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Article ; Online: Radiofrequency thermocoagulation under neuromonitoring guidance and general anesthesia for treatment of refractory trigeminal neuralgia.

Abboud, Tammam / Malinova, Vesna / Rohde, Veit / Mielke, Dorothee

2024 Volume 166, Issue 1, Page(s) 56

Abstract: Objective: Radiofrequency thermocoagulation (RFT) for refractory trigeminal neuralgia is usually performed in awake patients to localize the involved trigeminal branches. It is often a painful experience. Here, we present RFT under neuromonitoring ... ...

Abstract	Objective: Radiofrequency thermocoagulation (RFT) for refractory trigeminal neuralgia is usually performed in awake patients to localize the involved trigeminal branches. It is often a painful experience. Here, we present RFT under neuromonitoring guidance and general anesthesia. Method: Stimulation of trigeminal branches at the foramen ovale with the tip of the RFT cannula is performed under short general anesthesia. Antidromic sensory-evoked potentials (aSEP) are recorded from the 3 trigeminal branches. The cannula is repositioned until the desired branch can be stimulated and lesioned. Conclusion: aSEP enable accurate localization of involved trigeminal branches during RFT and allow performing the procedure under general anesthesia.
MeSH term(s)	Humans ; Trigeminal Neuralgia/surgery ; Electrocoagulation/methods ; Pain ; Radio Waves ; Foramen Ovale ; Treatment Outcome ; Trigeminal Ganglion
Language	English
Publishing date	2024-02-02
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-05964-9
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Article ; Online: Riluzole Reverses a Number of Undesirable Effects of Dexamethasone in Glioblastoma Cells.

Keul, Jonathan / Sperling, Swetlana / Rohde, Veit / Mielke, Dorothee / Ninkovic, Milena

Anticancer research

2024 Volume 44, Issue 5, Page(s) 1829–1835

Abstract: Background/aim: Glioblastoma multiforme (GBM)-induced oedema is a major cause of morbidity and mortality among patients with GBM. Dexamethasone (Dex) is the most common corticosteroid used pre-operatively to control cerebral oedema in patients with GBM. ...

Abstract	Background/aim: Glioblastoma multiforme (GBM)-induced oedema is a major cause of morbidity and mortality among patients with GBM. Dexamethasone (Dex) is the most common corticosteroid used pre-operatively to control cerebral oedema in patients with GBM. Dex is associated with many side effects, and shorter overall survival and progression-free survival of patients with GBM. These negative effects of Dex highlight the need for combinational therapy. Riluzole (Ril), a drug used to treat amyotrophic lateral sclerosis (ALS), is thought to have potential as a treatment for various cancers, with clinical trials underway. Here, we investigated whether Ril could reverse some of the undesirable effects of Dex. Materials and methods: The effect of Dex, Ril, and Ril-Dex treatment on cell migration was monitored using the xCELLigence system. Cell viability assays were performed using 3-(4, 5-dimethylthiazol)-2, 5-diphenyltetrazolium bromide (MTT). The expression of genes involved in migration, glucose metabolism, and stemness was examined using real-time polymerase chain reaction (PCR). Results: Pre-treating GBM cells with Ril reduced Dex-induced cell migration and altered Dex-induced effects on cell invasion, stem cell, and glucose metabolism markers. Furthermore, Ril remained effective in killing GBM cells in combination with Dex. Conclusion: Ril, which acts as an anti-tumorigenic drug, mediates some of the negative effects of Dex; therefore, it could be a potential drug to manage the side effects of Dex therapy in GBM.
MeSH term(s)	Riluzole/pharmacology ; Humans ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Glioblastoma/metabolism ; Dexamethasone/pharmacology ; Cell Movement/drug effects ; Cell Line, Tumor ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Brain Neoplasms/metabolism ; Cell Survival/drug effects
Chemical Substances	Riluzole (7LJ087RS6F) ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2024-04-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16984
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Article ; Online: Early localization of tissue at risk for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: blood distribution on initial imaging vs early CT perfusion.

