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  1. AU="Michelle Schinkel"
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  1. Article ; Online: The spread of the first introns in proto-eukaryotic paralogs

    Julian Vosseberg / Michelle Schinkel / Sjoerd Gremmen / Berend Snel

    Communications Biology, Vol 5, Iss 1, Pp 1-

    2022  Volume 9

    Abstract: Analysis of ancestral intron positions in two large sets of duplicated gene families suggests that introns may have originated earlier on in eukaryogenesis, before other complex eukaryotic features were established. ...

    Abstract Analysis of ancestral intron positions in two large sets of duplicated gene families suggests that introns may have originated earlier on in eukaryogenesis, before other complex eukaryotic features were established.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Composition and global distribution of the mosquito virome - A comprehensive database of insect-specific viruses

    Jurgen P. Moonen / Michelle Schinkel / Tom van der Most / Pascal Miesen / Ronald P. van Rij

    One Health, Vol 16, Iss , Pp 100490- (2023)

    2023  

    Abstract: Mosquitoes are vectors for emerging and re-emerging infectious viral diseases of humans, livestock and other animals. In addition to these arthropod-borne (arbo)viruses, mosquitoes are host to an array of insect-specific viruses, collectively referred to ...

    Abstract Mosquitoes are vectors for emerging and re-emerging infectious viral diseases of humans, livestock and other animals. In addition to these arthropod-borne (arbo)viruses, mosquitoes are host to an array of insect-specific viruses, collectively referred to as the mosquito virome. Mapping the mosquito virome and understanding if and how its composition modulates arbovirus transmission is critical to understand arboviral disease emergence and outbreak dynamics. In recent years, next-generation sequencing as well as PCR and culture-based methods have been extensively used to identify mosquito-associated viruses, providing insights into virus ecology and evolution. Until now, the large amount of mosquito virome data, specifically those acquired by metagenomic sequencing, has not been comprehensively integrated. We have constructed a searchable database of insect-specific viruses associated with vector mosquitoes from 175 studies, published between October 2000 and February 2022. We identify the most frequently detected and widespread viruses of the Culex, Aedes and Anopheles mosquito genera and report their global distribution. In addition, we highlight the challenges of extracting and integrating published virome data and we propose that a standardized reporting format will facilitate data interpretation and re-use by other scientists. We expect our comprehensive database, summarizing mosquito virome data collected over 20 years, to be a useful resource for future studies.
    Keywords Virome ; Insect-specific viruses ; Mosquito ; Aedes ; Culex ; Anopheles ; Medicine (General) ; R5-920
    Subject code 572
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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