MD / Hans Michell, MD / Christos Georgiades, MD PHD / Elie Portnoy, MD

    Radiology Case Reports, Vol 15, Iss 11, Pp 2367-

    2020  Volume 2370

    Abstract: Purpose: Hepatoblastoma is the most common primary neoplasm of the liver in the pediatric population, usually diagnosed during the first 5 years of life. Patients with large or peripheral hepatoblastomas are at risk for rupture and peritoneal hemorrhage. ...

    Abstract Purpose: Hepatoblastoma is the most common primary neoplasm of the liver in the pediatric population, usually diagnosed during the first 5 years of life. Patients with large or peripheral hepatoblastomas are at risk for rupture and peritoneal hemorrhage. Image-guided, minimally invasive interventions are offered for controlling hemorrhage. Case presentation: We present a 2-year-old female with an 11.8 cm hepatoblastoma in the right hepatic lobe involving segment 4A, who developed hemodynamic instability on day 8 of induction chemotherapy. Imaging revealed intraperitoneal hemorrhage secondary to her ruptured hepatoblastoma. The patient was successfully treated by celiac artery angiogram and transarterial bland embolization. Conclusion: Transarterial bland embolization of large hepatoblastomas may control and even prevent intraperitoneal/intracapsular hemorrhage, and may also enhance the efficacy of systematic chemotherapy in the pediatric patients with advanced hepatoblastoma.
    Keywords Hepatoblastoma ; Rupture ; Transarterial embolization ; Chemotherapy ; Pediatrics ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Subject code 610
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells.

    Tsata, Vasiliki / Kroehne, Volker / Reinhardt, Susanne / El-Armouche, Ali / Brand, Michael / Wagner, Michael / Reimer, Michell M

    Frontiers in cellular neuroscience

    2019  Volume 13, Page(s) 102

    Abstract: Low remyelination efficiency after spinal cord injury (SCI) is a major restraint to successful axonal and functional regeneration in mammals. In contrast, adult zebrafish can: (i) regenerate oligodendrocytes and myelin sheaths within 2 weeks post lesion; ...

    Abstract Low remyelination efficiency after spinal cord injury (SCI) is a major restraint to successful axonal and functional regeneration in mammals. In contrast, adult zebrafish can: (i) regenerate oligodendrocytes and myelin sheaths within 2 weeks post lesion; (ii) re-grow axonal projections across the lesion site and (iii) recover locomotor function within 6 weeks after spinal cord transection. However, little is known about the intrinsic properties of oligodendrocyte progenitor cells (OPCs), the remyelinating cells of the central nervous system (CNS). Here, we demonstrate that purified OPCs from the adult zebrafish spinal cord are electrically active. They functionally express voltage-gated K
    Language English
    Publishing date 2019-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2019.00102
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