Malinova, Vesna / Kranawetter, Beate / Tuzi, Sheri / Rohde, Veit / Mielke, Dorothee

Neurosurgical review

2024 Volume 47, Issue 1, Page(s) 223

Abstract: Objective: Delayed cerebral ischemia (DCI) is a potentially reversible adverse event after aneurysmal subarachnoid hemorrhage (aSAH), when early detected and treated. Computer tomography perfusion (CTP) is used to identify the tissue at risk for DCI. In ...

Abstract	Objective: Delayed cerebral ischemia (DCI) is a potentially reversible adverse event after aneurysmal subarachnoid hemorrhage (aSAH), when early detected and treated. Computer tomography perfusion (CTP) is used to identify the tissue at risk for DCI. In this study, the predictive power of early CTP was compared with that of blood distribution on initial CT for localization of tissue at risk for DCI. Methods: A consecutive patient cohort with aSAH treated between 2012 and 2020 was retrospectively analyzed. Blood distribution on CT was semi-quantitatively assessed with the Hijdra-score. The vessel territory with the most surrounding blood and the one with perfusion deficits on CTP performed on day 3 after ictus were considered to be at risk for DCI, respectively. Results: A total of 324 patients were included. Delayed infarction occurred in 17% (56/324) of patients. Early perfusion deficits were detected in 82% (46/56) of patients, 85% (39/46) of them developed infarction within the predicted vessel territory at risk. In 46% (25/56) a vessel territory at risk was reliably determined by the blood distribution. For the prediction of DCI, blood amount/distribution was inferior to CTP. Concerning the identification of "tissue at risk" for DCI, a combination of both methods resulted in an increase of sensitivity to 64%, positive predictive value to 58%, and negative predictive value to 92%. Conclusions: Regarding the DCI-prediction, early CTP was superior to blood amount/distribution, while a consideration of subarachnoid blood distribution may help identify the vessel territories at risk for DCI in patients without early perfusion deficits.
MeSH term(s)	Humans ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/diagnostic imaging ; Male ; Female ; Middle Aged ; Brain Ischemia/etiology ; Aged ; Tomography, X-Ray Computed/methods ; Retrospective Studies ; Adult ; Cerebrovascular Circulation/physiology ; Perfusion Imaging/methods
Language	English
Publishing date	2024-05-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6907-3
ISSN	1437-2320 ; 0344-5607
ISSN (online)	1437-2320
ISSN	0344-5607
DOI	10.1007/s10143-024-02457-2
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Article ; Online: Mini review: Current status and perspective of S100B protein as a biomarker in daily clinical practice for diagnosis and prognosticating of clinical outcome in patients with neurological diseases with focus on acute brain injury.

Abboud, Tammam / Rohde, Veit / Mielke, Dorothee

BMC neuroscience

2023 Volume 24, Issue 1, Page(s) 38

Abstract: Prognosticating the clinical outcome of neurological diseases is essential to guide treatment and facilitate decision-making. It usually depends on clinical and radiological findings. Biomarkers have been suggested to support this process, as they are ... ...

Abstract	Prognosticating the clinical outcome of neurological diseases is essential to guide treatment and facilitate decision-making. It usually depends on clinical and radiological findings. Biomarkers have been suggested to support this process, as they are deemed objective measures and can express the extent of tissue damage or reflect the degree of inflammation. Some of them are specific, and some are not. Few of them, however, reached the stage of daily application in clinical practice. This mini review covers available applications of the S100B protein in prognosticating clinical outcome in patients with various neurological disorders, particularly in those with traumatic brain injury, spontaneous subarachnoid hemorrhage and ischemic stroke. The aim is to provide an understandable picture of the clinical use of the S100B protein and give a brief overview of the current limitations that require future solutions.
MeSH term(s)	Humans ; Prognosis ; Biomarkers ; S100 Calcium Binding Protein beta Subunit/metabolism ; Brain Injuries/diagnosis ; Nervous System Diseases/diagnosis
Chemical Substances	Biomarkers ; S100 Calcium Binding Protein beta Subunit ; S100B protein, human
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2041344-0
ISSN	1471-2202 ; 1471-2202
ISSN (online)	1471-2202
ISSN	1471-2202
DOI	10.1186/s12868-023-00807-2
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Article ; Online: Positioning of epidural electrode for motor cortex stimulation in general anesthesia based on intraoperative electrophysiological monitoring to treat refractory trigeminal neuropathic pain.

