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Article ; Online: Maternal antenatal mental health and its associations with perinatal outcomes and the use of healthcare services in children from the NINFEA birth cohort study.

Bua, Adriana / Moirano, Giovenale / Pizzi, Costanza / Rusconi, Franca / Migliore, Enrica / Richiardi, Lorenzo / Popovic, Maja

European journal of pediatrics

2024

Abstract: To investigate the associations between maternal mental health disorders before and during pregnancy and perinatal outcomes and child healthcare utilization between 6 and 18 months of age. Among the 6814 mother-child pairs from the Italian Internet-based ...

Abstract	To investigate the associations between maternal mental health disorders before and during pregnancy and perinatal outcomes and child healthcare utilization between 6 and 18 months of age. Among the 6814 mother-child pairs from the Italian Internet-based NINFEA birth cohort, maternal depression, anxiety, and sleep disorders diagnosed by a physician before and during pregnancy were assessed through self-reported questionnaires completed during pregnancy and 6 months after delivery. Perinatal outcomes (preterm birth, birth weight, small for gestational age, congenital anomalies, and neonatal intensive care unit (NICU)) and children's healthcare utilization (emergency department (ED) visits, hospitalizations, and outpatient visits) were reported by mothers at 6 and 18 months postpartum. We used regression models adjusted for maternal age, education, parity, country of birth, region of delivery, and household income. Maternal mental health disorders were not associated with perinatal outcomes, except for depression, which increased the risk of offspring admission to NICU, and anxiety disorders during pregnancy, which were associated with preterm birth and lower birth weight. Children born to mothers with depression/anxiety disorders before pregnancy, compared to children of mothers without these disorders, had an increased odds of a visit to ED for any reason (odds ratio (OR
Language	English
Publishing date	2024-04-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-024-05525-3
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Article ; Online: Comment on 'Validation of the diagnosis of mesothelioma and BAP1 protein expression in a cohort of asbestos textile workers from Northern Italy'.

Brentisci, C / Gangemi, M / Migliore, E / Mirabelli, D / Stura, A

Annals of oncology : official journal of the European Society for Medical Oncology

2018 Volume 29, Issue 12, Page(s) 2395–2396

MeSH term(s)	Asbestos ; Humans ; Italy ; Lung Neoplasms ; Mesothelioma ; Textiles ; Tumor Suppressor Proteins ; Ubiquitin Thiolesterase
Chemical Substances	BAP1 protein, human ; Tumor Suppressor Proteins ; Asbestos (1332-21-4) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
Language	English
Publishing date	2018-10-14
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1093/annonc/mdy463
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Zs.A 2862: Show issues

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Article ; Online: Effect of carbonaceous fillers on adsorption behavior of multifunctional diatomite-based foams for wastewater treatment.

Galzerano, B / Aprea, P / Verdolotti, L / Salzano de Luna, M / Ascione, C / Caputo, D / Lavorgna, M / Migliore, E / Liguori, B

Chemosphere

2021 Volume 281, Page(s) 130999

Abstract: Nowadays the study of the potential applications of multifunctional materials for environmental remediation is one of the main goals of the materials engineering. Multifunctional porous materials, MPMs, incorporate, all in once, different and multiple ... ...

Abstract	Nowadays the study of the potential applications of multifunctional materials for environmental remediation is one of the main goals of the materials engineering. Multifunctional porous materials, MPMs, incorporate, all in once, different and multiple functionalities that make them suitable for several uses and can satisfy many purposes at the same time. Multifunctional diatomite-based foams with a hierarchical porosity, already produced and characterized to be applied in building as well as aerospace sectors, are proposed as adsorbents for inorganic and organic pollutants removal from wastewaters. Then, the effect of the addition of different carbonaceous nanofillers (graphite, graphene and graphene oxide) on the water purification efficiency of the adsorbent was evaluated. Firstly, pristine MPM showed the best performance in adsorbing Indigo Carmine due to its intrinsic chemism and hierarchical porosity (at macro-, micro- and nano-level), but it is not the best with respect to the Cd
MeSH term(s)	Adsorption ; Diatomaceous Earth ; Graphite ; Nanocomposites ; Water Pollutants, Chemical/analysis ; Water Purification
Chemical Substances	Water Pollutants, Chemical ; Diatomaceous Earth (61790-53-2) ; diatomite (68855-54-9) ; Graphite (7782-42-5)
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.130999
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Zs.A 2540: Show issues

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Article ; Online: Loneliness that destroys and upsets: A lesson from and beyond COVID-19.

