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  1. Article ; Online: Les vésicules extracellulaires - Un maillon essentiel du système immunitaire.

    Bosch, Steffi / Mignot, Grégoire

    Medecine sciences : M/S

    2021  Volume 37, Issue 12, Page(s) 1139–1145

    Abstract: Regulation of immune responses was among the first functions of extracellular vesicles to be identified, more than twenty years ago. What exactly defines the outcome of an immune response remains a challenging issue. Owing to their reduced size, ... ...

    Title translation Extracellular vesicles are players of the immune continuum.
    Abstract Regulation of immune responses was among the first functions of extracellular vesicles to be identified, more than twenty years ago. What exactly defines the outcome of an immune response remains a challenging issue. Owing to their reduced size, extracellular vesicles easily diffuse in interstitial and lymphatic fluids, where they can interact with the multiple effectors of the immune system. By accelerating and amplifying immune interactions, these ultra-mobile units may contribute to local and systemic coordination for efficient adaption to external and internal changes. Here we introduce the related ground-breaking studies of extracellular vesicle-mediated immune effects and present ongoing considerations on their potential roles in health and the development of immune disorders.
    MeSH term(s) Extracellular Vesicles ; Humans
    Language French
    Publishing date 2021-12-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ocular Leishmaniasis - A systematic review.

    Mignot, Guillaume / Bhattacharya, Yagnaseni / Reddy, Aravind

    Indian journal of ophthalmology

    2021  Volume 69, Issue 5, Page(s) 1052–1060

    Abstract: The incidence of leishmaniasis is reported to be up to 1 million per year. To date, there has been no comprehensive review describing the diversity of clinical presentations of ocular leishmaniasis (OL) and its treatment. This systematic review aims to ... ...

    Abstract The incidence of leishmaniasis is reported to be up to 1 million per year. To date, there has been no comprehensive review describing the diversity of clinical presentations of ocular leishmaniasis (OL) and its treatment. This systematic review aims to address this knowledge gap and provide a summary of the clinical presentation, natural course, and treatment options for OL. Our study identified a total of 57 published articles as describing cases of OL involving: adnexa (n = 26), orbit (n = 1), retina (n = 7), uvea (n = 18) and cornea (n = 6). Though well described and easily treated, palpebral leishmaniasis is often misdiagnosed and may lead to chronic issues if untreated. The retinal manifestations of Leishmaniasis consist of self-resolving hemorrhages secondary to thrombocytopenia. Two main uveitis etiologies have been identified: uveitis in the context of active Leishmanial infection (associated with immunosuppression) and uveitis occurring as an immune reconstitution syndrome. Corneal involvement in most geographic areas generally follows an aggressive course, most often ending in corneal perforation if left untreated. In the Americas, a chronic indolent interstitial keratitis may also occur. Topical steroids are of little use in keratitis (systemic antileishmanials being the cornerstone of treatment). However, these are essential in cases of uveitis, with or without concomitant systemic antileishmanial therapy. In conclusion, though ocular involvement in Leishmaniasis is rare, severe sight-threatening consequences follow if left untreated. Early diagnosis, enthusiastic follow-up and aggressive treatment are essential for good outcomes.
    MeSH term(s) Cornea ; Corneal Perforation ; Humans ; Keratitis ; Leishmaniasis ; Uveitis
    Language English
    Publishing date 2021-04-29
    Publishing country India
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_2232_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Epigenetic Mechanisms in Immune Disease: The Significance of Toll-Like Receptor-Binding Extracellular Vesicle-Encapsulated microRNA.

    Bosch, Steffi / Young, Nicholas A / Mignot, Grégoire / Bach, Jean-Marie

    Frontiers in genetics

    2020  Volume 11, Page(s) 578335

    Language English
    Publishing date 2020-10-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.578335
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  4. Article: Drug trials in epilepsy.

    Mignot, G

    BMJ (Clinical research ed.)

    1996  Volume 313, Issue 7066, Page(s) 1158

    MeSH term(s) Anticonvulsants/therapeutic use ; Drug Evaluation ; Epilepsy/drug therapy ; Humans
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 1996-11-09
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8138 ; 0959-8154 ; 0959-8146 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.313.7066.1158
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  5. Article ; Online: Pathogen exposure influences immune parameters around weaning in pigs reared in commercial farms.

    Hervé, Julie / Haurogné, Karine / Buchet, Arnaud / Bacou, Elodie / Mignot, Grégoire / Allard, Marie / Leblanc-Maridor, Mily / Gavaud, Solenn / Lehébel, Anne / Terenina, Elena / Mormède, Pierre / Merlot, Elodie / Belloc, Catherine / Bach, Jean-Marie / Lieubeau, Blandine

    BMC immunology

    2022  Volume 23, Issue 1, Page(s) 61

    Abstract: Background: Multiple antigenic stimulations are crucial to immune system training during early post-natal life. These stimulations can be either due to commensals, which accounts for the acquisition and maintenance of tolerance, or to pathogens, which ... ...

    Abstract Background: Multiple antigenic stimulations are crucial to immune system training during early post-natal life. These stimulations can be either due to commensals, which accounts for the acquisition and maintenance of tolerance, or to pathogens, which triggers immunity. In pig, only few works previously explored the influence of natural exposition to pathogens upon immune competence. We propose herein the results of a multicentric, field study, conducted on 265 piglets exposed to contrasted pathogen levels in their living environment. Piglets were housed in 15 different commercial farms, sorted in two groups, low (HS
    Results: Using animal-based measures, we compared the immune competence and growth performances of HS
    Conclusions: Altogether, our data, obtained in field conditions, provide evidence that early exposure to pathogens shapes the immune competence of piglets. They also document the negative impact of an overstimulation of the immune system on piglets' growth.
    Language English
    Publishing date 2022-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041500-X
    ISSN 1471-2172 ; 1471-2172
    ISSN (online) 1471-2172
    ISSN 1471-2172
    DOI 10.1186/s12865-022-00534-z
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  6. Article ; Online: International nonproprietary names for monoclonal antibodies: an evolving nomenclature system.