Malinova, Vesna / Abboud, Tammam / Rohde, Veit / Mielke, Dorothee

Acta neurochirurgica

2023 Volume 165, Issue 11, Page(s) 3403–3407

Abstract: Background: Motor cortex stimulation (MCS) represents a treatment option for refractory trigeminal neuralgia (TGN). Usually, patients need to be awake during surgery to confirm a correct position of the epidural electrode above the motor cortex, ... ...

Abstract	Background: Motor cortex stimulation (MCS) represents a treatment option for refractory trigeminal neuralgia (TGN). Usually, patients need to be awake during surgery to confirm a correct position of the epidural electrode above the motor cortex, reducing patient's comfort. Method: Epidural cortical mapping (ECM) and motor evoked potentials (MEPs) were intraoperatively performed for correct localization of motor cortex under general anesthesia that provided comparable results to test stimulation after letting the patient to be awake during the operation. Conclusion: Intraoperative ECM and MEPs facilitate a confirmation of correct MCS-electrode position above the motor cortex allowing the MCS-procedure to be performed under general anesthesia.
MeSH term(s)	Humans ; Trigeminal Neuralgia/surgery ; Motor Cortex/surgery ; Motor Cortex/physiology ; Electrodes, Implanted ; Neuralgia/therapy ; Anesthesia, General
Language	English
Publishing date	2023-09-15
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-023-05801-5
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Article ; Online: Optimal cerebral perfusion pressure in aneurysmal subarachnoid hemorrhage and its relation to perfusion deficits on CT-perfusion.

Malinova, Vesna / Kranawetter, Beate / Tuzi, Sheri / Moerer, Onnen / Rohde, Veit / Mielke, Dorothee

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

2024 , Page(s) 271678X241237879

Abstract: Preservation of optimal cerebral perfusion is a crucial part of the acute management after aneurysmal subarachnoid hemorrhage (aSAH). A few studies indicated possible benefits of maintaining a cerebral perfusion pressure (CPP) near the calculated optimal ...

Abstract	Preservation of optimal cerebral perfusion is a crucial part of the acute management after aneurysmal subarachnoid hemorrhage (aSAH). A few studies indicated possible benefits of maintaining a cerebral perfusion pressure (CPP) near the calculated optimal CPP (CPPopt), representing an individually optimal condition at which cerebral autoregulation functions at its best. This retrospective observational monocenter study was conducted to investigate, whether "suboptimal" perfusion with actual CPP deviating from CPPopt correlates with perfusion deficits detected by CT-perfusion (CTP). A consecutive cohort of aSAH-patients was reviewed and patients with available parameters for CPPopt-calculation, who simultaneously received CTP, were analyzed. By plotting the pressure reactivity index (PRx) versus CPP, CPP correlating the lowest PRx value was identified as CPPopt. Perfusion deficits on CTP were documented. In 86 out of 324 patients, the inclusion criteria were met. Perfusion deficits were detected in 47% (40/86) of patients. In 43% of patients, CPP was lower than CPPopt, which correlated with detected perfusion deficits (r = 0.23, p = 0.03). Perfusion deficits were found in 62% of patients with CPP<CPPopt compared to 34% in patients without deviation or CPP>CPPopt (OR 3, p = 0.01). These findings support the hypothesis, that a deviation of CPP from CPPopt is an indicator of suboptimal cerebral perfusion.
Language	English
Publishing date	2024-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	604628-9
ISSN	1559-7016 ; 0271-678X
ISSN (online)	1559-7016
ISSN	0271-678X
DOI	10.1177/0271678X241237879
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Article ; Online: Missing a Blood Blister-Like Aneurysm in the Setting of Aneurysmal Subarachnoid Hemorrhage in a Patient Harboring Multiple Aneurysms.