Bracco, Christian / Melchio, Remo / Migliore, Elena / Marrale, Chiara / Fenoglio, Luigi

European journal of internal medicine

2021 Volume 88, Page(s) 125

Language	English
Publishing date	2021-03-14
Publishing country	Netherlands
Document type	Letter ; Comment
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2021.03.003
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Zs.A 2608: Show issues

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Article ; Online: Immune-related thyroid dysfunctions during anti PD-1/PD-L1 inhibitors: new evidence from a single centre experience.

Nervo, Alice / Ferrari, Matteo / Gruosso, Giovanni / Migliore, Enrica / Basile, Sara / D'Angelo, Valentina / Roux, Anna / Piovesan, Alessandro / Arvat, Emanuela

Clinical and experimental medicine

2023 Volume 23, Issue 8, Page(s) 4817–4824

Abstract: The role of anti-thyroid peroxidase antibodies (anti-TPO Abs) in the development of abnormal thyroid function tests (DYSTHYR) during treatment with immune checkpoint inhibitors (ICIs) is not fully understood; moreover, controversial data exist about the ... ...

Abstract	The role of anti-thyroid peroxidase antibodies (anti-TPO Abs) in the development of abnormal thyroid function tests (DYSTHYR) during treatment with immune checkpoint inhibitors (ICIs) is not fully understood; moreover, controversial data exist about the relationship between ICI-related thyroid dysfunction (TD) and survival. We retrospectively analyzed the onset or the worsening of DYSTHYR in patients treated with programmed cell death protein-1 (PD-1) or its ligand (PD-L1) inhibitors between 2017 and 2020. In patients without previous TD, we focused on the association between baseline anti-TPO Abs level and DYSTHYR. Furthermore, the relationship between DYSTHYR and progression-free survival (PFS) or overall survival (OS) was explored. We included 324 patients treated with anti PD-1 (95.4%) or anti PD-L1 inhibitors. After a median of 3.3 months, DYSTHYR was registered in 24.7%, mostly hypothyroidism alone (17%). Patients with pre-existing TD (14.5% of the sample) were at higher risk of DYSTHYR compared to patients without previous TD (adjusted OR 2.44; 95% IC 1.26-4.74). In patients without known previous TD, high anti-TPO Abs level, even below the positivity cut-off, was a risk factor for developing DYSTHYR (adjusted OR 5.52; 95% IC 1.47-20.74). DYSTHYR was associated with a longer 12-month OS (87.3% vs 73.5%, p = 0.03); no statistically significant difference in terms of PFS was observed between the DYSTHYR+ and DYSTHYR- group. DYSTHYR is common during anti PD-1/anti PD-L1 treatment, especially in patients with pre-existing TD. In subjects without known previous TD, high anti-TPO Abs level at baseline can be a predictive biomarker of DYSTHYR. An improved OS is observed in patients with anti PD-1/anti PD-L1-induced DYSTHYR.
MeSH term(s)	Humans ; Thyroid Gland ; Immune Checkpoint Inhibitors/adverse effects ; Retrospective Studies ; B7-H1 Antigen ; Immune System Diseases ; Risk Factors ; Lung Neoplasms
Chemical Substances	Immune Checkpoint Inhibitors ; B7-H1 Antigen
Language	English
Publishing date	2023-04-27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-023-01082-5
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Zs.A 5481: Show issues

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Article: Quality of Life during Treatment with Lenvatinib for Thyroid Cancer: The Patients' Perspective beyond the Medical Evaluation.

Nervo, Alice / Ragni, Alberto / Piovesan, Alessandro / Marica, Valentina / Migliore, Enrica / Gallo, Marco / Arvat, Emanuela

European thyroid journal

2020 Volume 10, Issue 1, Page(s) 65–71

Abstract: Background: Lenvatinib (LEN) has shown great efficacy but important toxicity in patients with advanced radioactive iodine-refractory (RAI-R) thyroid cancer (TC); a focused evaluation of its impact on patients' quality of life (QoL) is still lacking. Our ...