    Guimaraes Koch, Sofia S / Thorpe, Robin / Kawasaki, Nana / Lefranc, Marie-Paule / Malan, Sarel / Martin, Andrew C R / Mignot, Gilles / Plückthun, Andreas / Rizzi, Menico / Shubat, Stephanie / Weisser, Karin / Balocco, Raffaella

    mAbs

    2022  Volume 14, Issue 1, Page(s) 2075078

    Abstract: Appropriate nomenclature for all pharmaceutical substances is important for clinical development, licensing, prescribing, pharmacovigilance, and identification of counterfeits. Nonproprietary names that are unique and globally recognized for all ... ...

    Abstract Appropriate nomenclature for all pharmaceutical substances is important for clinical development, licensing, prescribing, pharmacovigilance, and identification of counterfeits. Nonproprietary names that are unique and globally recognized for all pharmaceutical substances are assigned by the International Nonproprietary Names (INN) Programme of the World Health Organization (WHO). In 1991, the INN Programme implemented the first nomenclature scheme for monoclonal antibodies. To accompany biotechnological development, this nomenclature scheme has evolved over the years; however, since the scheme was introduced, all pharmacological substances that contained an immunoglobulin variable domain were coined with the stem -
    MeSH term(s) Antibodies, Monoclonal ; Pharmaceutical Preparations ; World Health Organization
    Chemical Substances Antibodies, Monoclonal ; Pharmaceutical Preparations
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2537838-7
    ISSN 1942-0870 ; 1942-0870
    ISSN (online) 1942-0870
    ISSN 1942-0870
    DOI 10.1080/19420862.2022.2075078
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  7. Article: Neuroleptiques et akathisie.

    Mignot, G

    Therapie

    1987  Volume 42, Issue 1, Page(s) 45–50

    Title translation Neuroleptics and akathisia.
    MeSH term(s) Akathisia, Drug-Induced ; Antipsychotic Agents/adverse effects ; Humans
    Chemical Substances Antipsychotic Agents
    Language French
    Publishing date 1987-01
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
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  8. Article: Le syndrome malin des neuroleptiques.

    Mignot, G

    Therapie

    1986  Volume 41, Issue 1, Page(s) 63–67

    Title translation Neuroleptic malignant syndrome.
    MeSH term(s) Antipsychotic Agents/administration & dosage ; Antipsychotic Agents/adverse effects ; Drug Interactions ; Humans ; Neuroleptic Malignant Syndrome/diagnosis ; Neuroleptic Malignant Syndrome/drug therapy ; Neuroleptic Malignant Syndrome/physiopathology ; Risk
    Chemical Substances Antipsychotic Agents
    Language French
    Publishing date 1986-01
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 603474-3
    ISSN 1958-5578 ; 0040-5957
    ISSN (online) 1958-5578
    ISSN 0040-5957
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  9. Article ; Online: Human FOXP3 and cancer.

    Martin, F / Ladoire, S / Mignot, G / Apetoh, L / Ghiringhelli, F

    Oncogene

    2010  Volume 29, Issue 29, Page(s) 4121–4129

    Abstract: FOXP3 is a transcription factor necessary and sufficient for induction of the immunosuppressive functions in regulatory T lymphocytes. Its expression was first considered as specific of this cell type, but FOXP3 can also be transiently expressed in T- ... ...

    Abstract FOXP3 is a transcription factor necessary and sufficient for induction of the immunosuppressive functions in regulatory T lymphocytes. Its expression was first considered as specific of this cell type, but FOXP3 can also be transiently expressed in T-cell antigen receptor-activated human nonregulatory T cells. Recent data indicate that FOXP3 is also expressed by some nonlymphoid cells, in which it can repress various oncogenes that are restored following FOXP3 deletion or mutation. This review summarizes major advances in (1) the understanding of Foxp3 functions in human regulatory T cells, (2) the prognostic significance of Foxp3-expressing T cells in human malignancies and (3) the significance of Foxp3 expression in human tumor cells.
    MeSH term(s) DNA Damage ; Epigenesis, Genetic ; Forkhead Transcription Factors/analysis ; Forkhead Transcription Factors/chemistry ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/physiology ; Gene Expression Regulation ; Genes, Tumor Suppressor ; Humans ; Neoplasms/etiology ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; Prognosis ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances FOXP3 protein, human ; Forkhead Transcription Factors
    Language English
    Publishing date 2010-07-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/onc.2010.174
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  10. Article ; Online: Optimization of an O

    Mouré, Anne / Bekir, Sawsen / Bacou, Elodie / Pruvost, Quentin / Haurogné, Karine / Allard, Marie / De Beaurepaire, Laurence / Bosch, Steffi / Riochet, David / Gauthier, Olivier / Blancho, Gilles / Soulillou, Jean-Paul / Poncelet, Denis / Mignot, Grégoire / Courcoux, Philippe / Jegou, Dominique / Bach, Jean-Marie / Mosser, Mathilde

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 4681

    Abstract: A bioartificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes therapy. However, the main limitation of this approach is ... ...

    Abstract A bioartificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes therapy. However, the main limitation of this approach is O
    MeSH term(s) Diabetes Mellitus, Type 1/therapy ; Humans ; Hypoxia ; Islets of Langerhans/physiology ; Islets of Langerhans Transplantation/methods ; Pancreas/physiology ; Pancreas, Artificial
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07887-w
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