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  1. Article ; Online: Central-line-associated bloodstream infections, multi-drug-resistant bacteraemias and infection control interventions: a 6-year time-series analysis in a tertiary care hospital in Greece.

    Papanikolopoulou, A / Maltezou, H C / Gargalianos-Kakolyris, P / Michou, I / Kalofissoudis, Y / Moussas, N / Pantazis, N / Kotteas, E / Syrigos, K N / Pantos, C / Tountas, Y / Tsakris, A / Kantzanou, M

    The Journal of hospital infection

    2022  Volume 123, Page(s) 27–33

    Abstract: Background: Central-line-associated bloodstream infections (CLABSIs) are serious healthcare-associated infections with substantial morbidity and hospital costs.: Aim: To investigate the association between the incidence of CLABSIs, the implementation ...

    Abstract Background: Central-line-associated bloodstream infections (CLABSIs) are serious healthcare-associated infections with substantial morbidity and hospital costs.
    Aim: To investigate the association between the incidence of CLABSIs, the implementation of specific infection control measures, and the incidence of multi-drug-resistant (MDR) bacteraemias in a tertiary care hospital in Greece from 2013 to 2018.
    Methods: Analysis was applied for the following indices, calculated monthly: CLABSI rate; use of hand hygiene disinfectants; isolation rate of patients with MDR bacteria; and incidence of bacteraemias [total Gram-negative carbapenem-resistant Acinetobacter baumanii, carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Klebsiella pneumoniae; and Gram-positive meticillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci].
    Findings: The total number of bacteraemias from carbapenem-resistant Gram-negative pathogens was significantly correlated with an increased CLABSI rate for all (total) hospital departments [incidence rate ratio (IRR) 1.17, 95% confidence interval (CI) 1.05-1.31, P=0.006] and the adult intensive care unit (ICU) (IRR 1.37, 95% CI 1.07-1.75, P=0.013). In the adult ICU, every increase in the incidence of each resistant Gram-negative pathogen was significantly correlated with a decreased CLABSI rate (carbapenem-resistant A. baumanii: IRR 0.59, 95% CI 0.39-0.90, P=0.015; carbapenem-resistant K. pneumoniae: IRR 0.48, 95% CI 0.25-0.94, P=0.031; carbapenem-resistant P. aeruginosa: IRR 0.54, 95% CI 0.33-0.89, P=0.015). The use of hand disinfectants was correlated with a decreased CLABSI rate 1-3 months before the application of this intervention for all (total) hospital departments (IRR 0.80, 95% CI 0.69-0.93, P=0.005), and for scrub disinfectants in the current month for the adult ICU (IRR 0.34, 95% CI 0.11-1.03, P=0.057). Isolation of patients with MDR pathogens was not associated with the incidence of CLABSIs.
    Conclusion: Hand hygiene was associated with a significant reduction in the incidence of CLABSIs at the study hospital. Time-series analysis is an important tool to evaluate infection control interventions.
    MeSH term(s) Adult ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Bacteremia/prevention & control ; Carbapenems ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/microbiology ; Catheter-Related Infections/prevention & control ; Cross Infection/epidemiology ; Cross Infection/microbiology ; Cross Infection/prevention & control ; Disinfectants ; Greece/epidemiology ; Humans ; Incidence ; Infection Control ; Intensive Care Units ; Klebsiella pneumoniae ; Methicillin-Resistant Staphylococcus aureus ; Tertiary Care Centers
    Chemical Substances Carbapenems ; Disinfectants
    Language English
    Publishing date 2022-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2022.01.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1586: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Molecular investigation of menstrual tissue for the presence of Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis collected by women with a history of infertility.

    Michou, I Vassiliki / Constantoulakis, Pantelis / Makarounis, Kostantinos / Georgoulias, Giorgos / Kapetanios, Vassilis / Tsilivakos, Vassilis

    The journal of obstetrics and gynaecology research

    2014  Volume 40, Issue 1, Page(s) 237–242

    Abstract: Aim: At present, routine laboratory investigation of the infectious agents implicated in female genital infections is mainly based on culture/direct fluorescence antibody (DFA) (immunofluorescence antibody test) results of cervicovaginal secretions. In ... ...

    Abstract Aim: At present, routine laboratory investigation of the infectious agents implicated in female genital infections is mainly based on culture/direct fluorescence antibody (DFA) (immunofluorescence antibody test) results of cervicovaginal secretions. In this study the use of the menstrual tissue is introduced for the molecular detection of pathogens which are implicated in female infertility.
    Material and methods: Cervicovaginal secretions and menstrual tissue samples of 87 women (mean age 34.07 ± 5.17) experiencing infertility problems were screened for Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis presence using polymerase chain reaction (PCR, light cycler-PCR). Cervicovaginal secretions were also tested by the culture/DFA technique. The results were compared using the binomial test.
    Results: In the overall study group, the prevalence of C. trachomatis was 25.3%, 18.3%, and 13.8%, the prevalence of U. urealyticum was 18.3%, 16.09% and 12.6% and the prevalence of M. hominis was 13.7%, 19.5% and 8.0% in the menstrual tissue, cervicovaginal secretions using PCR and cervicovaginal secretions culture/DFA, respectively. A statistically significant difference was revealed between the two methods for all three microbes and between menstrual tissue and cervicovaginal secretions PCR for chlamydia.
    Conclusions: The use of menstrual tissue along with the PCR method seems to be an effective and thus novel alternative for the investigation of the infectious agents lying in the genital tract. One of the main advantages of this technique compared to cervicovaginal secretions is that it is non-invasive and the sample can be collected at home, thus allowing the early detection and treatment of a condition that can otherwise lead to serious consequences, such as tubal obstruction, pelvic inflammatory disease, ectopic pregnancy, spontaneous abortions and unexplained infertility.
    MeSH term(s) Adult ; Cervix Uteri/microbiology ; Cervix Uteri/secretion ; Chlamydia Infections/epidemiology ; Chlamydia Infections/microbiology ; Chlamydia Infections/physiopathology ; Chlamydia trachomatis/classification ; Chlamydia trachomatis/isolation & purification ; Chlamydia trachomatis/metabolism ; DNA, Bacterial/metabolism ; Endometrium/microbiology ; Endometrium/secretion ; Female ; Greece/epidemiology ; Humans ; Infertility, Female/etiology ; Infertility, Female/microbiology ; Menstruation ; Molecular Typing ; Mycoplasma Infections/epidemiology ; Mycoplasma Infections/microbiology ; Mycoplasma Infections/physiopathology ; Mycoplasma hominis/classification ; Mycoplasma hominis/isolation & purification ; Mycoplasma hominis/metabolism ; Polymerase Chain Reaction ; Prevalence ; Reproductive Tract Infections/epidemiology ; Reproductive Tract Infections/microbiology ; Reproductive Tract Infections/physiopathology ; Ureaplasma Infections/epidemiology ; Ureaplasma Infections/microbiology ; Ureaplasma Infections/physiopathology ; Ureaplasma urealyticum/classification ; Ureaplasma urealyticum/isolation & purification ; Ureaplasma urealyticum/metabolism ; Vagina/microbiology ; Vagina/secretion
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2014-01
    Publishing country Australia
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/jog.12165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1810: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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