Abstract	Background: Lenvatinib (LEN) has shown great efficacy but important toxicity in patients with advanced radioactive iodine-refractory (RAI-R) thyroid cancer (TC); a focused evaluation of its impact on patients' quality of life (QoL) is still lacking. Our prospective study investigated the impact of this drug on QoL in a group of RAI-R TC patients treated at our centre. Methods: All patients filled in two questionnaires before and during treatment: (1) the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events adapted questionnaire, assessing prevalence, severity, and/or interference on daily activities of the most frequent symptomatic adverse events (AEs) reported in previous clinical trials during therapy with LEN, and (2) the European Quality of Life 5 Dimensions 3 Levels (EQ-5D-3L) questionnaire, providing the EQ-5D index and the EQ visual analogue scale (EQ-VAS). Data from baseline questionnaires were compared with those obtained 3, 6, and 12 months after the start of treatment. Results: In our population ( Conclusion: RAI-R TC patients reported a general increase in prevalence and interference on daily activities of symptomatic AEs during therapy with LEN. Self-perceived QoL initially decreased during therapy. However, our data suggest that QoL could be restored after 12 months; this trend might partly reflect the impact of therapy optimisation.
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2659767-6
ISSN	2235-0802 ; 2235-0640
ISSN (online)	2235-0802
ISSN	2235-0640
DOI	10.1159/000508186
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Article ; Online: Prediction of Early and Long-Term Hospital Readmission in Patients with Severe Obesity: A Retrospective Cohort Study.

Bioletto, Fabio / Evangelista, Andrea / Ciccone, Giovannino / Brunani, Amelia / Ponzo, Valentina / Migliore, Enrica / Pagano, Eva / Comazzi, Isabella / Merlo, Fabio Dario / Rahimi, Farnaz / Ghigo, Ezio / Bo, Simona

Nutrients

2023 Volume 15, Issue 16

Abstract: Adults with obesity have a higher risk of hospitalization and high hospitalization-related healthcare costs. However, a predictive model for the risk of readmission in patients with severe obesity is lacking. We conducted a retrospective cohort study ... ...

Abstract	Adults with obesity have a higher risk of hospitalization and high hospitalization-related healthcare costs. However, a predictive model for the risk of readmission in patients with severe obesity is lacking. We conducted a retrospective cohort study enrolling all patients admitted for severe obesity (BMI ≥ 40 kg/m
MeSH term(s)	Adult ; Humans ; Obesity, Morbid/complications ; Patient Readmission ; Retrospective Studies ; Obesity/complications ; Obesity/epidemiology ; Hospitalization
Language	English
Publishing date	2023-08-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15163648
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Article ; Online: Cartilage oligomeric matrix protein responses to a mechanical stimulus associate with ambulatory loading in individuals with anterior cruciate ligament reconstruction.

Erhart-Hledik, Jennifer C / Titchenal, Matthew R / Migliore, Eleonora / Asay, Jessica L / Andriacchi, Thomas P / Chu, Constance R

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

2021 Volume 40, Issue 4, Page(s) 791–798

Abstract: Mechanical factors have been implicated in the development of osteoarthritis after anterior cruciate ligament (ACL) reconstruction. This study tested for associations between ambulatory joint loading (total joint moment [TJM] and vertical ground reaction ...

Abstract	Mechanical factors have been implicated in the development of osteoarthritis after anterior cruciate ligament (ACL) reconstruction. This study tested for associations between ambulatory joint loading (total joint moment [TJM] and vertical ground reaction force [vGRF]) and changes in serum levels of cartilage oligomeric matrix protein (COMP) in response to a mechanical stimulus (30-min walk) in individuals with ACL reconstruction. Twenty-five subjects (mean age: 34.5 ± 9.8 years; 2.2 ± 0.2 years post-surgery) with primary unilateral ACL reconstruction underwent gait analysis for assessment of peak vGRF and TJM first (TJM1) and second (TJM2) peaks. Serum COMP concentrations were measured by enzyme-linked immunosorbent assay immediately before, 3.5 h, and 5.5 h after a 30-min walk. Pearson correlation coefficients and backward stepwise multiple linear regression analysis, with adjustments for age, sex, body mass index, and between-limb speed difference, assessed associations between changes in COMP and between-limb differences in joint loading parameters. Greater TJM1 (R = 0.542, p = 0.005), TJM2 (R = 0.460, p = 0.021), and vGRF (R = 0.577, p = 0.003) in the ACL-reconstructed limb as compared to the contralateral limb were associated with higher COMP values 3.5 h following the 30-min walk. Change in COMP at 5.5 h became a significant predictor of the between-limb difference in TJM1 and vGRF in multivariate analyses after accounting for the between-limb speed difference. These results demonstrate that higher TJM and vGRF in the ACLR limb as compared to the contralateral limb are associated with higher relative COMP levels 3.5 and 5.5 h after a 30-min walk. Future work should investigate the effect of therapies to alter joint loading on the biological response in individuals after ACL reconstruction.
MeSH term(s)	Adult ; Anterior Cruciate Ligament Injuries/surgery ; Anterior Cruciate Ligament Reconstruction/rehabilitation ; Antibodies, Monoclonal, Humanized ; Biomechanical Phenomena ; Cartilage Oligomeric Matrix Protein/metabolism ; Gait/physiology ; Humans ; Knee Joint/physiology ; Walking/physiology ; Young Adult
Chemical Substances	Antibodies, Monoclonal, Humanized ; Cartilage Oligomeric Matrix Protein
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	605542-4
ISSN	1554-527X ; 0736-0266
ISSN (online)	1554-527X
ISSN	0736-0266
DOI	10.1002/jor.25121
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Article: Cutaneous myiasis in a geriatric patient.

