Article ; Online: Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure-Activity Relationship.
ACS chemical biology
2023 Volume 18, Issue 3, Page(s) 456–464
Abstract: TRPM3 is an ion channel that is highly expressed in nociceptive neurons and plays a key role in pain perception. In the presence of the endogenous TRPM3 ligand, pregnenolone sulfate (PS), the antifungal compound clotrimazole (Clt) augments ... ...
| Abstract | TRPM3 is an ion channel that is highly expressed in nociceptive neurons and plays a key role in pain perception. In the presence of the endogenous TRPM3 ligand, pregnenolone sulfate (PS), the antifungal compound clotrimazole (Clt) augments Ca |
|---|---|
| MeSH term(s) | Humans ; Clotrimazole/pharmacology ; TRPM Cation Channels/metabolism ; Pain ; Structure-Activity Relationship |
| Chemical Substances | Clotrimazole (G07GZ97H65) ; TRPM Cation Channels ; TRPM3 protein, human |
| Language | English |
| Publishing date | 2023-02-10 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 1554-8937 |
| ISSN (online) | 1554-8937 |
| DOI | 10.1021/acschembio.2c00672 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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