Kranawetter, Beate / Hazaymeh, Mohammad / Mielke, Dorothee / Rohde, Veit / Abboud, Tammam

Stroke

2023 Volume 54, Issue 9, Page(s) e434–e437

MeSH term(s)	Humans ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/diagnostic imaging ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnostic imaging ; Aneurysm, Ruptured/complications ; Aneurysm, Ruptured/diagnostic imaging ; Cerebral Angiography ; Angiography, Digital Subtraction
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.123.042997
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Article: Mini Review: Impedance Measurement in Neuroscience and Its Prospective Application in the Field of Surgical Neurooncology.

Abboud, Tammam / Mielke, Dorothee / Rohde, Veit

Frontiers in neurology

2022 Volume 12, Page(s) 825012

Abstract: Impedance measurement of human tissue can be performed ... ...

Abstract	Impedance measurement of human tissue can be performed either
Language	English
Publishing date	2022-01-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.825012
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Article ; Online: Randomized controlled trials-a critical re-appraisal.

Mielke, Dorothee / Rohde, Veit

Neurosurgical review

2020 Volume 44, Issue 4, Page(s) 2085–2089

Abstract: Randomized controlled trials (RCTs) are considered to represent the gold standard of scientific studies and paved the way for evidence-based medicine (EBM). Besides the initial aim to improve the quality of patient care, EBM is used in the meanwhile for ... ...

Abstract	Randomized controlled trials (RCTs) are considered to represent the gold standard of scientific studies and paved the way for evidence-based medicine (EBM). Besides the initial aim to improve the quality of patient care, EBM is used in the meanwhile for political and economic decision-making and legal issues as well. A review of the literature was performed, followed by a search using links and references of the detected articles. Additionally, homepages for German institutions of public health were screened. Substantial limitations of RCTs and EBM health care could be identified. Based on the selected literature, 80% of the medical treatments have low evidence. RCTs are expensive and are mainly performed by the industry nowadays. A publication bias for positive results exists. Some RCTs are of low external validity. Many studies have a low fragility index. Nonetheless, negative RCTs could be of benefit for the patients. The results of RCTs, gained in a distinct patient population, are partially generalized. RCTs should be analyzed critically before adopting the results to daily clinical routine. It is not really justified to use RCTs and EBM for political and economic decision-making and legal issues as seen today.
MeSH term(s)	Evidence-Based Medicine ; Humans ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2020-10-06
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	6907-3
ISSN	1437-2320 ; 0344-5607
ISSN (online)	1437-2320
ISSN	0344-5607
DOI	10.1007/s10143-020-01401-4
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Zs.A 1445: Show issues

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Article: Das Schädel-Hirn-Trauma: Wann konservativ, wann operativ therapieren?

Rohde, Veit / Mielke, Dorothee

OP-Journal : wissenschaftliche, klinische und technische Informationen

2020 Volume 36, Issue 1, Page(s) 37–40

Abstract: Das korrekte Management eines Schädel-Hirn-Traumas (SHT) am Unfallort und im Krankenhaus ist eng verknüpft mit einer besseren Prognose. Von großer Bedeutung für die Einschätzung der Schwere des SHT und die sich daraus ableitenden diagnostischen und ... ...

Abstract	Das korrekte Management eines Schädel-Hirn-Traumas (SHT) am Unfallort und im Krankenhaus ist eng verknüpft mit einer besseren Prognose. Von großer Bedeutung für die Einschätzung der Schwere des SHT und die sich daraus ableitenden diagnostischen und therapeutischen Maßnahmen ist die Glasgow-Coma-Skala (GCS).
Keywords	Versorgung ; Traumaschwere ; Therapie
Language	German
Document type	Article
ZDB-ID	1016068-1
ISSN	0178-1715
ISSN	0178-1715
Database	bibnet.org

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