Dutto, M / Pomero, F / Migliore, E / Fenoglio, L

Parassitologia

2010 Volume 52, Issue 3-4, Page(s) 435–438

Abstract: Cutaneous myiasis in humans involving fly species endemic in Italy are uncommon and are not often present in the literature. In the present article we describe the case of cutaneous myiasis in a woman brought to the Emergency Department (ED) of the S. ... ...

Abstract	Cutaneous myiasis in humans involving fly species endemic in Italy are uncommon and are not often present in the literature. In the present article we describe the case of cutaneous myiasis in a woman brought to the Emergency Department (ED) of the S. Croce e Carle General Hospital in Cuneo, northwest Italy. The patient was in precarious hygienic condition, and was suffering from localized ulcerated foot ulcers with significant inflammation extending up to the knee. Fly larvae, subsequently identified as Lucilia sericata (Meigen, 1826), were found in the lesions. The patient was admitted to the Department of Internal Medicine where she was treated with antibiotics and the lesions were medicated, resulting in full recovery.
MeSH term(s)	Aged ; Animals ; Anti-Bacterial Agents/therapeutic use ; Diptera/growth & development ; Elder Abuse ; Female ; Humans ; Hygiene ; Italy ; Leg Ulcer/parasitology ; Malnutrition/complications ; Myiasis/parasitology ; Myiasis/prevention & control ; Myiasis/therapy ; Risk Factors ; Shoes ; Therapeutic Irrigation ; Venous Insufficiency/complications
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2010-12
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	412310-4
ISSN	0048-2951
ISSN	0048-2951
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Article: Effect of Bariatric Surgery on Survival and Hospitalizations in Patients with Severe Obesity. A Retrospective Cohort Study

Migliore, Enrica / Brunani, Amelia / Ciccone, Giovannino / Pagano, Eva / Arolfo, Simone / Rosso, Tiziana / Pellegrini, Marianna / Capodaglio, Paolo / Morino, Mario / Ghigo, Ezio / Bo, Simona

Nutrients. 2021 Sept. 09, v. 13, no. 9

2021

Abstract: Bariatric surgery (BS) confers a survival benefit in specific subsets of patients with severe obesity; otherwise, effects on hospital admissions are still uncertain. We assessed the long-term effect on mortality and on hospitalization of BS in patients ... ...

Abstract	Bariatric surgery (BS) confers a survival benefit in specific subsets of patients with severe obesity; otherwise, effects on hospital admissions are still uncertain. We assessed the long-term effect on mortality and on hospitalization of BS in patients with severe obesity. This was a retrospective cohort study, including all patients residing in Piedmont (age 18–60 years, BMI ≥ 40 kg/m²) admitted during 2002–2018 to the Istituto Auxologico Italiano. Adjusted hazard ratios (HR) for BS were estimated for mortality and hospitalization, considering surgery as a time-varying variable. Out of 2285 patients, 331 (14.5%) underwent BS; 64.4% received sleeve gastrectomy (SG), 18.7% Roux-en-Y gastric bypass (RYGB), and 16.9% adjustable gastric banding (AGB). After 10-year follow-up, 10 (3%) and 233 (12%) patients from BS and non-BS groups died, respectively (HR = 0.52; 95% CI 0.27–0.98, by a multivariable Cox proportional-hazards regression model). In patients undergoing SG or RYGB, the hospitalization probability decreased significantly in the after-BS group (HR = 0.77; 0.68–0.88 and HR = 0.78; 0.63–0.98, respectively) compared to non-BS group. When comparing hospitalization risk in the BS group only, a marked reduction after surgery was found for all BS types. In conclusion, BS significantly reduced the risk of all-cause mortality and hospitalization after 10-year follow-up.
Keywords	bariatric surgery ; cohort studies ; hospitals ; long term effects ; mortality ; obesity ; piedmont ; regression analysis ; risk
Language	English
Dates of publication	2021-0909
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13093150
Database	NAL-Catalogue (AGRICOLA)

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