Article ; Online: MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids.
Cancer research communications
2023 Volume 3, Issue 8, Page(s) 1501–1513
Abstract: Tumor-specific MHC class II (tsMHC-II) expression impacts tumor microenvironmental immunity. tsMHC-II positive cancer cells may act as surrogate antigen-presenting cells and targets for CD4: Significance: Cancer cell expression of MHC class II ... ...
| Abstract | Tumor-specific MHC class II (tsMHC-II) expression impacts tumor microenvironmental immunity. tsMHC-II positive cancer cells may act as surrogate antigen-presenting cells and targets for CD4 Significance: Cancer cell expression of MHC class II significantly impacts tumor microenvironmental immunity. Previous studies investigating mechanisms of repression of IFNγ-inducible class II expression using cell lines demonstrate epigenetic silencing of IFN pathway genes as a frequent immune evasion strategy. Unlike cell lines, patient-derived organoids maintain epigenetic fidelity to tissue of origin. In the first such study, we analyze patterns, dynamics, and epigenetic control of IFNγ-induced class II expression in a series of colorectal cancer organoids. |
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| MeSH term(s) | Humans ; Genes, MHC Class II ; Interferon-gamma/pharmacology ; Methylation ; Cell Line ; Colorectal Neoplasms/genetics |
| Chemical Substances | Interferon-gamma (82115-62-6) |
| Language | English |
| Publishing date | 2023-08-09 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2767-9764 |
| ISSN (online) | 2767-9764 |
| DOI | 10.1158/2767-9764.CRC-23-0091 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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